Other Species / Isoforms
  MCL1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K5-m1
___MFGLkRNAVIGL
0 1
MCL1 (human) ___MFGLkRNAVIGL K5-m1
MCL1 iso2 (human) ___MFGLKRNAVIGL K5
MCL1 (mouse) ___MFGLRRNAVIGL R5
MCL1 (rat) ___MFGLRRNAVIGL R5
K5-ub
___MFGLkRNAVIGL
0 1
MCL1 (human) ___MFGLkRNAVIGL K5-ub
MCL1 iso2 (human) ___MFGLKRNAVIGL K5
MCL1 (mouse) ___MFGLRRNAVIGL R5
MCL1 (rat) ___MFGLRRNAVIGL R5
K40-ac
GRLLATEkEASARRE
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
MCL1 (human) GRLLATEkEASARRE K40-ac
MCL1 iso2 (human) GRLLATEKEASARRE K40
MCL1 (mouse) AGARLVAEEAkARRE E36
MCL1 (rat) AGTRLAAEEAKARRE E36
K40-ub
GRLLATEkEASARRE
Upstream
Downstream
2 48
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • apoptosis, inhibited
Treatment
  • siRNA
MCL1 (human) GRLLATEkEASARRE K40-ub
MCL1 iso2 (human) GRLLATEKEASARRE K40
MCL1 (mouse) AGARLVAEEAkARRE E36
MCL1 (rat) AGTRLAAEEAKARRE E36
S43
LATEkEASARREIGG
0 1
MCL1 (human) LATEkEASARREIGG S43
MCL1 iso2 (human) LATEKEASARREIGG S43
MCL1 (mouse) RLVAEEAkARREGGG K39-ub
MCL1 (rat) RLAAEEAKARREGGG K39
S64-p
IGGSAGAsPPStLtP
Upstream
Downstream
8 5
MCL1 (human)
S64-p
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • JNK1 (human)
  • mTOR (human)
Putative in vivo kinases:
  • CDK2 (human)
  • mTOR (human)
Regulatory protein:
  • NOXA (human)
Treatment
  • aphidicolin
  • AZD8055
  • Cdk2/5_inhibitor
  • cisplatin
  • GSK-3_inhibitor_X
  • nocodazole
  • olomoucine
  • PD98059
  • purvalanol
  • SB203580
  • seliciclib
  • SP600125
  • SU9516
  • TRAIL
  • U0126
  • vinblastine
MCL1 (human) IGGSAGAsPPStLtP S64-p
MCL1 iso2 (human) IGGSAGASPPSTLTP S64
MCL1 (mouse) gap -
MCL1 (rat) gap -
T68-p
AGAsPPStLtPDSRR
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein stabilization
Treatment
  • vinblastine
MCL1 (human) AGAsPPStLtPDSRR T68-p
MCL1 iso2 (human) AGASPPSTLTPDSRR T68
MCL1 (mouse) gap -
MCL1 (rat) gap -
T70-p
AsPPStLtPDSRRVA
Upstream
Downstream
2 0
Effects on Modified Protein
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • CDK2 (human)
Putative in vivo kinases:
  • CDK2 (human)
Regulatory protein:
  • NOXA (human)
Treatment
  • vinblastine
MCL1 (human) AsPPStLtPDSRRVA T70-p
MCL1 iso2 (human) ASPPSTLTPDSRRVA T70
MCL1 (mouse) GGGEAALLPGARVVA L51
MCL1 (rat) GGGEAALLPGARVVA L51
T92-p
EVPDVTAtPARLLFF
Upstream
Downstream
7 5
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, altered
Kinase, in vitro:
  • CDK1 (human)
  • CDK5 (human)
  • ERK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
  • CDK2 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • CGP74514A
  • nocodazole
  • purvalanol
  • SB203580
  • seliciclib
  • SP600125
  • U0126
  • vinblastine
MCL1 (human) EVPDVTAtPARLLFF T92-p
MCL1 iso2 (human) EVPDVTATPARLLFF T92
MCL1 (mouse) EDPDVTASAERRLHK S73
MCL1 (rat) EDPDVTASAERRLLK S73
S121-p
PAADAIMsPEEELDG
Upstream
Downstream
7 4
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • CDK2 (human)
  • JNK1 (human)
Regulatory protein:
  • MKK4 (human)
  • P38A (human)
Treatment
  • H2O2
  • nocodazole
  • SB203580
  • vinblastine
MCL1 (human) PAADAIMsPEEELDG S121-p
MCL1 iso2 (human) PAADAIMSPEEELDG S121
MCL1 (mouse) SAAAAIVsPEEELDG S102-p
MCL1 (rat) ASAAAIMSPEEELDG S101
Y129-p
PEEELDGyEPEPLGk
0 1
MCL1 (human) PEEELDGyEPEPLGk Y129-p
MCL1 iso2 (human) PEEELDGYEPEPLGK Y129
MCL1 (mouse) PEEELDGCEPEAIGk C110
MCL1 (rat) PEEELDGCEPEVLSK C109
K136-ub
yEPEPLGkRPAVLPL
Upstream
Downstream
2 12
Effects on Modified Protein
  • protein degradation
Treatment
  • siRNA
MCL1 (human) yEPEPLGkRPAVLPL K136-ub
MCL1 iso2 (human) YEPEPLGKRPAVLPL K136
MCL1 (mouse) CEPEAIGkRPAVLPL K117-ub
MCL1 (rat) CEPEVLSKRPAVLPL K116
S150-p
LLELVGEsGNNtStD
0 2
MCL1 (human) LLELVGEsGNNtStD S150-p
MCL1 iso2 (human) LLELVGESGNNTSTD S150
MCL1 (mouse) LLERVSEAAkSsGAD A131
MCL1 (rat) LLERVSEAAKSSGAD A130
N152
ELVGEsGNNtStDGs
0 8
MCL1 (human) ELVGEsGNNtStDGs N152
MCL1 iso2 (human) ELVGESGNNTSTDGS N152
MCL1 (mouse) ERVSEAAkSsGADGs K133-ub
MCL1 (rat) ERVSEAAKSSGADGS K132
T154-p
VGEsGNNtStDGsLP
0 3
MCL1 (human) VGEsGNNtStDGsLP T154-p
MCL1 iso2 (human) VGESGNNTSTDGSLP T154
MCL1 (mouse) VSEAAkSsGADGsLP S135-p
MCL1 (rat) VSEAAKSSGADGSLP S134
T156-p
EsGNNtStDGsLPst
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Treatment
  • vinblastine
MCL1 (human) EsGNNtStDGsLPst T156-p
MCL1 iso2 (human) ESGNNTSTDGSLPST T156
MCL1 (mouse) EAAkSsGADGsLPSt A137
MCL1 (rat) EAAKSSGADGSLPSt A136
S159-p
NNtStDGsLPstPPP
Upstream
Downstream
17 8
MCL1 (mouse)
S140-p
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • SGK1 (human)
  • TRAF4 (human)
Treatment
  • 6-OHDA
  • ABT-737
  • AMG176
  • CHIR-611
  • deguelin
  • IL-3_withdrawal
  • ionizing_radiation
  • LY294002
  • MG132
  • nocodazole
  • okadaic_acid
  • PD98059
  • purvalanol
  • SB216763
  • siRNA
  • SU9516
  • tautomycetin
  • vinblastine
MCL1 (human) NNtStDGsLPstPPP S159-p
MCL1 iso2 (human) NNTSTDGSLPSTPPP S159
MCL1 (mouse) kSsGADGsLPStPPP S140-p
MCL1 (rat) KSSGADGSLPStPPP S139
S162-p
StDGsLPstPPPAEE
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Treatment
  • vinblastine
MCL1 (human) StDGsLPstPPPAEE S162-p
MCL1 iso2 (human) STDGSLPSTPPPAEE S162
MCL1 (mouse) GADGsLPStPPPPEE S143
MCL1 (rat) GADGSLPStPPPPEE S142
T163-p
tDGsLPstPPPAEEE
Upstream
Downstream
20 24
MCL1 (human)
T163-p
MCL1 iso2 (human)
T163-p
MCL1 (mouse)
T144-p
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
Putative in vivo kinases:
  • CDK2 (human)
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
  • MKK4 (human)
  • P38A (human)
  • P70S6KB (human)
  • PXN (human)
  • SGK1 (human)
Treatment
  • 6-OHDA
  • ABT-737
  • AMG-176
  • AZD5991
  • EGF
  • fingolimod
  • H2O2
  • nocodazole
  • okadaic_acid
  • phorbol_ester
  • purvalanol
  • SB203580
  • siRNA
  • SU9516
  • tautomycetin
  • taxol
  • Trametinib
  • U0126
  • venetoclax
  • vinblastine
MCL1 (human) tDGsLPstPPPAEEE T163-p
MCL1 iso2 (human) TDGSLPSTPPPAEEE T163
MCL1 (mouse) ADGsLPStPPPPEEE T144-p
MCL1 (rat) ADGSLPStPPPPEEE T143-p
K194-ub
REQATGAkDTkPMGR
Upstream
Downstream
4 37
Effects on Modified Protein
  • protein degradation
Treatment
  • siRNA
MCL1 (human) REQATGAkDTkPMGR K194-ub
MCL1 iso2 (human) REQATGAKDTKPMGR K194
MCL1 (mouse) REQATGSkDSkPLGE K175-ub
MCL1 (rat) REQATGSKDAKPLGE K174
K197-ub
ATGAkDTkPMGRSGA
Upstream
Downstream
4 32
Effects on Modified Protein
  • protein degradation
Treatment
  • siRNA
MCL1 (human) ATGAkDTkPMGRSGA K197-ub
MCL1 iso2 (human) ATGAKDTKPMGRSGA K197
MCL1 (mouse) ATGSkDSkPLGEAGA K178-ub
MCL1 (rat) ATGSKDAKPLGEAGA K177
K234-ub
AFQGMLRkLDIkNED
0 5
MCL1 (human) AFQGMLRkLDIkNED K234-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) AFQGMLRKLDIkNEG K215
MCL1 (rat) AFQGMLRKLDIKNED K214
K238-ub
MLRkLDIkNEDDVks
0 8
MCL1 (human) MLRkLDIkNEDDVks K238-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) MLRKLDIkNEGDVKS K219-ub
MCL1 (rat) MLRKLDIKNEDDVKS K218
K244-ub
IkNEDDVksLSRVMI
0 15
MCL1 (human) IkNEDDVksLSRVMI K244-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) IkNEGDVKSFSRVMV K225
MCL1 (rat) IKNEDDVKSFSRVMT K224
S245-p
kNEDDVksLSRVMIH
0 1
MCL1 (human) kNEDDVksLSRVMIH S245-p
MCL1 iso2 (human) gap -
MCL1 (mouse) kNEGDVKSFSRVMVH S226
MCL1 (rat) KNEDDVKSFSRVMTH S225
K276-ub
SFGAFVAkHLkTINQ
0 1
MCL1 (human) SFGAFVAkHLkTINQ K276-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) SFGAFVAKHLkSVNQ K257
MCL1 (rat) SFGAFVAKHLKSINQ K256
K279-ub
AFVAkHLkTINQESC
Upstream
Downstream
1 5
Effects on Modified Protein
  • protein degradation
Treatment
  • siRNA
MCL1 (human) AFVAkHLkTINQESC K279-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) AFVAKHLkSVNQESF K260-ub
MCL1 (rat) AFVAKHLKSINQESC K259
T301-p
ITDVLVRtkRDWLVk
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
Kinase, in vitro:
  • AurB (human)
MCL1 (human) ITDVLVRtkRDWLVk T301-p
MCL1 iso2 (human) gap -
MCL1 (mouse) ITDVLVRTKRDWLVK T282
MCL1 (rat) ITDVLVRTKRDWLVK T281
K302-ub
TDVLVRtkRDWLVkQ
0 1
MCL1 (human) TDVLVRtkRDWLVkQ K302-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) TDVLVRTKRDWLVKQ K283
MCL1 (rat) TDVLVRTKRDWLVKQ K282
K308-ub
tkRDWLVkQRGWDGF
Upstream
Downstream
1 10
Effects on Modified Protein
  • protein degradation
Treatment
  • siRNA
MCL1 (human) tkRDWLVkQRGWDGF K308-ub
MCL1 iso2 (human) gap -
MCL1 (mouse) TKRDWLVKQRGWDGF K289
MCL1 (rat) TKRDWLVKQRGWDGF K288
Y347-p
GVGAGLAyLIR____
0 1
MCL1 (human) GVGAGLAyLIR____ Y347-p
MCL1 iso2 (human) gap -
MCL1 (mouse) GVGAGLAYLIR____ Y328
MCL1 (rat) GVGAGLAYLIR____ Y327
-
gap
0 4
MCL1 (human) gap -
MCL1 iso2 (human) SWFGISNkIALL___ K267-ub
MCL1 (mouse) gap -
MCL1 (rat) gap -