|
T116
|
NPTDHLITAYRAHGF
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
NPTDHLItAyRAHGF
|
T116
|
|
PDHA1 iso2 (human)
|
NPTDHLITAYRAHGF
|
T123
|
|
PDHA1 iso4 (human)
|
NPTDHLITAYRAHGF
|
T154
|
|
PDHA1 (mouse)
|
NPTDHLITAYRAHGF
|
T116
|
|
PDHA1 (rat)
|
NPTDHLITAYRAHGF
|
T116
|
|
PDHA1 (pig)
|
NPTDHLITAYRAHGF
|
T115
|
|
|
Y118
|
TDHLITAYRAHGFTF
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
TDHLItAyRAHGFTF
|
Y118
|
|
PDHA1 iso2 (human)
|
TDHLITAYRAHGFTF
|
Y125
|
|
PDHA1 iso4 (human)
|
TDHLITAYRAHGFTF
|
Y156
|
|
PDHA1 (mouse)
|
TDHLITAYRAHGFTF
|
Y118
|
|
PDHA1 (rat)
|
TDHLITAYRAHGFTF
|
Y118
|
|
PDHA1 (pig)
|
TDHLITAYRAHGFTF
|
Y117
|
|
|
T139
|
RAILAELTGRRGGCA
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
REILAELtGRKGGCA
|
T139
|
|
PDHA1 iso2 (human)
|
REILAELTGRKGGCA
|
T146
|
|
PDHA1 iso4 (human)
|
REILAELTGRKGGCA
|
T177
|
|
PDHA1 (mouse)
|
RAILAELTGRRGGCA
|
T139
|
|
PDHA1 (rat)
|
RAILAELTGRRGGCA
|
T139
|
|
PDHA1 (pig)
|
REILAELTGRRGGCG
|
T138
|
|
|
Y227
|
FICENNRyGMGtsVE
|
|
|
0
|
10
|
|
|
|
PDHA1 (human)
|
FICENNRyGMGtsVE
|
Y227
|
|
PDHA1 iso2 (human)
|
FICENNRYGMGTSVE
|
Y234
|
|
PDHA1 iso4 (human)
|
FICENNRYGMGTSVE
|
Y265
|
|
PDHA1 (mouse)
|
FICENNRyGMGtsVE
|
Y227
|
|
PDHA1 (rat)
|
FICENNRyGMGtsVE
|
Y227
|
|
PDHA1 (pig)
|
FICENNRYGMGTsVE
|
Y226
|
|
|
T231
|
NNRyGMGtsVERAAA
|
Upstream
|
|
0
|
41
|
|
|
|
Regulatory protein:
|
|
Treatment
|
|
|
PDHA1 (human)
|
NNRyGMGtsVERAAA
|
T231
|
|
PDHA1 iso2 (human)
|
NNRYGMGTSVERAAA
|
T238
|
|
PDHA1 iso4 (human)
|
NNRYGMGTSVERAAA
|
T269
|
|
PDHA1 (mouse)
|
NNRyGMGtsVERAAA
|
T231
|
|
PDHA1 (rat)
|
NNRyGMGtsVERAAA
|
T231
|
|
PDHA1 (pig)
|
NNRYGMGTsVERAAA
|
T230
|
|
|
S232
|
NRyGMGtsVERAAAS
|
Upstream
|
Downstream
|
46
|
87
|
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, inhibited
|
|
Effects on Biological Processes:
- cell cycle regulation
- signaling pathway regulation
|
|
|
Putative in vivo kinases:
- PDHK1 (human)
- PDHK2 (human)
- PDK1 (human)
|
|
Regulatory protein:
- ADRB1 (mouse)
- FOXO1A (mouse)
- HSP90B (mouse)
- IL6 (mouse)
- MLYCD (mouse)
- Raptor (mouse)
- RICTOR (mouse)
- SIRT3 (human)
- STAU (mouse)
|
|
Treatment
- AS1842856
- DCA
- exercise
- fasting
- high-fat diet
- hypoxia
- refeeding
|
|
|
PDHA1 (human)
|
NRyGMGtsVERAAAs
|
S232
|
|
PDHA1 iso2 (human)
|
NRYGMGTSVERAAAS
|
S239
|
|
PDHA1 iso4 (human)
|
NRYGMGTSVERAAAS
|
S270
|
|
PDHA1 (mouse)
|
NRyGMGtsVERAAAS
|
S232
|
|
PDHA1 (rat)
|
NRyGMGtsVERAAAS
|
S232
|
|
PDHA1 (pig)
|
NRYGMGTsVERAAAS
|
S231
|
|
|
S239
|
sVERAAASTDyyKRG
|
|
|
1
|
0
|
|
|
|
PDHA1 (human)
|
sVERAAAstDyyKRG
|
S239
|
|
PDHA1 iso2 (human)
|
SVERAAASTDYYKRG
|
S246
|
|
PDHA1 iso4 (human)
|
SVERAAASTDYYKRG
|
S277
|
|
PDHA1 (mouse)
|
sVERAAASTDyyKRG
|
S239
|
|
PDHA1 (rat)
|
sVERAAASTDYYKRG
|
S239
|
|
PDHA1 (pig)
|
sVERAAASTDYYKRG
|
S238
|
|
|
T240
|
VERAAASTDyyKRGD
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
VERAAAstDyyKRGD
|
T240
|
|
PDHA1 iso2 (human)
|
VERAAASTDYYKRGD
|
T247
|
|
PDHA1 iso4 (human)
|
VERAAASTDYYKRGD
|
T278
|
|
PDHA1 (mouse)
|
VERAAASTDyyKRGD
|
T240
|
|
PDHA1 (rat)
|
VERAAASTDYYKRGD
|
T240
|
|
PDHA1 (pig)
|
VERAAASTDYYKRGD
|
T239
|
|
|
Y242
|
RAAASTDyyKRGDFI
|
|
|
0
|
49
|
|
|
|
PDHA1 (human)
|
RAAAstDyyKRGDFI
|
Y242
|
|
PDHA1 iso2 (human)
|
RAAASTDYYKRGDFI
|
Y249
|
|
PDHA1 iso4 (human)
|
RAAASTDYYKRGDFI
|
Y280
|
|
PDHA1 (mouse)
|
RAAASTDyyKRGDFI
|
Y242
|
|
PDHA1 (rat)
|
RAAASTDYYKRGDFI
|
Y242
|
|
PDHA1 (pig)
|
RAAASTDYYKRGDFI
|
Y241
|
|
|
Y243
|
AAASTDyyKRGDFIP
|
|
|
0
|
4
|
|
|
|
PDHA1 (human)
|
AAAstDyyKRGDFIP
|
Y243
|
|
PDHA1 iso2 (human)
|
AAASTDYYKRGDFIP
|
Y250
|
|
PDHA1 iso4 (human)
|
AAASTDYYKRGDFIP
|
Y281
|
|
PDHA1 (mouse)
|
AAASTDyyKRGDFIP
|
Y243
|
|
PDHA1 (rat)
|
AAASTDYYKRGDFIP
|
Y243
|
|
PDHA1 (pig)
|
AAASTDYYKRGDFIP
|
Y242
|
|
|
Y272
|
ATKFAAAYCRSGKGP
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
ATRFAAAyCRSGKGP
|
Y272
|
|
PDHA1 iso2 (human)
|
ATRFAAAYCRSGKGP
|
Y279
|
|
PDHA1 iso4 (human)
|
ATRFAAAYCRSGKGP
|
Y310
|
|
PDHA1 (mouse)
|
ATKFAAAYCRSGKGP
|
Y272
|
|
PDHA1 (rat)
|
ATKFAAAYCRSGKGP
|
Y272
|
|
PDHA1 (pig)
|
ATRFAAAYCRSGKGP
|
Y271
|
|
|
Y289
|
MELQTYRyHGHsMsD
|
|
|
1
|
464
|
|
|
|
PDHA1 (human)
|
MELQTYRyHGHsMsD
|
Y289
|
|
PDHA1 iso2 (human)
|
MELQTYRYHGHsMSD
|
Y296
|
|
PDHA1 iso4 (human)
|
MELQTYRYHGHSMSD
|
Y327
|
|
PDHA1 (mouse)
|
MELQTYRyHGHsMsD
|
Y289
|
|
PDHA1 (rat)
|
MELQTYRyHGHsMsD
|
Y289
|
|
PDHA1 (pig)
|
MELQTYRYHGHsMSD
|
Y288
|
|
|
S293
|
TYRyHGHsMsDPGVs
|
Upstream
|
Downstream
|
100
|
785
|
|
|
|
|
|
Effects on Modified Protein
- acetylation
- activity, induced
- enzymatic activity, inhibited
|
|
Effects on Biological Processes:
- carcinogenesis, altered
- cell cycle regulation
- cell differentiation, altered
|
|
|
Putative in vivo kinases:
- PDHK1 (human)
- PDHK3 (human)
- PDHK4 (human)
|
|
Regulatory protein:
- AMPKA2 (mouse)
- BCKDH E1-alpha (mouse)
- CRAT (mouse)
- FOXO1A (mouse)
- GAS7 (human)
- HBP1 (human)
- HSP90B (mouse)
- IL6 (mouse)
- MAF1 (mouse)
- MCU (mouse)
- MLYCD (mouse)
- SIRT3 (human)
- SLC15A4 (human)
|
|
Treatment
- 2-deoxyglucose
- AS1842856
- butyrate
- culturing_of_cells
- DCA
- deoxycholic_acid
- development
- etomoxir
- exercise
- fasting
- free_fatty_acids
- high-fat diet
- hypoxia
- isoproterenol
- meal feeding
- melatonin
- NaF
- palmitate
- pilocarpine
- PS10
- taurine
|
|
|
PDHA1 (human)
|
TYRyHGHsMsDPGVs
|
S293
|
|
PDHA1 iso2 (human)
|
TYRYHGHsMSDPGVS
|
S300
|
|
PDHA1 iso4 (human)
|
TYRYHGHSMSDPGVS
|
S331
|
|
PDHA1 (mouse)
|
TYRyHGHsMsDPGVs
|
S293
|
|
PDHA1 (rat)
|
TYRyHGHsMsDPGVs
|
S293
|
|
PDHA1 (pig)
|
TYRYHGHsMSDPGVs
|
S292
|
|
|
S295
|
RyHGHsMsDPGVsyR
|
Upstream
|
|
3
|
292
|
|
|
|
Regulatory protein:
- IL6 (mouse)
- leptin (mouse)
|
|
Treatment
|
|
|
PDHA1 (human)
|
RyHGHsMsDPGVsyR
|
S295
|
|
PDHA1 iso2 (human)
|
RYHGHsMSDPGVSYR
|
S302
|
|
PDHA1 iso4 (human)
|
RYHGHSMSDPGVSYR
|
S333
|
|
PDHA1 (mouse)
|
RyHGHsMsDPGVsyR
|
S295
|
|
PDHA1 (rat)
|
RyHGHsMsDPGVsyR
|
S295
|
|
PDHA1 (pig)
|
RYHGHsMSDPGVsYR
|
S294
|
|
|
S300
|
sMsDPGVsyRtREEI
|
Upstream
|
Downstream
|
53
|
553
|
|
|
|
Effects on Modified Protein
- enzymatic activity, inhibited
|
|
|
Putative in vivo kinases:
|
|
Regulatory protein:
- AMPKA2 (mouse)
- BCKDH E1-alpha (mouse)
- CRAT (mouse)
- FOXO1A (mouse)
- HAX1 (human)
- HSP90B (mouse)
- IL6 (mouse)
- SIRT3 (human)
|
|
Treatment
- AS1842856
- DCA
- exercise
- fasting
- high-fat diet
- hypoxia
- LPS
|
|
|
PDHA1 (human)
|
sMsDPGVsyRtREEI
|
S300
|
|
PDHA1 iso2 (human)
|
sMSDPGVSYRTREEI
|
S307
|
|
PDHA1 iso4 (human)
|
SMSDPGVSYRTREEI
|
S338
|
|
PDHA1 (mouse)
|
sMsDPGVsyRtREEI
|
S300
|
|
PDHA1 (rat)
|
sMsDPGVsyRTREEI
|
S300
|
|
PDHA1 (pig)
|
sMSDPGVsYRTREEI
|
S299
|
|
|
Y301
|
MsDPGVsyRtREEIQ
|
|
|
2
|
1418
|
|
|
|
PDHA1 (human)
|
MsDPGVsyRtREEIQ
|
Y301
|
|
PDHA1 iso2 (human)
|
MSDPGVSYRTREEIQ
|
Y308
|
|
PDHA1 iso4 (human)
|
MSDPGVSYRTREEIQ
|
Y339
|
|
PDHA1 (mouse)
|
MsDPGVsyRtREEIQ
|
Y301
|
|
PDHA1 (rat)
|
MsDPGVsyRTREEIQ
|
Y301
|
|
PDHA1 (pig)
|
MSDPGVsYRTREEIQ
|
Y300
|
|
|
T303
|
DPGVsyRtREEIQEV
|
|
|
0
|
43
|
|
|
|
PDHA1 (human)
|
DPGVsyRtREEIQEV
|
T303
|
|
PDHA1 iso2 (human)
|
DPGVSYRTREEIQEV
|
T310
|
|
PDHA1 iso4 (human)
|
DPGVSYRTREEIQEV
|
T341
|
|
PDHA1 (mouse)
|
DPGVsyRtREEIQEV
|
T303
|
|
PDHA1 (rat)
|
DPGVsyRTREEIQEV
|
T303
|
|
PDHA1 (pig)
|
DPGVsYRTREEIQEV
|
T302
|
|
|
S314
|
IQEVRSKsDPIMLLK
|
|
|
1
|
2
|
|
|
|
PDHA1 (human)
|
IQEVRSKsDPIMLLK
|
S314
|
|
PDHA1 iso2 (human)
|
IQEVRSKSDPIMLLK
|
S321
|
|
PDHA1 iso4 (human)
|
IQEVRSKSDPIMLLK
|
S352
|
|
PDHA1 (mouse)
|
IQEVRSKsDPIMLLK
|
S314
|
|
PDHA1 (rat)
|
IQEVRSKSDPIMLLK
|
S314
|
|
PDHA1 (pig)
|
IQEVRSKSDPIMLLK
|
S313
|
|
|
S331
|
MVNSNLAsVEELKEI
|
|
|
0
|
2
|
|
|
|
PDHA1 (human)
|
MVNSNLASVEELKEI
|
S331
|
|
PDHA1 iso2 (human)
|
MVNSNLASVEELKEI
|
S338
|
|
PDHA1 iso4 (human)
|
MVNSNLASVEELKEI
|
S369
|
|
PDHA1 (mouse)
|
MVNSNLAsVEELKEI
|
S331
|
|
PDHA1 (rat)
|
MVNSNLASVEELKEI
|
S331
|
|
PDHA1 (pig)
|
MVNSNLASVEELKEI
|
S330
|
|
|
Y366
|
PPLEELGYHIYSSDP
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
PPLEELGyHIySSDP
|
Y366
|
|
PDHA1 iso2 (human)
|
PPLEELGYHIYSSDP
|
Y373
|
|
PDHA1 iso4 (human)
|
PPLEELGYHIYSSDP
|
Y404
|
|
PDHA1 (mouse)
|
PPLEELGYHIYSSDP
|
Y366
|
|
PDHA1 (rat)
|
PPLEELGYHIYSSDP
|
Y366
|
|
PDHA1 (pig)
|
PPLEELGYHIYCNDP
|
Y365
|
|
|
Y369
|
EELGYHIYSSDPPFE
|
|
|
0
|
1
|
|
|
|
PDHA1 (human)
|
EELGyHIySSDPPFE
|
Y369
|
|
PDHA1 iso2 (human)
|
EELGYHIYSSDPPFE
|
Y376
|
|
PDHA1 iso4 (human)
|
EELGYHIYSSDPPFE
|
Y407
|
|
PDHA1 (mouse)
|
EELGYHIYSSDPPFE
|
Y369
|
|
PDHA1 (rat)
|
EELGYHIYSSDPPFE
|
Y369
|
|
PDHA1 (pig)
|
EELGYHIYCNDPPFE
|
Y368
|
|
