K2
|
______MKLNISFPA
|
|
|
0
|
1
|
|
|
S6 (human)
|
______MkLNIsFPA
|
K2-m1
|
S6 (mouse)
|
______MKLNISFPA
|
K2
|
S6 (rat)
|
______MKLNISFPA
|
K2
|
S6 (fruit fly)
|
______MKLNVSYPA
|
K2
|
S6 (cow)
|
______MKLNISFPA
|
K2
|
|
S6
|
__MKLNISFPATGCQ
|
|
|
0
|
5
|
|
|
S6 (human)
|
__MkLNIsFPATGCQ
|
S6-p
|
S6 (mouse)
|
__MKLNISFPATGCQ
|
S6
|
S6 (rat)
|
__MKLNISFPATGCQ
|
S6
|
S6 (fruit fly)
|
__MKLNVSYPATGCQ
|
S6
|
S6 (cow)
|
__MKLNISFPATGCQ
|
S6
|
|
K14-ub
|
FPATGCQkLIEVDDE
|
|
|
0
|
8
|
|
|
S6 (human)
|
FPATGCQkLIEVDDE
|
K14-ub
|
S6 (mouse)
|
FPATGCQkLIEVDDE
|
K14-ub
|
S6 (rat)
|
FPATGCQKLIEVDDE
|
K14
|
S6 (fruit fly)
|
YPATGCQKLFEVVDE
|
K14
|
S6 (cow)
|
FPATGCQKLIEVDDE
|
K14
|
|
K14
|
FPATGCQKLIEVDDE
|
|
|
0
|
3
|
|
|
S6 (human)
|
FPATGCQkLIEVDDE
|
K14-ac
|
S6 (mouse)
|
FPATGCQKLIEVDDE
|
K14
|
S6 (rat)
|
FPATGCQKLIEVDDE
|
K14
|
S6 (fruit fly)
|
YPATGCQKLFEVVDE
|
K14
|
S6 (cow)
|
FPATGCQKLIEVDDE
|
K14
|
|
R22
|
LIEVDDERKLRTFYE
|
|
|
0
|
1
|
|
|
S6 (human)
|
LIEVDDErkLRTFyE
|
R22-m1
|
S6 (mouse)
|
LIEVDDERKLRTFYE
|
R22
|
S6 (rat)
|
LIEVDDERKLRTFYE
|
R22
|
S6 (fruit fly)
|
LFEVVDEHKLRVFYE
|
H22
|
S6 (cow)
|
LIEVDDERKLRTFYE
|
R22
|
|
K23
|
IEVDDERKLRTFYEK
|
|
|
0
|
1
|
|
|
S6 (human)
|
IEVDDErkLRTFyEk
|
K23-ub
|
S6 (mouse)
|
IEVDDERKLRTFYEK
|
K23
|
S6 (rat)
|
IEVDDERKLRTFYEk
|
K23
|
S6 (fruit fly)
|
FEVVDEHKLRVFYEK
|
K23
|
S6 (cow)
|
IEVDDERKLRTFYEK
|
K23
|
|
Y28
|
ERKLRTFYEKRMATE
|
|
|
0
|
1
|
|
|
S6 (human)
|
ErkLRTFyEkRMATE
|
Y28-p
|
S6 (mouse)
|
ERKLRTFYEKRMATE
|
Y28
|
S6 (rat)
|
ERKLRTFYEkRMATE
|
Y28
|
S6 (fruit fly)
|
EHKLRVFYEKRMGQV
|
Y28
|
S6 (cow)
|
ERKLRTFYEKRMATE
|
Y28
|
|
K30
|
KLRTFYEKRMATEVA
|
|
|
0
|
2
|
|
|
S6 (human)
|
kLRTFyEkRMATEVA
|
K30-ac
|
S6 (mouse)
|
KLRTFYEKRMATEVA
|
K30
|
S6 (rat)
|
KLRTFYEkRMATEVA
|
K30-ac
|
S6 (fruit fly)
|
KLRVFYEKRMGQVVE
|
K30
|
S6 (cow)
|
KLRTFYEKRMATEVA
|
K30
|
|
K30
|
KLRTFYEKRMATEVA
|
|
|
0
|
1
|
|
|
S6 (human)
|
kLRTFyEkRMATEVA
|
K30-sc
|
S6 (mouse)
|
KLRTFYEKRMATEVA
|
K30
|
S6 (rat)
|
KLRTFYEKRMATEVA
|
K30
|
S6 (fruit fly)
|
KLRVFYEKRMGQVVE
|
K30
|
S6 (cow)
|
KLRTFYEKRMATEVA
|
K30
|
|
K30
|
KLRTFYEKRMATEVA
|
|
|
0
|
1
|
|
|
S6 (human)
|
kLRTFyEkRMATEVA
|
K30-ub
|
S6 (mouse)
|
KLRTFYEKRMATEVA
|
K30
|
S6 (rat)
|
KLRTFYEKRMATEVA
|
K30
|
S6 (fruit fly)
|
KLRVFYEKRMGQVVE
|
K30
|
S6 (cow)
|
KLRTFYEKRMATEVA
|
K30
|
|
K46-sc
|
DALGEEWkGYVVRIS
|
|
|
0
|
1
|
|
|
S6 (human)
|
DALGEEWKGyVVRIs
|
K46
|
S6 (mouse)
|
DALGEEWkGYVVRIS
|
K46-sc
|
S6 (rat)
|
DALGEEWKGYVVRIS
|
K46
|
S6 (fruit fly)
|
DILGDEWKGYQLRIA
|
K46
|
S6 (cow)
|
DALGEEWKGYVVRIS
|
K46
|
|
K46-ac
|
DALGEEWkGYVVRIS
|
|
|
0
|
1
|
|
|
S6 (human)
|
DALGEEWKGyVVRIs
|
K46
|
S6 (mouse)
|
DALGEEWkGYVVRIS
|
K46-ac
|
S6 (rat)
|
DALGEEWKGYVVRIS
|
K46
|
S6 (fruit fly)
|
DILGDEWKGYQLRIA
|
K46
|
S6 (cow)
|
DALGEEWKGYVVRIS
|
K46
|
|
K46
|
DALGEEWKGYVVRIS
|
|
|
0
|
1
|
|
|
S6 (human)
|
DALGEEWkGyVVRIs
|
K46-ub
|
S6 (mouse)
|
DALGEEWKGYVVRIS
|
K46
|
S6 (rat)
|
DALGEEWKGYVVRIS
|
K46
|
S6 (fruit fly)
|
DILGDEWKGYQLRIA
|
K46
|
S6 (cow)
|
DALGEEWKGYVVRIS
|
K46
|
|
Y48
|
LGEEWkGYVVRISGG
|
|
|
0
|
1
|
|
|
S6 (human)
|
LGEEWkGyVVRIsGG
|
Y48-p
|
S6 (mouse)
|
LGEEWkGYVVRISGG
|
Y48
|
S6 (rat)
|
LGEEWKGYVVRISGG
|
Y48
|
S6 (fruit fly)
|
LGDEWKGYQLRIAGG
|
Y48
|
S6 (cow)
|
LGEEWKGYVVRISGG
|
Y48
|
|
S53
|
kGYVVRISGGNDkQG
|
|
|
0
|
1
|
|
|
S6 (human)
|
kGyVVRIsGGNDkQG
|
S53-p
|
S6 (mouse)
|
kGYVVRISGGNDkQG
|
S53
|
S6 (rat)
|
KGYVVRISGGNDKQG
|
S53
|
S6 (fruit fly)
|
KGYQLRIAGGNDKQG
|
A53
|
S6 (cow)
|
KGYVVRISGGNDKQG
|
S53
|
|
K58-ac
|
RISGGNDkQGFPMKQ
|
|
|
0
|
2
|
|
|
S6 (human)
|
RIsGGNDKQGFPMkQ
|
K58
|
S6 (mouse)
|
RISGGNDkQGFPMKQ
|
K58-ac
|
S6 (rat)
|
RISGGNDKQGFPMkQ
|
K58
|
S6 (fruit fly)
|
RIAGGNDKQGFPMKQ
|
K58
|
S6 (cow)
|
RISGGNDKQGFPMKQ
|
K58
|
|
K58-ub
|
RISGGNDkQGFPMKQ
|
|
|
0
|
10
|
|
|
S6 (human)
|
RIsGGNDkQGFPMkQ
|
K58-ub
|
S6 (mouse)
|
RISGGNDkQGFPMKQ
|
K58-ub
|
S6 (rat)
|
RISGGNDKQGFPMkQ
|
K58
|
S6 (fruit fly)
|
RIAGGNDKQGFPMKQ
|
K58
|
S6 (cow)
|
RISGGNDKQGFPMKQ
|
K58
|
|
K64
|
DkQGFPMKQGVLTHG
|
|
|
0
|
4
|
|
|
S6 (human)
|
DkQGFPMkQGVLtHG
|
K64-ub
|
S6 (mouse)
|
DkQGFPMKQGVLTHG
|
K64
|
S6 (rat)
|
DKQGFPMKQGVLTHG
|
K64
|
S6 (fruit fly)
|
DKQGFPMKQGVLTHG
|
K64
|
S6 (cow)
|
DKQGFPMKQGVLTHG
|
K64
|
|
K64
|
DkQGFPMKQGVLTHG
|
|
|
0
|
1
|
|
|
S6 (human)
|
DkQGFPMKQGVLtHG
|
K64
|
S6 (mouse)
|
DkQGFPMKQGVLTHG
|
K64
|
S6 (rat)
|
DKQGFPMkQGVLTHG
|
K64-ac
|
S6 (fruit fly)
|
DKQGFPMKQGVLTHG
|
K64
|
S6 (cow)
|
DKQGFPMKQGVLTHG
|
K64
|
|
T69
|
PMKQGVLTHGRVRLL
|
|
|
0
|
2
|
|
|
S6 (human)
|
PMkQGVLtHGRVRLL
|
T69-p
|
S6 (mouse)
|
PMKQGVLTHGRVRLL
|
T69
|
S6 (rat)
|
PMkQGVLTHGRVRLL
|
T69
|
S6 (fruit fly)
|
PMKQGVLTHGRVRLL
|
T69
|
S6 (cow)
|
PMKQGVLTHGRVRLL
|
T69
|
|
S78
|
GRVRLLLSKGHSCYR
|
|
|
0
|
3
|
|
|
S6 (human)
|
GRVRLLLskGHsCYR
|
S78-p
|
S6 (mouse)
|
GRVRLLLSKGHSCYR
|
S78
|
S6 (rat)
|
GRVRLLLSKGHSCYR
|
S78
|
S6 (fruit fly)
|
GRVRLLLKKGHSCYR
|
K78
|
S6 (cow)
|
GRVRLLLSKGHSCYR
|
S78
|
|
K79
|
RVRLLLSKGHSCYRP
|
|
|
0
|
2
|
|
|
S6 (human)
|
RVRLLLskGHsCYRP
|
K79-ub
|
S6 (mouse)
|
RVRLLLSKGHSCYRP
|
K79
|
S6 (rat)
|
RVRLLLSKGHSCYRP
|
K79
|
S6 (fruit fly)
|
RVRLLLKKGHSCYRP
|
K79
|
S6 (cow)
|
RVRLLLSKGHSCYRP
|
K79
|
|
K79
|
RVRLLLSKGHSCYRP
|
|
|
0
|
1
|
|
|
S6 (human)
|
RVRLLLskGHsCYRP
|
K79-ac
|
S6 (mouse)
|
RVRLLLSKGHSCYRP
|
K79
|
S6 (rat)
|
RVRLLLSKGHSCYRP
|
K79
|
S6 (fruit fly)
|
RVRLLLKKGHSCYRP
|
K79
|
S6 (cow)
|
RVRLLLSKGHSCYRP
|
K79
|
|
S82
|
LLLSKGHSCYRPRRT
|
|
|
0
|
1
|
|
|
S6 (human)
|
LLLskGHsCYRPRRT
|
S82-p
|
S6 (mouse)
|
LLLSKGHSCYRPRRT
|
S82
|
S6 (rat)
|
LLLSKGHSCYRPRRT
|
S82
|
S6 (fruit fly)
|
LLLKKGHSCYRPRRT
|
S82
|
S6 (cow)
|
LLLSKGHSCYRPRRT
|
S82
|
|
K116-ub
|
LNLVIVKkGEkDIPG
|
|
|
0
|
2
|
|
|
S6 (human)
|
LNLVIVKkGEkDIPG
|
K116-ub
|
S6 (mouse)
|
LNLVIVKkGEkDIPG
|
K116-ub
|
S6 (rat)
|
LNLVIVKKGEKDIPG
|
K116
|
S6 (fruit fly)
|
LALVVLKKGEKDIPG
|
K116
|
S6 (cow)
|
LNLVIVKKGEKDIPG
|
K116
|
|
K119-ub
|
VIVKkGEkDIPGLTD
|
|
|
0
|
2
|
|
|
S6 (human)
|
VIVKkGEkDIPGLTD
|
K119-ub
|
S6 (mouse)
|
VIVKkGEkDIPGLTD
|
K119-ub
|
S6 (rat)
|
VIVKKGEKDIPGLTD
|
K119
|
S6 (fruit fly)
|
VVLKKGEKDIPGLTD
|
K119
|
S6 (cow)
|
VIVKKGEKDIPGLTD
|
K119
|
|
T128-p
|
IPGLTDTtVPRRLGP
|
|
|
0
|
2
|
|
|
S6 (human)
|
IPGLTDTtVPRRLGP
|
T128-p
|
S6 (mouse)
|
IPGLTDTtVPRRLGP
|
T128-p
|
S6 (rat)
|
IPGLTDTTVPRRLGP
|
T128
|
S6 (fruit fly)
|
IPGLTDTTIPRRLGP
|
T128
|
S6 (cow)
|
IPGLTDTTVPRRLGP
|
T128
|
|
K143-ub
|
KRASRIRkLFNLskE
|
|
|
0
|
5
|
|
|
S6 (human)
|
KRASRIRkLFNLskE
|
K143-ub
|
S6 (mouse)
|
KRASRIRkLFNLskE
|
K143-ub
|
S6 (rat)
|
KRASRIRKLFNLskE
|
K143
|
S6 (fruit fly)
|
KRASKIRKLYNLSKE
|
K143
|
S6 (cow)
|
KRASRIRKLFNLSKE
|
K143
|
|
K143
|
KRASRIRKLFNLskE
|
|
|
0
|
2
|
|
|
S6 (human)
|
KRASRIRkLFNLskE
|
K143-ac
|
S6 (mouse)
|
KRASRIRKLFNLskE
|
K143
|
S6 (rat)
|
KRASRIRKLFNLskE
|
K143
|
S6 (fruit fly)
|
KRASKIRKLYNLSKE
|
K143
|
S6 (cow)
|
KRASRIRKLFNLSKE
|
K143
|
|
S148-p
|
IRkLFNLskEDDVRQ
|
|
|
0
|
11
|
|
|
S6 (human)
|
IRkLFNLskEDDVrQ
|
S148-p
|
S6 (mouse)
|
IRkLFNLskEDDVRQ
|
S148-p
|
S6 (rat)
|
IRKLFNLskEDDVRQ
|
S148-p
|
S6 (fruit fly)
|
IRKLYNLSKEDDVRR
|
S148
|
S6 (cow)
|
IRKLFNLSKEDDVRQ
|
S148
|
|
K149-ub
|
RkLFNLskEDDVRQY
|
|
|
0
|
10
|
|
|
S6 (human)
|
RkLFNLskEDDVrQY
|
K149-ub
|
S6 (mouse)
|
RkLFNLskEDDVRQY
|
K149-ub
|
S6 (rat)
|
RKLFNLsKEDDVRQY
|
K149
|
S6 (fruit fly)
|
RKLYNLSKEDDVRRF
|
K149
|
S6 (cow)
|
RKLFNLSKEDDVRQY
|
K149
|
|
K149-sc
|
RkLFNLskEDDVRQY
|
|
|
0
|
1
|
|
|
S6 (human)
|
RkLFNLskEDDVrQY
|
K149-sc
|
S6 (mouse)
|
RkLFNLskEDDVRQY
|
K149-sc
|
S6 (rat)
|
RKLFNLsKEDDVRQY
|
K149
|
S6 (fruit fly)
|
RKLYNLSKEDDVRRF
|
K149
|
S6 (cow)
|
RKLFNLSKEDDVRQY
|
K149
|
|
K149
|
RkLFNLsKEDDVRQY
|
|
|
0
|
1
|
|
|
S6 (human)
|
RkLFNLsKEDDVrQY
|
K149
|
S6 (mouse)
|
RkLFNLsKEDDVRQY
|
K149
|
S6 (rat)
|
RKLFNLskEDDVRQY
|
K149-ac
|
S6 (fruit fly)
|
RKLYNLSKEDDVRRF
|
K149
|
S6 (cow)
|
RKLFNLSKEDDVRQY
|
K149
|
|
R154
|
LskEDDVRQYVVRKP
|
|
|
0
|
1
|
|
|
S6 (human)
|
LskEDDVrQYVVRkP
|
R154-m1
|
S6 (mouse)
|
LskEDDVRQYVVRKP
|
R154
|
S6 (rat)
|
LskEDDVRQYVVRKP
|
R154
|
S6 (fruit fly)
|
LSKEDDVRRFVVRRP
|
R154
|
S6 (cow)
|
LSKEDDVRQYVVRKP
|
R154
|
|
K160
|
VRQYVVRKPLNKEGK
|
|
|
0
|
1
|
|
|
S6 (human)
|
VrQYVVRkPLNKEGK
|
K160-ub
|
S6 (mouse)
|
VRQYVVRKPLNKEGK
|
K160
|
S6 (rat)
|
VRQYVVRKPLNKEGK
|
K160
|
S6 (fruit fly)
|
VRRFVVRRPLPAKDN
|
R160
|
S6 (cow)
|
VRQYVVRKPLNKDGK
|
K160
|
|
T181
|
PKIQRLVTPRVLQHK
|
|
|
0
|
2
|
|
|
S6 (human)
|
PKIQRLVtPRVLQHK
|
T181-p
|
S6 (mouse)
|
PKIQRLVTPRVLQHK
|
T181
|
S6 (rat)
|
PKIQRLVTPRVLQHK
|
T181
|
S6 (fruit fly)
|
PKIQRLITPVVLQRK
|
T182
|
S6 (cow)
|
PKIQRLVTPRVLQHK
|
T181
|
|
K203-ac
|
KQRTKKNkEEAAEyA
|
Upstream
|
|
0
|
3
|
|
|
|
S6 (human)
|
KQRTKKNKEEAAEyA
|
K203
|
S6 (mouse)
|
KQRTKKNkEEAAEyA
|
K203-ac
|
S6 (rat)
|
KQRTKKNkEEAAEYA
|
K203-ac
|
S6 (fruit fly)
|
KKRQIASKEASADYA
|
K204
|
S6 (cow)
|
KQRTKKNKEEAAEYA
|
K203
|
|
K203-ub
|
KQRTKKNkEEAAEyA
|
|
|
0
|
7
|
|
|
S6 (human)
|
KQRTKKNkEEAAEyA
|
K203-ub
|
S6 (mouse)
|
KQRTKKNkEEAAEyA
|
K203-ub
|
S6 (rat)
|
KQRTKKNKEEAAEYA
|
K203
|
S6 (fruit fly)
|
KKRQIASKEASADYA
|
K204
|
S6 (cow)
|
KQRTKKNKEEAAEYA
|
K203
|
|
K203-sc
|
KQRTKKNkEEAAEyA
|
|
|
0
|
1
|
|
|
S6 (human)
|
KQRTKKNKEEAAEyA
|
K203
|
S6 (mouse)
|
KQRTKKNkEEAAEyA
|
K203-sc
|
S6 (rat)
|
KQRTKKNKEEAAEYA
|
K203
|
S6 (fruit fly)
|
KKRQIASKEASADYA
|
K204
|
S6 (cow)
|
KQRTKKNKEEAAEYA
|
K203
|
|
Y209-p
|
NkEEAAEyAkLLAKR
|
Upstream
|
|
0
|
20
|
|
|
|
S6 (human)
|
NkEEAAEyAkLLAKR
|
Y209-p
|
S6 (mouse)
|
NkEEAAEyAkLLAKR
|
Y209-p
|
S6 (rat)
|
NkEEAAEYAkLLAKR
|
Y209
|
S6 (fruit fly)
|
SKEASADYAKLLVQR
|
Y210
|
S6 (cow)
|
NKEEAAEYAKLLAKR
|
Y209
|
|
K211-ac
|
EEAAEyAkLLAKRMK
|
Upstream
|
|
0
|
5
|
|
|
|
S6 (human)
|
EEAAEyAkLLAKRMk
|
K211-ac
|
S6 (mouse)
|
EEAAEyAkLLAKRMK
|
K211-ac
|
S6 (rat)
|
EEAAEYAkLLAKRMK
|
K211-ac
|
S6 (fruit fly)
|
EASADYAKLLVQRKK
|
K212
|
S6 (cow)
|
EEAAEYAKLLAKRMK
|
K211
|
|
K211-ub
|
EEAAEyAkLLAKRMK
|
|
|
0
|
10
|
|
|
S6 (human)
|
EEAAEyAkLLAKRMk
|
K211-ub
|
S6 (mouse)
|
EEAAEyAkLLAKRMK
|
K211-ub
|
S6 (rat)
|
EEAAEYAKLLAKRMK
|
K211
|
S6 (fruit fly)
|
EASADYAKLLVQRKK
|
K212
|
S6 (cow)
|
EEAAEYAKLLAKRMK
|
K211
|
|
K218
|
kLLAKRMKEAKEKRQ
|
|
|
0
|
1
|
|
|
S6 (human)
|
kLLAKRMkEAKEKRQ
|
K218-ac
|
S6 (mouse)
|
kLLAKRMKEAKEKRQ
|
K218
|
S6 (rat)
|
kLLAKRMKEAKEKRQ
|
K218
|
S6 (fruit fly)
|
KLLVQRKKESKAKRE
|
K219
|
S6 (cow)
|
KLLAKRMKEAKEKRQ
|
K218
|
|
S235-p
|
IAKRRRLssLRAsts
|
Upstream
|
Downstream
|
265
|
1028
|
|
|
|
Effects on Biological Processes:
- autophagy, inhibited
- carcinogenesis, induced
- carcinogenesis, inhibited
- cell growth, induced
- neural plasticity
- signaling pathway regulation
- transcription, inhibited
- translation, induced
|
|
|
S6 (human)
|
IAKRRRLssLRAsts
|
S235-p
|
S6 (mouse)
|
IAKRRRLssLRAsts
|
S235-p
|
S6 (rat)
|
IAKRRRLssLRAsts
|
S235-p
|
S6 (fruit fly)
|
EAKRRRSASIRESKS
|
A234
|
S6 (cow)
|
IAKRRRLssLRAsTS
|
S235-p
|
|
S236-p
|
AKRRRLssLRAstsK
|
Upstream
|
Downstream
|
258
|
1191
|
|
|
|
Effects on Biological Processes:
- autophagy, inhibited
- carcinogenesis, induced
- carcinogenesis, inhibited
- cell growth, induced
- neural plasticity
- signaling pathway regulation
- transcription, inhibited
- translation, induced
|
|
|
S6 (human)
|
AKRRRLssLRAstsK
|
S236-p
|
S6 (mouse)
|
AKRRRLssLRAstsK
|
S236-p
|
S6 (rat)
|
AKRRRLssLRAstsK
|
S236-p
|
S6 (fruit fly)
|
AKRRRSASIRESKSS
|
S235
|
S6 (cow)
|
AKRRRLssLRAsTSK
|
S236-p
|
|
S240-p
|
RLssLRAstsKsEss
|
Upstream
|
Downstream
|
123
|
912
|
|
|
|
Effects on Modified Protein
- intracellular localization
|
Effects on Biological Processes:
- carcinogenesis, induced
- carcinogenesis, inhibited
|
|
Regulatory protein:
- Akt1 (mouse)
- Akt2 (mouse)
- APP (human)
- FLT3 (mouse)
- FOXO1A (mouse)
- Fyn (mouse)
- GADD34 (human)
- leptin (mouse)
- LKB1 (mouse)
- Mnk1 (human)
- Mnk2 (human)
- mTOR (mouse)
- PAK4 (human)
- PDK1 (mouse)
- PSEN1 (human)
- Raptor (human)
- RHEB (mouse)
- ROCK1 (mouse)
- SGK1 (human)
- Sin1 (human)
- Sin1 (mouse)
- SynGAP (human)
- Tau (human)
- TSC1 (human)
- TSC1 (mouse)
- TSC2 (human)
- TSC2 (mouse)
- USP1 (human)
|
Treatment
- actinomycin_D
- amino_acid_starvation
- antibody
- argimesna
- AZD8055
- BI-D1870
- BX795
- cannabidiol
- CL316,243
- dactolisib
- dapagliflozin
- DON
- eFT508
- EGF
- ethanol
- exercise
- fasting
- glutamine
- H-CHO
- H2
- high-fat diet
- IBMX
- IGF-1
- IKK_inhibitor_VII
- IL-2
- IL-33
- injury
- INK-128
- insulin
- leucine
- lithium
- low_temperature
- LPS
- LY294002
- meal feeding
- MK-2206
- myriocin
- NKH_477
- NP68
- palbociclib
- palmitate
- PD184352
- phorbol_ester
- PIK90
- PP2
- PP242
- RAD001
- RAMH
- rapamycin
- refeeding
- retinoic_acid
- RMC-6272
- serum
- streptozotocin
- Torin1
- U0126
- Wnt10b
- Wnt3a
- wortmannin
|
|
S6 (human)
|
RLssLRAstsKsEss
|
S240-p
|
S6 (mouse)
|
RLssLRAstsKsEss
|
S240-p
|
S6 (rat)
|
RLssLRAstsKsESs
|
S240-p
|
S6 (fruit fly)
|
RSASIRESKSSVSSD
|
S239
|
S6 (cow)
|
RLssLRAsTSKSESS
|
S240-p
|
|
T241-p
|
LssLRAstsKsEssQ
|
Upstream
|
|
1
|
286
|
|
|
Regulatory protein:
- leptin (mouse)
- TSC1 (human)
|
Treatment
|
|
S6 (human)
|
LssLRAstsKsEssQ
|
T241-p
|
S6 (mouse)
|
LssLRAstsKsEssQ
|
T241-p
|
S6 (rat)
|
LssLRAstsKsESsQ
|
T241-p
|
S6 (fruit fly)
|
SASIRESKSSVSSDK
|
K240
|
S6 (cow)
|
LssLRAsTSKSESSQ
|
T241
|
|
S242-p
|
ssLRAstsKsEssQK
|
Upstream
|
|
1
|
293
|
|
|
Regulatory protein:
|
Treatment
|
|
S6 (human)
|
ssLRAstsKsEssQK
|
S242-p
|
S6 (mouse)
|
ssLRAstsKsEssQK
|
S242-p
|
S6 (rat)
|
ssLRAstsKsESsQK
|
S242-p
|
S6 (fruit fly)
|
ASIRESKSSVSSDKK
|
S241
|
S6 (cow)
|
ssLRAsTSKSESSQK
|
S242
|
|
S244-p
|
LRAstsKsEssQK__
|
Upstream
|
Downstream
|
120
|
595
|
|
|
|
Effects on Modified Protein
- activity, induced
- intracellular localization
|
Effects on Biological Processes:
- carcinogenesis, induced
- carcinogenesis, inhibited
- neural plasticity
- transcription, altered
- transcription, induced
|
|
Regulatory protein:
- Akt1 (mouse)
- Akt2 (mouse)
- APP (human)
- CDC42 (mouse)
- FOXO1A (mouse)
- Fyn (mouse)
- GADD34 (human)
- LKB1 (mouse)
- Mnk1 (human)
- Mnk2 (human)
- mTOR (mouse)
- PAK4 (human)
- PAK4 (mouse)
- PDK1 (mouse)
- PSEN1 (human)
- Raptor (human)
- RHEB (mouse)
- ROCK1 (mouse)
- SGK1 (human)
- Sin1 (human)
- Sin1 (mouse)
- SynGAP (human)
- Tau (human)
- TSC1 (human)
- TSC1 (mouse)
- TSC2 (human)
- TSC2 (mouse)
- USP1 (human)
|
Treatment
- 2-APB
- actinomycin_D
- amino_acid_starvation
- antibody
- argimesna
- AZD8055
- BI-D1870
- BX795
- cannabidiol
- CL316,243
- CNO
- contextual fear conditioning
- dactolisib
- dapagliflozin
- DON
- eFT508
- EGF
- ethanol
- exercise
- fasting
- glutamine
- H-CHO
- H2
- high-fat diet
- IBMX
- IGF-1
- IKK_inhibitor_VII
- IL-2
- injury
- insulin
- JMV2959
- leucine
- lithium
- low_temperature
- LPS
- LY294002
- meal feeding
- myriocin
- NKH_477
- NP68
- palbociclib
- palmitate
- PD184352
- phorbol_ester
- PIK90
- PP2
- PP242
- RAMH
- rapamycin
- refeeding
- retinoic_acid
- serum
- SKF81297
- sleep deprivation
- streptozotocin
- Torin1
- U0126
- Wnt10b
- Wnt3a
- wortmannin
|
|
S6 (human)
|
LRAstsKsEssQK__
|
S244-p
|
S6 (mouse)
|
LRAstsKsEssQK__
|
S244-p
|
S6 (rat)
|
LRAstsKsESsQK__
|
S244-p
|
S6 (fruit fly)
|
IRESKSSVSSDKK__
|
V243
|
S6 (cow)
|
LRAsTSKSESSQK__
|
S244
|
|
S246-p
|
AstsKsEssQK____
|
Upstream
|
|
2
|
133
|
|
|
Regulatory protein:
|
Treatment
- INK-128
- insulin
- LY294002
- MK-2206
- RAD001
- rapamycin
- RMC-6272
|
|
S6 (human)
|
AstsKsEssQK____
|
S246-p
|
S6 (mouse)
|
AstsKsEssQK____
|
S246-p
|
S6 (rat)
|
AstsKsESsQK____
|
S246
|
S6 (fruit fly)
|
ESKSSVSSDKK____
|
S245
|
S6 (cow)
|
AsTSKSESSQK____
|
S246
|
|
S247-p
|
stsKsEssQK_____
|
Upstream
|
Downstream
|
7
|
324
|
|
|
Effects on Biological Processes:
- carcinogenesis, induced
- transcription, altered
- transcription, induced
|
|
Regulatory protein:
- KRas (mouse)
- TSC1 (human)
|
Treatment
- CNO
- contextual fear conditioning
- insulin
- MK-2206
- rapamycin
- sleep deprivation
|
|
S6 (human)
|
stsKsEssQK_____
|
S247-p
|
S6 (mouse)
|
stsKsEssQK_____
|
S247-p
|
S6 (rat)
|
stsKsESsQK_____
|
S247-p
|
S6 (fruit fly)
|
SKSSVSSDKK_____
|
D246
|
S6 (cow)
|
sTSKSESSQK_____
|
S247
|
|