Other Species / Isoforms
  SHP-1 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S10-p
RWFHRDLsGPDAETL
0 17
SHP-1 (human) RWFHRDLsGLDAETL S10-p
SHP-1 iso2 (human) gap -
SHP-1 iso3 (human) GWFHRDLSGLDAETL S12
SHP-1 iso4 (human) RWFHRDLSGLDAETL S10
SHP-1 (mouse) RWFHRDLsGPDAETL S10-p
SHP-1 (rat) GWFHRDLsGPDAETL S12-p
K19
PDAETLLKGRGVPGS
0 8
SHP-1 (human) LDAETLLkGRGVHGs K19-ub
SHP-1 iso2 (human) gap -
SHP-1 iso3 (human) LDAETLLKGRGVHGS K21
SHP-1 iso4 (human) LDAETLLKGRGVHGS K19
SHP-1 (mouse) PDAETLLKGRGVPGS K19
SHP-1 (rat) PDAETLLKGRGVPGs K21
S26
KGRGVPGSFLARPSR
0 4
SHP-1 (human) kGRGVHGsFLARPSR S26-p
SHP-1 iso2 (human) gap -
SHP-1 iso3 (human) KGRGVHGSFLARPSR S28
SHP-1 iso4 (human) KGRGVHGSFLARPSR S26
SHP-1 (mouse) KGRGVPGSFLARPSR S26
SHP-1 (rat) KGRGVPGsFLARPSR S28-p
K34
FLARPSRKNQGDFSL
0 1
SHP-1 (human) FLARPSRkNQGDFSL K34-ub
SHP-1 iso2 (human) gap -
SHP-1 iso3 (human) FLARPSRKNQGDFSL K36
SHP-1 iso4 (human) FLARPSRKNQGDFSL K34
SHP-1 (mouse) FLARPSRKNQGDFSL K34
SHP-1 (rat) FLARPSRKNQGDFSL K36
S57-p
THIRIQNsGDFYDLy
0 5
SHP-1 (human) THIRIQNsGDFyDLy S57-p
SHP-1 iso2 (human) THIRIQNSGDFYDLY S18
SHP-1 iso3 (human) THIRIQNSGDFYDLY S59
SHP-1 iso4 (human) THIRIQNSGDFYDLY S57
SHP-1 (mouse) THIRIQNsGDFYDLy S57-p
SHP-1 (rat) THIRIQNSGDFYDLY S59
Y61
IQNsGDFYDLyGGEK
0 26
SHP-1 (human) IQNsGDFyDLyGGEK Y61-p
SHP-1 iso2 (human) IQNSGDFYDLYGGEK Y22
SHP-1 iso3 (human) IQNSGDFYDLYGGEK Y63
SHP-1 iso4 (human) IQNSGDFYDLYGGEK Y61
SHP-1 (mouse) IQNsGDFYDLyGGEK Y61
SHP-1 (rat) IQNSGDFYDLYGGEK Y63
Y64-p
sGDFYDLyGGEKFAT
0 35
SHP-1 (human) sGDFyDLyGGEKFAT Y64-p
SHP-1 iso2 (human) SGDFYDLYGGEKFAT Y25
SHP-1 iso3 (human) SGDFYDLYGGEKFAT Y66
SHP-1 iso4 (human) SGDFYDLYGGEKFAT Y64
SHP-1 (mouse) sGDFYDLyGGEKFAT Y64-p
SHP-1 (rat) SGDFYDLYGGEKFAT Y66
K97
DGTIIHLKyPLNCSD
0 1
SHP-1 (human) DGTIIHLkyPLNCSD K97-ub
SHP-1 iso2 (human) DGTIIHLKYPLNCSD K58
SHP-1 iso3 (human) DGTIIHLKYPLNCSD K99
SHP-1 iso4 (human) DGTIIHLKYPLNCSD K97
SHP-1 (mouse) DGTIIHLKyPLNCSD K97
SHP-1 (rat) DGTIIHLKYPLNCSD K99
Y98-p
GTIIHLKyPLNCSDP
0 3
SHP-1 (human) GTIIHLkyPLNCSDP Y98-p
SHP-1 iso2 (human) GTIIHLKYPLNCSDP Y59
SHP-1 iso3 (human) GTIIHLKYPLNCSDP Y100
SHP-1 iso4 (human) GTIIHLKYPLNCSDP Y98
SHP-1 (mouse) GTIIHLKyPLNCSDP Y98-p
SHP-1 (rat) GTIIHLKYPLNCSDP Y100
Y111
DPTSERWYHGHISGG
0 1
SHP-1 (human) DPTSERWyHGHMSGG Y111-p
SHP-1 iso2 (human) DPTSERWYHGHMSGG Y72
SHP-1 iso3 (human) DPTSERWYHGHMSGG Y113
SHP-1 iso4 (human) DPTSERWYHGHMSGG Y111
SHP-1 (mouse) DPTSERWYHGHISGG Y111
SHP-1 (rat) DPTSERWYHGHMSGG Y113
S140
FLVRESLSQPGDFVL
0 1
SHP-1 (human) FLVRESLsQPGDFVL S140-p
SHP-1 iso2 (human) FLVRESLSQPGDFVL S101
SHP-1 iso3 (human) FLVRESLSQPGDFVL S142
SHP-1 iso4 (human) FLVRESLSQPGDFVL S140
SHP-1 (mouse) FLVRESLSQPGDFVL S140
SHP-1 (rat) FLVRESLSQPGDFVL S142
K155
SVLNDQPKAGPGSPL
0 1
SHP-1 (human) SVLSDQPkAGPGSPL K155-ub
SHP-1 iso2 (human) SVLSDQPKAGPGSPL K116
SHP-1 iso3 (human) SVLSDQPKAGPGSPL K157
SHP-1 iso4 (human) SVLSDQPKAGPGSPL K155
SHP-1 (mouse) SVLNDQPKAGPGSPL K155
SHP-1 (rat) SVLNDQPKAAPGSPL K157
K168
PLRVTHIKVMCEGGR
0 1
SHP-1 (human) PLRVTHIkVMCEGGR K168-ub
SHP-1 iso2 (human) PLRVTHIKVMCEGGR K129
SHP-1 iso3 (human) PLRVTHIKVMCEGGR K170
SHP-1 iso4 (human) PLRVTHIKVMCEGGR K168
SHP-1 (mouse) PLRVTHIKVMCEGGR K168
SHP-1 (rat) PLRVTHIKVMCEGGR K170
Y176
VMCEGGRYTVGGSET
0 1
SHP-1 (human) VMCEGGRytVGGLET Y176-p
SHP-1 iso2 (human) VMCEGGRYTVGGLET Y137
SHP-1 iso3 (human) VMCEGGRYTVGGLET Y178
SHP-1 iso4 (human) VMCEGGRYTVGGLET Y176
SHP-1 (mouse) VMCEGGRYTVGGSET Y176
SHP-1 (rat) VMCEGGRYTVGGSET Y178
T177
MCEGGRYTVGGSETF
0 1
SHP-1 (human) MCEGGRytVGGLETF T177-p
SHP-1 iso2 (human) MCEGGRYTVGGLETF T138
SHP-1 iso3 (human) MCEGGRYTVGGLETF T179
SHP-1 iso4 (human) MCEGGRYTVGGLETF T177
SHP-1 (mouse) MCEGGRYTVGGSETF T177
SHP-1 (rat) MCEGGRYTVGGSETF T179
S186
GGSETFDSLtDLVEH
0 5
SHP-1 (human) GGLETFDsLtDLVEH S186-p
SHP-1 iso2 (human) GGLETFDSLTDLVEH S147
SHP-1 iso3 (human) GGLETFDSLTDLVEH S188
SHP-1 iso4 (human) GGLETFDSLTDLVEH S186
SHP-1 (mouse) GGSETFDSLtDLVEH S186
SHP-1 (rat) GGSETFDSLTDLVEH S188
T188-p
SETFDSLtDLVEHFK
0 3
SHP-1 (human) LETFDsLtDLVEHFk T188-p
SHP-1 iso2 (human) LETFDSLTDLVEHFK T149
SHP-1 iso3 (human) LETFDSLTDLVEHFK T190
SHP-1 iso4 (human) LETFDSLTDLVEHFK T188
SHP-1 (mouse) SETFDSLtDLVEHFK T188-p
SHP-1 (rat) SETFDSLTDLVEHFK T190
K195
tDLVEHFKKTGIEEA
0 1
SHP-1 (human) tDLVEHFkkTGIEEA K195-ub
SHP-1 iso2 (human) TDLVEHFKKTGIEEA K156
SHP-1 iso3 (human) TDLVEHFKKTGIEEA K197
SHP-1 iso4 (human) TDLVEHFKKTGIEEA K195
SHP-1 (mouse) tDLVEHFKKTGIEEA K195
SHP-1 (rat) TDLVEHFKKTGIEEA K197
K196
DLVEHFKKTGIEEAS
0 1
SHP-1 (human) DLVEHFkkTGIEEAS K196-ub
SHP-1 iso2 (human) DLVEHFKKTGIEEAS K157
SHP-1 iso3 (human) DLVEHFKKTGIEEAS K198
SHP-1 iso4 (human) DLVEHFKKTGIEEAS K196
SHP-1 (mouse) DLVEHFKKTGIEEAS K196
SHP-1 (rat) DLVEHFKKTGIEEAS K198
Y208-p
EASGAFVyLRQPyyA
Downstream
1 0
Effects on Modified Protein
  • protein processing
SHP-1 (human) EASGAFVYLRQPyyA Y208
SHP-1 iso2 (human) EASGAFVYLRQPYYA Y169
SHP-1 iso3 (human) EASGAFVYLRQPYYA Y210
SHP-1 iso4 (human) EASGAFVYLRQPYYA Y208
SHP-1 (mouse) EASGAFVyLRQPyyA Y208-p
SHP-1 (rat) EASGAFVYLRQPYYA Y210
Y213-p
FVyLRQPyyATRVNA
0 3
SHP-1 (human) FVYLRQPyyATRVNA Y213-p
SHP-1 iso2 (human) FVYLRQPYYATRVNA Y174
SHP-1 iso3 (human) FVYLRQPYYATRVNA Y215
SHP-1 iso4 (human) FVYLRQPYYATRVNA Y213
SHP-1 (mouse) FVyLRQPyyATRVNA Y213-p
SHP-1 (rat) FVYLRQPYYATRVNA Y215
Y214-p
VyLRQPyyATRVNAA
0 6
SHP-1 (human) VYLRQPyyATRVNAA Y214-p
SHP-1 iso2 (human) VYLRQPYYATRVNAA Y175
SHP-1 iso3 (human) VYLRQPYYATRVNAA Y216
SHP-1 iso4 (human) VYLRQPYYATRVNAA Y214
SHP-1 (mouse) VyLRQPyyATRVNAA Y214-p
SHP-1 (rat) VYLRQPYYATRVNAA Y216
K232
NRVLELNKKQESEDT
0 1
SHP-1 (human) NRVLELNkKQESEDT K232-ub
SHP-1 iso2 (human) NRVLELNKKQESEDT K193
SHP-1 iso3 (human) NRVLELNKKQESEDT K234
SHP-1 iso4 (human) NRVLELNKKQESEDT K232
SHP-1 (mouse) NRVLELNKKQESEDT K232
SHP-1 (rat) NRVLELNKKQESEDT K234
K241
QESEDTAKAGFWEEF
0 1
SHP-1 (human) QESEDTAkAGFWEEF K241-ub
SHP-1 iso2 (human) QESEDTAKAGFWEEF K202
SHP-1 iso3 (human) QESEDTAKAGFWEEF K243
SHP-1 iso4 (human) QESEDTAKAGFWEEF K241
SHP-1 (mouse) QESEDTAKAGFWEEF K241
SHP-1 (rat) QESEDTAKAGFWEEF K243
S250-p
GFWEEFEsLQKQEVK
0 5
SHP-1 (human) GFWEEFEsLQkQEVk S250-p
SHP-1 iso2 (human) GFWEEFESLQKQEVK S211
SHP-1 iso3 (human) GFWEEFESLQKQEVK S252
SHP-1 iso4 (human) GFWEEFESLQKQEVK S250
SHP-1 (mouse) GFWEEFEsLQKQEVK S250-p
SHP-1 (rat) GFWEEFESLQKQEAK S252
K253
EEFEsLQKQEVKNLH
0 2
SHP-1 (human) EEFEsLQkQEVkNLH K253-ub
SHP-1 iso2 (human) EEFESLQKQEVKNLH K214
SHP-1 iso3 (human) EEFESLQKQEVKNLH K255
SHP-1 iso4 (human) EEFESLQKQEVKNLH K253
SHP-1 (mouse) EEFEsLQKQEVKNLH K253
SHP-1 (rat) EEFESLQKQEAKNLH K255
K257
sLQKQEVKNLHQRLE
0 1
SHP-1 (human) sLQkQEVkNLHQRLE K257-ub
SHP-1 iso2 (human) SLQKQEVKNLHQRLE K218
SHP-1 iso3 (human) SLQKQEVKNLHQRLE K259
SHP-1 iso4 (human) SLQKQEVKNLHQRLE K257
SHP-1 (mouse) sLQKQEVKNLHQRLE K257
SHP-1 (rat) SLQKQEAKNLHQRLE K259
K271
EGQRPENKSKNRyKN
0 1
SHP-1 (human) EGQRPENkGKNRykN K271-ub
SHP-1 iso2 (human) EGQRPENKGKNRYKN K232
SHP-1 iso3 (human) EGQRPENKGKNRYKN K273
SHP-1 iso4 (human) EGQRPENKGKNRYKN K271
SHP-1 (mouse) EGQRPENKSKNRyKN K271
SHP-1 (rat) EGQRPENKSKNRYKN K273
Y276-p
ENKSKNRyKNILPFD
1 42
SHP-1 (human) ENkGKNRykNILPFD Y276-p
SHP-1 iso2 (human) ENKGKNRYKNILPFD Y237
SHP-1 iso3 (human) ENKGKNRYKNILPFD Y278
SHP-1 iso4 (human) ENKGKNRYKNILPFD Y276
SHP-1 (mouse) ENKSKNRyKNILPFD Y276-p
SHP-1 (rat) ENKSKNRYKNILPFD Y278
K277
NKSKNRyKNILPFDH
0 1
SHP-1 (human) NkGKNRykNILPFDH K277-ac
SHP-1 iso2 (human) NKGKNRYKNILPFDH K238
SHP-1 iso3 (human) NKGKNRYKNILPFDH K279
SHP-1 iso4 (human) NKGKNRYKNILPFDH K277
SHP-1 (mouse) NKSKNRyKNILPFDH K277
SHP-1 (rat) NKSKNRYKNILPFDH K279
K277
NKSKNRyKNILPFDH
0 3
SHP-1 (human) NkGKNRykNILPFDH K277-ub
SHP-1 iso2 (human) NKGKNRYKNILPFDH K238
SHP-1 iso3 (human) NKGKNRYKNILPFDH K279
SHP-1 iso4 (human) NKGKNRYKNILPFDH K277
SHP-1 (mouse) NKSKNRyKNILPFDH K277
SHP-1 (rat) NKSKNRYKNILPFDH K279
S285
NILPFDHSRVILQGR
0 1
SHP-1 (human) NILPFDHsrVILQGR S285-p
SHP-1 iso2 (human) NILPFDHSRVILQGR S246
SHP-1 iso3 (human) NILPFDHSRVILQGR S287
SHP-1 iso4 (human) NILPFDHSRVILQGR S285
SHP-1 (mouse) NILPFDHSRVILQGR S285
SHP-1 (rat) NILPFDHSRVILQGR S287
R286
ILPFDHSRVILQGRD
0 1
SHP-1 (human) ILPFDHsrVILQGRD R286-m1
SHP-1 iso2 (human) ILPFDHSRVILQGRD R247
SHP-1 iso3 (human) ILPFDHSRVILQGRD R288
SHP-1 iso4 (human) ILPFDHSRVILQGRD R286
SHP-1 (mouse) ILPFDHSRVILQGRD R286
SHP-1 (rat) ILPFDHSRVILQGRD R288
S299
RDSNIPGSDYINANY
0 2
SHP-1 (human) RDSNIPGsDyINANy S299-p
SHP-1 iso2 (human) RDSNIPGSDYINANY S260
SHP-1 iso3 (human) RDSNIPGSDYINANY S301
SHP-1 iso4 (human) RDSNIPGSDYINANY S299
SHP-1 (mouse) RDSNIPGSDYINANY S299
SHP-1 (rat) RDSNIPGSDYINANY S301
Y301
SNIPGSDYINANYVK
1 69
SHP-1 (human) SNIPGsDyINANyIk Y301-p
SHP-1 iso2 (human) SNIPGSDYINANYIK Y262
SHP-1 iso3 (human) SNIPGSDYINANYIK Y303
SHP-1 iso4 (human) SNIPGSDYINANYIK Y301
SHP-1 (mouse) SNIPGSDYINANYVK Y301
SHP-1 (rat) SNIPGSDYINANYVK Y303
Y306
SDYINANYVKNQLLG
0 9
SHP-1 (human) sDyINANyIkNQLLG Y306-p
SHP-1 iso2 (human) SDYINANYIKNQLLG Y267
SHP-1 iso3 (human) SDYINANYIKNQLLG Y308
SHP-1 iso4 (human) SDYINANYIKNQLLG Y306
SHP-1 (mouse) SDYINANYVKNQLLG Y306
SHP-1 (rat) SDYINANYVKNQLLG Y308
K308
YINANYVKNQLLGPD
0 2
SHP-1 (human) yINANyIkNQLLGPD K308-ub
SHP-1 iso2 (human) YINANYIKNQLLGPD K269
SHP-1 iso3 (human) YINANYIKNQLLGPD K310
SHP-1 iso4 (human) YINANYIKNQLLGPD K308
SHP-1 (mouse) YINANYVKNQLLGPD K308
SHP-1 (rat) YINANYVKNQLLGPD K310
K360
EVEKGRNKCVPYWPE
0 2
SHP-1 (human) EVEKGRNkCVPyWPE K360-ub
SHP-1 iso2 (human) EVEKGRNKCVPYWPE K321
SHP-1 iso3 (human) EVEKGRNKCVPYWPE K362
SHP-1 iso4 (human) EVEKGRNKCVPYWPE K360
SHP-1 (mouse) EVEKGRNKCVPYWPE K360
SHP-1 (rat) EVEKGRNKCVPYWPE K362
Y364
GRNKCVPYWPEVGTQ
0 1
SHP-1 (human) GRNkCVPyWPEVGMQ Y364-p
SHP-1 iso2 (human) GRNKCVPYWPEVGMQ Y325
SHP-1 iso3 (human) GRNKCVPYWPEVGMQ Y366
SHP-1 iso4 (human) GRNKCVPYWPEVGMQ Y364
SHP-1 (mouse) GRNKCVPYWPEVGTQ Y364
SHP-1 (rat) GRNKCVPYWPEVGTQ Y366
Y374
EVGTQRVYGLySVTN
0 1
SHP-1 (human) EVGMQRAyGPysVTN Y374-p
SHP-1 iso2 (human) EVGMQRAYGPYSVTN Y335
SHP-1 iso3 (human) EVGMQRAYGPYSVTN Y376
SHP-1 iso4 (human) EVGMQRAYGPYSVTN Y374
SHP-1 (mouse) EVGTQRVYGLySVTN Y374
SHP-1 (rat) EVGTQRVYGLYSVTN Y376
Y377-p
TQRVYGLySVTNSRE
Upstream
0 6
Regulatory protein:
  • FCER1A (mouse)
SHP-1 (human) MQRAyGPysVTNCGE Y377-p
SHP-1 iso2 (human) MQRAYGPYSVTNCGE Y338
SHP-1 iso3 (human) MQRAYGPYSVTNCGE Y379
SHP-1 iso4 (human) MQRAYGPYSVTNCGE Y377
SHP-1 (mouse) TQRVYGLySVTNSRE Y377-p
SHP-1 (rat) TQRVYGLYSVTNCKE Y379
S378
QRVYGLySVTNSREH
0 1
SHP-1 (human) QRAyGPysVTNCGEH S378-p
SHP-1 iso2 (human) QRAYGPYSVTNCGEH S339
SHP-1 iso3 (human) QRAYGPYSVTNCGEH S380
SHP-1 iso4 (human) QRAYGPYSVTNCGEH S378
SHP-1 (mouse) QRVYGLySVTNSREH S378
SHP-1 (rat) QRVYGLYSVTNCKEH S380
K391-ub
EHDTAEYkLRtLQIS
0 5
SHP-1 (human) EHDTTEYkLRtLQVs K391-ub
SHP-1 iso2 (human) EHDTTEYKLRTLQVS K352
SHP-1 iso3 (human) EHDTTEYKLRTLQVS K393
SHP-1 iso4 (human) EHDTTEYKLRTLQVS K391
SHP-1 (mouse) EHDTAEYkLRtLQIS K391-ub
SHP-1 (rat) EHDTAEYKLRTLQIS K393
T394-p
TAEYkLRtLQISPLD
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (mouse)
Treatment
  • SF1670
SHP-1 (human) TTEYkLRtLQVsPLD T394-p
SHP-1 iso2 (human) TTEYKLRTLQVSPLD T355
SHP-1 iso3 (human) TTEYKLRTLQVSPLD T396
SHP-1 iso4 (human) TTEYKLRTLQVSPLD T394
SHP-1 (mouse) TAEYkLRtLQISPLD T394-p
SHP-1 (rat) TAEYKLRTLQISPLD T396
S398
kLRtLQISPLDNGDL
0 3
SHP-1 (human) kLRtLQVsPLDNGDL S398-p
SHP-1 iso2 (human) KLRTLQVSPLDNGDL S359
SHP-1 iso3 (human) KLRTLQVSPLDNGDL S400
SHP-1 iso4 (human) KLRTLQVSPLDNGDL S398
SHP-1 (mouse) kLRtLQISPLDNGDL S398
SHP-1 (rat) KLRTLQISPLDNGDL S400
K486
DCDIDIQKTIQMVRA
0 1
SHP-1 (human) DCDIDIQkTIQMVRA K486-ub
SHP-1 iso2 (human) DCDIDIQKTIQMVRA K447
SHP-1 iso3 (human) DCDIDIQKTIQMVRA K488
SHP-1 iso4 (human) DCDIDIQKTIQMVRA K486
SHP-1 (mouse) DCDIDIQKTIQMVRA K486
SHP-1 (rat) DCDIDIQKTIQMVRA K488
S496
QMVRAQRSGMVQTEA
0 1
SHP-1 (human) QMVRAQRsGMVQTEA S496-p
SHP-1 iso2 (human) QMVRAQRSGMVQTEA S457
SHP-1 iso3 (human) QMVRAQRSGMVQTEA S498
SHP-1 iso4 (human) QMVRAQRSGMVQTEA S496
SHP-1 (mouse) QMVRAQRSGMVQTEA S496
SHP-1 (rat) QMVRAQRSGMVQTEA S498
Y509
EAQYKFIYVAIAQFI
0 2
SHP-1 (human) EAQYKFIyVAIAQFI Y509-p
SHP-1 iso2 (human) EAQYKFIYVAIAQFI Y470
SHP-1 iso3 (human) EAQYKFIYVAIAQFI Y511
SHP-1 iso4 (human) EAQYKFIYVAIAQFI Y509
SHP-1 (mouse) EAQYKFIYVAIAQFI Y509
SHP-1 (rat) EAQYKFIYVAIAQFI Y511
K521
QFIETTKKKLEIIQs
0 1
SHP-1 (human) QFIETTKkkLEVLQs K521-ub
SHP-1 iso2 (human) QFIETTKKKLEVLQS K482
SHP-1 iso3 (human) QFIETTKKKLEVLQS K523
SHP-1 iso4 (human) QFIETTKKKLEVLQS K521
SHP-1 (mouse) QFIETTKKKLEIIQs K521
SHP-1 (rat) QFIETTKKKLEIIQS K523
K522
FIETTKKKLEIIQsQ
0 2
SHP-1 (human) FIETTKkkLEVLQsQ K522-ub
SHP-1 iso2 (human) FIETTKKKLEVLQSQ K483
SHP-1 iso3 (human) FIETTKKKLEVLQSQ K524
SHP-1 iso4 (human) FIETTKKKLEVLQSQ K522
SHP-1 (mouse) FIETTKKKLEIIQsQ K522
SHP-1 (rat) FIETTKKKLEIIQSQ K524
S528-p
KKLEIIQsQKGQEsE
0 5
SHP-1 (human) kkLEVLQsQkGQEsE S528-p
SHP-1 iso2 (human) KKLEVLQSQKGQESE S489
SHP-1 iso3 (human) KKLEVLQSQKGQESE S530
SHP-1 iso4 (human) KKLEVLQSQKGQESE S528
SHP-1 (mouse) KKLEIIQsQKGQEsE S528-p
SHP-1 (rat) KKLEIIQSQRGQESE S530
K530
LEIIQsQKGQEsEyG
0 1
SHP-1 (human) LEVLQsQkGQEsEyG K530-ub
SHP-1 iso2 (human) LEVLQSQKGQESEYG K491
SHP-1 iso3 (human) LEVLQSQKGQESEYG K532
SHP-1 iso4 (human) LEVLQSQKGQESEYG K530
SHP-1 (mouse) LEIIQsQKGQEsEyG K530
SHP-1 (rat) LEIIQSQRGQESEyG R532
S534-p
QsQKGQEsEyGNIty
0 91
SHP-1 (human) QsQkGQEsEyGNIty S534-p
SHP-1 iso2 (human) QSQKGQESEYGNITY S495
SHP-1 iso3 (human) QSQKGQESEYGNITY S536
SHP-1 iso4 (human) QSQKGQESEYGNITY S534
SHP-1 (mouse) QsQKGQEsEyGNIty S534-p
SHP-1 (rat) QSQRGQESEyGNITy S536
Y536-p
QKGQEsEyGNItyPP
Upstream
Downstream
20 649
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • LYN (human)
Putative in vivo kinases:
  • LYN (mouse)
Treatment
  • antibody
  • insulin
  • PP2
  • thrombin
SHP-1 (human) QkGQEsEyGNItyPP Y536-p
SHP-1 iso2 (human) QKGQESEYGNITYPP Y497
SHP-1 iso3 (human) QKGQESEYGNITYPP Y538
SHP-1 iso4 (human) QKGQESEYGNITYPP Y536
SHP-1 (mouse) QKGQEsEyGNItyPP Y536-p
SHP-1 (rat) QRGQESEyGNITyPP Y538-p
T540-p
EsEyGNItyPPAVRS
0 25
SHP-1 (human) EsEyGNItyPPAMkN T540-p
SHP-1 iso2 (human) ESEYGNITYPPAMKN T501
SHP-1 iso3 (human) ESEYGNITYPPAMKN T542
SHP-1 iso4 (human) ESEYGNITYPPAMKN T540
SHP-1 (mouse) EsEyGNItyPPAVRS T540-p
SHP-1 (rat) ESEyGNITyPPALRS T542
Y541-p
sEyGNItyPPAVRSA
1 210
SHP-1 (human) sEyGNItyPPAMkNA Y541-p
SHP-1 iso2 (human) SEYGNITYPPAMKNA Y502
SHP-1 iso3 (human) SEYGNITYPPAMKNA Y543
SHP-1 iso4 (human) SEYGNITYPPAMKNA Y541
SHP-1 (mouse) sEyGNItyPPAVRSA Y541-p
SHP-1 (rat) SEyGNITyPPALRSA Y543-p
R546
ItyPPAVRSAHAKAS
0 1
SHP-1 (human) ItyPPAMkNAHAKAs K546-ub
SHP-1 iso2 (human) ITYPPAMKNAHAKAS K507
SHP-1 iso3 (human) ITYPPAMKNAHAKAS K548
SHP-1 iso4 (human) ITYPPAMKNAHAKAS K546
SHP-1 (mouse) ItyPPAVRSAHAKAS R546
SHP-1 (rat) ITyPPALRSAHAKAS R548
S553
RSAHAKASRTssKHK
1 2
SHP-1 (human) kNAHAKAsRtssKHk S553-p
SHP-1 iso2 (human) KNAHAKASRTSSKHK S514
SHP-1 iso3 (human) KNAHAKASRTSSKHK S555
SHP-1 iso4 (human) KNAHAKASRTSSKSL S553
SHP-1 (mouse) RSAHAKASRTssKHK S553
SHP-1 (rat) RSAHAKASRTSSKHK S555
T555
AHAKASRTssKHKEE
0 4
SHP-1 (human) AHAKAsRtssKHkED T555-p
SHP-1 iso2 (human) AHAKASRTSSKHKED T516
SHP-1 iso3 (human) AHAKASRTSSKHKED T557
SHP-1 iso4 (human) AHAKASRTSSKSLES T555
SHP-1 (mouse) AHAKASRTssKHKEE T555
SHP-1 (rat) AHAKASRTSSKHKEE T557
S556-p
HAKASRTssKHKEEV
1 7
SHP-1 (human) HAKAsRtssKHkEDV S556-p
SHP-1 iso2 (human) HAKASRTSSKHKEDV S517
SHP-1 iso3 (human) HAKASRTSSKHKEDV S558
SHP-1 iso4 (human) HAKASRTSSKSLESs S556
SHP-1 (mouse) HAKASRTssKHKEEV S556-p
SHP-1 (rat) HAKASRTSSKHKEEV S558
S557-p
AKASRTssKHKEEVy
1 69
SHP-1 (human) AKAsRtssKHkEDVy S557-p
SHP-1 iso2 (human) AKASRTSSKHKEDVY S518
SHP-1 iso3 (human) AKASRTSSKHKEDVY S559
SHP-1 iso4 (human) AKASRTSSKSLESsA S557
SHP-1 (mouse) AKASRTssKHKEEVy S557-p
SHP-1 (rat) AKASRTSSKHKEEVY S559
-
gap
0 1
SHP-1 (human) gap -
SHP-1 iso2 (human) gap -
SHP-1 iso3 (human) gap -
SHP-1 iso4 (human) SSKSLESsAGTVAAS S563-p
SHP-1 (mouse) gap -
SHP-1 (rat) gap -
K560
SRTssKHKEEVyENV
0 1
SHP-1 (human) sRtssKHkEDVyENL K560-ub
SHP-1 iso2 (human) SRTSSKHKEDVYENL K521
SHP-1 iso3 (human) SRTSSKHKEDVYENL K562
SHP-1 iso4 (human) gap -
SHP-1 (mouse) SRTssKHKEEVyENV K560
SHP-1 (rat) SRTSSKHKEEVYENV K562
Y564-p
sKHKEEVyENVHsKS
Upstream
Downstream
18 783
SHP-1 (human)
Y564-p
SHP-1 (mouse)
Y564-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell growth, altered
Putative in vivo kinases:
  • LYN (mouse)
Regulatory protein:
  • HLAA (human)
  • THEMIS (human)
Treatment
  • antibody
  • latrunculin_A
  • PP1
SHP-1 (human) sKHkEDVyENLHTkN Y564-p
SHP-1 iso2 (human) SKHKEDVYENLHTKN Y525
SHP-1 iso3 (human) SKHKEDVYENLHTKN Y566
SHP-1 iso4 (human) gap -
SHP-1 (mouse) sKHKEEVyENVHsKS Y564-p
SHP-1 (rat) SKHKEEVYENVHSKN Y566
S569-p
EVyENVHsKSKKEEK
0 1
SHP-1 (human) DVyENLHTkNKREEK T569
SHP-1 iso2 (human) DVYENLHTKNKREEK T530
SHP-1 iso3 (human) DVYENLHTKNKREEK T571
SHP-1 iso4 (human) gap -
SHP-1 (mouse) EVyENVHsKSKKEEK S569-p
SHP-1 (rat) EVYENVHSKNKKEEK S571
K570
VyENVHsKSKKEEKV
0 1
SHP-1 (human) VyENLHTkNKREEKV K570-ub
SHP-1 iso2 (human) VYENLHTKNKREEKV K531
SHP-1 iso3 (human) VYENLHTKNKREEKV K572
SHP-1 iso4 (human) gap -
SHP-1 (mouse) VyENVHsKSKKEEKV K570
SHP-1 (rat) VYENVHSKNKKEEKV K572
S582
EKVKKQRSADKEKNK
0 3
SHP-1 (human) EKVKKQRsADKEKsK S582-p
SHP-1 iso2 (human) EKVKKQRSADKEKSK S543
SHP-1 iso3 (human) EKVKKQRSADKEKSK S584
SHP-1 iso4 (human) gap -
SHP-1 (mouse) EKVKKQRSADKEKNK S582
SHP-1 (rat) EKVKKQRSADKEKNK S584
N588
RSADKEKNKGsLKRK
0 2
SHP-1 (human) RsADKEKsKGsLKRK S588-p
SHP-1 iso2 (human) RSADKEKSKGSLKRK S549
SHP-1 iso3 (human) RSADKEKSKGSLKRK S590
SHP-1 iso4 (human) gap -
SHP-1 (mouse) RSADKEKNKGsLKRK N588
SHP-1 (rat) RSADKEKNKGSLKRN N590
S591-p
DKEKNKGsLKRK___
Upstream
Downstream
9 17
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • protein processing
Kinase, in vitro:
  • CDK2 (human)
Putative in vivo kinases:
  • CDK2 (human)
  • PKCT (human)
Regulatory protein:
  • Fyn (mouse)
  • PKCA (mouse)
Treatment
  • antibody
  • bisindolylmaleimide
  • GF109203X
  • LY294002
  • PD98059
SHP-1 (human) DKEKsKGsLKRK___ S591-p
SHP-1 iso2 (human) DKEKSKGSLKRK___ S552
SHP-1 iso3 (human) DKEKSKGSLKRK___ S593
SHP-1 iso4 (human) gap -
SHP-1 (mouse) DKEKNKGsLKRK___ S591-p
SHP-1 (rat) DKEKNKGSLKRNISL S593