NBS1 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

K3-ac

_____MWkLLPAAGP

NBS1 (human)	_____MWkLLPAAGP	K3-ac
NBS1 (mouse)	_____MWKLLPAAGA	K3
NBS1 (rat)	_____MWKLLPAASA	K3

K3-ub

_____MWkLLPAAGP

NBS1 (human)	_____MWkLLPAAGP	K3-ub
NBS1 (mouse)	_____MWKLLPAAGA	K3
NBS1 (rat)	_____MWKLLPAASA	K3

Y16-p

GPAGGEPyRLLTGVE

NBS1 (human)	GPAGGEPyRLLTGVE	Y16-p
NBS1 (mouse)	GAAPGEPYRLLAGVE	Y16
NBS1 (rat)	SAAPGEPCRLLAGVE	C16

Y24-p

RLLTGVEyVVGRKNC

NBS1 (human)	RLLTGVEyVVGRKNC	Y24-p
NBS1 (mouse)	RLLAGVEYVVGRKNC	Y24
NBS1 (rat)	RLLAGVEYIVGRKNC	Y24

S58-p

NFSVTNLsQtDEIPV

Upstream

Treatment

nocodazole
UV

NBS1 (human)	NFSVTNLsQtDEIPV	S58-p
NBS1 (mouse)	NFPVTSLsQTDEIPT	S58-p
NBS1 (rat)	NFPVTSLSQTDEIPT	S58

T60-p

SVTNLsQtDEIPVLT

NBS1 (human)	SVTNLsQtDEIPVLT	T60-p
NBS1 (mouse)	PVTSLsQTDEIPTLT	T60
NBS1 (rat)	PVTSLSQTDEIPTLT	T60

S72

VLTLKDNSkYGTFVN

NBS1 (human)	VLTLKDNSkYGTFVN	S72
NBS1 (mouse)	TLTIKDNsKYGTFVN	S72-p
NBS1 (rat)	TLTIKDNSKYGTFIN	S72

K73-ub

LTLKDNSkYGTFVNE

NBS1 (human)	LTLKDNSkYGTFVNE	K73-ub
NBS1 (mouse)	LTIKDNsKYGTFVNE	K73
NBS1 (rat)	LTIKDNSKYGTFINE	K73

K82-ub

GTFVNEEkMQNGFSR

NBS1 (human)	GTFVNEEkMQNGFSR	K82-ub
NBS1 (mouse)	GTFVNEEKMQTGLSC	K82
NBS1 (rat)	GTFINEEKMQNGLSS	K82

K188-ub

LKAVESKkQPPQIEs

NBS1 (human)	LKAVESKkQPPQIEs	K188-ub
NBS1 (mouse)	LKAVESKKQPPDIES	K188
NBS1 (rat)	LKAVESKTQPPEIES	T188

S195-p

kQPPQIEsFyPPLDE

NBS1 (human)	kQPPQIEsFyPPLDE	S195-p
NBS1 (mouse)	KQPPDIESFYPPIDE	S195
NBS1 (rat)	TQPPEIESFYPPIDE	S195

Y197-p

PPQIEsFyPPLDEPS

NBS1 (human)	PPQIEsFyPPLDEPS	Y197-p
NBS1 (mouse)	PPDIESFYPPIDEPA	Y197
NBS1 (rat)	PPEIESFYPPIDEPA	Y197

K208-ac

DEPSIGSkNVDLSGR

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

DNA repair, inhibited
apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
selisistat
siRNA
trichostatin_A

NBS1 (human)	DEPSIGSkNVDLSGR	K208-ac
NBS1 (mouse)	DEPAIGSKSVDLSGR	K208
NBS1 (rat)	DEPAIGNKSVDLSGR	K208

K208-ub

DEPSIGSkNVDLSGR

NBS1 (human)	DEPSIGSkNVDLSGR	K208-ub
NBS1 (mouse)	DEPAIGSKSVDLSGR	K208
NBS1 (rat)	DEPAIGNKSVDLSGR	K208

K233-ac

TFIFLNAkQHKKLSS

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

DNA repair, inhibited
apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
selisistat
siRNA
trichostatin_A

NBS1 (human)	TFIFLNAkQHKKLSS	K233-ac
NBS1 (mouse)	TFVFLNAKQHKKLSS	K233
NBS1 (rat)	TFVFLNAKQHKKLGS	K233

S278-p

VDTGITNsQTLIPDC

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation
chromatin organization, altered

Kinase, in vitro:

ATM (human)

Putative in vivo kinases:

ATM (human)

Treatment

hydroxyurea
ionizing_radiation

NBS1 (human)	VDTGITNsQTLIPDC	S278-p
NBS1 (mouse)	VDVGITNtQLIISHS	T278-p
NBS1 (rat)	VDVGITNTQLIITDS	T278

S292-p

CQKKWIQsIMDMLQR

NBS1 (human)	CQKKWIQsIMDMLQR	S292-p
NBS1 (mouse)	SQKKWIHLIMDTLQR	L292
NBS1 (rat)	SQRKWIHLIMDILQR	L292

K334-ac

GHPSTGLktTtPGPs

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	GHPSTGLktTtPGPs	K334-ac
NBS1 (mouse)	GQPCTELKTTTPGPS	K334
NBS1 (rat)	GQPCTEVKTTTPGPS	K334

K334-ub

GHPSTGLktTtPGPs

NBS1 (human)	GHPSTGLktTtPGPs	K334-ub
NBS1 (mouse)	GQPCTELKTTTPGPS	K334
NBS1 (rat)	GQPCTEVKTTTPGPS	K334

T335-p

HPSTGLktTtPGPsL

NBS1 (human)	HPSTGLktTtPGPsL	T335-p
NBS1 (mouse)	QPCTELKTTTPGPSL	T335
NBS1 (rat)	QPCTEVKTTTPGPSL	T335

T337-p

STGLktTtPGPsLsQ

Upstream

Treatment

ionizing_radiation
UV

NBS1 (human)	STGLktTtPGPsLsQ	T337-p
NBS1 (mouse)	CTELKTTTPGPSLSQ	T337
NBS1 (rat)	CTEVKTTTPGPSLSQ	T337

S341-p

ktTtPGPsLsQGVsV

Upstream

Treatment

ionizing_radiation

NBS1 (human)	ktTtPGPsLsQGVsV	S341-p
NBS1 (mouse)	KTTTPGPSLSQVLSA	S341
NBS1 (rat)	KTTTPGPSLSQGLSA	S341

S343-p

TtPGPsLsQGVsVDE

Upstream

Downstream

NBS1 (human)
S343-p

3001 : Phospho-p95/NBS1 (Ser343) Antibody

NBS1 (mouse)
S343-p

3001 : Phospho-p95/NBS1 (Ser343) Antibody

Effects on Modified Protein

acetylation
activity, induced
phosphorylation

Effects on Biological Processes:

DNA repair, induced
apoptosis, induced
carcinogenesis, induced
cell cycle regulation
cell growth, altered
chromatin organization, altered

Kinase, in vitro:

ATM (human)
ATR (human)

Putative in vivo kinases:

ATM (human)
ATR (human)

Regulatory protein:

ATM (human)
ATR (human)
Bcr (human)
NBS1 (human)
OBFC2B (human)
PDE1A (human)
RAD17 (human)
TRF2 (human)
TRIM24 (human)
VCP (human)

Treatment

adavosertib
adriamycin
aminothiazole_compound_25
beta-lapachone
caffeine
cell_adhesion
cisplatin
DSBs
etoposide
galunisertib
GM-CSF
hydroxyurea
IL-3
ionizing_radiation
KU-55933
mitomycin_C
NAC
NMS-873
NU7026
NU7441
PDTC
SCF
siRNA
SJG-136
UV
wortmannin

NBS1 (human)	TtPGPsLsQGVsVDE	S343-p
NBS1 (mouse)	TTPGPSLSQVLSANG	S343
NBS1 (rat)	TTPGPSLSQGLSANG	S343

S347-p

PsLsQGVsVDEKLMP

Upstream

Treatment

ischemia

NBS1 (human)	PsLsQGVsVDEKLMP	S347-p
NBS1 (mouse)	PSLSQVLSANGKIIP	S347
NBS1 (rat)	PSLSQGLSANGKVIP	S347

T367-p

TTTYVADtESEQADT

NBS1 (human)	TTTYVADtESEQADT	T367-p
NBS1 (mouse)	MTTYVADTESEPADT	T367
NBS1 (rat)	MTTYVADTESEPADT	T367

K388-m1

PKEIKVSkMEQKFRM

NBS1 (human)	PKEIKVSkMEQKFRM	K388-m1
NBS1 (mouse)	PEEVKIPGLEQSSRK	G389
NBS1 (rat)	PEEVKIFGLDQNSRK	G389

S397-p

EQKFRMLsQDAPtVK

Upstream

Kinase, in vitro:

ATM (human)

Putative in vivo kinases:

ATM (human)

Treatment

ionizing_radiation
ischemia

NBS1 (human)	EQKFRMLsQDAPtVK	S397-p
NBS1 (mouse)	EQSSRKLsQEtFNIK	S398-p
NBS1 (rat)	DQNSRKLLQGTCNIK	L398

A400

FRMLsQDAPtVKESC

NBS1 (human)	FRMLsQDAPtVKESC	A400
NBS1 (mouse)	SRKLsQEtFNIKEAP	T401-p
NBS1 (rat)	SRKLLQGTCNIKETS	T401

T402-p

MLsQDAPtVKESCKT

NBS1 (human)	MLsQDAPtVKESCKT	T402-p
NBS1 (mouse)	KLsQEtFNIKEAPKP	N403
NBS1 (rat)	KLLQGTCNIKETSNQ	N403

S418-p

SNNNSMVsNtLAkMR

NBS1 (human)	SNNNSMVsNtLAkMR	S418-p
NBS1 (mouse)	SKANNVASDTLVRGK	S419
NBS1 (rat)	SNSNNAASNTLVRGK	S419

T420-p

NNSMVsNtLAkMRIP

NBS1 (human)	NNSMVsNtLAkMRIP	T420-p
NBS1 (mouse)	ANNVASDTLVRGKtP	T421
NBS1 (rat)	SNNAASNTLVRGKAP	T421

K423-ub

MVsNtLAkMRIPNyQ

NBS1 (human)	MVsNtLAkMRIPNyQ	K423-ub
NBS1 (mouse)	VASDTLVRGKtPsYQ	R424
NBS1 (rat)	AASNTLVRGKAPNYQ	R424

I426

NtLAkMRIPNyQLsP

NBS1 (human)	NtLAkMRIPNyQLsP	I426
NBS1 (mouse)	DTLVRGKtPsYQLsP	T427-p
NBS1 (rat)	NTLVRGKAPNYQLsP	A427

N428

LAkMRIPNyQLsPtK

NBS1 (human)	LAkMRIPNyQLsPtK	N428
NBS1 (mouse)	LVRGKtPsYQLsPMK	S429-p
NBS1 (rat)	LVRGKAPNYQLsPMK	N429

Y429-p

AkMRIPNyQLsPtKL

Upstream

Treatment

nocodazole

NBS1 (human)	AkMRIPNyQLsPtKL	Y429-p
NBS1 (mouse)	VRGKtPsYQLsPMKF	Y430
NBS1 (rat)	VRGKAPNYQLsPMKC	Y430

S432-p

RIPNyQLsPtKLPsI

Upstream

Downstream

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, altered
apoptosis, inhibited
cell cycle regulation
chromatin organization, altered

Kinase, in vitro:

CDK2 (human)

Putative in vivo kinases:

CDK2 (human)

Putative upstream phosphatases:

PPP1CA (human)

Regulatory protein:

PNUTS (human)

Treatment

3-MB-PP1
aphidicolin
DRB
EGF
galunisertib
ionizing_radiation
nocodazole
purvalanol
seliciclib

NBS1 (human)	RIPNyQLsPtKLPsI	S432-p
NBS1 (mouse)	KtPsYQLsPMKFPVA	S433-p
NBS1 (rat)	KAPNYQLsPMKCPAA	S433-p

T434-p

PNyQLsPtKLPsINk

NBS1 (human)	PNyQLsPtKLPsINk	T434-p
NBS1 (mouse)	PsYQLsPMKFPVANK	M435
NBS1 (rat)	PNYQLsPMKCPAASK	M435

S438-p

LsPtKLPsINksKDR

Upstream

Treatment

nocodazole

NBS1 (human)	LsPtKLPsINksKDR	S438-p
NBS1 (mouse)	LsPMKFPVANKNKDW	V439
NBS1 (rat)	LsPMKCPAASKNKDW	A439

K441-ac

tKLPsINksKDRAsQ

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	tKLPsINksKDRAsQ	K441-ac
NBS1 (mouse)	MKFPVANKNKDWTSQ	K442
NBS1 (rat)	MKCPAASKNKDWSSQ	K442

S442-p

KLPsINksKDRAsQQ

NBS1 (human)	KLPsINksKDRAsQQ	S442-p
NBS1 (mouse)	KFPVANKNKDWTSQQ	N443
NBS1 (rat)	KCPAASKNKDWSSQQ	N443

S447-p

NksKDRAsQQQQTNS

NBS1 (human)	NksKDRAsQQQQTNS	S447-p
NBS1 (mouse)	NKNKDWTSQQQQNSI	S448
NBS1 (rat)	SKNKDWSSQQQLNSI	S448

Y458-p

QTNSIRNyFQPsTKK

NBS1 (human)	QTNSIRNyFQPsTKK	Y458-p
NBS1 (mouse)	QQNSIKNYFQPCTRK	Y458
NBS1 (rat)	QLNSIKNYFQPCSRK	Y458

S462-p

IRNyFQPsTKKRERD

NBS1 (human)	IRNyFQPsTKKRERD	S462-p
NBS1 (mouse)	IKNYFQPCTRKRERD	C462
NBS1 (rat)	IKNYFQPCSRKRERD	C462

S488-p

ARIETSCsLLEQTQP

NBS1 (human)	ARIETSCsLLEQTQP	S488-p
NBS1 (mouse)	SRMELSCSLLEQTQP	S488
NBS1 (rat)	SRVELSCSLLEQTQP	S488

T497-p

LEQTQPAtPSLWKNk

Upstream

Treatment

ischemia

NBS1 (human)	LEQTQPAtPSLWKNk	T497-p
NBS1 (mouse)	LEQTQPAGPSLWKSK	G497
NBS1 (rat)	LEQTQPAGPSLWKSK	G497

K504-ac

tPSLWKNkEQHLsEN

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	tPSLWKNkEQHLsEN	K504-ac
NBS1 (mouse)	GPSLWKSKEHQsQNA	K504
NBS1 (rat)	GPSLWKSKDHESQSE	K504

S509-p

KNkEQHLsENEPVDt

NBS1 (human)	KNkEQHLsENEPVDt	S509-p
NBS1 (mouse)	WKSKEHQsQNATLDR	S508-p
NBS1 (rat)	WKSKDHESQSETLDR	S508

T516-p

sENEPVDtNsDNNLF

NBS1 (human)	sENEPVDtNsDNNLF	T516-p
NBS1 (mouse)	sQNATLDREADTSSV	R515
NBS1 (rat)	SQSETLDRASNASSV	R515

S518-p

NEPVDtNsDNNLFtD

NBS1 (human)	NEPVDtNsDNNLFtD	S518-p
NBS1 (mouse)	NATLDREADTSSVGG	A517
NBS1 (rat)	SETLDRASNASSVGG	S517

T524-p

NsDNNLFtDTDLkSI

NBS1 (human)	NsDNNLFtDTDLkSI	T524-p
NBS1 (mouse)	EADTSSVGGMDIELN	G523
NBS1 (rat)	ASNASSVGGIDIKPN	G523

K529-ub

LFtDTDLkSIVKNsA

NBS1 (human)	LFtDTDLkSIVKNsA	K529-ub
NBS1 (mouse)	SVGGMDIELNRKsPD	E528
NBS1 (rat)	SVGGIDIKPNGKSPD	K528

N534

DLkSIVKNsASKSHA

NBS1 (human)	DLkSIVKNsASKSHA	N534
NBS1 (mouse)	DIELNRKsPDRKPLP	S533-p
NBS1 (rat)	DIKPNGKSPDSKSFS	S533

S535-p

LkSIVKNsASKSHAA

NBS1 (human)	LkSIVKNsASKSHAA	S535-p
NBS1 (mouse)	IELNRKsPDRKPLPT	P534
NBS1 (rat)	IKPNGKSPDSKSFST	P534

K544-ac

SKSHAAEkLRSNKkR

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	SKSHAAEkLRSNKkR	K544-ac
NBS1 (mouse)	RKPLPTETLRPRKRK	T543
NBS1 (rat)	SKSFSTEDLRARKRK	D543

K550-ac

EkLRSNKkREMDDVA

NBS1 (human)	EkLRSNKkREMDDVA	K550-ac
NBS1 (mouse)	ETLRPRKRKDVDLAT	R549
NBS1 (rat)	EDLRARKRKEVDLST	R549

K568-ac

EVLEQLFkDTKPELE

NBS1 (human)	EVLEQLFkDTKPELE	K568-ac
NBS1 (mouse)	EVLEELLRSTKPELA	R566
NBS1 (rat)	EVLEELLRSTKPELA	R566

K582-sm

EIDVKVQkQEEDVNV

NBS1 (human)	EIDVKVQkQEEDVNV	K582-sm
NBS1 (mouse)	AVQVKVEKQEADDTI	K580
NBS1 (rat)	AVQVKVEKQEADVSI	K580

T602-p

MDIETNDtFsDEAVP

NBS1 (human)	MDIETNDtFsDEAVP	T602-p
NBS1 (mouse)	MDAERNRPLNGGsEP	P600
NBS1 (rat)	MDAERNQHLNGGPVP	H600

S604-p

IETNDtFsDEAVPEs

NBS1 (human)	IETNDtFsDEAVPEs	S604-p
NBS1 (mouse)	AERNRPLNGGsEPES	N602
NBS1 (rat)	AERNQHLNGGPVPES	N602

A607

NDtFsDEAVPEssKI

NBS1 (human)	NDtFsDEAVPEssKI	A607
NBS1 (mouse)	NRPLNGGsEPESNSA	S605-p
NBS1 (rat)	NQHLNGGPVPESNSA	P605

S611-p

sDEAVPEssKIsQEN

NBS1 (human)	sDEAVPEssKIsQEN	S611-p
NBS1 (mouse)	NGGsEPESNSALQED	S609
NBS1 (rat)	NGGPVPESNSALQED	S609

S612-p

DEAVPEssKIsQENE

NBS1 (human)	DEAVPEssKIsQENE	S612-p
NBS1 (mouse)	GGsEPESNSALQEDE	N610
NBS1 (rat)	GGPVPESNSALQEDE	N610

S615-p

VPEssKIsQENEIGK

Upstream

Kinase, in vitro:

ATM (human)

Putative in vivo kinases:

ATM (human)
ATR (human)

Treatment

ionizing_radiation
UV

NBS1 (human)	VPEssKIsQENEIGK	S615-p
NBS1 (mouse)	EPESNSALQEDEREK	L613
NBS1 (rat)	VPESNSALQEDETGK	L613

K627-ub

IGKKRELkEDsLWSA

NBS1 (human)	IGKKRELkEDsLWSA	K627-ub
NBS1 (mouse)	REKKDELQTESWSTK	Q625
NBS1 (rat)	TGKKDELQIEAWSTK	Q625

S630-p

KRELkEDsLWSAkEI

NBS1 (human)	KRELkEDsLWSAkEI	S630-p
NBS1 (mouse)	KDELQTESWSTKHEI	S628
NBS1 (rat)	KDELQIEAWSTKREV	A628

K635-ub

EDsLWSAkEISNNDK

NBS1 (human)	EDsLWSAkEISNNDK	K635-ub
NBS1 (mouse)	QTESWSTKHEIANSD	K632
NBS1 (rat)	QIEAWSTKREVSNTD	K632

K665-ac

EFRSLVIkNSTSRNP

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	EFRSLVIkNSTSRNP	K665-ac
NBS1 (mouse)	EFRSLVVSNHNSTSR	S663
NBS1 (rat)	gap	-

K665-ub

EFRSLVIkNSTSRNP

NBS1 (human)	EFRSLVIkNSTSRNP	K665-ub
NBS1 (mouse)	EFRSLVVSNHNSTSR	S663
NBS1 (rat)	gap	-

S673-p

NSTSRNPsGINDDyG

NBS1 (human)	NSTSRNPsGINDDyG	S673-p
NBS1 (mouse)	NSTSRNLCVNECGPL	C673
NBS1 (rat)	NNSSRNLCVLNGRGE	C671

Y679-p

PsGINDDyGQLkNFK

NBS1 (human)	PsGINDDyGQLkNFK	Y679-p
NBS1 (mouse)	RNLCVNECGPLKNFK	C677
NBS1 (rat)	gap	-

K683-ub

NDDyGQLkNFKKFKk

Upstream

Treatment

MG132

NBS1 (human)	NDDyGQLkNFKKFKk	K683-ub
NBS1 (mouse)	VNECGPLKNFKKFKK	K681
NBS1 (rat)	LNGRGELKNFKKFKK	K680

K690-ac

kNFKKFKkVTyPGAG

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

DNA repair, inhibited
apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
selisistat
siRNA
trichostatin_A

NBS1 (human)	kNFKKFKkVTyPGAG	K690-ac
NBS1 (mouse)	KNFKKFKKATFPGAG	K688
NBS1 (rat)	KNFKKFKKATCPGAG	K687

Y693-p

KKFKkVTyPGAGkLP

NBS1 (human)	KKFKkVTyPGAGkLP	Y693-p
NBS1 (mouse)	KKFKKATFPGAGKLP	F691
NBS1 (rat)	KKFKKATCPGAGKLP	C690

K698-ac

VTyPGAGkLPHIIGG

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	VTyPGAGkLPHIIGG	K698-ac
NBS1 (mouse)	ATFPGAGKLPHIIGG	K696
NBS1 (rat)	ATCPGAGKLPHIIGG	K695

S706-p

LPHIIGGsDLIAHHA

NBS1 (human)	LPHIIGGsDLIAHHA	S706-p
NBS1 (mouse)	LPHIIGGSDLVGHHA	S704
NBS1 (rat)	LPHIIGGSDLIGHHA	S703

K715-ac

LIAHHARkNTELEEW

Upstream

Downstream

Effects on Modified Protein

phosphorylation

Effects on Biological Processes:

apoptosis, induced
cell cycle regulation

Regulatory protein:

CBP (human)
SIRT2 (human)
SIRT3 (human)
SIRT4 (human)
SIRT6 (human)
SIRT7 (human)

Treatment

nicotinamide
siRNA
trichostatin_A

NBS1 (human)	LIAHHARkNTELEEW	K715-ac
NBS1 (mouse)	LVGHHARKNTELEEW	K713
NBS1 (rat)	LIGHHARKNTELEEW	K712

K715-m1

LIAHHARkNTELEEW

NBS1 (human)	LIAHHARkNTELEEW	K715-m1
NBS1 (mouse)	LVGHHARKNTELEEW	K713
NBS1 (rat)	LIGHHARKNTELEEW	K712

K715-ub

LIAHHARkNTELEEW

NBS1 (human)	LIAHHARkNTELEEW	K715-ub
NBS1 (mouse)	LVGHHARKNTELEEW	K713
NBS1 (rat)	LIGHHARKNTELEEW	K712

S738-p

NQHAKEEsLADDLFR

NBS1 (human)	NQHAKEEsLADDLFR	S738-p
NBS1 (mouse)	KQQAKEESLADDLFR	S736
NBS1 (rat)	KQQAKEDSLADDLFR	S735

K751-m1

FRYNPYLkRRR____

NBS1 (human)	FRYNPYLkRRR____	K751-m1
NBS1 (mouse)	FRYNPNVKRR_____	K749
NBS1 (rat)	FRYNPNVKRR_____	K748

K751-ub

FRYNPYLkRRR____

NBS1 (human)	FRYNPYLkRRR____	K751-ub
NBS1 (mouse)	FRYNPNVKRR_____	K749
NBS1 (rat)	FRYNPNVKRR_____	K748