Other Species / Isoforms
  Cot (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S62-p
QNEERSEsLLRSGQE
Downstream
2 2
Effects on Modified Protein
  • molecular association, regulation
Cot (human) QNDERSKsLLLSGQE S62-p
Cot (mouse) QNEERSEsLLRSGQE S62-p
Cot (rat) QNKEHSESLLRSGQE S62
T80
LSSVRYGTVEDLLAF
0 1
Cot (human) LSSVRYGTVEDLLAF T80
Cot (mouse) LSSVRYGTVEDLLAF T80
Cot (rat) LSSVRYGtVEDLLAF T80-p
S125
NGRYQIDSDVLLVPW
0 1
Cot (human) NGRYQIDsDVLLIPW S125-p
Cot (mouse) NGRYQIDSDVLLVPW S125
Cot (rat) NGRYQIDSDVLLVPW S125
Y136
LVPWKLTYRNIGsGF
0 1
Cot (human) LIPWKLTyRNIGsDF Y136-p
Cot (mouse) LVPWKLTYRNIGsGF Y136
Cot (rat) LVPWKLTYRsIGsGF Y136
N138
PWKLTYRNIGsGFVP
0 1
Cot (human) PWKLTyRNIGsDFIP N138
Cot (mouse) PWKLTYRNIGsGFVP N138
Cot (rat) PWKLTYRsIGsGFVP S138-p
S141-p
LTYRNIGsGFVPRGA
Upstream
0 32
Treatment
  • LPS
Cot (human) LTyRNIGsDFIPRGA S141-p
Cot (mouse) LTYRNIGsGFVPRGA S141-p
Cot (rat) LTYRsIGsGFVPRGA S141-p
Y153
RGAFGKVYLAQDMKT
0 1
Cot (human) RGAFGKVyLAQDIKT Y153-p
Cot (mouse) RGAFGKVYLAQDMKT Y153
Cot (rat) RGAFGKVYLAQDMKT Y153
T290-p
LPKDLRGtEIYMSPE
Upstream
Downstream
5 0
Effects on Modified Protein
  • enzymatic activity, induced
Putative in vivo kinases:
  • IKKB (mouse)
Regulatory protein:
  • Cot (mouse)
Treatment
  • LPS
  • PS-1145
  • siRNA
  • TNF
Cot (human) FPKDLRGtEIYMSPE T290-p
Cot (mouse) LPKDLRGtEIYMSPE T290-p
Cot (rat) LPKDLRGTEIYMSPE T290
S334
WVKRYPRSAYPSYLY
0 1
Cot (human) WVKRYPRsAYPSYLY S334-p
Cot (mouse) WVKRYPRSAYPSYLY S334
Cot (rat) WVKRYPRSAYPSYLY S334
A368
MRELIEAALERNPNH
0 2
Cot (human) MRELIEAsLERNPNH S368-p
Cot (mouse) MRELIEAALERNPNH A368
Cot (rat) MRELIEAALERNPNH A368
S400-p
EDQPRCQsLDSALFE
Upstream
Downstream
3 2
Cot (human)
S400-p
Cot (mouse)
S400-p
Cot (rat)
S400-p
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Regulatory protein:
  • Cot (mouse)
  • IKKB (human)
  • NFkB-p105 (mouse)
Treatment
  • IL-1b
  • LPS
  • LY294002
  • wortmannin
Cot (human) EDQPRCQsLDSALLE S400-p
Cot (mouse) EDQPRCQsLDSALFE S400-p
Cot (rat) EDQPRCQsLDSALFD S400-p
S413-p
FERKRLLsRKELQLP
Upstream
1 0
Regulatory protein:
  • Cot (mouse)
  • NFkB-p105 (mouse)
Treatment
  • LPS
Cot (human) LERKRLLSRKELELP S413
Cot (mouse) FERKRLLsRKELQLP S413-p
Cot (rat) FDRKRLLSRKELELP S413
S443-p
EVLRRQRsLYIDLGA
Upstream
Downstream
1 2
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • molecular association, regulation
Putative in vivo kinases:
  • Cot (human)
Treatment
  • BI605906
  • IL-1b
  • Tpl2_inhibitor
Cot (human) EMLKRQRsLYIDLGA S443-p
Cot (mouse) EVLRRQRsLYIDLGA S443-p
Cot (rat) EVLRRQRsLYIDLGA S443-p