Other Species / Isoforms
  CREB (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
1 0
CREB (human) gap -
CREB iso1 (human) QTVQSSCKDLKRLFs K91
CREB (mouse) gap -
CREB iso1 (mouse) QTVQSSCKDLKRLFs K91
CREB (rat) QTVQSSCkDLkRLFS K91-ac
-
gap
1 0
CREB (human) gap -
CREB iso1 (human) QSSCKDLKRLFsGtQ K94
CREB (mouse) gap -
CREB iso1 (mouse) QSSCKDLKRLFsGtQ K94
CREB (rat) QSSCkDLkRLFSGTQ K94-ac
-
gap
2 0
CREB (human) gap -
CREB iso1 (human) KDLKRLFsGtQISTI S98-p
CREB (mouse) gap -
CREB iso1 (mouse) KDLKRLFsGtQISTI S98-p
CREB (rat) kDLkRLFSGTQISTI S98
-
gap
3 0
CREB (human) gap -
CREB iso1 (human) LKRLFsGtQISTIAE T100-p
CREB (mouse) gap -
CREB iso1 (mouse) LKRLFsGtQISTIAE T100-p
CREB (rat) LkRLFSGTQISTIAE T100
S94-p
QISTIAEsEDsQEsV
Upstream
Downstream
7 3
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK1A (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • CK1A (human)
  • P38A (human)
Treatment
  • anisomycin
  • colcemid
  • cycloheximide
  • D4476
  • etoposide
  • high_cell_density
  • ionizing_radiation
  • MG132
  • nocodazole
  • okadaic_acid
  • SB202190
  • SB203580
  • siRNA
  • SP600125
  • TBB
  • UV
  • Zeocin
CREB (human) QISTIAEsEDsQEsV S94-p
CREB iso1 (human) QISTIAESEDSQESV S108
CREB (mouse) QISTIAEsEDsQEsV S94-p
CREB iso1 (mouse) QISTIAESEDSQESV S108
CREB (rat) QISTIAEsEDsQEsV S108-p
S97-p
TIAEsEDsQEsVDsV
Upstream
Downstream
8 6
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • ATM (human)
  • CK2A1 (human)
Putative in vivo kinases:
  • CK1A (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • CK1A (human)
  • P38A (human)
Treatment
  • anisomycin
  • colcemid
  • cycloheximide
  • D4476
  • etoposide
  • H2O2
  • high_cell_density
  • ionizing_radiation
  • MG132
  • nocodazole
  • okadaic_acid
  • SB202190
  • SB203580
  • siRNA
  • SP600125
  • TBB
  • UV
  • Zeocin
CREB (human) TIAEsEDsQEsVDsV S97-p
CREB iso1 (human) TIAESEDSQESVDSV S111
CREB (mouse) TIAEsEDsQEsVDsV S97-p
CREB iso1 (mouse) TIAESEDSQESVDSV S111
CREB (rat) TIAEsEDsQEsVDsV S111-p
S100-p
EsEDsQEsVDsVtDs
Upstream
Downstream
7 2
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Kinase, in vitro:
  • CK1A (human)
Putative in vivo kinases:
  • CK1A (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • CK1A (human)
  • P38A (human)
Treatment
  • anisomycin
  • colcemid
  • cycloheximide
  • D4476
  • etoposide
  • high_cell_density
  • ionizing_radiation
  • MG132
  • nocodazole
  • okadaic_acid
  • SB202190
  • SB203580
  • siRNA
  • SP600125
  • TBB
  • UV
  • Zeocin
CREB (human) EsEDsQEsVDsVtDs S100-p
CREB iso1 (human) ESEDSQESVDSVTDS S114
CREB (mouse) EsEDsQEsVDsVTDs S100-p
CREB iso1 (mouse) ESEDSQESVDSVTDS S114
CREB (rat) EsEDsQEsVDsVtDs S114-p
S103-p
DsQEsVDsVtDsQKR
Upstream
Downstream
4 0
Effects on Modified Protein
  • phosphorylation
Treatment
  • ionizing_radiation
CREB (human) DsQEsVDsVtDsQKR S103-p
CREB iso1 (human) DSQESVDSVTDSQKR S117
CREB (mouse) DsQEsVDsVTDsQKR S103-p
CREB iso1 (mouse) DSQESVDSVTDSQKR S117
CREB (rat) DsQEsVDsVtDsQKR S117-p
T105-p
QEsVDsVtDsQKRRE
1 1
CREB (human) QEsVDsVtDsQKRRE T105-p
CREB iso1 (human) QESVDSVTDSQKRRE T119
CREB (mouse) QEsVDsVTDsQKRRE T105
CREB iso1 (mouse) QESVDSVTDSQKRRE T119
CREB (rat) QEsVDsVtDsQKRRE T119-p
S107-p
sVDsVtDsQKRREIL
Upstream
Downstream
11 0
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • ATM (human)
  • ATR (human)
Putative in vivo kinases:
  • ATM (human)
  • ATR (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • aphidicolin
  • colcemid
  • D4476
  • deferoxamine
  • etoposide
  • H2O2
  • hydroxyurea
  • ionizing_radiation
  • nocodazole
  • okadaic_acid
  • retinoic_acid
  • TBB
  • UV
CREB (human) sVDsVtDsQKRREIL S107-p
CREB iso1 (human) SVDSVTDSQKRREIL S121
CREB (mouse) sVDsVTDsQKRREIL S107-p
CREB iso1 (mouse) SVDSVTDSQKRREIL S121
CREB (rat) sVDsVtDsQKRREIL S121-p
S115-p
QKRREILsRRPsyRk
Upstream
Downstream
10 2
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, induced
  • transcription, induced
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • colforsin
  • SB216763
  • TNF
CREB (human) QKRREILsRRPsyRk S115-p
CREB iso1 (human) QKRREILSRRPsYRK S129
CREB (mouse) QKRREILsRRPsyRk S115-p
CREB iso1 (mouse) QKRREILSRRPSYRK S129
CREB (rat) QKRREILsRRPsYRk S129-p
S119-p
EILsRRPsyRkILND
Upstream
Downstream
249 65
CREB (human)
S119-p
CREB (mouse)
S119-p
CREB (rat)
S133-p
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell differentiation, altered
  • cell differentiation, induced
  • cell growth, induced
  • cell motility, altered
  • neural plasticity
  • transcription, altered
  • transcription, induced
  • translation, inhibited
Kinase, in vitro:
  • ATM (human)
  • CAMK4 (human)
  • Cot (human)
  • MAPKAPK2 (human)
  • MSK1 (human)
  • p90RSK (human)
  • PKACA (human)
  • PKACA (mouse)
  • PRKD1 (human)
  • SGK1 (human)
  • TSSK4 (human)
Putative in vivo kinases:
  • ATM (human)
  • DYRK3 (mouse)
  • MAPKAPK2 (human)
  • MSK1 (human)
  • MSK2 (human)
  • p90RSK (human)
  • PKCE (human)
  • PRKD1 (human)
  • RSK2 (human)
  • RSK3 (human)
  • SGK1 (mouse)
Regulatory protein:
  • 5-HT(7) (human)
  • AIF1 (mouse)
  • AKIP (human)
  • Akt1 (human)
  • DARPP-32 (human)
  • GSK3B (human)
  • HDAC1 (human)
  • JNK1 (mouse)
  • MSK1 (human)
  • NFkB-p100 (human)
  • NRas (human)
  • NRas (mouse)
  • p90RSK (human)
  • PHLPP2 (human)
  • PKAR2B (human)
  • PTGER2 (human)
  • PTGER2 (mouse)
  • PTGER3 (mouse)
  • PTGER4 (human)
  • TORC1 (human)
  • TORC2 (human)
  • TRPC7 (mouse)
  • WNT5A (human)
Treatment
  • 2-deoxyglucose
  • 5-HT
  • 8-CPT-2Me-cAMP
  • adriamycin
  • AG1478
  • AH6809
  • androgen_withdrawal
  • angiotensin
  • anisomycin
  • anti-CD3/CD28
  • anti-IgM
  • arsenite
  • ascomycin
  • BayK8644
  • BDNF
  • bisindolylmaleimide_II
  • BIX02188
  • cAMP_analog
  • carbachol
  • cisplatin
  • cocaine
  • colforsin
  • CRF
  • D600
  • depolarization
  • dexamethasone
  • dimethylfumarate
  • EGF
  • exercise
  • FGF1
  • fluid_shear_stress
  • fumaric_acid
  • genistein
  • GF109203X
  • GM-CSF
  • Go_6976
  • Go_6983
  • H-7
  • H-89
  • H2O2
  • HA-1004
  • HGF
  • histamine
  • IBMX
  • IGF-1
  • IL-1b
  • IL-2
  • IL-3
  • IL-4
  • insulin
  • ionizing_radiation
  • ionomycin
  • KN-62
  • KN-93
  • KT-5926
  • KT5720
  • kynurenine
  • LIF
  • linoleic_acid
  • lithium
  • losartan
  • LPA
  • LPS
  • LY294002
  • methylhydrogenfumarate
  • metribolone
  • morphine
  • morphine_withdrawal
  • MSH
  • N6-benzoyl-cAMP
  • nifedipine
  • NKH_477
  • NMDA
  • NPC-15342
  • NS398
  • NSC-127102
  • OAG
  • okadaic_acid
  • oleic_acid
  • ONOO(-)
  • PD123319
  • PD98059
  • PDGF
  • phorbol_ester
  • PlGF
  • PP1
  • prostaglandin_E
  • pup exposure
  • rapamycin
  • retinoic_acid
  • Ro31-8220
  • rolipram
  • Rp-cAMPS
  • SB202190
  • SB203580
  • SB216763
  • semaxanib
  • serum
  • siRNA
  • staurosporine
  • sulprostone
  • t-butanol
  • tautomycin
  • taxol
  • TNF
  • trichostatin_A
  • U0126
  • UV
  • vanadate
  • VE-821
  • VEGF
  • VIP
  • virus infection
  • wortmannin
CREB (human) EILsRRPsyRkILND S119-p
CREB iso1 (human) EILSRRPsYRKILND S133-p
CREB (mouse) EILsRRPsyRkILND S119-p
CREB iso1 (mouse) EILSRRPSYRKILND S133
CREB (rat) EILsRRPsYRkILND S133-p
Y120-p
ILsRRPsyRkILNDL
2 4
CREB (human) ILsRRPsyRkILNDL Y120-p
CREB iso1 (human) ILSRRPsYRKILNDL Y134
CREB (mouse) ILsRRPsyRkILNDL Y120-p
CREB iso1 (mouse) ILSRRPSYRKILNDL Y134
CREB (rat) ILsRRPsYRkILNDL Y134
K122-ac
sRRPsyRkILNDLss
Downstream
4 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
CREB (human) sRRPsyRkILNDLss K122-ac
CREB iso1 (human) SRRPsYRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ac
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) sRRPsYRkILNDLss K136-ac
K122-ub
sRRPsyRkILNDLss
0 4
CREB (human) sRRPsyRkILNDLss K122-ub
CREB iso1 (human) SRRPsYRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ub
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) sRRPsYRKILNDLss K136
S128-p
RkILNDLssDAPGVP
Upstream
10 22
Treatment
  • angiotensin_2
  • ischemia
  • selumetinib
  • vemurafenib
CREB (human) RkILNDLssDAPGVP S128-p
CREB iso1 (human) RKILNDLSSDAPGVP S142
CREB (mouse) RkILNDLssDAPGVP S128-p
CREB iso1 (mouse) RKILNDLSSDAPGVP S142
CREB (rat) RkILNDLssDAPGVP S142-p
S129-p
kILNDLssDAPGVPR
4 1
CREB (human) kILNDLssDAPGVPR S129-p
CREB iso1 (human) KILNDLSSDAPGVPR S143
CREB (mouse) kILNDLssDAPGVPR S129-p
CREB iso1 (mouse) KILNDLSSDAPGVPR S143
CREB (rat) kILNDLssDAPGVPR S143-p
S142-p
PRIEEEKsEEETSAP
Upstream
2 0
Kinase, in vitro:
  • CK1A (human)
Phosphatases, in vitro:
  • PPP2CA (human)
CREB (human) PRIEEEKsEEETSAP S142-p
CREB iso1 (human) PRIEEEKSEEETSAP S156
CREB (mouse) PRIEEEKsEEETSAP S142-p
CREB iso1 (mouse) PRIEEEKSEEETSAP S156
CREB (rat) PRIEEEKSEEETSAP S156
T242-p
VQTYQIRtAPTSTIA
0 1
CREB (human) VQTYQIRtAPTSTIA T242-p
CREB iso1 (human) VQTYQIRTAPTSTIA T256
CREB (mouse) VQTYQIRTAPTstIA T242
CREB iso1 (mouse) VQTYQIRTAPTSTIA T256
CREB (rat) VQTYQIRTAPTSTIA T256
S246
QIRtAPTSTIAPGVV
0 1
CREB (human) QIRtAPTSTIAPGVV S246
CREB iso1 (human) QIRTAPTSTIAPGVV S260
CREB (mouse) QIRTAPTstIAPGVV S246-p
CREB iso1 (mouse) QIRTAPTSTIAPGVV S260
CREB (rat) QIRTAPTSTIAPGVV S260
T247
IRtAPTSTIAPGVVM
0 1
CREB (human) IRtAPTSTIAPGVVM T247
CREB iso1 (human) IRTAPTSTIAPGVVM T261
CREB (mouse) IRTAPTstIAPGVVM T247-p
CREB iso1 (mouse) IRTAPTSTIAPGVVM T261
CREB (rat) IRTAPTSTIAPGVVM T261
S256-p
APGVVMAssPALPTQ
Upstream
Downstream
1 2
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, inhibited
Kinase, in vitro:
  • CDK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
Treatment
  • BI2536
  • nocodazole
CREB (human) APGVVMAssPALPTQ S256-p
CREB iso1 (human) APGVVMASSPALPTQ S270
CREB (mouse) APGVVMAssPALPTQ S256-p
CREB iso1 (mouse) APGVVMASSPALPTQ S270
CREB (rat) APGVVMASSPALPTQ S270
S257-p
PGVVMAssPALPTQP
Upstream
Downstream
3 8
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • CDK1 (human)
  • HIPK2 (human)
Putative in vivo kinases:
  • CDK1 (human)
  • HIPK2 (human)
Treatment
  • BI2536
  • cisplatin
  • etoposide
  • nocodazole
CREB (human) PGVVMAssPALPTQP S257-p
CREB iso1 (human) PGVVMASSPALPTQP S271
CREB (mouse) PGVVMAssPALPTQP S257-p
CREB iso1 (mouse) PGVVMASSPALPTQP S271
CREB (rat) PGVVMASSPALPTQP S271
K271-sm
PAEEAARkREVRLMK
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • transcription, induced
Treatment
  • hypoxia
CREB (human) PAEEAARkREVRLMK K271-sm
CREB iso1 (human) PAEEAARKREVRLMK K285
CREB (mouse) PAEEAARKREVRLMK K271
CREB iso1 (mouse) PAEEAARKREVRLMK K285
CREB (rat) PAEEAARKREVRLMK K285
K290-sm
ARECRRKkKEYVKCL
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Effects on Biological Processes:
  • transcription, induced
Treatment
  • hypoxia
CREB (human) ARECRRKkKEYVKCL K290-sm
CREB iso1 (human) ARECRRKKKEYVKCL K304
CREB (mouse) ARECRRKKKEYVKCL K290
CREB iso1 (mouse) ARECRRKKKEYVKCL K304
CREB (rat) ARECRRKKKEYVKCL K304
K316-ub
KTLIEELkALKDLYC
0 5
CREB (human) KTLIEELkALKDLYC K316-ub
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELkALKDLYC K316-ub
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELKALKDLYC K330
K316
KTLIEELKALKDLYC
0 1
CREB (human) KTLIEELKALKDLYC K316
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELKALKDLYC K316
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELkALKDLYC K330-ac
K325-ub
LKDLYCHksD_____
0 1
CREB (human) LKDLYCHksD_____ K325-ub
CREB iso1 (human) LKDLYCHKSD_____ K339
CREB (mouse) LKDLYCHKsD_____ K325
CREB iso1 (mouse) LKDLYCHKSD_____ K339
CREB (rat) LKDLYCHKSD_____ K339
S326-p
KDLYCHksD______
1 10
CREB (human) KDLYCHksD______ S326-p
CREB iso1 (human) KDLYCHKSD______ S340
CREB (mouse) KDLYCHKsD______ S326-p
CREB iso1 (mouse) KDLYCHKSD______ S340
CREB (rat) KDLYCHKSD______ S340