Other Species / Isoforms
  CREB (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
1 0
CREB (human) gap -
CREB iso1 (human) QTVQSSCKDLKRLFs K91
CREB (mouse) gap -
CREB iso1 (mouse) QTVQSSCKDLKRLFs K91
CREB (rat) gap -
CREB iso1 (rat) QTVQSSCkDLkRLFS K91-ac
-
gap
1 0
CREB (human) gap -
CREB iso1 (human) QSSCKDLKRLFsGtQ K94
CREB (mouse) gap -
CREB iso1 (mouse) QSSCKDLKRLFsGtQ K94
CREB (rat) gap -
CREB iso1 (rat) QSSCkDLkRLFSGTQ K94-ac
-
gap
2 0
CREB (human) gap -
CREB iso1 (human) KDLKRLFsGtQISTI S98-p
CREB (mouse) gap -
CREB iso1 (mouse) KDLKRLFsGtQISTI S98-p
CREB (rat) gap -
CREB iso1 (rat) kDLkRLFSGTQISTI S98
-
gap
3 0
CREB (human) gap -
CREB iso1 (human) LKRLFsGtQISTIAE T100-p
CREB (mouse) gap -
CREB iso1 (mouse) LKRLFsGtQISTIAE T100-p
CREB (rat) gap -
CREB iso1 (rat) LkRLFSGTQISTIAE T100
S94-p
QISTIAEsEDsQEsV
Upstream
8 3
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • calicheamicin
  • D4476
  • NKH_477
  • TBB
CREB (human) QISTIAEsEDsQEsV S94-p
CREB iso1 (human) QISTIAESEDSQESV S108
CREB (mouse) QISTIAEsEDsQEsV S94-p
CREB iso1 (mouse) QISTIAESEDSQESV S108
CREB (rat) QISTIAESEDSQESV S94
CREB iso1 (rat) QISTIAEsEDsQEsV S108-p
S97-p
TIAEsEDsQEsVDsV
Upstream
9 6
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • calicheamicin
  • D4476
  • NKH_477
  • TBB
CREB (human) TIAEsEDsQEsVDsV S97-p
CREB iso1 (human) TIAESEDSQESVDSV S111
CREB (mouse) TIAEsEDsQEsVDsV S97-p
CREB iso1 (mouse) TIAESEDSQESVDSV S111
CREB (rat) TIAESEDSQESVDSV S97
CREB iso1 (rat) TIAEsEDsQEsVDsV S111-p
S100-p
EsEDsQEsVDsVTDs
Upstream
8 2
Kinase, in vitro:
  • Nik (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • calicheamicin
  • D4476
  • NKH_477
  • TBB
CREB (human) EsEDsQEsVDsVtDs S100-p
CREB iso1 (human) ESEDSQESVDSVTDS S114
CREB (mouse) EsEDsQEsVDsVTDs S100-p
CREB iso1 (mouse) ESEDSQESVDSVTDS S114
CREB (rat) ESEDSQESVDSVTDS S100
CREB iso1 (rat) EsEDsQEsVDsVtDs S114-p
S103-p
DsQEsVDsVTDsQKR
Upstream
5 0
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • calicheamicin
  • D4476
  • NKH_477
  • TBB
CREB (human) DsQEsVDsVtDsQKR S103-p
CREB iso1 (human) DSQESVDSVTDSQKR S117
CREB (mouse) DsQEsVDsVTDsQKR S103-p
CREB iso1 (mouse) DSQESVDSVTDSQKR S117
CREB (rat) DSQESVDSVTDSQKR S103
CREB iso1 (rat) DsQEsVDsVtDsQKR S117-p
T105
QEsVDsVTDsQKRRE
1 1
CREB (human) QEsVDsVtDsQKRRE T105-p
CREB iso1 (human) QESVDSVTDSQKRRE T119
CREB (mouse) QEsVDsVTDsQKRRE T105
CREB iso1 (mouse) QESVDSVTDSQKRRE T119
CREB (rat) QESVDSVTDSQKRRE T105
CREB iso1 (rat) QEsVDsVtDsQKRRE T119-p
S107-p
sVDsVTDsQKRREIL
Upstream
Downstream
12 0
Effects on Modified Protein
  • intracellular localization
Putative in vivo kinases:
  • ATM (mouse)
  • ATR (mouse)
Regulatory protein:
  • ATM (mouse)
Treatment
  • calicheamicin
  • differentiation
  • hydroxyurea
  • ionizing_radiation
  • KU-55933
  • siRNA
  • UV
  • wortmannin
CREB (human) sVDsVtDsQKRREIL S107-p
CREB iso1 (human) SVDSVTDSQKRREIL S121
CREB (mouse) sVDsVTDsQKRREIL S107-p
CREB iso1 (mouse) SVDSVTDSQKRREIL S121
CREB (rat) SVDSVTDSQKRREIL S107
CREB iso1 (rat) sVDsVtDsQKRREIL S121-p
S115-p
QKRREILsRRPsyRk
Upstream
10 2
Treatment
  • acadesine
  • compound_C
  • L803-mts
CREB (human) QKRREILsRRPsyRk S115-p
CREB iso1 (human) QKRREILSRRPsYRK S129
CREB (mouse) QKRREILsRRPsyRk S115-p
CREB iso1 (mouse) QKRREILSRRPSYRK S129
CREB (rat) QKRREILSRRPSYRK S115
CREB iso1 (rat) QKRREILsRRPsYRk S129-p
S119-p
EILsRRPsyRkILND
Upstream
Downstream
309 66
CREB (human)
S119-p
CREB (mouse)
S119-p
CREB iso1 (rat)
S133-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • apoptosis, induced
  • autophagy, inhibited
  • carcinogenesis, induced
  • cell growth, altered
  • cell growth, induced
  • exocytosis, induced
  • neural plasticity
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
  • translation, inhibited
Kinase, in vitro:
  • MAPKAPK2 (human)
  • p90RSK (mouse)
Putative in vivo kinases:
  • CAMK2A (human)
  • MSK1 (human)
  • Nik (mouse)
  • PKACA (human)
Putative upstream phosphatases:
  • PPP1CB (human)
  • PPP2CA (human)
Regulatory protein:
  • 5-HT(1B) (mouse)
  • 5-HT(2C) (human)
  • ADRA1A (human)
  • AHR (human)
  • ARRB2 (human)
  • ATG7 (human)
  • BMAL1 (mouse)
  • CAMK2A (mouse)
  • CAMK4 (mouse)
  • CARD9 (mouse)
  • CC2D1A (mouse)
  • CDK5R1 (mouse)
  • CDKL5 (human)
  • COL1A1 (human)
  • dectin-1 (mouse)
  • DPP4 (human)
  • GLUD1 (human)
  • IRE1 (mouse)
  • Kv2.1 (human)
  • MAPKAPK2 (human)
  • MSK1 (mouse)
  • MSK2 (mouse)
  • neurogranin (mouse)
  • NFkB-p100 (mouse)
  • nNOS (mouse)
  • PAX6 (human)
  • PHLPP2 (mouse)
  • PKACA (mouse)
  • PKIB (mouse)
  • PPP1CA (mouse)
  • RPS23 (mouse)
  • RSK2 (human)
  • SMOC1 (mouse)
  • TTC10 (human)
  • WWTR1 (human)
  • YAP1 (human)
Treatment
  • 5-HT
  • 666-15
  • 8-Br-AMP
  • 8-Rp-cAMP
  • acadesine
  • alpha-ketoglutarate
  • alpha2-macroglobulin
  • amino_acid_starvation
  • amphoterin
  • angiotensin_2
  • anisomycin
  • antibody
  • apelin
  • argimesna
  • bacterial infection
  • BAPTA-AM
  • BDNF
  • bicuculline
  • bisindolylmaleimide
  • bryostatin_1
  • butyrate
  • C75
  • caffeine
  • calicheamicin
  • calphostin_C
  • cAMP_analog
  • CBU91
  • CGRP
  • CGS_21680
  • CH223191
  • chelerythrine
  • cocaine
  • colforsin
  • contextual fear conditioning
  • corticosterone
  • curdlan
  • D4476
  • depolarization
  • diabetes
  • Diphtheria toxin
  • DT-3
  • EGF
  • electrical_stimulation
  • Epo
  • exenatide
  • fasting
  • fluoxetine
  • forced swim test
  • FPL_64176
  • gelatin
  • genistein
  • glibenclamide
  • GLP-1
  • glucagon
  • glucose
  • glucose_starvation
  • glutamic acid
  • glutamine
  • Go_6850
  • Go_6976
  • H-89
  • heat_shock
  • HG9-91-01
  • high-fat diet
  • high_glucose
  • IBMX
  • indole-3-aldehyde
  • insulin
  • ionomycin
  • ischemia
  • isoflurane
  • isoproterenol
  • K252a
  • KCl
  • ketamine
  • KN-62
  • KN-93
  • KT5720
  • L-NAME
  • L803-mts
  • laminin-1
  • LB-100
  • learning
  • leucine
  • levamfetamine
  • LH
  • LIF
  • light
  • lithium
  • long-term_potentiation
  • low_glucose
  • LPS
  • LY294002
  • manumycin_A
  • MG132
  • MK-2206
  • MK801
  • motor skill learning
  • MRT67307
  • nicotinamide
  • nifedipine
  • nimodipine
  • NKH_477
  • NMDA
  • NOC-12
  • norepinephrine
  • obesity-inducing diet
  • okadaic_acid
  • ONOO(-)
  • palmitate
  • PD184352
  • PD98059
  • peptide inhibitor
  • peptones
  • PF4
  • PGE2
  • phenformin
  • phorbol_ester
  • PKI
  • propofol
  • propolis
  • protopanaxadiol
  • pterosin_B
  • quinpirole
  • racepinefrine
  • refeeding
  • restraint stress
  • retinoic_acid
  • Ro31-8220
  • rolipram
  • rottlerin
  • S107
  • SB203580
  • SB431542
  • seliciclib
  • serum
  • siRNA
  • SKF38393
  • SNAP
  • streptozotocin
  • TBB
  • TGF-beta
  • trichostatin_A
  • TRIM
  • TTX
  • U0126
  • U73122
  • UV
  • valproic acid
  • visual experience
CREB (human) EILsRRPsyRkILND S119-p
CREB iso1 (human) EILSRRPsYRKILND S133-p
CREB (mouse) EILsRRPsyRkILND S119-p
CREB iso1 (mouse) EILSRRPSYRKILND S133
CREB (rat) EILSRRPSYRKILND S119
CREB iso1 (rat) EILsRRPsYRkILND S133-p
Y120-p
ILsRRPsyRkILNDL
Downstream
4 4
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • neural plasticity
  • transcription, inhibited
CREB (human) ILsRRPsyRkILNDL Y120-p
CREB iso1 (human) ILSRRPsYRKILNDL Y134
CREB (mouse) ILsRRPsyRkILNDL Y120-p
CREB iso1 (mouse) ILSRRPSYRKILNDL Y134
CREB (rat) ILSRRPSYRKILNDL Y120
CREB iso1 (rat) ILsRRPsYRkILNDL Y134
K122-ac
sRRPsyRkILNDLss
Downstream
4 0
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
CREB (human) sRRPsyRkILNDLss K122-ac
CREB iso1 (human) SRRPsYRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ac
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) SRRPSYRKILNDLSS K122
CREB iso1 (rat) sRRPsYRkILNDLss K136-ac
K122-ub
sRRPsyRkILNDLss
0 4
CREB (human) sRRPsyRkILNDLss K122-ub
CREB iso1 (human) SRRPsYRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ub
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) SRRPSYRKILNDLSS K122
CREB iso1 (rat) sRRPsYRKILNDLss K136
S128-p
RkILNDLssDAPGVP
Upstream
Downstream
11 22
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • neural plasticity
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Nik (human)
Treatment
  • glutamic acid
  • K252a
  • KCl
  • light
  • MK801
  • TTX
  • visual experience
CREB (human) RkILNDLssDAPGVP S128-p
CREB iso1 (human) RKILNDLSSDAPGVP S142
CREB (mouse) RkILNDLssDAPGVP S128-p
CREB iso1 (mouse) RKILNDLSSDAPGVP S142
CREB (rat) RKILNDLSSDAPGVP S128
CREB iso1 (rat) RkILNDLssDAPGVP S142-p
S129-p
kILNDLssDAPGVPR
Upstream
Downstream
5 1
Effects on Biological Processes:
  • neural plasticity
  • transcription, induced
Treatment
  • KCl
  • visual experience
CREB (human) kILNDLssDAPGVPR S129-p
CREB iso1 (human) KILNDLSSDAPGVPR S143
CREB (mouse) kILNDLssDAPGVPR S129-p
CREB iso1 (mouse) KILNDLSSDAPGVPR S143
CREB (rat) KILNDLSSDAPGVPR S129
CREB iso1 (rat) kILNDLssDAPGVPR S143-p
S142-p
PRIEEEKsEEETSAP
2 0
CREB (human) PRIEEEKsEEETSAP S142-p
CREB iso1 (human) PRIEEEKSEEETSAP S156
CREB (mouse) PRIEEEKsEEETSAP S142-p
CREB iso1 (mouse) PRIEEEKSEEETSAP S156
CREB (rat) PRIEEEKSEEETSAP S142
CREB iso1 (rat) PRIEEEKSEEETSAP S156
T242
VQTYQIRTAPTstIA
0 1
CREB (human) VQTYQIRtAPTSTIA T242-p
CREB iso1 (human) VQTYQIRTAPTSTIA T256
CREB (mouse) VQTYQIRTAPTstIA T242
CREB iso1 (mouse) VQTYQIRTAPTSTIA T256
CREB (rat) VQTYQIRTAPTSTIA T242
CREB iso1 (rat) VQTYQIRTAPTSTIA T256
S246-p
QIRTAPTstIAPGVV
0 1
CREB (human) QIRtAPTSTIAPGVV S246
CREB iso1 (human) QIRTAPTSTIAPGVV S260
CREB (mouse) QIRTAPTstIAPGVV S246-p
CREB iso1 (mouse) QIRTAPTSTIAPGVV S260
CREB (rat) QIRTAPTSTIAPGVV S246
CREB iso1 (rat) QIRTAPTSTIAPGVV S260
T247-p
IRTAPTstIAPGVVM
0 1
CREB (human) IRtAPTSTIAPGVVM T247
CREB iso1 (human) IRTAPTSTIAPGVVM T261
CREB (mouse) IRTAPTstIAPGVVM T247-p
CREB iso1 (mouse) IRTAPTSTIAPGVVM T261
CREB (rat) IRTAPTSTIAPGVVM T247
CREB iso1 (rat) IRTAPTSTIAPGVVM T261
S256-p
APGVVMAssPALPTQ
1 2
CREB (human) APGVVMAssPALPTQ S256-p
CREB iso1 (human) APGVVMASSPALPTQ S270
CREB (mouse) APGVVMAssPALPTQ S256-p
CREB iso1 (mouse) APGVVMASSPALPTQ S270
CREB (rat) APGVVMASSPALPTQ S256
CREB iso1 (rat) APGVVMASSPALPTQ S270
S257-p
PGVVMAssPALPTQP
4 8
CREB (human) PGVVMAssPALPTQP S257-p
CREB iso1 (human) PGVVMASSPALPTQP S271
CREB (mouse) PGVVMAssPALPTQP S257-p
CREB iso1 (mouse) PGVVMASSPALPTQP S271
CREB (rat) PGVVMASSPALPTQP S257
CREB iso1 (rat) PGVVMASSPALPTQP S271
K271
PAEEAARKREVRLMK
2 0
CREB (human) PAEEAARkREVRLMK K271-sm
CREB iso1 (human) PAEEAARKREVRLMK K285
CREB (mouse) PAEEAARKREVRLMK K271
CREB iso1 (mouse) PAEEAARkREVRLMK K285-sm
CREB (rat) PAEEAARKREVRLMK K271
CREB iso1 (rat) PAEEAARKREVRLMK K285
K290
ARECRRKKKEYVKCL
2 0
CREB (human) ARECRRKkKEYVKCL K290-sm
CREB iso1 (human) ARECRRKKKEYVKCL K304
CREB (mouse) ARECRRKKKEYVKCL K290
CREB iso1 (mouse) ARECRRKkKEYVKCL K304-sm
CREB (rat) ARECRRKKKEYVKCL K290
CREB iso1 (rat) ARECRRKKKEYVKCL K304
K316-ub
KTLIEELkALKDLYC
0 5
CREB (human) KTLIEELkALKDLYC K316-ub
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELkALKDLYC K316-ub
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELKALKDLYC K316
CREB iso1 (rat) KTLIEELKALKDLYC K330
K316
KTLIEELKALKDLYC
0 1
CREB (human) KTLIEELKALKDLYC K316
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELKALKDLYC K316
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELKALKDLYC K316
CREB iso1 (rat) KTLIEELkALKDLYC K330-ac
K325
LKDLYCHKsD_____
0 1
CREB (human) LKDLYCHksD_____ K325-ub
CREB iso1 (human) LKDLYCHKSD_____ K339
CREB (mouse) LKDLYCHKsD_____ K325
CREB iso1 (mouse) LKDLYCHKSD_____ K339
CREB (rat) LKDLYCHKSD_____ K325
CREB iso1 (rat) LKDLYCHKSD_____ K339
S326-p
KDLYCHKsD______
1 10
CREB (human) KDLYCHksD______ S326-p
CREB iso1 (human) KDLYCHKSD______ S340
CREB (mouse) KDLYCHKsD______ S326-p
CREB iso1 (mouse) KDLYCHKSD______ S340
CREB (rat) KDLYCHKSD______ S326
CREB iso1 (rat) KDLYCHKSD______ S340