Other Species / Isoforms
  TH (rat)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T3
_____MPTPSAPsPQ
0 1
TH (human) _____MPtPDATTPQ T3-p
TH iso2 (human) _____MPTPDATTPQ T3
TH iso3 (human) _____MPTPDATTPQ T3
TH iso4 (human) _____MPTPDATTPQ T3
TH (mouse) _____MPTPSASSPQ T3
TH (rat) _____MPTPSAPsPQ T3
TH (cow) _____MPTPNAASPQ T3
S8-p
MPTPSAPsPQPKGFR
Upstream
Downstream
5 1
Effects on Modified Protein
  • protein stabilization
Kinase, in vitro:
  • ERK2 (human)
  • ERK2 (rat)
Treatment
  • colforsin
  • depolarization
  • EGF
  • electrical_stimulation
  • okadaic_acid
  • PDGF
  • phorbol_ester
TH (human) MPtPDATTPQAKGFR T8
TH iso2 (human) MPTPDATTPQAKGFR T8
TH iso3 (human) MPTPDATTPQAKGFR T8
TH iso4 (human) MPTPDATTPQAKGFR T8
TH (mouse) MPTPSASSPQPKGFR S8
TH (rat) MPTPSAPsPQPKGFR S8-p
TH (cow) MPTPNAASPQAKGFR S8
S19-p
KGFRRAVsEQDAKQA
Upstream
Downstream
46 13
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Kinase, in vitro:
  • CAMK1A (human)
  • CAMK2A (rat)
Phosphatases, in vitro:
  • PPP2CB (rat)
Putative upstream phosphatases:
  • PPP2CB (rat)
Regulatory protein:
  • GFRA1 (rat)
  • GLT1 (rat)
Treatment
  • A23187
  • angiotensin
  • apomorphine
  • APV
  • Ba(2+)
  • bradykinin
  • butyrolactone
  • CHIR99021
  • cocaine
  • colforsin
  • depolarization
  • DHPG
  • Dihydrokainic acid
  • EGF
  • EGTA
  • electrical_stimulation
  • eticlopride
  • GDNF
  • genistein
  • glutamic acid
  • insulin
  • lithium
  • LPS
  • nerve_damage
  • nicotine
  • NMDA
  • NSD-1015
  • okadaic_acid
  • PD98059
  • phorbol_ester
  • PRL
  • quinpirole
  • Time
  • veratridine
TH (human) KGFRRAVsELDAKQA S19-p
TH iso2 (human) KGFRRAVsELDAKQA S19-p
TH iso3 (human) KGFRRAVsELDAKQA S19-p
TH iso4 (human) KGFRRAVsELDAKQA S19-p
TH (mouse) KGFRRAVsEQDtKQA S19-p
TH (rat) KGFRRAVsEQDAKQA S19-p
TH (cow) KGFRRAVsELDAKQA S19-p
A23
RAVsEQDAKQAEAVt
0 1
TH (human) RAVsELDAKQAEAIM A23
TH iso2 (human) RAVsELDAKQAEAIM A23
TH iso3 (human) RAVsELDAKQAEAIM A23
TH iso4 (human) RAVsELDAKQAEAIM A23
TH (mouse) RAVsEQDtKQAEAVt T23-p
TH (rat) RAVsEQDAKQAEAVt A23
TH (cow) RAVsELDAKQAEAIM A23
T30-p
AKQAEAVtsPRFIGR
1 2
TH (human) AKQAEAIMVRGQGAP M30
TH iso2 (human) AKQAEAIMGAPGPSL M30
TH iso3 (human) AKQAEAIMsPRFIGR M30
TH iso4 (human) AKQAEAIMVRGQsPR M30
TH (mouse) tKQAEAVtsPRFIGR T30-p
TH (rat) AKQAEAVtsPRFIGR T30-p
TH (cow) AKQAEAIMsPRFVGR M30
S31-p
KQAEAVtsPRFIGRR
Upstream
Downstream
43 8
TH (mouse)
S31-p
TH (rat)
S31-p
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK1 (rat)
  • ERK2 (human)
  • ERK2 (mouse)
  • ERK2 (rat)
Phosphatases, in vitro:
  • PPP2CB (rat)
Putative in vivo kinases:
  • CDK5 (rat)
  • ERK1 (rat)
  • ERK2 (rat)
  • MEK1 (rat)
  • PKCB (rat)
Putative upstream phosphatases:
  • PPP2CB (rat)
Regulatory protein:
  • GFRA1 (rat)
Treatment
  • A23187
  • angiotensin
  • apomorphine
  • ATP
  • Ba(2+)
  • bradykinin
  • butyrolactone
  • CHIR99021
  • cocaine
  • colforsin
  • depolarization
  • EGF
  • electrical_stimulation
  • GDNF
  • genistein
  • haloperidol
  • insulin
  • lithium
  • LPS
  • muscarine
  • nerve_damage
  • NGF
  • NSD-1015
  • okadaic_acid
  • olomoucine
  • PD98059
  • PDGF
  • phorbol_ester
  • PRL
  • quinpirole
  • rottlerin
  • seliciclib
  • t-Bu2BHQ
  • thapsigargin
  • Time
  • U0126
TH (human) SYTPTPRsPRFIGRR S62-p
TH iso2 (human) SYTPTPRsPRFIGRR S58-p
TH iso3 (human) KQAEAIMsPRFIGRR S31-p
TH iso4 (human) AIMVRGQsPRFIGRR S35-p
TH (mouse) KQAEAVtsPRFIGRR S31-p
TH (rat) KQAEAVtsPRFIGRR S31-p
TH (cow) KQAEAIMsPRFVGRR S31-p
S40-p
RFIGRRQsLIEDARK
Upstream
Downstream
62 17
TH (human)
S71-p
TH iso2 (human)
S67-p
TH iso3 (human)
S40-p
TH iso4 (human)
S44-p
TH (mouse)
S40-p
TH (rat)
S40-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Kinase, in vitro:
  • CAMK1A (human)
  • CAMK2A (rat)
  • PKACA (human)
  • PKACA (rat)
  • PKCA (human)
Phosphatases, in vitro:
  • PPP2CA (rat)
  • PPP2CB (rat)
  • PPPM1A (human)
Putative in vivo kinases:
  • PKACA (rat)
Putative upstream phosphatases:
  • PPP2CA (mouse)
  • PPP2CB (rat)
Regulatory protein:
  • GFRA1 (rat)
Treatment
  • angiotensin
  • apomorphine
  • ATP
  • bradykinin
  • butyrolactone
  • caffeine
  • cAMP_analog
  • CHIR99021
  • cocaine
  • colforsin
  • depolarization
  • EGF
  • electrical_stimulation
  • eticlopride
  • food deprivation
  • GDNF
  • genistein
  • high-fat diet
  • hypoxia
  • insulin
  • KN-62
  • leptin
  • levamfetamine
  • lithium
  • LPS
  • muscarine
  • nerve_damage
  • neurotensin
  • NGF
  • NMDA
  • NSD-1015
  • okadaic_acid
  • PD98059
  • phorbol_ester
  • PKI
  • PRL
  • quinpirole
  • Ro-20-1724
  • rottlerin
  • secretin human
  • somatostatin
  • substance_P
  • t-Bu2BHQ
  • thapsigargin
  • Theophylline
  • Time
  • VIP
TH (human) RFIGRRQsLIEDARK S71-p
TH iso2 (human) RFIGRRQsLIEDARK S67-p
TH iso3 (human) RFIGRRQsLIEDARK S40-p
TH iso4 (human) RFIGRRQsLIEDARK S44-p
TH (mouse) RFIGRRQsLIEDARK S40-p
TH (rat) RFIGRRQsLIEDARK S40-p
TH (cow) RFVGRRQsLIQDARK S40-p
S88
AVLNLLFSLRGTKPS
0 1
TH (human) AVLNLLFsPRATKPS S118-p
TH iso2 (human) AVLNLLFSPRATKPS S114
TH iso3 (human) AVLNLLFSPRATKPS S87
TH iso4 (human) AVLNLLFSPRATKPS S91
TH (mouse) AVLNLLFSLRGTKPS S88
TH (rat) AVLNLLFSLRGTKPS S88
TH (cow) AVLTLLFALPPTRPP A81
S153-p
LSSVRRVsDDVRSAR
Upstream
1 0
Kinase, in vitro:
  • PKACA (human)
TH (human) LSGVRQVSEDVRSPA S183
TH iso2 (human) LSGVRQVSEDVRSPA S179
TH iso3 (human) LSGVRQVSEDVRSPA S152
TH iso4 (human) LSGVRQVSEDVRSPA S156
TH (mouse) LSSVRRVSDDVRSAR S153
TH (rat) LSSVRRVsDDVRSAR S153-p
TH (cow) LSALRRVAEDVRAAG A146
Y200
PGFSDQVYRQRRKLI
0 1
TH (human) PGFSDQVyRQRRKLI Y230-p
TH iso2 (human) PGFSDQVYRQRRKLI Y226
TH iso3 (human) PGFSDQVYRQRRKLI Y199
TH iso4 (human) PGFSDQVYRQRRKLI Y203
TH (mouse) PGFSDQAYRQRRKLI Y200
TH (rat) PGFSDQVYRQRRKLI Y200
TH (cow) PGFSDQAYRQRRKLI Y193
Y389
QNGELKAYGAGLLSS
0 1
TH (human) QNGEVKAyGAGLLSS Y419-p
TH iso2 (human) QNGEVKAYGAGLLSS Y415
TH iso3 (human) QNGEVKAYGAGLLSS Y388
TH iso4 (human) QNGEVKAYGAGLLSS Y392
TH (mouse) QNGELKAYGAGLLSS Y389
TH (rat) QNGELKAYGAGLLSS Y389
TH (cow) QNGEVKAYGAGLLSS Y382
S405
GELLHSLSEEPEVRA
1 0
TH (human) GELLHCLSEEPEIRA S435
TH iso2 (human) GELLHCLSEEPEIRA S431
TH iso3 (human) GELLHCLsEEPEIRA S404-p
TH iso4 (human) GELLHCLSEEPEIRA S408
TH (mouse) GELLHSLSEEPEVRA S405
TH (rat) GELLHSLSEEPEVRA S405
TH (cow) GELLHSLSEEPEIRA S398
S472-p
LAIDVLDsPHTIQRS
Upstream
0 4
Treatment
  • PDGF
TH (human) LAIDVLDsPQAVRRS S502-p
TH iso2 (human) LAIDVLDSPQAVRRS S498
TH iso3 (human) LAIDVLDSPQAVRRS S471
TH iso4 (human) LAIDVLDSPQAVRRS S475
TH (mouse) LAIDVLDsPHTIRRS S472-p
TH (rat) LAIDVLDsPHTIQRS S472-p
TH (cow) LAIDVLDSPHAIRHA S465
-
gap
1 0
TH (human) GQGAPGPsLTGSPWP S40-p
TH iso2 (human) IMGAPGPSLTGSPWP S36
TH iso3 (human) gap -
TH iso4 (human) gap -
TH (mouse) gap -
TH (rat) gap -
TH (cow) gap -