Other Species / Isoforms
  PSEN1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
N32
TVRSQNDNRERQEHN
0 1
PSEN1 (human) TVRSQNDNRERQEHN N32
PSEN1 iso2 (human) HLSNTNDNRERQEHN N28
PSEN1 iso3 (human) HLSNTNDNRERQEHN N28
PSEN1 (mouse) AIRSQNDsQERQQQH S32-p
PSEN1 (rat) SVRSQNDNQERQQHH N31
S43-p
QEHNDRRsLGHPEPL
0 14
PSEN1 (human) QEHNDRRsLGHPEPL S43-p
PSEN1 iso2 (human) QEHNDRRSLGHPEPL S39
PSEN1 iso3 (human) QEHNDRRSLGHPEPL S39
PSEN1 (mouse) QQQHDRQRLDNPEPI R43
PSEN1 (rat) QQHHDRQRLDNPESI R42
S51-p
LGHPEPLsNGRPQGN
0 5
PSEN1 (human) LGHPEPLsNGRPQGN S51-p
PSEN1 iso2 (human) LGHPEPLSNGRPQGN S47
PSEN1 iso3 (human) LGHPEPLSNGRPQGN S47
PSEN1 (mouse) LDNPEPISNGRPQsN S51
PSEN1 (rat) LDNPESIsNGRPQSN S50-p
G57
LsNGRPQGNsRQVVE
0 1
PSEN1 (human) LsNGRPQGNsRQVVE G57
PSEN1 iso2 (human) LSNGRPQGNSRQVVE G53
PSEN1 iso3 (human) LSNGRPQGNSRQVVE G53
PSEN1 (mouse) ISNGRPQsNSRQVVE S57-p
PSEN1 (rat) IsNGRPQSNFTRQVI S56
S59-p
NGRPQGNsRQVVEQD
0 3
PSEN1 (human) NGRPQGNsRQVVEQD S59-p
PSEN1 iso2 (human) NGRPQGNSRQVVEQD S55
PSEN1 iso3 (human) NGRPQGNSRQVVEQD S55
PSEN1 (mouse) NGRPQsNSRQVVEQD S59
PSEN1 (rat) GRPQSNFTRQVIEQD T59
T74-p
EEEDEELtLkYGAKH
Downstream
1 0
Effects on Modified Protein
  • protein conformation
PSEN1 (human) EEEDEELtLkYGAKH T74-p
PSEN1 iso2 (human) EEEDEELTLKYGAKH T70
PSEN1 iso3 (human) EEEDEELTLKYGAKH T70
PSEN1 (mouse) EEEDEELTLKYGAKH T74
PSEN1 (rat) EEEDEELTLKYGAKH T74
K76-ub
EDEELtLkYGAKHVI
0 1
PSEN1 (human) EDEELtLkYGAKHVI K76-ub
PSEN1 iso2 (human) EDEELTLKYGAKHVI K72
PSEN1 iso3 (human) EDEELTLKYGAKHVI K72
PSEN1 (mouse) EDEELTLKYGAKHVI K76
PSEN1 (rat) EDEELTLKYGAKHVI K76
S102-p
VVVATIKsVsFYTRk
0 1
PSEN1 (human) VVVATIKsVsFYTRk S102-p
PSEN1 iso2 (human) VVVATIKSVSFYTRK S98
PSEN1 iso3 (human) VVVATIKSVSFYTRK S98
PSEN1 (mouse) VVVATIKSVSFYTRK S102
PSEN1 (rat) VVVATIKSVSFYTRK S102
S104-p
VATIKsVsFYTRkDG
0 1
PSEN1 (human) VATIKsVsFYTRkDG S104-p
PSEN1 iso2 (human) VATIKSVSFYTRKDG S100
PSEN1 iso3 (human) VATIKSVSFYTRKDG S100
PSEN1 (mouse) VATIKSVSFYTRKDG S104
PSEN1 (rat) VATIKSVSFYTRKDG S104
K109-ub
sVsFYTRkDGQLIYT
0 2
PSEN1 (human) sVsFYTRkDGQLIYT K109-ub
PSEN1 iso2 (human) SVSFYTRKDGQLIYT K105
PSEN1 iso3 (human) SVSFYTRKDGQLIYT K105
PSEN1 (mouse) SVSFYTRKDGQLIYT K109
PSEN1 (rat) SVSFYTRKDGQLIYT K109
Y154-p
TILLVVLyKYRCYKV
0 1
PSEN1 (human) TILLVVLyKYRCYKV Y154-p
PSEN1 iso2 (human) TILLVVLYKYRCYKV Y150
PSEN1 iso3 (human) TILLVVLYKYRCYKV Y150
PSEN1 (mouse) TILLVVLYKYRCYKV Y154
PSEN1 (rat) TILLVVLYKYRCYKV Y154
Y240-p
MALVFIKyLPEWTAW
0 1
PSEN1 (human) MALVFIKyLPEWTAW Y240-p
PSEN1 iso2 (human) MALVFIKYLPEWTAW Y236
PSEN1 iso3 (human) MALVFIKYLPEWTAW Y236
PSEN1 (mouse) MALVFIKYLPEWTAW Y240
PSEN1 (rat) MALVFIKYLPEWTAW Y240
Y256-p
ILAVISVyDLVAVLC
0 1
PSEN1 (human) ILAVISVyDLVAVLC Y256-p
PSEN1 iso2 (human) ILAVISVYDLVAVLC Y252
PSEN1 iso3 (human) ILAVISVYDLVAVLC Y252
PSEN1 (mouse) ILAVISVYDLVAVLC Y256
PSEN1 (rat) ILAVISVYDLVAVLC Y256
S310-p
PEAQRRVsKNskyNA
Upstream
2 0
Kinase, in vitro:
  • PKACA (cow)
PSEN1 (human) PEAQRRVsKNskyNA S310-p
PSEN1 iso2 (human) PEAQRRVSKNSKYNA S306
PSEN1 iso3 (human) PEAQRRVSKNSKYNA S306
PSEN1 (mouse) PEAQRRVPKNPKYNT P310
PSEN1 (rat) PEAQRRVPKNPKYST P310
S313-p
QRRVsKNskyNAEst
Downstream
1 1
Effects on Modified Protein
  • protein conformation
PSEN1 (human) QRRVsKNskyNAEst S313-p
PSEN1 iso2 (human) QRRVSKNSKYNAEST S309
PSEN1 iso3 (human) QRRVSKNSKYNAERA S309
PSEN1 (mouse) QRRVPKNPKYNTQRA P313
PSEN1 (rat) QRRVPKNPKYSTQGT P313
K314-ub
RRVsKNskyNAEstE
0 4
PSEN1 (human) RRVsKNskyNAEstE K314-ub
PSEN1 iso2 (human) RRVSKNSKYNAESTE K310
PSEN1 iso3 (human) RRVSKNSKYNAERAC K310
PSEN1 (mouse) RRVPKNPKYNTQRAE K314
PSEN1 (rat) RRVPKNPKYSTQGTE K314
Y315-p
RVsKNskyNAEstER
0 1
PSEN1 (human) RVsKNskyNAEstER Y315-p
PSEN1 iso2 (human) RVSKNSKYNAESTER Y311
PSEN1 iso3 (human) RVSKNSKYNAERACL Y311
PSEN1 (mouse) RVPKNPKYNTQRAER Y315
PSEN1 (rat) RVPKNPKYSTQGTER Y315
-
gap
0 1
PSEN1 (human) gap -
PSEN1 iso2 (human) gap -
PSEN1 iso3 (human) QRMMMAGsVRNGKPR S363-p
PSEN1 (mouse) gap -
PSEN1 (rat) gap -
S319-p
NskyNAEstEREsQD
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Kinase, in vitro:
  • JNK2 (human)
Putative in vivo kinases:
  • JNK2 (human)
Treatment
  • SP600125
  • TNF
PSEN1 (human) NskyNAEstEREsQD S319-p
PSEN1 iso2 (human) NSKYNAESTERESQD S315
PSEN1 iso3 (human) gap -
PSEN1 (mouse) gap -
PSEN1 (rat) NPKYSTQGTEREETQ G319
T320-p
skyNAEstEREsQDT
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Kinase, in vitro:
  • JNK2 (human)
Putative in vivo kinases:
  • JNK2 (human)
Treatment
  • SP600125
  • TNF
PSEN1 (human) skyNAEstEREsQDT T320-p
PSEN1 iso2 (human) SKYNAESTERESQDT T316
PSEN1 iso3 (human) gap -
PSEN1 (mouse) gap -
PSEN1 (rat) PKYSTQGTEREETQD T320
S324-p
AEstEREsQDTVAEN
0 4
PSEN1 (human) AEstEREsQDTVAEN S324-p
PSEN1 iso2 (human) AESTERESQDTVAEN S320
PSEN1 iso3 (human) gap -
PSEN1 (mouse) TQRAEREtQDsGsGN T324-p
PSEN1 (rat) QGTEREETQDTGtGs T325
T327
tEREsQDTVAENDDG
0 1
PSEN1 (human) tEREsQDTVAENDDG T327
PSEN1 iso2 (human) TERESQDTVAENDDG T323
PSEN1 iso3 (human) gap -
PSEN1 (mouse) AEREtQDsGsGNDDG S327-p
PSEN1 (rat) EREETQDTGtGsDDG T328
A329
REsQDTVAENDDGGF
0 12
PSEN1 (human) REsQDTVAENDDGGF A329
PSEN1 iso2 (human) RESQDTVAENDDGGF A325
PSEN1 iso3 (human) gap -
PSEN1 (mouse) REtQDsGsGNDDGGF S329-p
PSEN1 (rat) EETQDTGtGsDDGGF T330-p
N331
sQDTVAENDDGGFSE
0 2
PSEN1 (human) sQDTVAENDDGGFSE N331
PSEN1 iso2 (human) SQDTVAENDDGGFSE N327
PSEN1 iso3 (human) gap -
PSEN1 (mouse) tQDsGsGNDDGGFSE N331
PSEN1 (rat) TQDTGtGsDDGGFSE S332-p
S346-p
EWEAQRDsHLGPHRs
Upstream
Downstream
1 1
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • PKCA (rat)
Treatment
  • phorbol_ester
PSEN1 (human) EWEAQRDsHLGPHRs S346-p
PSEN1 iso2 (human) EWEAQRDSHLGPHRS S342
PSEN1 iso3 (human) gap -
PSEN1 (mouse) EWEAQRDSHLGPHRS S346
PSEN1 (rat) EWEAQRDSHLGPHRS S347
S353-p
sHLGPHRstPEsRAA
Upstream
Downstream
3 9
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • GSK-3_inhibitor_VIII
  • okadaic_acid
PSEN1 (human) sHLGPHRstPEsRAA S353-p
PSEN1 iso2 (human) SHLGPHRSTPESRAA S349
PSEN1 iso3 (human) gap -
PSEN1 (mouse) SHLGPHRStPESRAA S353
PSEN1 (rat) SHLGPHRSTPESRAA S354
T354-p
HLGPHRstPEsRAAV
Upstream
Downstream
2 24
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Kinase, in vitro:
  • CDK5 (human)
Putative in vivo kinases:
  • CDK5 (human)
  • DYRK1A (mouse)
Treatment
  • peptide_antagonist
PSEN1 (human) HLGPHRstPEsRAAV T354-p
PSEN1 iso2 (human) HLGPHRSTPESRAAV T350
PSEN1 iso3 (human) gap -
PSEN1 (mouse) HLGPHRStPESRAAV T354-p
PSEN1 (rat) HLGPHRSTPESRAAV T355
S357-p
PHRstPEsRAAVQEL
Upstream
Downstream
3 11
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • GSK-3_inhibitor_VIII
  • okadaic_acid
PSEN1 (human) PHRstPEsRAAVQEL S357-p
PSEN1 iso2 (human) PHRSTPESRAAVQEL S353
PSEN1 iso3 (human) gap -
PSEN1 (mouse) PHRStPESRAAVQEL S357
PSEN1 (rat) PHRSTPESRAAVQEL S358
S365-p
RAAVQELsssILAGE
Downstream
2 16
Effects on Modified Protein
  • protein conformation
PSEN1 (human) RAAVQELsssILAGE S365-p
PSEN1 iso2 (human) RAAVQELSSSILAGE S361
PSEN1 iso3 (human) gap -
PSEN1 (mouse) RAAVQELsGsILtsE S365-p
PSEN1 (rat) RAAVQELSGsILtsE S366
S366-p
AAVQELsssILAGED
Upstream
Downstream
1 13
Effects on Modified Protein
  • protein conformation
Treatment
  • metastatic potential
PSEN1 (human) AAVQELsssILAGED S366-p
PSEN1 iso2 (human) AAVQELSSSILAGED S362
PSEN1 iso3 (human) gap -
PSEN1 (mouse) AAVQELsGsILtsED G366
PSEN1 (rat) AAVQELSGsILtsED G367
S367-p
AVQELsssILAGEDP
Upstream
Downstream
2 49
Effects on Modified Protein
  • protein conformation
Treatment
  • metastatic potential
  • MG132_withdrawal
  • nocodazole
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PSEN1 (human) AVQELsssILAGEDP S367-p
PSEN1 iso2 (human) AVQELSSSILAGEDP S363
PSEN1 iso3 (human) gap -
PSEN1 (mouse) AVQELsGsILtsEDP S367-p
PSEN1 (rat) AVQELSGsILtsEDP S368-p
A370
ELsssILAGEDPEER
0 30
PSEN1 (human) ELsssILAGEDPEER A370
PSEN1 iso2 (human) ELSSSILAGEDPEER A366
PSEN1 iso3 (human) gap -
PSEN1 (mouse) ELsGsILtsEDPEER T370-p
PSEN1 (rat) ELSGsILtsEDPEER T371-p
G371
LsssILAGEDPEERG
0 17
PSEN1 (human) LsssILAGEDPEERG G371
PSEN1 iso2 (human) LSSSILAGEDPEERG G367
PSEN1 iso3 (human) gap -
PSEN1 (mouse) LsGsILtsEDPEERG S371-p
PSEN1 (rat) LSGsILtsEDPEERG S372-p