Other Species / Isoforms
  CLOCK (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K31-ac
GLVEEDDkDKAKRVS
0 1
CLOCK (human) GLVEEDDkDKAKRVS K31-ac
CLOCK (mouse) GLVEEDDKDKAKRVs K31
CLOCK (rat) GLVEEDDKDKAKRVS K31
S38
kDKAKRVSRNkSEKK
1 1
CLOCK (human) kDKAKRVSRNkSEKK S38
CLOCK (mouse) KDKAKRVsRNKsEKK S38-p
CLOCK (rat) KDKAKRVSRNKSEKK S38
K41-ac
AKRVSRNkSEKKRRD
0 1
CLOCK (human) AKRVSRNkSEKKRRD K41-ac
CLOCK (mouse) AKRVsRNKsEKKRRD K41
CLOCK (rat) AKRVSRNKSEKKRRD K41
S42
KRVSRNkSEKKRRDQ
1 1
CLOCK (human) KRVSRNkSEKKRRDQ S42
CLOCK (mouse) KRVsRNKsEKKRRDQ S42-p
CLOCK (rat) KRVSRNKSEKKRRDQ S42
S59-p
VLIKELGsMLPGNAR
0 1
CLOCK (human) VLIKELGsMLPGNAR S59-p
CLOCK (mouse) VLIKELGSMLPGNAR S59
CLOCK (rat) VLIKELGSMLPGNAR S59
K67-sm
MLPGNARkMDKSTVL
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
Regulatory protein:
  • SENP2 (human)
  • SENP3 (human)
Treatment
  • 17-beta-estradiol
CLOCK (human) MLPGNARkMDKSTVL K67-sm
CLOCK (mouse) MLPGNARKMDKSTVL K67
CLOCK (rat) MLPGNARKMDKSTVL K67
K76-ub
DKSTVLQkSIDFLRK
0 1
CLOCK (human) DKSTVLQkSIDFLRK K76-ub
CLOCK (mouse) DKSTVLQKSIDFLRK K76
CLOCK (rat) DKSTVLQKSIDFLRK K76
K85-ub
IDFLRKHkEITAQSD
0 1
CLOCK (human) IDFLRKHkEITAQSD K85-ub
CLOCK (mouse) IDFLRKHKETTAQSD K85
CLOCK (rat) IDFLRKHKEITAQSD K85
S164-p
FIPEGEHsEVYKILS
0 2
CLOCK (human) FIPEGEHsEVYKILS S164-p
CLOCK (mouse) FIPEGEHSEVYKILS S164
CLOCK (rat) FIPEGEHSEVYKILS S164
S177-p
LSTHLLEsDSLTPEY
0 1
CLOCK (human) LSTHLLEsDSLTPEY S177-p
CLOCK (mouse) LSTHLLESDSLTPEY S177
CLOCK (rat) LSTHLLESDSLTPED S177
K186-ub
SLTPEYLkSKNQLEF
0 2
CLOCK (human) SLTPEYLkSKNQLEF K186-ub
CLOCK (mouse) SLTPEYLkSKNQLEF K186-ub
CLOCK (rat) SLTPEDLKSKNQLEF K186
K205-ub
LRGTIDPkEPSTYEY
0 1
CLOCK (human) LRGTIDPkEPSTYEY K205-ub
CLOCK (mouse) LRGTIDPKEPSTYEY K205
CLOCK (rat) LRGTIDPKEPSTYEY K205
Y331-p
CHEHLMQyGKGKSCY
0 15
CLOCK (human) CHEHLMQyGKGKSCY Y331-p
CLOCK (mouse) CHEHLMQyGKGKSCY Y331-p
CLOCK (rat) CHEHLMQYGKGKSCY Y331
T372
RPEFIVCTHTVVSYA
0 1
CLOCK (human) RPEFIVCTHTVVSYA T372
CLOCK (mouse) RPEFIVCtHTVVSyA T372-p
CLOCK (rat) RPEFIVCTHTVVSYA T372
Y378
CTHTVVSYAEVRAER
0 1
CLOCK (human) CTHTVVSYAEVRAER Y378
CLOCK (mouse) CtHTVVSyAEVRAER Y378-p
CLOCK (rat) CTHTVVSYAEVRAER Y378
K402-ub
LPETAADksQDsGsD
0 1
CLOCK (human) LPETAADksQDsGsD K402-ub
CLOCK (mouse) LPETAADKSQDsGsD K402
CLOCK (rat) LPETAADKSQDsGsD K402
S403-p
PETAADksQDsGsDN
0 3
CLOCK (human) PETAADksQDsGsDN S403-p
CLOCK (mouse) PETAADKSQDsGsDN S403
CLOCK (rat) PETAADKSQDsGsDN S403
S406-p
AADksQDsGsDNRIN
0 8
CLOCK (human) AADksQDsGsDNRIN S406-p
CLOCK (mouse) AADKSQDsGsDNRIN S406-p
CLOCK (rat) AADKSQDsGsDNRIN S406-p
S408-p
DksQDsGsDNRINTV
0 6
CLOCK (human) DksQDsGsDNRINTV S408-p
CLOCK (mouse) DKSQDsGsDNRINTV S408-p
CLOCK (rat) DKSQDsGsDNRINtV S408-p
T414
GsDNRINTVSLkEAL
0 1
CLOCK (human) GsDNRINTVSLkEAL T414
CLOCK (mouse) GsDNRINTVSLKEAL T414
CLOCK (rat) GsDNRINtVsLKEAL T414-p
S416
DNRINTVSLkEALER
0 1
CLOCK (human) DNRINTVSLkEALER S416
CLOCK (mouse) DNRINTVSLKEALER S416
CLOCK (rat) DNRINtVsLKEALER S416-p
K418-ub
RINTVSLkEALERFD
0 2
CLOCK (human) RINTVSLkEALERFD K418-ub
CLOCK (mouse) RINTVSLKEALERFD K418
CLOCK (rat) RINtVsLKEALERFD K418
S427-p
ALERFDHsPtPsASs
Upstream
Downstream
2 9
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Putative in vivo kinases:
  • GSK3B (human)
Regulatory protein:
  • BMAL1 (human)
Treatment
  • LY294002
CLOCK (human) ALERFDHsPtPsASs S427-p
CLOCK (mouse) ALERFDHsPTPSASS S427-p
CLOCK (rat) ALERFDHSPtPsAsS S427
T429-p
ERFDHsPtPsASsRS
0 2
CLOCK (human) ERFDHsPtPsASsRS T429-p
CLOCK (mouse) ERFDHsPTPSASSRS T429
CLOCK (rat) ERFDHSPtPsAsSRS T429-p
S431-p
FDHsPtPsASsRSsR
Upstream
Downstream
1 1
Effects on Modified Protein
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • BMAL1 (human)
Treatment
  • LY294002
CLOCK (human) FDHsPtPsASsRSsR S431-p
CLOCK (mouse) FDHsPTPSASSRSSR S431
CLOCK (rat) FDHSPtPsAsSRSSR S431-p
S433
HsPtPsASsRSsRKS
0 1
CLOCK (human) HsPtPsASsRSsRKS S433
CLOCK (mouse) HsPTPSASSRSSRKS S433
CLOCK (rat) HSPtPsAsSRSSRKS S433-p
S434-p
sPtPsASsRSsRKSS
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • BMAL1 (human)
CLOCK (human) sPtPsASsRSsRKSS S434-p
CLOCK (mouse) sPTPSASSRSSRKSS S434
CLOCK (rat) SPtPsAsSRSSRKSS S434
S437-p
PsASsRSsRKSSHtA
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • BMAL1 (human)
CLOCK (human) PsASsRSsRKSSHtA S437-p
CLOCK (mouse) PSASSRSSRKSSHtA S437
CLOCK (rat) PsAsSRSSRKSSHTA S437
T443-p
SsRKSSHtAVsDPSS
0 2
CLOCK (human) SsRKSSHtAVsDPSS T443-p
CLOCK (mouse) SSRKSSHtAVsDPSS T443-p
CLOCK (rat) SSRKSSHTAVSDPSS T443
S446-p
KSSHtAVsDPSStPT
0 5
CLOCK (human) KSSHtAVsDPSStPT S446-p
CLOCK (mouse) KSSHtAVsDPSSTPT S446-p
CLOCK (rat) KSSHTAVSDPSSTPT S446
T451-p
AVsDPSStPTKIPTD
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • CDK5 (human)
Putative in vivo kinases:
  • CDK5 (human)
CLOCK (human) AVsDPSStPTKIPTD T451-p
CLOCK (mouse) AVsDPSSTPTKIPTD T451
CLOCK (rat) AVSDPSSTPTKIPTD T451
S460-p
TKIPTDTstPPRQHL
0 1
CLOCK (human) TKIPTDTstPPRQHL S460-p
CLOCK (mouse) TKIPTDTStPPRQHL S460
CLOCK (rat) TKIPTDTSTPPRPHL S460
T461-p
KIPTDTstPPRQHLP
Upstream
Downstream
1 5
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • CDK5 (human)
Putative in vivo kinases:
  • CDK5 (human)
CLOCK (human) KIPTDTstPPRQHLP T461-p
CLOCK (mouse) KIPTDTStPPRQHLP T461-p
CLOCK (rat) KIPTDTSTPPRPHLP T461
R702-m2
FTQDRQIrFSQGQQL
0 4
CLOCK (human) FTQDRQIrFSQGQQL R702-m2
CLOCK (mouse) FTQDRQIrFSQGQQL R698-m2
CLOCK (rat) FTQDRQIRFSQGQQL R701
T834
QQLSRHRTDsLPDPS
0 1
CLOCK (human) QQLSRHRTDsLPDPS T834
CLOCK (mouse) QQLPRHRtDsLTDPS T843-p
CLOCK (rat) QQLHRHRTDSLTDPS T850
S836-p
LSRHRTDsLPDPSkV
1 7
CLOCK (human) LSRHRTDsLPDPSkV S836-p
CLOCK (mouse) LPRHRtDsLTDPSKV S845-p
CLOCK (rat) LHRHRTDSLTDPSKV S852
K842-sm
DsLPDPSkVQPQ___
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
Regulatory protein:
  • SENP2 (human)
  • SENP3 (human)
Treatment
  • 17-beta-estradiol
CLOCK (human) DsLPDPSkVQPQ___ K842-sm
CLOCK (mouse) DsLTDPSKVQPQ___ K851
CLOCK (rat) DSLTDPSKVQPQ___ K858