PRKD1 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

Y95-p

KFPECGFyGMYDKIL

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation

Putative in vivo kinases:

Src (human)

Treatment

H2O2
phorbol_ester
PP2

PRKD1 (human)	KFPECGFyGMYDKIL	Y95-p
PRKD1 (mouse)	KFPECGFyGLYDKIL	Y93-p
PRKD1 (rat)	KFPECGFYGLYDKIL	Y93

S205-p

GVRRRRLsNVsLtGV

Upstream

Downstream

121

Effects on Modified Protein

molecular association, regulation

Treatment

angiotensin_2
Go_6976
Go_6983
H2O2
ischemia
LPA
PGE2
SII_angiotensin_2

PRKD1 (human)	GVRRRRLsNVsLtGV	S205-p
PRKD1 (mouse)	GVRRRRLsNVsLTGL	S203-p
PRKD1 (rat)	GVRRRRLsNVsLTGL	S203-p

S208-p

RRRLsNVsLtGVSTI

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Regulatory protein:

PRKD1 (human)

Treatment

angiotensin_2
Go_6976
Go_6983
H2O2
ischemia
LPA
SII_angiotensin_2

PRKD1 (human)	RRRLsNVsLtGVSTI	S208-p
PRKD1 (mouse)	RRRLsNVsLTGLGtV	S206-p
PRKD1 (rat)	RRRLsNVsLTGLGTV	S206-p

T210-p

RLsNVsLtGVSTIRt

Upstream

Treatment

angiotensin_2
SII_angiotensin_2

PRKD1 (human)	RLsNVsLtGVSTIRt	T210-p
PRKD1 (mouse)	RLsNVsLTGLGtVRT	T208
PRKD1 (rat)	RLsNVsLTGLGTVRT	T208

T214

VsLtGVSTIRtSsAE

PRKD1 (human)	VsLtGVSTIRtSsAE	T214
PRKD1 (mouse)	VsLTGLGtVRTASAE	T212-p
PRKD1 (rat)	VsLTGLGTVRTASAE	T212

T217-p

tGVSTIRtSsAELst

PRKD1 (human)	tGVSTIRtSsAELst	T217-p
PRKD1 (mouse)	TGLGtVRTASAEFST	T215
PRKD1 (rat)	TGLGTVRTASAEFST	T215

S219-p

VSTIRtSsAELstsA

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Treatment

Go_6976
Go_6983
H2O2

PRKD1 (human)	VSTIRtSsAELstsA	S219-p
PRKD1 (mouse)	LGtVRTASAEFSTSV	S217
PRKD1 (rat)	LGTVRTASAEFSTSA	S217

S223-p

RtSsAELstsAPDEP

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Treatment

Go_6976
Go_6983
H2O2

PRKD1 (human)	RtSsAELstsAPDEP	S223-p
PRKD1 (mouse)	RTASAEFSTSVPDEP	S221
PRKD1 (rat)	RTASAEFSTSAPDEP	S221

T224-p

tSsAELstsAPDEPL

PRKD1 (human)	tSsAELstsAPDEPL	T224-p
PRKD1 (mouse)	TASAEFSTSVPDEPL	T222
PRKD1 (rat)	TASAEFSTSAPDEPL	T222

S225-p

SsAELstsAPDEPLL

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	SsAELstsAPDEPLL	S225-p
PRKD1 (mouse)	ASAEFSTSVPDEPLL	S223
PRKD1 (rat)	ASAEFSTSAPDEPLL	S223

S235-p

DEPLLQKsPsEsFIG

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	DEPLLQKsPsEsFIG	S235-p
PRKD1 (mouse)	SPGFEQKsPsESFIG	S241-p
PRKD1 (rat)	SPGFEQKSPSESFIG	S241

S237-p

PLLQKsPsEsFIGRE

Upstream

Regulatory protein:

PRKD1 (human)

Treatment

angiotensin_2
LPA

PRKD1 (human)	PLLQKsPsEsFIGRE	S237-p
PRKD1 (mouse)	GFEQKsPsESFIGRE	S243-p
PRKD1 (rat)	GFEQKSPSESFIGRE	S243

S239-p

LQKsPsEsFIGREKR

PRKD1 (human)	LQKsPsEsFIGREKR	S239-p
PRKD1 (mouse)	EQKsPsESFIGREKR	S245
PRKD1 (rat)	EQKSPSESFIGREKR	S245

S247-p

FIGREKRsNsQSYIG

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	FIGREKRsNsQSYIG	S247-p
PRKD1 (mouse)	FIGREKRsNsQSYIG	S253-p
PRKD1 (rat)	FIGREKRSNSQSYVG	S253

S249-p

GREKRsNsQSYIGRP

Upstream

Regulatory protein:

PRKD1 (human)

Treatment

ischemia
LPA

PRKD1 (human)	GREKRsNsQSYIGRP	S249-p
PRKD1 (mouse)	GREKRsNsQSYIGRP	S255-p
PRKD1 (rat)	GREKRSNSQSYVGRP	S255

K292-ub

QYCKKLLkGLFRQGL

PRKD1 (human)	QYCKKLLkGLFRQGL	K292-ub
PRKD1 (mouse)	QFCKKLLkGLFRQGL	K298-ub
PRKD1 (rat)	QFCKKLLKGLFRQGL	K298

S345-p

DVVMEEGsDDNDSER

PRKD1 (human)	DVVMEEGsDDNDSER	S345-p
PRKD1 (mouse)	DVVMEEGSDDNDSER	S351
PRKD1 (rat)	DVVMEEGSDDNDSER	S351

S379-p

MAECQNDsGEMQDPD

PRKD1 (human)	MAECQNDsGEMQDPD	S379-p
PRKD1 (mouse)	LAEGQSGGAEMQDPD	G385
PRKD1 (rat)	LAEGQSDGAEMQDPD	G385

T395-p

DHEDANRtIsPStsN

Upstream

Treatment

angiotensin_2
SII_angiotensin_2

PRKD1 (human)	DHEDANRtIsPStsN	T395-p
PRKD1 (mouse)	DQEDSNRtIsPStsN	T401-p
PRKD1 (rat)	DQEDSNRTIsPSTSN	T401

S397-p

EDANRtIsPStsNNI

Upstream

Treatment

PRKD1 (human)	EDANRtIsPStsNNI	S397-p
PRKD1 (mouse)	EDSNRtIsPStsNNI	S403-p
PRKD1 (rat)	EDSNRTIsPSTSNNI	S403-p

T400-p

NRtIsPStsNNIPLM

PRKD1 (human)	NRtIsPStsNNIPLM	T400-p
PRKD1 (mouse)	NRtIsPStsNNIPLM	T406-p
PRKD1 (rat)	NRTIsPSTSNNIPLM	T406

S401-p

RtIsPStsNNIPLMR

Upstream

Regulatory protein:

PRKD1 (human)

Treatment

angiotensin_2
SII_angiotensin_2

PRKD1 (human)	RtIsPStsNNIPLMR	S401-p
PRKD1 (mouse)	RtIsPStsNNIPLMR	S407-p
PRKD1 (rat)	RTIsPSTSNNIPLMR	S407

S412-p

PLMRVVQsVKHTKRK

Upstream

Kinase, in vitro:

PKCA (human)
PKCD (human)

Putative in vivo kinases:

PKCD (human)

Regulatory protein:

PKCD (human)

Treatment

endothelin
Go_6976
Go_6983
isoproterenol
norepinephrine
phenylephrine
phorbol_ester

PRKD1 (human)	PLMRVVQsVKHTKRK	S412-p
PRKD1 (mouse)	PLMRVVQSVKHTKRR	S418
PRKD1 (rat)	PLMRVVQSVKHTKRR	S418

S421-p

KHTKRKSstVMKEGW

Upstream

Putative in vivo kinases:

PKACA (human)

Treatment

8-Rp-cAMP
CID755673
H-89
isoproterenol
NKH_477

PRKD1 (human)	KHTKRKSstVMKEGW	S421-p
PRKD1 (mouse)	KHTKRRSsTVMKEGW	S427-p
PRKD1 (rat)	KHTKRRSSTVMKEGW	S427

T422-p

HTKRKSstVMKEGWM

PRKD1 (human)	HTKRKSstVMKEGWM	T422-p
PRKD1 (mouse)	HTKRRSsTVMKEGWM	T428
PRKD1 (rat)	HTKRRSSTVMKEGWM	T428

Y432-p

KEGWMVHyTSKDTLR

Upstream

Putative in vivo kinases:

Src (human)

PRKD1 (human)	KEGWMVHyTSKDTLR	Y432-p
PRKD1 (mouse)	KEGWMVHYTSKDTLR	Y438
PRKD1 (rat)	KEGWMVHYTSKDTLR	Y438

Y443-p

DTLRKRHyWRLDsKC

PRKD1 (human)	DTLRKRHyWRLDsKC	Y443-p
PRKD1 (mouse)	DTLRKRHYWRLDSKC	Y449
PRKD1 (rat)	DTLRKRHYWRLDSKS	Y449

S448-p

RHyWRLDsKCITLFQ

PRKD1 (human)	RHyWRLDsKCITLFQ	S448-p
PRKD1 (mouse)	RHYWRLDSKCITLFQ	S454
PRKD1 (rat)	RHYWRLDSKSITLFQ	S454

S460-p

LFQNDTGsRYyKEIP

PRKD1 (human)	LFQNDTGsRYyKEIP	S460-p
PRKD1 (mouse)	LFQNDTGSRYyKEIP	S466
PRKD1 (rat)	LFQNDTGSRYYKEIP	S466

Y463-p

NDTGsRYyKEIPLSE

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
phosphorylation
protein conformation

Effects on Biological Processes:

apoptosis, inhibited
cell differentiation, altered
cell growth, altered
transcription, altered
transcription, induced

Kinase, in vitro:

Abl (human)

Putative in vivo kinases:

Abl (human)
Src (human)

Treatment

bradykinin
H2O2
phorbol_ester
resveratrol
vanadate
VEGF

PRKD1 (human)	NDTGsRYyKEIPLSE	Y463-p
PRKD1 (mouse)	NDTGSRYyKEIPLSE	Y469-p
PRKD1 (rat)	NDTGSRYYKEIPLSE	Y469

S473-p

IPLSEILsLEPVKTS

PRKD1 (human)	IPLSEILsLEPVKTS	S473-p
PRKD1 (mouse)	IPLSEILCLEPAKPS	C479
PRKD1 (rat)	IPLSEILCLEPAKPS	C479

Y502-p

TTANVVYyVGENVVN

Upstream

Putative in vivo kinases:

Src (human)

PRKD1 (human)	TTANVVYyVGENVVN	Y502-p
PRKD1 (mouse)	TTANVVYYVGENVVN	Y508
PRKD1 (rat)	TTANVVYYVGENVVN	Y508

S548-p

MPVIPKGssVGTGTN

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	MPVIPKGssVGTGTN	S548-p
PRKD1 (mouse)	MPVIPKGSSVGSGSN	S554
PRKD1 (rat)	MPVIPKGSSVGSGTN	S554

S549-p

PVIPKGssVGTGTNL

PRKD1 (human)	PVIPKGssVGTGTNL	S549-p
PRKD1 (mouse)	PVIPKGSSVGSGSNS	S555
PRKD1 (rat)	PVIPKGSSVGSGTNS	S555

K612-ac

TGRDVAIkIIDKLRF

PRKD1 (human)	TGRDVAIkIIDKLRF	K612-ac
PRKD1 (mouse)	TGRDVAIKIIDKLRF	K618
PRKD1 (rat)	TGRDVAIKIIDKLRF	K618

K737-ub

FARIIGEksFRRsVV

PRKD1 (human)	FARIIGEksFRRsVV	K737-ub
PRKD1 (mouse)	FARIIGEksFRRsVV	K743-ub
PRKD1 (rat)	FARIIGEKsFRRsVV	K743

S738-p

ARIIGEksFRRsVVG

Upstream

Downstream

PRKD1 (human)
S738-p

2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody

PRKD1 (mouse)
S744-p

2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody

Effects on Modified Protein

enzymatic activity, induced
intracellular localization
molecular association, regulation
ubiquitination

Effects on Biological Processes:

cell cycle regulation
cell differentiation, altered
cell growth, induced
cell motility, altered
signaling pathway regulation
transcription, altered

Kinase, in vitro:

PKCA (human)
PKCD (human)
PKCE (human)
PKCH (human)

Putative in vivo kinases:

PKCA (human)
PKCD (human)
PKCH (human)
PRKD1 (human)
PRKD3 (human)

Regulatory protein:

Abl (human)
AKAP13 (human)
PKCD (human)
PRKD1 (human)
Src (human)

Treatment

antibody
aphidicolin
arachidonic_acid
ATP
BAPTA-AM
bisindolylmaleimide
bombesin
bradykinin
BSO
CID755673
colforsin
DTBR
EGF
endothelin
exercise
fibronectin
GF109203X
Go_6976
Go_6983
H-89
H2O2
HB-EGF
IBMX
IGF-1
isoproterenol
LPA
LXS-196
neurotensin
nocodazole
norepinephrine
oxytocin
PDGF
peptide_antagonist
phenylephrine
phorbol_ester
polyHEMA
resveratrol
RO-3306
Ro31-8220
RSL3
salicylate
STLC
taxol
TeTx
TGF-beta
thrombin
tPA
Trametinib
U73122
U73343
vanadate
vasopressin
VEGF
virus infection
wortmannin
YM-254890
ZM447439

PRKD1 (human)	ARIIGEksFRRsVVG	S738-p
PRKD1 (mouse)	ARIIGEksFRRsVVG	S744-p
PRKD1 (rat)	ARIIGEKsFRRsVVG	S744-p

S742-p

GEksFRRsVVGtPAy

Upstream

Downstream

100

PRKD1 (mouse)
S748-p

2054 : Phospho-PKD/PKCmu (Ser744/748) Antibody

Effects on Modified Protein

enzymatic activity, induced
enzymatic activity, inhibited
molecular association, regulation
ubiquitination

Effects on Biological Processes:

cell cycle regulation
cell differentiation, altered
cell growth, induced
cell motility, altered
signaling pathway regulation
transcription, altered

Kinase, in vitro:

PKCA (human)
PKCD (human)
PKCE (human)
PKCH (human)

Putative in vivo kinases:

PKCA (human)
PKCD (human)
PKCH (human)
PRKD1 (human)
PRKD3 (human)

Regulatory protein:

Abl (human)
AKAP13 (human)
CD38 (human)
PKCD (human)
PRKD1 (human)
Src (human)

Treatment

antibody
arachidonic_acid
ATP
BAPTA-AM
bisindolylmaleimide
bombesin
bradykinin
BSO
CID755673
colforsin
DTBR
EGF
endothelin
exercise
fibronectin
GF109203X
Go_6976
Go_6983
H2O2
HB-EGF
IBMX
IGF-1
isoproterenol
LPA
LXS-196
neurotensin
nocodazole
norepinephrine
oxytocin
PDGF
peptide_antagonist
phenylephrine
phorbol_ester
polyHEMA
resveratrol
RO-3306
Ro31-8220
RSL3
salicylate
STLC
taxol
TGF-beta
thrombin
TNF
tPA
Trametinib
U73122
U73343
vanadate
vasopressin
VEGF
virus infection
wortmannin
YM-254890

PRKD1 (human)	GEksFRRsVVGtPAy	S742-p
PRKD1 (mouse)	GEksFRRsVVGtPAy	S748-p
PRKD1 (rat)	GEKsFRRsVVGTPAY	S748-p

T746-p

FRRsVVGtPAyLAPE

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	FRRsVVGtPAyLAPE	T746-p
PRKD1 (mouse)	FRRsVVGtPAyLAPE	T752-p
PRKD1 (rat)	FRRsVVGTPAYLAPE	T752

Y749-p

sVVGtPAyLAPEVLR

PRKD1 (human)	sVVGtPAyLAPEVLR	Y749-p
PRKD1 (mouse)	sVVGtPAyLAPEVLR	Y755-p
PRKD1 (rat)	sVVGTPAYLAPEVLR	Y755

S890-p

HLINPSAsHsDTPET

PRKD1 (human)	HLINPSAsHsDTPET	S890-p
PRKD1 (mouse)	HLISLSASHSDSPEA	S896
PRKD1 (rat)	HLINLSASHGDSPEA	S896

S892-p

INPSAsHsDTPETEE

Upstream

Regulatory protein:

PRKD1 (human)

PRKD1 (human)	INPSAsHsDTPETEE	S892-p
PRKD1 (mouse)	ISLSASHSDSPEAEE	S898
PRKD1 (rat)	INLSASHGDSPEAEE	G898

S910-p

KALGERVsIL_____

Upstream

Downstream

PRKD1 (human)
S910-p

PRKD1 (mouse)
S916-p

Effects on Modified Protein

enzymatic activity, induced
enzymatic activity, inhibited
phosphorylation

Effects on Biological Processes:

signaling pathway regulation

Kinase, in vitro:

PRKD1 (human)

Putative in vivo kinases:

PRKD1 (human)
PRKD1 (mouse)

Regulatory protein:

PLCE1 (human)

Treatment

AFN700
antibody
arachidonic_acid
ATP
BAA473
bisindolylmaleimide
bombesin
bryostatin_1
carbachol
CGP044892
CID755673
CRT0066101
endothelin
fibronectin
genistein
GF109203X
Go_6976
Go_6983
gramicidin
H2O2
ischemia
isoproterenol
kb_NB_142-70
LPA
MCC950
MSU crystals
neurotensin
niclosamide
nigericin
norepinephrine
PD98059
phenylephrine
phorbol_ester
polyHEMA
rapamycin
resveratrol
salicylate
Salmonella typhimurium PrgI protein
SB203580
serum
siRNA
thrombin
virus infection
wortmannin

PRKD1 (human)	KALGERVsIL_____	S910-p
PRKD1 (mouse)	KALSERVsIL_____	S916-p
PRKD1 (rat)	KALSERVsIL_____	S916-p