T3
|
_____MPTPSAPsPQ
|
|
|
0
|
1
|
|
|
TH (human)
|
_____MPtPDATTPQ
|
T3-p
|
TH iso2 (human)
|
_____MPTPDATTPQ
|
T3
|
TH iso3 (human)
|
_____MPTPDATTPQ
|
T3
|
TH iso4 (human)
|
_____MPTPDATTPQ
|
T3
|
TH (mouse)
|
_____MPTPSASSPQ
|
T3
|
TH (rat)
|
_____MPTPSAPsPQ
|
T3
|
TH (cow)
|
_____MPTPNAASPQ
|
T3
|
|
S8-p
|
MPTPSAPsPQPKGFR
|
Upstream
|
Downstream
|
5
|
1
|
|
|
Effects on Modified Protein
|
|
Kinase, in vitro:
|
Treatment
- colforsin
- depolarization
- EGF
- electrical_stimulation
- okadaic_acid
- PDGF
- phorbol_ester
|
|
TH (human)
|
MPtPDATTPQAKGFR
|
T8
|
TH iso2 (human)
|
MPTPDATTPQAKGFR
|
T8
|
TH iso3 (human)
|
MPTPDATTPQAKGFR
|
T8
|
TH iso4 (human)
|
MPTPDATTPQAKGFR
|
T8
|
TH (mouse)
|
MPTPSASSPQPKGFR
|
S8
|
TH (rat)
|
MPTPSAPsPQPKGFR
|
S8-p
|
TH (cow)
|
MPTPNAASPQAKGFR
|
S8
|
|
S19-p
|
KGFRRAVsEQDAKQA
|
Upstream
|
Downstream
|
46
|
13
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- molecular association, regulation
- protein conformation
- protein stabilization
|
|
Kinase, in vitro:
- CAMK1A (human)
- CAMK2A (rat)
|
Phosphatases, in vitro:
|
Putative upstream phosphatases:
|
Regulatory protein:
|
Treatment
- A23187
- angiotensin
- apomorphine
- APV
- Ba(2+)
- bradykinin
- butyrolactone
- CHIR99021
- cocaine
- colforsin
- depolarization
- DHPG
- Dihydrokainic acid
- EGF
- EGTA
- electrical_stimulation
- eticlopride
- GDNF
- genistein
- glutamic acid
- insulin
- lithium
- LPS
- nerve_damage
- nicotine
- NMDA
- NSD-1015
- okadaic_acid
- PD98059
- phorbol_ester
- PRL
- quinpirole
- Time
- veratridine
|
|
TH (human)
|
KGFRRAVsELDAKQA
|
S19-p
|
TH iso2 (human)
|
KGFRRAVsELDAKQA
|
S19-p
|
TH iso3 (human)
|
KGFRRAVsELDAKQA
|
S19-p
|
TH iso4 (human)
|
KGFRRAVsELDAKQA
|
S19-p
|
TH (mouse)
|
KGFRRAVsEQDtKQA
|
S19-p
|
TH (rat)
|
KGFRRAVsEQDAKQA
|
S19-p
|
TH (cow)
|
KGFRRAVsELDAKQA
|
S19-p
|
|
A23
|
RAVsEQDAKQAEAVt
|
|
|
0
|
1
|
|
|
TH (human)
|
RAVsELDAKQAEAIM
|
A23
|
TH iso2 (human)
|
RAVsELDAKQAEAIM
|
A23
|
TH iso3 (human)
|
RAVsELDAKQAEAIM
|
A23
|
TH iso4 (human)
|
RAVsELDAKQAEAIM
|
A23
|
TH (mouse)
|
RAVsEQDtKQAEAVt
|
T23-p
|
TH (rat)
|
RAVsEQDAKQAEAVt
|
A23
|
TH (cow)
|
RAVsELDAKQAEAIM
|
A23
|
|
T30-p
|
AKQAEAVtsPRFIGR
|
|
|
1
|
2
|
|
|
TH (human)
|
AKQAEAIMVRGQGAP
|
M30
|
TH iso2 (human)
|
AKQAEAIMGAPGPSL
|
M30
|
TH iso3 (human)
|
AKQAEAIMsPRFIGR
|
M30
|
TH iso4 (human)
|
AKQAEAIMVRGQsPR
|
M30
|
TH (mouse)
|
tKQAEAVtsPRFIGR
|
T30-p
|
TH (rat)
|
AKQAEAVtsPRFIGR
|
T30-p
|
TH (cow)
|
AKQAEAIMsPRFVGR
|
M30
|
|
S31-p
|
KQAEAVtsPRFIGRR
|
Upstream
|
Downstream
|
43
|
8
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- protein stabilization
|
|
Kinase, in vitro:
- ERK1 (mouse)
- ERK1 (rat)
- ERK2 (human)
- ERK2 (mouse)
- ERK2 (rat)
|
Phosphatases, in vitro:
|
Putative in vivo kinases:
- CDK5 (rat)
- ERK1 (rat)
- ERK2 (rat)
- MEK1 (rat)
- PKCB (rat)
|
Putative upstream phosphatases:
|
Regulatory protein:
|
Treatment
- A23187
- angiotensin
- apomorphine
- ATP
- Ba(2+)
- bradykinin
- butyrolactone
- CHIR99021
- cocaine
- colforsin
- depolarization
- EGF
- electrical_stimulation
- GDNF
- genistein
- haloperidol
- insulin
- lithium
- LPS
- muscarine
- nerve_damage
- NGF
- NSD-1015
- okadaic_acid
- olomoucine
- PD98059
- PDGF
- phorbol_ester
- PRL
- quinpirole
- rottlerin
- seliciclib
- t-Bu2BHQ
- thapsigargin
- Time
- U0126
|
|
TH (human)
|
SYTPTPRsPRFIGRR
|
S62-p
|
TH iso2 (human)
|
SYTPTPRsPRFIGRR
|
S58-p
|
TH iso3 (human)
|
KQAEAIMsPRFIGRR
|
S31-p
|
TH iso4 (human)
|
AIMVRGQsPRFIGRR
|
S35-p
|
TH (mouse)
|
KQAEAVtsPRFIGRR
|
S31-p
|
TH (rat)
|
KQAEAVtsPRFIGRR
|
S31-p
|
TH (cow)
|
KQAEAIMsPRFVGRR
|
S31-p
|
|
S40-p
|
RFIGRRQsLIEDARK
|
Upstream
|
Downstream
|
62
|
17
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- molecular association, regulation
- protein conformation
- protein stabilization
|
|
Kinase, in vitro:
- CAMK1A (human)
- CAMK2A (rat)
- PKACA (human)
- PKACA (rat)
- PKCA (human)
|
Phosphatases, in vitro:
- PPP2CA (rat)
- PPP2CB (rat)
- PPPM1A (human)
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
- PPP2CA (mouse)
- PPP2CB (rat)
|
Regulatory protein:
|
Treatment
- angiotensin
- apomorphine
- ATP
- bradykinin
- butyrolactone
- caffeine
- cAMP_analog
- CHIR99021
- cocaine
- colforsin
- depolarization
- EGF
- electrical_stimulation
- eticlopride
- food deprivation
- GDNF
- genistein
- high-fat diet
- hypoxia
- insulin
- KN-62
- leptin
- levamfetamine
- lithium
- LPS
- muscarine
- nerve_damage
- neurotensin
- NGF
- NMDA
- NSD-1015
- okadaic_acid
- PD98059
- phorbol_ester
- PKI
- PRL
- quinpirole
- Ro-20-1724
- rottlerin
- secretin human
- somatostatin
- substance_P
- t-Bu2BHQ
- thapsigargin
- Theophylline
- Time
- VIP
|
|
TH (human)
|
RFIGRRQsLIEDARK
|
S71-p
|
TH iso2 (human)
|
RFIGRRQsLIEDARK
|
S67-p
|
TH iso3 (human)
|
RFIGRRQsLIEDARK
|
S40-p
|
TH iso4 (human)
|
RFIGRRQsLIEDARK
|
S44-p
|
TH (mouse)
|
RFIGRRQsLIEDARK
|
S40-p
|
TH (rat)
|
RFIGRRQsLIEDARK
|
S40-p
|
TH (cow)
|
RFVGRRQsLIQDARK
|
S40-p
|
|
S88
|
AVLNLLFSLRGTKPS
|
|
|
0
|
1
|
|
|
TH (human)
|
AVLNLLFsPRATKPS
|
S118-p
|
TH iso2 (human)
|
AVLNLLFSPRATKPS
|
S114
|
TH iso3 (human)
|
AVLNLLFSPRATKPS
|
S87
|
TH iso4 (human)
|
AVLNLLFSPRATKPS
|
S91
|
TH (mouse)
|
AVLNLLFSLRGTKPS
|
S88
|
TH (rat)
|
AVLNLLFSLRGTKPS
|
S88
|
TH (cow)
|
AVLTLLFALPPTRPP
|
A81
|
|
S153-p
|
LSSVRRVsDDVRSAR
|
Upstream
|
|
1
|
0
|
|
|
|
TH (human)
|
LSGVRQVSEDVRSPA
|
S183
|
TH iso2 (human)
|
LSGVRQVSEDVRSPA
|
S179
|
TH iso3 (human)
|
LSGVRQVSEDVRSPA
|
S152
|
TH iso4 (human)
|
LSGVRQVSEDVRSPA
|
S156
|
TH (mouse)
|
LSSVRRVSDDVRSAR
|
S153
|
TH (rat)
|
LSSVRRVsDDVRSAR
|
S153-p
|
TH (cow)
|
LSALRRVAEDVRAAG
|
A146
|
|
Y200
|
PGFSDQVYRQRRKLI
|
|
|
0
|
1
|
|
|
TH (human)
|
PGFSDQVyRQRRKLI
|
Y230-p
|
TH iso2 (human)
|
PGFSDQVYRQRRKLI
|
Y226
|
TH iso3 (human)
|
PGFSDQVYRQRRKLI
|
Y199
|
TH iso4 (human)
|
PGFSDQVYRQRRKLI
|
Y203
|
TH (mouse)
|
PGFSDQAYRQRRKLI
|
Y200
|
TH (rat)
|
PGFSDQVYRQRRKLI
|
Y200
|
TH (cow)
|
PGFSDQAYRQRRKLI
|
Y193
|
|
Y389
|
QNGELKAYGAGLLSS
|
|
|
0
|
1
|
|
|
TH (human)
|
QNGEVKAyGAGLLSS
|
Y419-p
|
TH iso2 (human)
|
QNGEVKAYGAGLLSS
|
Y415
|
TH iso3 (human)
|
QNGEVKAYGAGLLSS
|
Y388
|
TH iso4 (human)
|
QNGEVKAYGAGLLSS
|
Y392
|
TH (mouse)
|
QNGELKAYGAGLLSS
|
Y389
|
TH (rat)
|
QNGELKAYGAGLLSS
|
Y389
|
TH (cow)
|
QNGEVKAYGAGLLSS
|
Y382
|
|
S405
|
GELLHSLSEEPEVRA
|
|
|
1
|
0
|
|
|
TH (human)
|
GELLHCLSEEPEIRA
|
S435
|
TH iso2 (human)
|
GELLHCLSEEPEIRA
|
S431
|
TH iso3 (human)
|
GELLHCLsEEPEIRA
|
S404-p
|
TH iso4 (human)
|
GELLHCLSEEPEIRA
|
S408
|
TH (mouse)
|
GELLHSLSEEPEVRA
|
S405
|
TH (rat)
|
GELLHSLSEEPEVRA
|
S405
|
TH (cow)
|
GELLHSLSEEPEIRA
|
S398
|
|
S472-p
|
LAIDVLDsPHTIQRS
|
Upstream
|
|
0
|
4
|
|
|
|
TH (human)
|
LAIDVLDsPQAVRRS
|
S502-p
|
TH iso2 (human)
|
LAIDVLDSPQAVRRS
|
S498
|
TH iso3 (human)
|
LAIDVLDSPQAVRRS
|
S471
|
TH iso4 (human)
|
LAIDVLDSPQAVRRS
|
S475
|
TH (mouse)
|
LAIDVLDsPHTIRRS
|
S472-p
|
TH (rat)
|
LAIDVLDsPHTIQRS
|
S472-p
|
TH (cow)
|
LAIDVLDSPHAIRHA
|
S465
|
|
-
|
gap
|
|
|
1
|
0
|
|
|
|