Other Species / Isoforms
  p27Kip1 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2
______MSNVRVsNG
1 1
p27Kip1 (human) ______MsNVRVSNG S2-gl
p27Kip1 (mouse) ______MSNVRVsNG S2
p27Kip1 (rat) ______MSNVRVSNG S2
S7-p
_MSNVRVsNGsPsLE
0 2
p27Kip1 (human) _MsNVRVSNGsPsLE S7
p27Kip1 (mouse) _MSNVRVsNGsPsLE S7-p
p27Kip1 (rat) _MSNVRVSNGsPSLE S7
S10-p
NVRVsNGsPsLERMD
Upstream
Downstream
46 37
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
Kinase, in vitro:
  • Akt1 (human)
  • DYRK1B (mouse)
Putative in vivo kinases:
  • CDK5 (mouse)
  • DYRK1B (mouse)
Regulatory protein:
  • CCND1 (mouse)
Treatment
  • high_cell_density
  • IL-3
  • NAG-thiazoline
  • okadaic_acid
  • ponasterone_A
  • PUGNAc
  • serum_starvation
  • urethane
p27Kip1 (human) NVRVSNGsPsLErMD S10-p
p27Kip1 (mouse) NVRVsNGsPsLERMD S10-p
p27Kip1 (rat) NVRVSNGsPSLERMD S10-p
S12-p
RVsNGsPsLERMDAR
Upstream
0 6
Kinase, in vitro:
  • IKKA (mouse)
p27Kip1 (human) RVSNGsPsLErMDAR S12-p
p27Kip1 (mouse) RVsNGsPsLERMDAR S12-p
p27Kip1 (rat) RVSNGsPSLERMDAR S12
R15
NGsPsLERMDARQAE
0 1
p27Kip1 (human) NGsPsLErMDARQAE R15-m1
p27Kip1 (mouse) NGsPsLERMDARQAE R15
p27Kip1 (rat) NGsPSLERMDARQTE R15
K25
ARQAEHPKPSACRNL
0 1
p27Kip1 (human) ARQAEHPKPSACRNL K25
p27Kip1 (mouse) ARQAEHPKPSACRNL K25
p27Kip1 (rat) ARQTEHPkPSACRNL K25-ac
K25
ARQAEHPKPSACRNL
0 1
p27Kip1 (human) ARQAEHPkPSACRNL K25-ub
p27Kip1 (mouse) ARQAEHPKPSACRNL K25
p27Kip1 (rat) ARQTEHPKPSACRNL K25
T42-p
PVNHEELtRDLEKHC
Upstream
0 1
Kinase, in vitro:
  • IKKA (mouse)
p27Kip1 (human) PVDHEELTRDLEKHC T42
p27Kip1 (mouse) PVNHEELtRDLEKHC T42-p
p27Kip1 (rat) PVNHEELTRDLEKHC T42
K59
MEEASQRKWNFDFQN
0 1
p27Kip1 (human) MEEASQRKWNFDFQN K59
p27Kip1 (mouse) MEEASQRKWNFDFQN K59
p27Kip1 (rat) MEEASQRkWNFDFQN K59-ac
K68
NFDFQNHKPLEGRYE
0 1
p27Kip1 (human) NFDFQNHKPLEGKyE K68
p27Kip1 (mouse) NFDFQNHKPLEGRYE K68
p27Kip1 (rat) NFDFQNHkPLEGRYE K68-ac
K68
NFDFQNHKPLEGRYE
0 1
p27Kip1 (human) NFDFQNHkPLEGKyE K68-ub
p27Kip1 (mouse) NFDFQNHKPLEGRYE K68
p27Kip1 (rat) NFDFQNHKPLEGRYE K68
Y74
HKPLEGRYEWQEVER
7 0
p27Kip1 (human) HkPLEGKyEWQEVEk Y74-p
p27Kip1 (mouse) HKPLEGRYEWQEVER Y74
p27Kip1 (rat) HkPLEGRYEWQEVER Y74
R81
YEWQEVERGsLPEFy
0 1
p27Kip1 (human) yEWQEVEkGsLPEFy K81-ac
p27Kip1 (mouse) YEWQEVERGsLPEFy R81
p27Kip1 (rat) YEWQEVERGSLPEFY R81
R81
YEWQEVERGsLPEFy
0 1
p27Kip1 (human) yEWQEVEkGsLPEFy K81-ub
p27Kip1 (mouse) YEWQEVERGsLPEFy R81
p27Kip1 (rat) YEWQEVERGSLPEFY R81
S83-p
WQEVERGsLPEFyYR
Upstream
2 0
Kinase, in vitro:
  • AMPKA1 (rat)
p27Kip1 (human) WQEVEkGsLPEFyyR S83-p
p27Kip1 (mouse) WQEVERGsLPEFyYR S83-p
p27Kip1 (rat) WQEVERGSLPEFYYR S83
Y88-p
RGsLPEFyYRPPRPP
Upstream
Downstream
10 0
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • JAK2 (mouse)
Putative in vivo kinases:
  • JAK2 (mouse)
Treatment
  • angiotensin_2
  • IL-3
  • JAK_inhibitor_I
  • SKI-606
p27Kip1 (human) kGsLPEFyyRPPRPP Y88-p
p27Kip1 (mouse) RGsLPEFyYRPPRPP Y88-p
p27Kip1 (rat) RGSLPEFYYRPPRPP Y88
Y89
GsLPEFyYRPPRPPK
6 0
p27Kip1 (human) GsLPEFyyRPPRPPK Y89-p
p27Kip1 (mouse) GsLPEFyYRPPRPPK Y89
p27Kip1 (rat) GSLPEFYYRPPRPPK Y89
K100
RPPKSACKVLAQEsQ
0 1
p27Kip1 (human) RPPKGACKVPAQEsQ K100
p27Kip1 (mouse) RPPKSACKVLAQEsQ K100
p27Kip1 (rat) RPPKSACkVPAQEsL K100-ac
S106-p
CKVLAQEsQDVSGSR
0 13
p27Kip1 (human) CKVPAQESQDVsGSR S106
p27Kip1 (mouse) CKVLAQEsQDVSGSR S106-p
p27Kip1 (rat) CkVPAQEsLDVSGSR S106-p
S106
CKVLAQESQDVSGSR
1 1
p27Kip1 (human) CKVPAQEsQDVsGSR S106-gl
p27Kip1 (mouse) CKVLAQESQDVSGSR S106
p27Kip1 (rat) CkVPAQESLDVSGSR S106
S110
AQEsQDVSGSRQAVP
1 1
p27Kip1 (human) AQEsQDVsGSRPAAP S110-gl
p27Kip1 (mouse) AQEsQDVSGSRQAVP S110
p27Kip1 (rat) AQEsLDVSGSRQAVP S110
M134
DRHLVDQMPDSSDNP
1 0
p27Kip1 (human) DTHLVDPkTDPSDsQ K134-ub
p27Kip1 (mouse) DRHLVDQMPDSSDNP M134
p27Kip1 (rat) DRHLVDQMPDSSDSP M134
N140
QMPDSSDNPAGLAEQ
2 5
p27Kip1 (human) PkTDPSDsQTGLAEQ S140-p
p27Kip1 (mouse) QMPDSSDNPAGLAEQ N140
p27Kip1 (rat) QMPDSSDSPAGLAEQ S140
K153
EQCPGMRKRPAAEDS
1 1
p27Kip1 (human) EQCAGIRkrPAtDDS K153-ub
p27Kip1 (mouse) EQCPGMRKRPAAEDS K153
p27Kip1 (rat) EQCPGMRKRPAAEDS K153
R154
QCPGMRKRPAAEDSS
0 1
p27Kip1 (human) QCAGIRkrPAtDDSS R154-m2
p27Kip1 (mouse) QCPGMRKRPAAEDSS R154
p27Kip1 (rat) QCPGMRKRPAAEDSS R154
A157
GMRKRPAAEDSSSQN
24 1
p27Kip1 (human) GIRkrPAtDDSSTQN T157-p
p27Kip1 (mouse) GMRKRPAAEDSSSQN A157
p27Kip1 (rat) GMRKRPAAEDSSSQN A157
A157
GMRKRPAAEDSSSQN
1 1
p27Kip1 (human) GIRkrPAtDDSSTQN T157-gl
p27Kip1 (mouse) GMRKRPAAEDSSSQN A157
p27Kip1 (rat) GMRKRPAAEDSSSQN A157
K165
EDSSSQNKRANRtEE
1 0
p27Kip1 (human) DDSSTQNkRANRTEE K165-ub
p27Kip1 (mouse) EDSSSQNKRANRtEE K165
p27Kip1 (rat) EDSSSQNKRANRTEE K165
T170-p
QNKRANRtEENVsDG
Upstream
Downstream
2 0
Effects on Modified Protein
  • intracellular localization
Kinase, in vitro:
  • AMPKA1 (rat)
Putative in vivo kinases:
  • CAMK1A (human)
p27Kip1 (human) QNkRANRTEENVsDG T170
p27Kip1 (mouse) QNKRANRtEENVsDG T170-p
p27Kip1 (rat) QNKRANRTEENVSDG T170
S175-p
NRtEENVsDGsPNAG
Upstream
Downstream
1 3
Effects on Modified Protein
  • phosphorylation
Kinase, in vitro:
  • IKKA (mouse)
p27Kip1 (human) NRTEENVsDGsPNAG S175-p
p27Kip1 (mouse) NRtEENVsDGsPNAG S175-p
p27Kip1 (rat) NRTEENVSDGsPNAG S175
S178-p
EENVsDGsPNAGtVE
Upstream
Downstream
4 14
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, altered
Kinase, in vitro:
  • IKKA (mouse)
p27Kip1 (human) EENVsDGsPNAGsVE S178-p
p27Kip1 (mouse) EENVsDGsPNAGtVE S178-p
p27Kip1 (rat) EENVSDGsPNAGTVE S178-p
T183-p
DGsPNAGtVEQtPKK
Upstream
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
Kinase, in vitro:
  • IKKA (mouse)
Putative in vivo kinases:
  • IKKA (human)
Regulatory protein:
  • Nik (human)
Treatment
  • siRNA
p27Kip1 (human) DGsPNAGsVEQtPKK S183-p
p27Kip1 (mouse) DGsPNAGtVEQtPKK T183-p
p27Kip1 (rat) DGsPNAGTVEQTPKK T183
T187-p
NAGtVEQtPKKPGLR
Upstream
Downstream
46 1
Effects on Modified Protein
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, altered
  • cell growth, induced
Kinase, in vitro:
  • CDK5 (mouse)
Putative in vivo kinases:
  • CDK5 (mouse)
Treatment
  • IL-3
  • ponasterone_A
p27Kip1 (human) NAGsVEQtPKKPGLR T187-p
p27Kip1 (mouse) NAGtVEQtPKKPGLR T187-p
p27Kip1 (rat) NAGTVEQTPKKPGLR T187
T197-p
KPGLRRQt_______
Upstream
25 6
Kinase, in vitro:
  • AMPKA1 (human)
  • AMPKA1 (rat)
Putative in vivo kinases:
  • CAMK1A (human)
Regulatory protein:
  • LKB1 (mouse)
Treatment
  • acadesine
  • glucose_starvation
  • IL-3
  • ponasterone_A
  • siRNA
p27Kip1 (human) PGLRRRQt_______ T198-p
p27Kip1 (mouse) KPGLRRQt_______ T197-p
p27Kip1 (rat) KPGLRRQT_______ T197
T197
KPGLRRQT_______
1 1
p27Kip1 (human) PGLRRRQt_______ T198-gl
p27Kip1 (mouse) KPGLRRQT_______ T197
p27Kip1 (rat) KPGLRRQT_______ T197