Other Species / Isoforms
  Lck (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y25
DVCENCHYPIVPLDS
0 16
Lck (human) DVCENCHyPIVPLDG Y25-p
Lck iso3 (human) DVCENCHYPIVPLDG Y25
Lck (mouse) DVCENCHYPIVPLDS Y25
Lck (rat) DVCENCHYPIVPLDS Y25
S35-p
VPLDSKIsLPIRNGs
0 7
Lck (human) VPLDGKGtLLIRNGs T35-p
Lck iso3 (human) VPLDGKGTLLIRNGS T35
Lck (mouse) VPLDSKIsLPIRNGs S35-p
Lck (rat) VPLDSKStLPIRTGs T35-p
S42-p
sLPIRNGsEVRDPLV
2 34
Lck (human) tLLIRNGsEVRDPLV S42-p
Lck iso3 (human) TLLIRNGSEVRDPLV S42
Lck (mouse) sLPIRNGsEVRDPLV S42-p
Lck (rat) tLPIRTGsEVRDPLV S42-p
T50
EVRDPLVTYEGSLPP
0 3
Lck (human) EVRDPLVtyEGSNPP T50-p
Lck iso3 (human) EVRDPLVTYEGSNPP T50
Lck (mouse) EVRDPLVTYEGSLPP T50
Lck (rat) EVRDPLVTYEGSLPP T50
Y51
VRDPLVTYEGSLPPA
0 8
Lck (human) VRDPLVtyEGSNPPA Y51-p
Lck iso3 (human) VRDPLVTYEGSNPPA Y51
Lck (mouse) VRDPLVTYEGSLPPA Y51
Lck (rat) VRDPLVTYEGSLPPA Y51
S59-p
EGSLPPAsPLQDNLV
Upstream
Downstream
10 8
Effects on Modified Protein
  • enzymatic activity, inhibited
Effects on Biological Processes:
  • cell growth, inhibited
Treatment
  • anti-IgG
  • nocodazole
  • PD98059
  • phorbol_ester
  • SB203580
  • U0126
Lck (human) EGSNPPAsPLQDNLV S59-p
Lck iso3 (human) EGSNPPASPLQDNLV S59
Lck (mouse) EGSLPPAsPLQDNLV S59-p
Lck (rat) EGSLPPASPLQDNLV S59
K84
DGDLGFEKGEQLRIL
0 2
Lck (human) DGDLGFEkGEQLRIL K84-ub
Lck iso3 (human) DGDLGFEKGEQLRIL K84
Lck (mouse) DGDLGFEKGEQLRIL K84
Lck (rat) DGDLGFEKGEQLRIL K84
S94
QLRILEQSGEWWKAQ
0 3
Lck (human) QLRILEQsGEWWkAQ S94-p
Lck iso3 (human) QLRILEQSGEWWKAQ S94
Lck (mouse) QLRILEQSGEWWKAQ S94
Lck (rat) QLRILEQsGEWWKAQ S94-p
K99
EQSGEWWKAQSLTTG
0 1
Lck (human) EQsGEWWkAQsLTTG K99-ub
Lck iso3 (human) EQSGEWWKAQSLTTG K99
Lck (mouse) EQSGEWWKAQSLTTG K99
Lck (rat) EQsGEWWKAQSLTTG K99
S102
GEWWKAQSLTTGQEG
0 5
Lck (human) GEWWkAQsLTTGQEG S102-p
Lck iso3 (human) GEWWKAQSLTTGQEG S102
Lck (mouse) GEWWKAQSLTTGQEG S102
Lck (rat) GEWWKAQSLTTGQEG S102
K118
IPFNFVAKANSLEPE
0 1
Lck (human) IPFNFVAkANsLEPE K118-ub
Lck iso3 (human) IPFNFVAKANSLEPE K118
Lck (mouse) IPFNFVAKANSLEPE K118
Lck (rat) IPFNFVAKANSLEPE K118
S121
NFVAKANSLEPEPWF
0 1
Lck (human) NFVAkANsLEPEPWF S121-p
Lck iso3 (human) NFVAKANSLEPEPWF S121
Lck (mouse) NFVAKANSLEPEPWF S121
Lck (rat) NFVAKANSLEPEPWF S121
K130
EPEPWFFKNLSRKDA
0 3
Lck (human) EPEPWFFkNLsRKDA K130-ub
Lck iso3 (human) EPEPWFFKNLSRKDA K130
Lck (mouse) EPEPWFFKNLSRKDA K130
Lck (rat) EPEPWFFKNLSRKDA K130
S133
PWFFKNLSRKDAERQ
0 1
Lck (human) PWFFkNLsRKDAERQ S133-p
Lck iso3 (human) PWFFKNLSRKDAERQ S133
Lck (mouse) PWFFKNLSRKDAERQ S133
Lck (rat) PWFFKNLSRKDAERQ S133
S150
APGNTHGSFLIRESE
0 1
Lck (human) APGNTHGsFLIREsE S150-p
Lck iso3 (human) APGNTHGSFLIRESE S150
Lck (mouse) APGNTHGSFLIRESE S150
Lck (rat) APGNTHGSFLIRESE S150
S156
GSFLIRESESTAGSF
0 1
Lck (human) GsFLIREsEstAGsF S156-p
Lck iso3 (human) GSFLIRESESTAGSF S156
Lck (mouse) GSFLIRESESTAGSF S156
Lck (rat) GSFLIRESESTAGSF S156
S158
FLIRESESTAGSFSL
1 3
Lck (human) FLIREsEstAGsFSL S158-p
Lck iso3 (human) FLIRESESTAGSFSL S158
Lck (mouse) FLIRESESTAGSFSL S158
Lck (rat) FLIRESESTAGSFSL S158
T159
LIRESESTAGSFSLS
0 1
Lck (human) LIREsEstAGsFSLS T159-p
Lck iso3 (human) LIRESESTAGSFSLS T159
Lck (mouse) LIRESESTAGSFSLS T159
Lck (rat) LIRESESTAGSFSLS T159
S162
ESESTAGSFSLSVRD
0 7
Lck (human) EsEstAGsFSLSVRD S162-p
Lck iso3 (human) ESESTAGSFSLSVRD S162
Lck (mouse) ESESTAGSFSLSVRD S162
Lck (rat) ESESTAGSFSLSVRD S162
K179
QNQGEVVKHYKIRNL
0 3
Lck (human) QNQGEVVkHykIRNL K179-ac
Lck iso3 (human) QNQGEVVKHYKIRNL K179
Lck (mouse) QNQGEVVKHYKIRNL K179
Lck (rat) QNQGEVVkHYKIRNL K179-ac
K179
QNQGEVVKHYKIRNL
0 6
Lck (human) QNQGEVVkHykIRNL K179-ub
Lck iso3 (human) QNQGEVVKHYKIRNL K179
Lck (mouse) QNQGEVVKHYKIRNL K179
Lck (rat) QNQGEVVKHYKIRNL K179
Y181
QGEVVKHYKIRNLDN
0 1
Lck (human) QGEVVkHykIRNLDN Y181-p
Lck iso3 (human) QGEVVKHYKIRNLDN Y181
Lck (mouse) QGEVVKHYKIRNLDN Y181
Lck (rat) QGEVVkHYKIRNLDN Y181
K182
GEVVKHYKIRNLDNG
0 1
Lck (human) GEVVkHykIRNLDNG K182-ub
Lck iso3 (human) GEVVKHYKIRNLDNG K182
Lck (mouse) GEVVKHYKIRNLDNG K182
Lck (rat) GEVVkHYKIRNLDNG K182
Y192-p
NLDNGGFyISPRITF
Upstream
Downstream
3 1083
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
  • protein conformation
Treatment
  • anti-CD3
Lck (human) NLDNGGFyIsPRItF Y192-p
Lck iso3 (human) NLDNGGFYISPRITF Y192
Lck (mouse) NLDNGGFyISPRITF Y192-p
Lck (rat) NLDNGGFyISPRITF Y192-p
S194
DNGGFyISPRITFPG
1 12
Lck (human) DNGGFyIsPRItFPG S194-p
Lck iso3 (human) DNGGFYISPRITFPG S194
Lck (mouse) DNGGFyISPRITFPG S194
Lck (rat) DNGGFyISPRITFPG S194
T198
FyISPRITFPGLHDL
0 3
Lck (human) FyIsPRItFPGLHEL T198-p
Lck iso3 (human) FYISPRITFPGLHEL T198
Lck (mouse) FyISPRITFPGLHDL T198
Lck (rat) FyISPRITFPGLHDL T198
Y209
LHDLVRHYTNASDGL
0 1
Lck (human) LHELVRHytNAsDGL Y209-p
Lck iso3 (human) LHELVRHYTNASDGL Y209
Lck (mouse) LHDLVRHYTNASDGL Y209
Lck (rat) LHDLVRHYTNASDGL Y209
T210
HDLVRHYTNASDGLC
0 3
Lck (human) HELVRHytNAsDGLC T210-p
Lck iso3 (human) HELVRHYTNASDGLC T210
Lck (mouse) HDLVRHYTNASDGLC T210
Lck (rat) HDLVRHYTNASDGLC T210
S213
VRHYTNASDGLCTKL
0 2
Lck (human) VRHytNAsDGLCTRL S213-p
Lck iso3 (human) VRHYTNASDGLCTRL S213
Lck (mouse) VRHYTNASDGLCTKL S213
Lck (rat) VRHYTNASDGLCTKL S213
K228
SRPCQTQKPQKPWWE
0 1
Lck (human) SRPCQTQkPQkPWWE K228-ub
Lck iso3 (human) SRPCQTQKPQKPWWE K228
Lck (mouse) SRPCQTQKPQKPWWE K228
Lck (rat) SRPCQTQKPQKPWWE K228
K231
CQTQKPQKPWWEDEW
0 1
Lck (human) CQTQkPQkPWWEDEW K231-ub
Lck iso3 (human) CQTQKPQKPWWEDEW K231
Lck (mouse) CQTQKPQKPWWEDEW K231
Lck (rat) CQTQKPQKPWWEDEW K231
K246
EVPRETLKLVERLGA
0 4
Lck (human) EVPRETLkLVERLGA K246-ub
Lck iso3 (human) EVPRETLKLVERLGA K246
Lck (mouse) EVPRETLKLVERLGA K246
Lck (rat) EVPRETLKLVERLGA K246
Y263
FGEVWMGYYNGHTKV
0 68
Lck (human) FGEVWMGyyNGHtkV Y263-p
Lck iso3 (human) FGEVWMGYYNGHTKV Y263
Lck (mouse) FGEVWMGYYNGHTKV Y263
Lck (rat) FGEVWMGYYNGHTKV Y263
Y264
GEVWMGYYNGHTKVA
0 19
Lck (human) GEVWMGyyNGHtkVA Y264-p
Lck iso3 (human) GEVWMGYYNGHTKVA Y264
Lck (mouse) GEVWMGYYNGHTKVA Y264
Lck (rat) GEVWMGYYNGHTKVA Y264
T268
MGYYNGHTKVAVKSL
0 1
Lck (human) MGyyNGHtkVAVKsL T268-p
Lck iso3 (human) MGYYNGHTKVAVKSL T268
Lck (mouse) MGYYNGHTKVAVKSL T268
Lck (rat) MGYYNGHTKVAVKSL T268
K269
GYYNGHTKVAVKSLK
0 3
Lck (human) GyyNGHtkVAVKsLk K269-ub
Lck iso3 (human) GYYNGHTKVAVKSLK K269
Lck (mouse) GYYNGHTKVAVKSLK K269
Lck (rat) GYYNGHTKVAVKSLK K269
S274
HTKVAVKSLKQGSMS
0 3
Lck (human) HtkVAVKsLkQGSMs S274-p
Lck iso3 (human) HTKVAVKSLKQGSMS S274
Lck (mouse) HTKVAVKSLKQGSMS S274
Lck (rat) HTKVAVKSLKQGSMS S274
K276
KVAVKSLKQGSMSPD
0 3
Lck (human) kVAVKsLkQGSMsPD K276-ub
Lck iso3 (human) KVAVKSLKQGSMSPD K276
Lck (mouse) KVAVKSLKQGSMSPD K276
Lck (rat) KVAVKSLKQGSMSPD K276
S281
SLKQGSMSPDAFLAE
0 1
Lck (human) sLkQGSMsPDAFLAE S281-p
Lck iso3 (human) SLKQGSMSPDAFLAE S281
Lck (mouse) SLKQGSMSPDAFLAE S281
Lck (rat) SLKQGSMSPDAFLAE S281
K293
LAEANLMKQLQHPRL
0 3
Lck (human) LAEANLMkQLQHQRL K293-ub
Lck iso3 (human) LAEANLMKQLQHQRL K293
Lck (mouse) LAEANLMKQLQHPRL K293
Lck (rat) LAEANLMKQLQHPRL K293
K335
LKTPSGIKLNVNKLL
0 2
Lck (human) LKTPSGIkLTINKLL K335-ub
Lck iso3 (human) LKTPSGIKLTINKLL K365
Lck (mouse) LKTPSGIKLNVNKLL K335
Lck (rat) LKTPSGIKLNVNKLL K335
T375
ANILVSDTLSCKIAD
0 4
Lck (human) ANILVSDtLSCkIAD T375-p
Lck iso3 (human) ANILVSDTLSCKIAD T405
Lck (mouse) ANILVSDTLSCKIAD T375
Lck (rat) ANILVSDTLSCKIAD T375
K379
VSDTLSCKIADFGLA
0 11
Lck (human) VSDtLSCkIADFGLA K379-ub
Lck iso3 (human) VSDTLSCKIADFGLA K409
Lck (mouse) VSDTLSCKIADFGLA K379
Lck (rat) VSDTLSCKIADFGLA K379
Y394-p
RLIEDNEytAREGAK
Upstream
Downstream
41 3034
Lck (human)
Y394-p
Lck iso3 (human)
Y424-p
Lck (mouse)
Y394-p
Lck (rat)
Y394-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell motility, altered
Kinase, in vitro:
  • Lck (mouse)
Phosphatases, in vitro:
  • SHP-1 (human)
Putative upstream phosphatases:
  • CD45 (mouse)
  • SHP-1 (human)
Regulatory protein:
  • CBL (mouse)
  • Cbl-b (mouse)
  • DUSP6 (mouse)
  • SHP-2 (mouse)
  • Src iso1 (mouse)
Treatment
  • anti-CD3
  • anti-CD4
  • cell_adhesion
  • hypoxia/reoxygenation
  • miR-181a
  • NSC-87877
  • PAO
Lck (human) RLIEDNEytAREGAK Y394-p
Lck iso3 (human) RLIEDNEYTAREGAK Y424
Lck (mouse) RLIEDNEytAREGAK Y394-p
Lck (rat) RLIEDNEyTAREGAK Y394-p
T395-p
LIEDNEytAREGAKF
1 30
Lck (human) LIEDNEytAREGAKF T395-p
Lck iso3 (human) LIEDNEYTAREGAKF T425
Lck (mouse) LIEDNEytAREGAKF T395-p
Lck (rat) LIEDNEyTAREGAKF T395
K405
EGAKFPIKWTAPEAI
0 3
Lck (human) EGAKFPIkWTAPEAI K405-ub
Lck iso3 (human) EGAKFPIKWTAPEAI K435
Lck (mouse) EGAKFPIKWTAPEAI K405
Lck (rat) EGAKFPIKWTAPEAI K405
Y414
TAPEAINYGTFTIKS
0 44
Lck (human) TAPEAINyGtFTIKS Y414-p
Lck iso3 (human) TAPEAINYGTFTIKS Y444
Lck (mouse) TAPEAINYGTFTIKS Y414
Lck (rat) TAPEAINYGTFTIKS Y414
T416
PEAINYGTFTIKSDV
0 5
Lck (human) PEAINyGtFTIKSDV T416-p
Lck iso3 (human) PEAINYGTFTIKSDV T446
Lck (mouse) PEAINYGTFTIKSDV T416
Lck (rat) PEAINYGTFTIKSDV T416
Y470
DNCPEELYHLMMLCW
0 163
Lck (human) DNCPEELyQLMRLCW Y470-p
Lck iso3 (human) DNCPEELYQLMRLCW Y500
Lck (mouse) DNCPEELYHLMMLCW Y470
Lck (rat) DNCPEELYHLMMLCW Y470
K478
HLMMLCWKERPEDRP
0 2
Lck (human) QLMRLCWkERPEDRP K478-ub
Lck iso3 (human) QLMRLCWKERPEDRP K508
Lck (mouse) HLMMLCWKERPEDRP K478
Lck (rat) HLMMLCWKERPEDRP K478
Y489
EDRPTFDYLRSVLDD
0 3
Lck (human) EDRPTFDyLRsVLED Y489-p
Lck iso3 (human) EDRPTFDYLRSVLED Y519
Lck (mouse) EDRPTFDYLRSVLDD Y489
Lck (rat) EDRPTFDYLRSVLDD Y489
S492
PTFDYLRSVLDDFFT
0 1
Lck (human) PTFDyLRsVLEDFFT S492-p
Lck iso3 (human) PTFDYLRSVLEDFFT S522
Lck (mouse) PTFDYLRSVLDDFFT S492
Lck (rat) PTFDYLRSVLDDFFT S492
T501
LDDFFTATEGQyQPQ
0 11
Lck (human) LEDFFTAtEGQyQPQ T501-p
Lck iso3 (human) LEDFFTATEGQYQPQ T531
Lck (mouse) LDDFFTATEGQyQPQ T501
Lck (rat) LDDFFTATEGQyQPQ T501
Y505-p
FTATEGQyQPQP___
Upstream
Downstream
42 822
Lck (human)
Y505-p
Lck (mouse)
Y505-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, altered
  • cell cycle regulation
Kinase, in vitro:
  • Lck (mouse)
Phosphatases, in vitro:
  • CD45 (mouse)
Putative in vivo kinases:
  • CSK (mouse)
Putative upstream phosphatases:
  • CD45 (mouse)
Regulatory protein:
  • CD4 (mouse)
  • CD45 (mouse)
Treatment
  • anti-CD3
  • cell_adhesion
  • H2O2
  • hypoxia/reoxygenation
  • ionomycin
  • miR-181a
  • PAO
  • thapsigargin
  • vanadate
Lck (human) FTAtEGQyQPQP___ Y505-p
Lck iso3 (human) FTATEGQYQPQP___ Y535
Lck (mouse) FTATEGQyQPQP___ Y505-p
Lck (rat) FTATEGQyQPQP___ Y505-p