-
|
gap
|
|
|
0
|
1
|
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
K35
|
IPVAVEVKPVLPGAM
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
IPVTVEVkPVLPRAM
|
K35-sm
|
HDAC5 iso2 (human)
|
IPVTVEVKPVLPRAM
|
K35
|
HDAC5 iso3 (human)
|
IPVTVEVKPVLPRAM
|
K36
|
HDAC5 (mouse)
|
IPVAVEVKPVLPGAM
|
K35
|
HDAC5 (rat)
|
gap
|
-
|
|
S53-p
|
MGGGGGGsPSPVELR
|
Upstream
|
|
0
|
6
|
|
|
|
HDAC5 (human)
|
MGGGGGGsPsPVELR
|
S53-p
|
HDAC5 iso2 (human)
|
MGGGGGGSPSPVELR
|
S53
|
HDAC5 iso3 (human)
|
MGGGGGGSPSPVELR
|
S54
|
HDAC5 (mouse)
|
MGGGGGGsPSPVELR
|
S53-p
|
HDAC5 (rat)
|
gap
|
-
|
|
S55
|
GGGGGsPSPVELRGA
|
|
|
0
|
2
|
|
|
HDAC5 (human)
|
GGGGGsPsPVELRGA
|
S55-p
|
HDAC5 iso2 (human)
|
GGGGGSPSPVELRGA
|
S55
|
HDAC5 iso3 (human)
|
GGGGGSPSPVELRGA
|
S56
|
HDAC5 (mouse)
|
GGGGGsPSPVELRGA
|
S55
|
HDAC5 (rat)
|
gap
|
-
|
|
P66
|
LRGALAGPMDPALRE
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
LRGALVGsVDPtLRE
|
S66-p
|
HDAC5 iso2 (human)
|
LRGALVGSVDPTLRE
|
S66
|
HDAC5 iso3 (human)
|
LRGALVGSVDPTLRE
|
S67
|
HDAC5 (mouse)
|
LRGALAGPMDPALRE
|
P66
|
HDAC5 (rat)
|
gap
|
-
|
|
A70
|
LAGPMDPALREQQLQ
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
LVGsVDPtLREQQLQ
|
T70-p
|
HDAC5 iso2 (human)
|
LVGSVDPTLREQQLQ
|
T70
|
HDAC5 iso3 (human)
|
LVGSVDPTLREQQLQ
|
T71
|
HDAC5 (mouse)
|
LAGPMDPALREQQLQ
|
A70
|
HDAC5 (rat)
|
gap
|
-
|
|
K84
|
QQELLVLKQQQQLQK
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QQELLALkQQQQLQK
|
K84-ub
|
HDAC5 iso2 (human)
|
QQELLALKQQQQLQK
|
K84
|
HDAC5 iso3 (human)
|
QQELLALKQQQQLQK
|
K85
|
HDAC5 (mouse)
|
QQELLVLKQQQQLQK
|
K84
|
HDAC5 (rat)
|
gap
|
-
|
|
K115
|
QHEVQLQKHLKQQQE
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QHEVQLQkHLKQQQE
|
K115-ub
|
HDAC5 iso2 (human)
|
QHEVQLQKHLKQQQE
|
K115
|
HDAC5 iso3 (human)
|
QHEVQLQKHLKQQQE
|
K116
|
HDAC5 (mouse)
|
QHEVQLQKHLKQQQE
|
K115
|
HDAC5 (rat)
|
gap
|
-
|
|
K127
|
QQEMLAAKRQQELEQ
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QQEMLAAkRQQELEQ
|
K136-ub
|
HDAC5 iso2 (human)
|
QQEMLAAKRQQELEQ
|
K136
|
HDAC5 iso3 (human)
|
QQEMLAAKRQQELEQ
|
K137
|
HDAC5 (mouse)
|
QQEMLAAKRQQELEQ
|
K127
|
HDAC5 (rat)
|
gap
|
-
|
|
S171
|
SKESAIASTEVKLRL
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
SKESAIAstEVKLRL
|
S180-p
|
HDAC5 iso2 (human)
|
SKESAIASTEVKLRL
|
S180
|
HDAC5 iso3 (human)
|
SKESAIASTEVKLRL
|
S181
|
HDAC5 (mouse)
|
SKESAIASTEVKLRL
|
S171
|
HDAC5 (rat)
|
____AIASTEVKLRL
|
S4
|
|
T172
|
KESAIASTEVKLRLQ
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
KESAIAstEVKLRLQ
|
T181-p
|
HDAC5 iso2 (human)
|
KESAIASTEVKLRLQ
|
T181
|
HDAC5 iso3 (human)
|
KESAIASTEVKLRLQ
|
T182
|
HDAC5 (mouse)
|
KESAIASTEVKLRLQ
|
T172
|
HDAC5 (rat)
|
___AIASTEVKLRLQ
|
T5
|
|
S197
|
TPGGLNHSLPQHPKC
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
TPGGLNHsLPQHPKC
|
S206-p
|
HDAC5 iso2 (human)
|
TPGGLNHSLPQHPKC
|
S206
|
HDAC5 iso3 (human)
|
TPGGLNHSLPQHPKC
|
S207
|
HDAC5 (mouse)
|
TPGGLNHSLPQHPKC
|
S197
|
HDAC5 (rat)
|
TPGGLNHSLPQHPKC
|
S30
|
|
S211
|
CWGAHHASLDQSSPP
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
CWGAHHAsLDQSSPP
|
S220-p
|
HDAC5 iso2 (human)
|
CWGAHHASLDQSSPP
|
S220
|
HDAC5 iso3 (human)
|
CWGAHHASLDQSSPP
|
S221
|
HDAC5 (mouse)
|
CWGAHHASLDQSSPP
|
S211
|
HDAC5 (rat)
|
CWGAHHASLDQSSPP
|
S44
|
|
T225
|
PQSGPPGTPPSYKLP
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
PQSGPPGtPPSYKLP
|
T234-p
|
HDAC5 iso2 (human)
|
PQSGPPGTPPSYKLP
|
T234
|
HDAC5 iso3 (human)
|
PQSGPPGTPPSYKLP
|
T235
|
HDAC5 (mouse)
|
PQSGPPGTPPSYKLP
|
T225
|
HDAC5 (rat)
|
PQSGPPGTPPSYKLP
|
T58
|
|
S250-p
|
FPLRKTAsEPNLKVR
|
|
Downstream
|
25
|
47
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
HDAC5 (human)
|
FPLRKTAsEPNLKVR
|
S259-p
|
HDAC5 iso2 (human)
|
FPLRKTASEPNLKVR
|
S259
|
HDAC5 iso3 (human)
|
FPLRKTASEPNLKVR
|
S260
|
HDAC5 (mouse)
|
FPLRKTAsEPNLKVR
|
S250-p
|
HDAC5 (rat)
|
FPLRKTAsEPNLKVR
|
S83-p
|
|
S269-p
|
QKVAERRssPLLRRK
|
|
|
2
|
14
|
|
|
HDAC5 (human)
|
QKVAERRssPLLRRK
|
S278-p
|
HDAC5 iso2 (human)
|
QKVAERRSSPLLRRK
|
S278
|
HDAC5 iso3 (human)
|
QKVAERRSSPLLRRK
|
S279
|
HDAC5 (mouse)
|
QKVAERRssPLLRRK
|
S269-p
|
HDAC5 (rat)
|
QKVAERRSsPLLRRK
|
S102
|
|
S270-p
|
KVAERRssPLLRRKD
|
Upstream
|
|
6
|
20
|
|
|
Kinase, in vitro:
|
Treatment
|
|
HDAC5 (human)
|
KVAERRssPLLRRKD
|
S279-p
|
HDAC5 iso2 (human)
|
KVAERRSSPLLRRKD
|
S279
|
HDAC5 iso3 (human)
|
KVAERRSSPLLRRKD
|
S280
|
HDAC5 (mouse)
|
KVAERRssPLLRRKD
|
S270-p
|
HDAC5 (rat)
|
KVAERRSsPLLRRKD
|
S103-p
|
|
T279
|
LLRRKDGTVISTFKK
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
LLRRKDGtVIstFKK
|
T288-p
|
HDAC5 iso2 (human)
|
LLRRKDGTVISTFKK
|
T288
|
HDAC5 iso3 (human)
|
LLRRKDGTVISTFKK
|
T289
|
HDAC5 (mouse)
|
LLRRKDGTVISTFKK
|
T279
|
HDAC5 (rat)
|
LLRRKDGTVISTFKK
|
T112
|
|
S282
|
RKDGTVISTFKKRAV
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
RKDGtVIstFKKRAV
|
S291-p
|
HDAC5 iso2 (human)
|
RKDGTVISTFKKRAV
|
S291
|
HDAC5 iso3 (human)
|
RKDGTVISTFKKRAV
|
S292
|
HDAC5 (mouse)
|
RKDGTVISTFKKRAV
|
S282
|
HDAC5 (rat)
|
RKDGTVISTFKKRAV
|
S115
|
|
T283
|
KDGTVISTFKKRAVE
|
|
|
1
|
1
|
|
|
HDAC5 (human)
|
KDGtVIstFKKRAVE
|
T292-p
|
HDAC5 iso2 (human)
|
KDGTVISTFKKRAVE
|
T292
|
HDAC5 iso3 (human)
|
KDGTVISTFKKRAVE
|
T293
|
HDAC5 (mouse)
|
KDGTVISTFKKRAVE
|
T283
|
HDAC5 (rat)
|
KDGTVISTFKKRAVE
|
T116
|
|
S359
|
FSLYTSPSLPNISLG
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
FSLYTSPsLPNISLG
|
S368-p
|
HDAC5 iso2 (human)
|
FSLYTSPSLPNISLG
|
S368
|
HDAC5 iso3 (human)
|
FSLYTSPSLPNISLG
|
S369
|
HDAC5 (mouse)
|
FSLYTSPSLPNISLG
|
S359
|
HDAC5 (rat)
|
FSLYTSPSLPNISLG
|
S192
|
|
S459
|
AVPLHGQSPLVTGER
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
AVPLHGQsPLVTGER
|
S469-p
|
HDAC5 iso2 (human)
|
AVPLHGQSPLVTGER
|
S469
|
HDAC5 iso3 (human)
|
AVPLHGQSPLVTGER
|
S470
|
HDAC5 (mouse)
|
AVPLHGQSPLVTGER
|
S459
|
HDAC5 (rat)
|
AVPLHGQSPLVTGER
|
S293
|
|
T486-p
|
RHRPLSRtQsSPLPQ
|
|
|
0
|
2
|
|
|
HDAC5 (human)
|
RHRPLSRtQsSPLPQ
|
T496-p
|
HDAC5 iso2 (human)
|
RHRPLSRTQSSPLPQ
|
T496
|
HDAC5 iso3 (human)
|
RHRPLSRTQSSPLPQ
|
T497
|
HDAC5 (mouse)
|
RHRPLSRtQsSPLPQ
|
T486-p
|
HDAC5 (rat)
|
RHRPLSRTQsSPLPQ
|
T320
|
|
S488-p
|
RPLSRtQsSPLPQSP
|
Upstream
|
Downstream
|
24
|
10
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
Putative in vivo kinases:
|
Treatment
- caffeine
- glucagon
- KN-93
- phenformin
- phenylephrine
|
|
HDAC5 (human)
|
RPLSRtQsSPLPQsP
|
S498-p
|
HDAC5 iso2 (human)
|
RPLSRTQSSPLPQSP
|
S498
|
HDAC5 iso3 (human)
|
RPLSRTQSSPLPQSP
|
S499
|
HDAC5 (mouse)
|
RPLSRtQsSPLPQSP
|
S488-p
|
HDAC5 (rat)
|
RPLSRTQsSPLPQSP
|
S322-p
|
|
S494
|
QsSPLPQSPQALQQL
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QsSPLPQsPQALQQL
|
S504-p
|
HDAC5 iso2 (human)
|
QSSPLPQSPQALQQL
|
S504
|
HDAC5 iso3 (human)
|
QSSPLPQSPQALQQL
|
S505
|
HDAC5 (mouse)
|
QsSPLPQSPQALQQL
|
S494
|
HDAC5 (rat)
|
QsSPLPQSPQALQQL
|
S328
|
|
K523
|
QQQMQLGKILTKTGE
|
|
|
0
|
2
|
|
|
HDAC5 (human)
|
QQQLQLGkILTkTGE
|
K533-ac
|
HDAC5 iso2 (human)
|
QQQLQLGKILTKTGE
|
K533
|
HDAC5 iso3 (human)
|
QQQLQLGKILTKTGE
|
K534
|
HDAC5 (mouse)
|
QQQMQLGKILTKTGE
|
K523
|
HDAC5 (rat)
|
QQQMQLGKILTKTGE
|
K357
|
|
K523
|
QQQMQLGKILTKTGE
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QQQLQLGkILTkTGE
|
K533-sm
|
HDAC5 iso2 (human)
|
QQQLQLGKILTKTGE
|
K533
|
HDAC5 iso3 (human)
|
QQQLQLGKILTKTGE
|
K534
|
HDAC5 (mouse)
|
QQQMQLGKILTKTGE
|
K523
|
HDAC5 (rat)
|
QQQMQLGKILTKTGE
|
K357
|
|
K527
|
QLGKILTKTGELSRQ
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
QLGkILTkTGELPRQ
|
K537-ub
|
HDAC5 iso2 (human)
|
QLGKILTKTGELPRQ
|
K537
|
HDAC5 iso3 (human)
|
QLGKILTKTGELPRQ
|
K538
|
HDAC5 (mouse)
|
QLGKILTKTGELSRQ
|
K527
|
HDAC5 (rat)
|
QLGKILTKTGELSRQ
|
K361
|
|
T536-p
|
GELSRQPtTHPEETE
|
|
|
0
|
9
|
|
|
HDAC5 (human)
|
GELPRQPttHPEETE
|
T546-p
|
HDAC5 iso2 (human)
|
GELPRQPTTHPEETE
|
T546
|
HDAC5 iso3 (human)
|
GELPRQPTTHPEETE
|
T547
|
HDAC5 (mouse)
|
GELSRQPtTHPEETE
|
T536-p
|
HDAC5 (rat)
|
GELSRQPTTHPEETE
|
T370
|
|
T537
|
ELSRQPtTHPEETEE
|
|
|
0
|
4
|
|
|
HDAC5 (human)
|
ELPRQPttHPEETEE
|
T547-p
|
HDAC5 iso2 (human)
|
ELPRQPTTHPEETEE
|
T547
|
HDAC5 iso3 (human)
|
ELPRQPTTHPEETEE
|
T548
|
HDAC5 (mouse)
|
ELSRQPtTHPEETEE
|
T537
|
HDAC5 (rat)
|
ELSRQPTTHPEETEE
|
T371
|
|
K594
|
EEDCIQVKDEDGEsG
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
EEDCIQVkDEEGEsG
|
K605-sm
|
HDAC5 iso2 (human)
|
EEDCIQVKDEEGESG
|
K605
|
HDAC5 iso3 (human)
|
EEDCIQVKDEEGESG
|
K606
|
HDAC5 (mouse)
|
EEDCIQVKDEDGEsG
|
K594
|
HDAC5 (rat)
|
EEDCIQVKDEDGEsG
|
K427
|
|
S600-p
|
VKDEDGEsGPDEGPD
|
|
|
2
|
19
|
|
|
HDAC5 (human)
|
VkDEEGEsGAEEGPD
|
S611-p
|
HDAC5 iso2 (human)
|
VKDEEGESGAEEGPD
|
S611
|
HDAC5 iso3 (human)
|
VKDEEGESGAEEGPD
|
S612
|
HDAC5 (mouse)
|
VKDEDGEsGPDEGPD
|
S600-p
|
HDAC5 (rat)
|
VKDEDGEsGPDEGAD
|
S433-p
|
|
Y631
|
QLQPLQVYQAPLSLA
|
|
|
1
|
1
|
|
|
HDAC5 (human)
|
PLQPLQVyQAPLSLA
|
Y642-p
|
HDAC5 iso2 (human)
|
PLQPLQVYQAPLSLA
|
Y642
|
HDAC5 iso3 (human)
|
PLQPLQVYQAPLSLA
|
Y643
|
HDAC5 (mouse)
|
QLQPLQVYQAPLSLA
|
Y631
|
HDAC5 (rat)
|
QLQPLQVYQAPLSLA
|
Y464
|
|
S650-p
|
QALGRTQsSPAAPGs
|
Upstream
|
|
2
|
39
|
|
|
|
HDAC5 (human)
|
QALGRTQsSPAAPGG
|
S661-p
|
HDAC5 iso2 (human)
|
QALGRTQSSPAAPGG
|
S661
|
HDAC5 iso3 (human)
|
QALGRTQSSPAAPGG
|
S662
|
HDAC5 (mouse)
|
QALGRTQsSPAAPGs
|
S650-p
|
HDAC5 (rat)
|
QALGRTQSSPAAPGS
|
S483
|
|
S657-p
|
sSPAAPGsMKsPtDQ
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
sSPAAPGGMKsPPDQ
|
G668
|
HDAC5 iso2 (human)
|
SSPAAPGGMKSPPDQ
|
G668
|
HDAC5 iso3 (human)
|
SSPAAPGGMKSPPDQ
|
G669
|
HDAC5 (mouse)
|
sSPAAPGsMKsPtDQ
|
S657-p
|
HDAC5 (rat)
|
SSPAAPGSMKSPTDH
|
S490
|
|
S660-p
|
AAPGsMKsPtDQPTV
|
|
|
0
|
5
|
|
|
HDAC5 (human)
|
AAPGGMKsPPDQPVK
|
S671-p
|
HDAC5 iso2 (human)
|
AAPGGMKSPPDQPVK
|
S671
|
HDAC5 iso3 (human)
|
AAPGGMKSPPDQPVK
|
S672
|
HDAC5 (mouse)
|
AAPGsMKsPtDQPTV
|
S660-p
|
HDAC5 (rat)
|
AAPGSMKSPTDHPTV
|
S493
|
|
T662-p
|
PGsMKsPtDQPTVVK
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
PGGMKsPPDQPVKHL
|
P673
|
HDAC5 iso2 (human)
|
PGGMKSPPDQPVKHL
|
P673
|
HDAC5 iso3 (human)
|
PGGMKSPPDQPVKHL
|
P674
|
HDAC5 (mouse)
|
PGsMKsPtDQPTVVK
|
T662-p
|
HDAC5 (rat)
|
PGSMKSPTDHPTVER
|
T495
|
|
S746
|
HTLLYGTSPLNRQKL
|
|
|
2
|
2
|
|
|
HDAC5 (human)
|
HTLLYGTsPLNRQKL
|
S755-p
|
HDAC5 iso2 (human)
|
gap
|
-
|
HDAC5 iso3 (human)
|
HTLLYGTSPLNRQKL
|
S756
|
HDAC5 (mouse)
|
HTLLYGTSPLNRQKL
|
S746
|
HDAC5 (rat)
|
HTLLYGTSPLNRQKL
|
S579
|
|
Y767
|
GPISQKMYAMLPCGG
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
GPISQKMyAVLPCGG
|
Y776-p
|
HDAC5 iso2 (human)
|
GPISQKMYAVLPCGG
|
Y691
|
HDAC5 iso3 (human)
|
GPISQKMYAVLPCGG
|
Y777
|
HDAC5 (mouse)
|
GPISQKMYAMLPCGG
|
Y767
|
HDAC5 (rat)
|
GPISQKMYAMLPCGG
|
Y600
|
|
S789
|
VWNEMHSSSAVRMAV
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
VWNEMHSssAVRMAV
|
S798-p
|
HDAC5 iso2 (human)
|
VWNEMHSSSAVRMAV
|
S713
|
HDAC5 iso3 (human)
|
VWNEMHSSSAVRMAV
|
S799
|
HDAC5 (mouse)
|
VWNEMHSSSAVRMAV
|
S789
|
HDAC5 (rat)
|
VWNEMHSSSAVRMAV
|
S622
|
|
S790
|
WNEMHSSSAVRMAVG
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
WNEMHSssAVRMAVG
|
S799-p
|
HDAC5 iso2 (human)
|
WNEMHSSSAVRMAVG
|
S714
|
HDAC5 iso3 (human)
|
WNEMHSSSAVRMAVG
|
S800
|
HDAC5 (mouse)
|
WNEMHSSSAVRMAVG
|
S790
|
HDAC5 (rat)
|
WNEMHSSSAVRMAVG
|
S623
|
|
S1031-p
|
AVLQQKPsVNAVATL
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
AVLQQKPNINAVATL
|
N1040
|
HDAC5 iso2 (human)
|
AVLQQKPNINAVATL
|
N955
|
HDAC5 iso3 (human)
|
AVLQQKPNINAVATL
|
N1041
|
HDAC5 (mouse)
|
AVLQQKPsVNAVATL
|
S1031-p
|
HDAC5 (rat)
|
AVLQQKPSINAVATL
|
S864
|
|
S1050-p
|
EIQSKHWsCVQRFAA
|
|
|
0
|
1
|
|
|
HDAC5 (human)
|
EIQSKHWSCVQKFAA
|
S1059
|
HDAC5 iso2 (human)
|
EIQSKHWSCVQKFAA
|
S974
|
HDAC5 iso3 (human)
|
EIQSKHWSCVQKFAA
|
S1060
|
HDAC5 (mouse)
|
EIQSKHWsCVQRFAA
|
S1050-p
|
HDAC5 (rat)
|
EIQSKHWSCVQRFAT
|
S883
|
|
S1062-p
|
FAAGLGCsLREAQTG
|
|
|
0
|
2
|
|
|
HDAC5 (human)
|
FAAGLGRsLREAQAG
|
S1071-p
|
HDAC5 iso2 (human)
|
FAAGLGRSLREAQAG
|
S986
|
HDAC5 iso3 (human)
|
FAAGLGRSLREAQAG
|
S1072
|
HDAC5 (mouse)
|
FAAGLGCsLREAQTG
|
S1062-p
|
HDAC5 (rat)
|
FATGLGCSLREAQTG
|
S895
|
|
S1099
|
AVATQEHSPRPAEEP
|
|
|
2
|
25
|
|
|
HDAC5 (human)
|
AAAAREHsPRPAEEP
|
S1108-p
|
HDAC5 iso2 (human)
|
AAAAREHSPRPAEEP
|
S1023
|
HDAC5 iso3 (human)
|
AAAAREHSPRPAEEP
|
S1109
|
HDAC5 (mouse)
|
AVATQEHSPRPAEEP
|
S1099
|
HDAC5 (rat)
|
AAATQEHSPRPAEEP
|
S932
|
|