Other Species / Isoforms
  HER2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
N68
ELTYLPTNASLSFLQ
0 1
HER2 (human) ELTYLPTNASLSFLQ N68
HER2 iso2 (human) gap -
HER2 iso5 (human) ELTYLPTNASLSFLQ N38
HER2 (mouse) ELTYLPAnASLSFLQ N68-ng
HER2 (rat) ELTYVPANASLSFLQ N68
N125
DNGDPLNNTTPVTGA
0 1
HER2 (human) DNGDPLNNTTPVTGA N125
HER2 iso2 (human) gap -
HER2 iso5 (human) DNGDPLNNTTPVTGA N95
HER2 (mouse) DNRDPLDnVTTAAPG N125-ng
HER2 (rat) DNRDPQDNVAASTPG N125
K150-ub
RSLTEILkGGVLIQR
0 1
HER2 (human) RSLTEILkGGVLIQR K150-ub
HER2 iso2 (human) gap -
HER2 iso5 (human) RSLTEILKGGVLIQR K120
HER2 (mouse) RSLTEILKGGVLIRG K151
HER2 (rat) RSLTEILKGGVLIRG K151
K175-ub
LWKDIFHkNNQLALt
0 1
HER2 (human) LWKDIFHkNNQLALt K175-ub
HER2 iso2 (human) gap -
HER2 iso5 (human) LWKDIFHKNNQLALT K145
HER2 (mouse) LWKDVLRKNNQLAPV K176
HER2 (rat) LWKDVFRKNNQLAPV K176
K175-m3
LWKDIFHkNNQLALt
1 0
HER2 (human) LWKDIFHkNNQLALt K175-m3
HER2 iso2 (human) gap -
HER2 iso5 (human) LWKDIFHKNNQLALT K145
HER2 (mouse) LWKDVLRKNNQLAPV K176
HER2 (rat) LWKDVFRKNNQLAPV K176
T182-p
kNNQLALtLIDTNRS
0 1
HER2 (human) kNNQLALtLIDTNRS T182-p
HER2 iso2 (human) gap -
HER2 iso5 (human) KNNQLALTLIDTNRS T152
HER2 (mouse) KNNQLAPVDMDTnRS V183
HER2 (rat) KNNQLAPVDIDTNRS V183
N187
ALtLIDTNRSRACHP
0 1
HER2 (human) ALtLIDTNRSRACHP N187
HER2 iso2 (human) gap -
HER2 iso5 (human) ALTLIDTNRSRACHP N157
HER2 (mouse) APVDMDTnRSRACPP N188-ng
HER2 (rat) APVDIDTNRSRACPP N188
S196-p
SRACHPCsPMCKGSR
0 1
HER2 (human) SRACHPCsPMCKGSR S196-p
HER2 iso2 (human) gap -
HER2 iso5 (human) SRACHPCSPMCKGSR S166
HER2 (mouse) SRACPPCAPTCKDNH A197
HER2 (rat) SRACPPCAPACKDNH A197
N259
CLACLHFNHSGICEL
0 1
HER2 (human) CLACLHFNHSGICEL N259
HER2 iso2 (human) gap -
HER2 iso5 (human) CLACLHFNHSGICEL N229
HER2 (mouse) CLACLHFnHSGICEL N260-ng
HER2 (rat) CLACLHFNHSGICEL N260
N530
PGPTQCVNCSQFLRG
0 1
HER2 (human) PGPTQCVNCSQFLRG N530
HER2 iso2 (human) gap -
HER2 iso5 (human) PGPTQCVNCSQFLRG N500
HER2 (mouse) PGPTQCVnCSQFLRG N531-ng
HER2 (rat) PGPTQCVNCSHFLRG N532
N571
HPECQPQNGSVTCFG
0 1
HER2 (human) HPECQPQNGSVTCFG N571
HER2 iso2 (human) gap -
HER2 iso5 (human) HPECQPQNGSVTCFG N541
HER2 (mouse) HPECQPQnSSETCYG N572-ng
HER2 (rat) HPECQPQNSSETCFG N573
N629
ACQPCPINCTHSCVD
0 1
HER2 (human) ACQPCPINCTHSCVD N629
HER2 iso2 (human) ACQPCPINCTHSCVD N19
HER2 iso5 (human) ACQPCPINCTHSCVD N599
HER2 (mouse) ICQPCPInCTHSCVD N630-ng
HER2 (rat) ICQPCPINCTHSCVD N631
T686-p
QQKIRKYtMRRLLQE
Upstream
Downstream
6 1
HER2 (human)
T686-p
HER2 iso2 (human)
T76-p
HER2 iso5 (human)
T656-p
HER2 (mouse)
T687-p
HER2 (rat)
T688-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • phosphorylation
  • receptor internalization, altered
Kinase, in vitro:
  • PKACA (human)
  • PKCA (rat)
Putative in vivo kinases:
  • PKACA (human)
  • PKCA (human)
  • PKG2 (human)
Treatment
  • 8pCPT-cGMP
  • adenosine
  • colforsin
  • isoproterenol
  • phorbol_ester
  • racepinefrine
  • vanadate
HER2 (human) QQKIRKYtMRRLLQE T686-p
HER2 iso2 (human) QQKIRKYTMRRLLQE T76
HER2 iso5 (human) QQKIRKYTMRRLLQE T656
HER2 (mouse) RQKIRKYtMRRLLQE T687-p
HER2 (rat) RQKIRKYtMRRLLQE T688-p
T701-p
TELVEPLtPsGAMPN
Upstream
Downstream
4 36
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
  • receptor internalization, inhibited
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
Treatment
  • adriamycin
  • cisplatin
  • ischemia
  • phorbol_ester
  • SCH772984
  • selumetinib
  • tPA
  • Trametinib
  • U0126
  • vemurafenib
HER2 (human) TELVEPLtPsGAMPN T701-p
HER2 iso2 (human) TELVEPLTPSGAMPN T91
HER2 iso5 (human) TELVEPLTPSGAMPN T671
HER2 (mouse) TELVEPLtPsGAVPN T702-p
HER2 (rat) TELVEPLTPSGAMPN T703
S703-p
LVEPLtPsGAMPNQA
0 2
HER2 (human) LVEPLtPsGAMPNQA S703-p
HER2 iso2 (human) LVEPLTPSGAMPNQA S93
HER2 iso5 (human) LVEPLTPSGAMPNQA S673
HER2 (mouse) LVEPLtPsGAVPNQA S704-p
HER2 (rat) LVEPLTPSGAMPNQA S705
K716-ub
QAQMRILkETELRKV
0 1
HER2 (human) QAQMRILkETELRKV K716-ub
HER2 iso2 (human) QAQMRILKETELRKV K106
HER2 iso5 (human) QAQMRILKETELRKV K686
HER2 (mouse) QAQMRILKETELRKL K717
HER2 (rat) QAQMRILKETELRKV K718
K724-ub
ETELRKVkVLGSGAF
0 2
HER2 (human) ETELRKVkVLGSGAF K724-ub
HER2 iso2 (human) ETELRKVKVLGSGAF K114
HER2 iso5 (human) ETELRKVKVLGSGAF K694
HER2 (mouse) ETELRKLkVLGSGAF K725-ub
HER2 (rat) ETELRKVKVLGSGAF K726
T733-p
LGSGAFGtVykGIWI
0 9
HER2 (human) LGSGAFGtVykGIWI T733-p
HER2 iso2 (human) LGSGAFGTVYKGIWI T123
HER2 iso5 (human) LGSGAFGTVYKGIWI T703
HER2 (mouse) LGSGAFGTVyKGIWI T734
HER2 (rat) LGSGAFGTVYKGIWI T735
Y735-p
SGAFGtVykGIWIPD
Downstream
1 160
Effects on Modified Protein
  • molecular association, regulation
HER2 (human) SGAFGtVykGIWIPD Y735-p
HER2 iso2 (human) SGAFGTVYKGIWIPD Y125
HER2 iso5 (human) SGAFGTVYKGIWIPD Y705
HER2 (mouse) SGAFGTVyKGIWIPD Y736-p
HER2 (rat) SGAFGTVYKGIWIPD Y737
K736-ub
GAFGtVykGIWIPDG
0 3
HER2 (human) GAFGtVykGIWIPDG K736-ub
HER2 iso2 (human) GAFGTVYKGIWIPDG K126
HER2 iso5 (human) GAFGTVYKGIWIPDG K706
HER2 (mouse) GAFGTVyKGIWIPDG K737
HER2 (rat) GAFGTVYKGIWIPDG K738
K747-ub
IPDGENVkIPVAIkV
0 6
HER2 (human) IPDGENVkIPVAIkV K747-ub
HER2 iso2 (human) IPDGENVKIPVAIKV K137
HER2 iso5 (human) IPDGENVKIPVAIKV K717
HER2 (mouse) IPDGENVkIPVAIKV K748-ub
HER2 (rat) IPDGENVKIPVAIKV K749
K753-ub
VkIPVAIkVLRENtS
0 3
HER2 (human) VkIPVAIkVLRENtS K753-ub
HER2 iso2 (human) VKIPVAIKVLRENTS K143
HER2 iso5 (human) VKIPVAIKVLRENTS K723
HER2 (mouse) VkIPVAIKVLRENTS K754
HER2 (rat) VKIPVAIKVLRENTS K755
T759-p
IkVLRENtSPKANKE
0 1
HER2 (human) IkVLRENtSPKANKE T759-p
HER2 iso2 (human) IKVLRENTSPKANKE T149
HER2 iso5 (human) IKVLRENTSPKANKE T729
HER2 (mouse) IKVLRENTSPKANKE T760
HER2 (rat) IKVLRENTSPKANKE T761
Y772-p
KEILDEAyVMAGVGS
0 4
HER2 (human) KEILDEAyVMAGVGS Y772-p
HER2 iso2 (human) KEILDEAYVMAGVGS Y162
HER2 iso5 (human) KEILDEAYVMAGVGS Y742
HER2 (mouse) KEILDEAYVMAGVGS Y773
HER2 (rat) KEILDEAYVMAGVGS Y774
S819-p
ENRGRLGsQDLLNWC
0 1
HER2 (human) ENRGRLGsQDLLNWC S819-p
HER2 iso2 (human) ENRGRLGSQDLLNWC S209
HER2 iso5 (human) ENRGRLGSQDLLNWC S789
HER2 (mouse) EHRGRLGSQDLLNWC S820
HER2 (rat) EHRGRLGSQDLLNWC S821
T875-p
RLLDIDEtEyHADGG
0 10
HER2 (human) RLLDIDEtEyHADGG T875-p
HER2 iso2 (human) RLLDIDETEYHADGG T265
HER2 iso5 (human) RLLDIDETEYHADGG T845
HER2 (mouse) RLLDIDETEyHADGG T876
HER2 (rat) RLLDIDETEyHADGG T877
Y877-p
LDIDEtEyHADGGkV
Upstream
Downstream
19 123
HER2 (human)
Y877-p
HER2 iso2 (human)
Y267-p
HER2 iso5 (human)
Y847-p
HER2 (mouse)
Y878-p
HER2 (rat)
Y879-p
Effects on Modified Protein
  • enzymatic activity, induced
  • protein conformation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, altered
Kinase, in vitro:
  • Src (human)
Putative in vivo kinases:
  • Fyn (human)
  • HER2 (human)
  • Src (human)
  • Yes (human)
Putative upstream phosphatases:
  • ACPP (human)
Treatment
  • 2-deoxyglucose
  • AEE788
  • anti-HER2
  • colforsin
  • EGF
  • erlotinib
  • estradiol
  • FGF2
  • Herceptin/rGel
  • heregulin
  • lapatinib
  • neuregulin
  • PD168393
  • pertuzumab
  • PP1
  • tamoxifen
  • TGF-alpha
HER2 (human) LDIDEtEyHADGGkV Y877-p
HER2 iso2 (human) LDIDETEYHADGGKV Y267
HER2 iso5 (human) LDIDETEYHADGGKV Y847
HER2 (mouse) LDIDETEyHADGGKV Y878-p
HER2 (rat) LDIDETEyHADGGKV Y879-p
K883-ub
EyHADGGkVPIkWMA
0 2
HER2 (human) EyHADGGkVPIkWMA K883-ub
HER2 iso2 (human) EYHADGGKVPIKWMA K273
HER2 iso5 (human) EYHADGGKVPIKWMA K853
HER2 (mouse) EyHADGGKVPIKWMA K884
HER2 (rat) EyHADGGKVPIKWMA K885
K887-ub
DGGkVPIkWMALESI
0 1
HER2 (human) DGGkVPIkWMALESI K887-ub
HER2 iso2 (human) DGGKVPIKWMALESI K277
HER2 iso5 (human) DGGKVPIKWMALESI K857
HER2 (mouse) DGGKVPIKWMALESI K888
HER2 (rat) DGGKVPIKWMALESI K889
T900-p
SILRRRFtHQSDVWS
Upstream
1 0
Kinase, in vitro:
  • AMPKA1 (human)
HER2 (human) SILRRRFtHQSDVWS T900-p
HER2 iso2 (human) SILRRRFTHQSDVWS T290
HER2 iso5 (human) SILRRRFTHQSDVWS T870
HER2 (mouse) SILRRRFTHQSDVWS T901
HER2 (rat) SILRRRFTHQSDVWS T902
Y923-p
MTFGAKPyDGIPARE
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
HER2 (human) MTFGAKPyDGIPARE Y923-p
HER2 iso2 (human) MTFGAKPYDGIPARE Y313
HER2 iso5 (human) MTFGAKPYDGIPARE Y893
HER2 (mouse) MTFGAKPyDGIPARE Y924-p
HER2 (rat) MTFGAKPYDGIPARE Y925
K937-ub
EIPDLLEkGERLPQP
0 3
HER2 (human) EIPDLLEkGERLPQP K937-ub
HER2 iso2 (human) EIPDLLEKGERLPQP K327
HER2 iso5 (human) EIPDLLEKGERLPQP K907
HER2 (mouse) EIPDLLEkGERLPQP K938-ub
HER2 (rat) EIPDLLEKGERLPQP K939
S974-p
PRFRELVsEFsRMAR
0 1
HER2 (human) PRFRELVsEFsRMAR S974-p
HER2 iso2 (human) PRFRELVSEFSRMAR S364
HER2 iso5 (human) PRFRELVSEFSRMAR S944
HER2 (mouse) PRFRELVSEFSRMAR S975
HER2 (rat) PRFRELVSEFSRMAR S976
S977-p
RELVsEFsRMARDPQ
0 1
HER2 (human) RELVsEFsRMARDPQ S977-p
HER2 iso2 (human) RELVSEFSRMARDPQ S367
HER2 iso5 (human) RELVSEFSRMARDPQ S947
HER2 (mouse) RELVSEFSRMARDPQ S978
HER2 (rat) RELVSEFSRMARDPQ S979
S998-p
NEDLGPAsPLDstFy
Upstream
0 8
Treatment
  • ischemia
  • lapatinib
HER2 (human) NEDLGPAsPLDstFy S998-p
HER2 iso2 (human) NEDLGPASPLDSTFY S388
HER2 iso5 (human) NEDLGPASPLDSTFY S968
HER2 (mouse) NEDLGPSSPMDSTFY S999
HER2 (rat) NEDLGPSSPMDSTFY S1000
S1002-p
GPAsPLDstFyRsLL
0 8
HER2 (human) GPAsPLDstFyRsLL S1002-p
HER2 iso2 (human) GPASPLDSTFYRSLL S392
HER2 iso5 (human) GPASPLDSTFYRSLL S972
HER2 (mouse) GPSSPMDSTFYRSLL S1003
HER2 (rat) GPSSPMDSTFYRSLL S1004
T1003-p
PAsPLDstFyRsLLE
0 4
HER2 (human) PAsPLDstFyRsLLE T1003-p
HER2 iso2 (human) PASPLDSTFYRSLLE T393
HER2 iso5 (human) PASPLDSTFYRSLLE T973
HER2 (mouse) PSSPMDSTFYRSLLE T1004
HER2 (rat) PSSPMDSTFYRSLLE T1005
Y1005-p
sPLDstFyRsLLEDD
Upstream
Downstream
1 78
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • erlotinib
HER2 (human) sPLDstFyRsLLEDD Y1005-p
HER2 iso2 (human) SPLDSTFYRSLLEDD Y395
HER2 iso5 (human) SPLDSTFYRSLLEDD Y975
HER2 (mouse) SPMDSTFYRSLLEDD Y1006
HER2 (rat) SPMDSTFYRSLLEDD Y1007
S1007-p
LDstFyRsLLEDDDM
0 1
HER2 (human) LDstFyRsLLEDDDM S1007-p
HER2 iso2 (human) LDSTFYRSLLEDDDM S397
HER2 iso5 (human) LDSTFYRSLLEDDDM S977
HER2 (mouse) MDSTFYRSLLEDDDM S1008
HER2 (rat) MDSTFYRSLLEDDDM S1009
Y1023-p
DLVDAEEyLVPQQGF
Upstream
Downstream
7 39
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell growth, altered
Kinase, in vitro:
  • HER2 (human)
Treatment
  • erlotinib
  • heregulin
  • TGF-alpha
HER2 (human) DLVDAEEyLVPQQGF Y1023-p
HER2 iso2 (human) DLVDAEEYLVPQQGF Y413
HER2 iso5 (human) DLVDAEEYLVPQQGF Y993
HER2 (mouse) ELVDAEEYLVPQQGF Y1024
HER2 (rat) DLVDAEEyLVPQQGF Y1025-p
S1049-p
MVHHRHRssstRsGG
0 3
HER2 (human) MVHHRHRssstRsGG S1049-p
HER2 iso2 (human) MVHHRHRSSSTRSGG S439
HER2 iso5 (human) MVHHRHRSSSTRSGG S1019
HER2 (mouse) TAHRRHRSSSARsGG S1050
HER2 (rat) TAHRRHRSSSTRsGG S1051
S1050-p
VHHRHRssstRsGGG
Upstream
0 6
Treatment
  • lapatinib
HER2 (human) VHHRHRssstRsGGG S1050-p
HER2 iso2 (human) VHHRHRSSSTRSGGG S440
HER2 iso5 (human) VHHRHRSSSTRSGGG S1020
HER2 (mouse) AHRRHRSSSARsGGG S1051
HER2 (rat) AHRRHRSSSTRsGGG S1052
S1051-p
HHRHRssstRsGGGD
Upstream
0 7
Treatment
  • lapatinib
HER2 (human) HHRHRssstRsGGGD S1051-p
HER2 iso2 (human) HHRHRSSSTRSGGGD S441
HER2 iso5 (human) HHRHRSSSTRSGGGD S1021
HER2 (mouse) HRRHRSSSARsGGGE S1052
HER2 (rat) HRRHRSSSTRsGGGE S1053
T1052-p
HRHRssstRsGGGDL
Upstream
0 3
Treatment
  • lapatinib
HER2 (human) HRHRssstRsGGGDL T1052-p
HER2 iso2 (human) HRHRSSSTRSGGGDL T442
HER2 iso5 (human) HRHRSSSTRSGGGDL T1022
HER2 (mouse) RRHRSSSARsGGGEL A1053
HER2 (rat) RRHRSSSTRsGGGEL T1054
S1054-p
HRssstRsGGGDLtL
Upstream
0 25
Treatment
  • EGF
  • ischemia
  • lapatinib
  • metastatic potential
  • selumetinib
  • vemurafenib
HER2 (human) HRssstRsGGGDLtL S1054-p
HER2 iso2 (human) HRSSSTRSGGGDLTL S444
HER2 iso5 (human) HRSSSTRSGGGDLTL S1024
HER2 (mouse) HRSSSARsGGGELTL S1055-p
HER2 (rat) HRSSSTRsGGGELTL S1056-p
T1060-p
RsGGGDLtLGLEPsE
0 1
HER2 (human) RsGGGDLtLGLEPsE T1060-p
HER2 iso2 (human) RSGGGDLTLGLEPSE T450
HER2 iso5 (human) RSGGGDLTLGLEPSE T1030
HER2 (mouse) RsGGGELTLGLEPSE T1061
HER2 (rat) RsGGGELTLGLEPSE T1062
S1066-p
LtLGLEPsEEEAPRs
0 4
HER2 (human) LtLGLEPsEEEAPRs S1066-p
HER2 iso2 (human) LTLGLEPSEEEAPRS S456
HER2 iso5 (human) LTLGLEPSEEEAPRS S1036
HER2 (mouse) LTLGLEPSEEEPPRS S1067
HER2 (rat) LTLGLEPSEEGPPRS S1068
S1073-p
sEEEAPRsPLAPsEG
0 2
HER2 (human) sEEEAPRsPLAPsEG S1073-p
HER2 iso2 (human) SEEEAPRSPLAPSEG S463
HER2 iso5 (human) SEEEAPRSPLAPSEG S1043
HER2 (mouse) SEEEPPRSPLAPSEG S1074
HER2 (rat) SEEGPPRSPLAPsEG S1075
S1078-p
PRsPLAPsEGAGsDV
Upstream
0 7
Treatment
  • ischemia
HER2 (human) PRsPLAPsEGAGsDV S1078-p
HER2 iso2 (human) PRSPLAPSEGAGSDV S468
HER2 iso5 (human) PRSPLAPSEGAGSDV S1048
HER2 (mouse) PRSPLAPSEGAGsDV S1079
HER2 (rat) PRSPLAPsEGAGsDV S1080-p
S1083-p
APsEGAGsDVFDGDL
Upstream
0 11
Treatment
  • ischemia
  • lapatinib
HER2 (human) APsEGAGsDVFDGDL S1083-p
HER2 iso2 (human) APSEGAGSDVFDGDL S473
HER2 iso5 (human) APSEGAGSDVFDGDL S1053
HER2 (mouse) APSEGAGsDVFDGDL S1084-p
HER2 (rat) APsEGAGsDVFDGDL S1085-p
S1100-p
GAAKGLQsLPtHDPs
0 5
HER2 (human) GAAKGLQsLPtHDPs S1100-p
HER2 iso2 (human) GAAKGLQSLPTHDPS S490
HER2 iso5 (human) GAAKGLQSLPTHDPS S1070
HER2 (mouse) GVTKGLQSLSPHDLS S1101
HER2 (rat) GVTKGLQSLSPHDLS S1102
T1103-p
KGLQsLPtHDPsPLQ
0 2
HER2 (human) KGLQsLPtHDPsPLQ T1103-p
HER2 iso2 (human) KGLQSLPTHDPSPLQ T493
HER2 iso5 (human) KGLQSLPTHDPSPLQ T1073
HER2 (mouse) KGLQSLSPHDLSPLQ P1104
HER2 (rat) KGLQSLSPHDLSPLQ P1105
S1107-p
sLPtHDPsPLQRySE
Upstream
0 11
Treatment
  • lapatinib
  • nocodazole
HER2 (human) sLPtHDPsPLQRySE S1107-p
HER2 iso2 (human) SLPTHDPSPLQRYSE S497
HER2 iso5 (human) SLPTHDPSPLQRYSE S1077
HER2 (mouse) SLSPHDLSPLQRysE S1108
HER2 (rat) SLSPHDLSPLQRySE S1109
Y1112-p
DPsPLQRySEDPTVP
Upstream
Downstream
8 3
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Kinase, in vitro:
  • HER2 (human)
Putative upstream phosphatases:
  • PTP-PEST (human)
Treatment
  • erlotinib
  • gefitinib
HER2 (human) DPsPLQRySEDPTVP Y1112-p
HER2 iso2 (human) DPSPLQRYSEDPTVP Y502
HER2 iso5 (human) DPSPLQRYSEDPTVP Y1082
HER2 (mouse) DLSPLQRysEDPTLP Y1113-p
HER2 (rat) DLSPLQRySEDPTLP Y1114-p
S1113
PsPLQRySEDPTVPL
1 0
HER2 (human) PsPLQRySEDPTVPL S1113
HER2 iso2 (human) PSPLQRYSEDPTVPL S503
HER2 iso5 (human) PSPLQRYSEDPTVPL S1083
HER2 (mouse) LSPLQRysEDPTLPL S1114-p
HER2 (rat) LSPLQRySEDPTLPL S1115
S1122-p
DPTVPLPsEtDGyVA
0 1
HER2 (human) DPTVPLPsEtDGyVA S1122-p
HER2 iso2 (human) DPTVPLPSETDGYVA S512
HER2 iso5 (human) DPTVPLPSETDGYVA S1092
HER2 (mouse) DPTLPLPPETDGYVA P1123
HER2 (rat) DPTLPLPPETDGYVA P1124
T1124-p
TVPLPsEtDGyVAPL
0 1
HER2 (human) TVPLPsEtDGyVAPL T1124-p
HER2 iso2 (human) TVPLPSETDGYVAPL T514
HER2 iso5 (human) TVPLPSETDGYVAPL T1094
HER2 (mouse) TLPLPPETDGYVAPL T1125
HER2 (rat) TLPLPPETDGYVAPL T1126
Y1127-p
LPsEtDGyVAPLtCs
Upstream
0 13
Treatment
  • gefitinib
HER2 (human) LPsEtDGyVAPLtCs Y1127-p
HER2 iso2 (human) LPSETDGYVAPLTCS Y517
HER2 iso5 (human) LPSETDGYVAPLTCS Y1097
HER2 (mouse) LPPETDGYVAPLACS Y1128
HER2 (rat) LPPETDGYVAPLACS Y1129
T1132-p
DGyVAPLtCsPQPEy
0 2
HER2 (human) DGyVAPLtCsPQPEy T1132-p
HER2 iso2 (human) DGYVAPLTCSPQPEY T522
HER2 iso5 (human) DGYVAPLTCSPQPEY T1102
HER2 (mouse) DGYVAPLACSPQPEY A1133
HER2 (rat) DGYVAPLACSPQPEy A1134
S1134-p
yVAPLtCsPQPEyVN
0 6
HER2 (human) yVAPLtCsPQPEyVN S1134-p
HER2 iso2 (human) YVAPLTCSPQPEYVN S524
HER2 iso5 (human) YVAPLTCSPQPEYVN S1104
HER2 (mouse) YVAPLACSPQPEYVN S1135
HER2 (rat) YVAPLACSPQPEyVN S1136
Y1139-p
tCsPQPEyVNQPDVR
Upstream
Downstream
11 50
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell growth, altered
  • cell motility, altered
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • HER2 (human)
Regulatory protein:
  • MUC4 (human)
HER2 (human) tCsPQPEyVNQPDVR Y1139-p
HER2 iso2 (human) TCSPQPEYVNQPDVR Y529
HER2 iso5 (human) TCSPQPEYVNQPDVR Y1109
HER2 (mouse) ACSPQPEYVNQPEVR Y1140
HER2 (rat) ACSPQPEyVNQSEVQ Y1141-p
S1151-p
DVRPQPPsPREGPLP
0 51
HER2 (human) DVRPQPPsPREGPLP S1151-p
HER2 iso2 (human) DVRPQPPSPREGPLP S541
HER2 iso5 (human) DVRPQPPSPREGPLP S1121
HER2 (mouse) VRPQSPLTPEGPPPP T1153
HER2 (rat) VQPQPPLTPEGPLPP T1154
T1166-p
AARPAGAtLERPKtL
Upstream
0 12
Treatment
  • EGF
HER2 (human) AARPAGAtLERPKtL T1166-p
HER2 iso2 (human) AARPAGATLERPKTL T556
HER2 iso5 (human) AARPAGATLERPKTL T1136
HER2 (mouse) PIRPAGATLERPKtL T1167
HER2 (rat) PVRPAGATLERPKTL T1168
T1172-p
AtLERPKtLsPGKNG
Upstream
Downstream
1 2
Effects on Modified Protein
  • receptor desensitization, altered
Kinase, in vitro:
  • CAMK2A (rat)
Putative in vivo kinases:
  • CAMK2A (rat)
Treatment
  • EGF
  • thapsigargin
HER2 (human) AtLERPKtLsPGKNG T1172-p
HER2 iso2 (human) ATLERPKTLSPGKNG T562
HER2 iso5 (human) ATLERPKTLSPGKNG T1142
HER2 (mouse) ATLERPKtLsPGKNG T1173-p
HER2 (rat) ATLERPKTLsPGKNG T1174
S1174-p
LERPKtLsPGKNGVV
Upstream
1 8
Treatment
  • ischemia
HER2 (human) LERPKtLsPGKNGVV S1174-p
HER2 iso2 (human) LERPKTLSPGKNGVV S564
HER2 iso5 (human) LERPKTLSPGKNGVV S1144
HER2 (mouse) LERPKtLsPGKNGVV S1175-p
HER2 (rat) LERPKTLsPGKNGVV S1176-p
Y1196-p
GAVENPEyLtPQGGA
Upstream
Downstream
12 8
HER2 (human)
Y1196-p
HER2 iso2 (human)
Y586-p
HER2 iso5 (human)
Y1166-p
HER2 (mouse)
Y1197-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell motility, altered
  • signaling pathway regulation
  • transcription, induced
Putative in vivo kinases:
  • HER2 (human)
Putative upstream phosphatases:
  • PTP-PEST (human)
Regulatory protein:
  • AMPKA1 (human)
Treatment
  • heregulin
  • LY294002
  • phorbol_ester
  • PKI166
  • PP2
  • PP3
  • SB203580
  • Trametinib
  • U0126
  • U73122
HER2 (human) GAVENPEyLtPQGGA Y1196-p
HER2 iso2 (human) GAVENPEYLTPQGGA Y586
HER2 iso5 (human) GAVENPEYLTPQGGA Y1166
HER2 (mouse) GAVENPEyLAPRAGT Y1197-p
HER2 (rat) GAVENPEyLVPREGT Y1198-p
T1198-p
VENPEyLtPQGGAAP
0 1
HER2 (human) VENPEyLtPQGGAAP T1198-p
HER2 iso2 (human) VENPEYLTPQGGAAP T588
HER2 iso5 (human) VENPEYLTPQGGAAP T1168
HER2 (mouse) VENPEyLAPRAGTAS A1199
HER2 (rat) VENPEyLVPREGTAS V1200
S1214-p
PHPPPAFsPAFDNLy
0 3
HER2 (human) PHPPPAFsPAFDNLy S1214-p
HER2 iso2 (human) PHPPPAFSPAFDNLY S604
HER2 iso5 (human) PHPPPAFSPAFDNLY S1184
HER2 (mouse) PHPSPAFSPAFDNLy S1215
HER2 (rat) PHPSPAFSPAFDNLy S1216
Y1221-p
sPAFDNLyyWDQDPP
Upstream
Downstream
23 16
HER2 (human)
Y1221-p
HER2 iso2 (human)
Y611-p
HER2 iso5 (human)
Y1191-p
HER2 (mouse)
Y1222-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell growth, altered
  • cell motility, altered
Kinase, in vitro:
  • HER2 (human)
Putative upstream phosphatases:
  • ACPP (human)
Regulatory protein:
  • BTG2 (human)
  • HRas (human)
Treatment
  • acadesine
  • AEE788
  • anti-HER2
  • beta-amyloid
  • calcitonin
  • colforsin
  • EGF
  • erlotinib
  • gefitinib
  • Herceptin/rGel
  • heregulin
  • lapatinib
  • LY294002
  • neuregulin
  • PP2
  • PP3
  • SB203580
  • U0126
  • U73122
HER2 (human) sPAFDNLyyWDQDPP Y1221-p
HER2 iso2 (human) SPAFDNLYYWDQDPP Y611
HER2 iso5 (human) SPAFDNLYYWDQDPP Y1191
HER2 (mouse) SPAFDNLyyWDQNSS Y1222-p
HER2 (rat) SPAFDNLyyWDQNSS Y1223-p
Y1222-p
PAFDNLyyWDQDPPE
Upstream
Downstream
27 10
HER2 (human)
Y1222-p
HER2 iso2 (human)
Y612-p
HER2 iso5 (human)
Y1192-p
HER2 (mouse)
Y1223-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, altered
  • cell motility, altered
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • HER2 (human)
Putative in vivo kinases:
  • HER2 (human)
Putative upstream phosphatases:
  • ACPP (human)
Regulatory protein:
  • BTG2 (human)
  • HRas (human)
Treatment
  • acadesine
  • AEE788
  • anti-HER2
  • beta-amyloid
  • calcitonin
  • colforsin
  • EGF
  • erlotinib
  • gefitinib
  • Herceptin/rGel
  • heregulin
  • lapatinib
  • LY294002
  • neuregulin
  • PDGF
  • phorbol_ester
  • PP2
  • PP3
  • SB203580
  • U0126
  • U73122
HER2 (human) PAFDNLyyWDQDPPE Y1222-p
HER2 iso2 (human) PAFDNLYYWDQDPPE Y612
HER2 iso5 (human) PAFDNLYYWDQDPPE Y1192
HER2 (mouse) PAFDNLyyWDQNSSE Y1223-p
HER2 (rat) PAFDNLyyWDQNSSE Y1224-p
S1235-p
PERGAPPstFKGtPt
0 1
HER2 (human) PERGAPPstFKGtPt S1235-p
HER2 iso2 (human) PERGAPPSTFKGTPT S625
HER2 iso5 (human) PERGAPPSTFKGTPT S1205
HER2 (mouse) SEQGPPPSTFEGTPT S1236
HER2 (rat) SEQGPPPSNFEGTPT S1237
T1236-p
ERGAPPstFKGtPtA
0 1
HER2 (human) ERGAPPstFKGtPtA T1236-p
HER2 iso2 (human) ERGAPPSTFKGTPTA T626
HER2 iso5 (human) ERGAPPSTFKGTPTA T1206
HER2 (mouse) EQGPPPSTFEGTPTA T1237
HER2 (rat) EQGPPPSNFEGTPTA N1238
T1240-p
PPstFKGtPtAENPE
Upstream
0 11
Treatment
  • ischemia
HER2 (human) PPstFKGtPtAENPE T1240-p
HER2 iso2 (human) PPSTFKGTPTAENPE T630
HER2 iso5 (human) PPSTFKGTPTAENPE T1210
HER2 (mouse) PPSTFEGTPTAENPE T1241
HER2 (rat) PPSNFEGTPTAENPE T1242
T1242-p
stFKGtPtAENPEyL
0 2
HER2 (human) stFKGtPtAENPEyL T1242-p
HER2 iso2 (human) STFKGTPTAENPEYL T632
HER2 iso5 (human) STFKGTPTAENPEYL T1212
HER2 (mouse) STFEGTPTAENPEyL T1243
HER2 (rat) SNFEGTPTAENPEyL T1244
Y1248-p
PtAENPEyLGLDVPV
Upstream
Downstream
52 213
HER2 (human)
Y1248-p
HER2 iso2 (human)
Y638-p
HER2 iso5 (human)
Y1218-p
HER2 (mouse)
Y1249-p
HER2 (rat)
Y1250-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, induced
  • cell motility, altered
  • cytoskeletal reorganization
  • signaling pathway regulation
  • transcription, induced