Other Species / Isoforms
  Bcl-2 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y9
AQAGRTGYDNREIVM
0 1
Bcl-2 (human) AHAGRTGyDNREIVM Y9-p
Bcl-2 (mouse) AQAGRTGYDNREIVM Y9
Bcl-2 (rat) AQAGRTGYDNREIVM Y9
K17
DNREIVMKYIHYKLS
1 0
Bcl-2 (human) DNREIVMkYIHYkLS K17-ub
Bcl-2 (mouse) DNREIVMKYIHYKLS K17
Bcl-2 (rat) DNREIVMKYIHYKLs K17
K22
VMKYIHYKLSQRGYE
1 1
Bcl-2 (human) VMkYIHYkLSQRGYE K22-ub
Bcl-2 (mouse) VMKYIHYKLSQRGYE K22
Bcl-2 (rat) VMKYIHYKLsQRGYE K22
S24
KYIHYKLSQRGYEWD
1 0
Bcl-2 (human) kYIHYkLSQRGYEWD S24
Bcl-2 (mouse) KYIHYKLSQRGYEWD S24
Bcl-2 (rat) KYIHYKLsQRGYEWD S24-p
N56
FSFQPESNPMPAVHR
12 1
Bcl-2 (human)
T56-p
Bcl-2 (human) FSSQPGHtPHPAASR T56-p
Bcl-2 (mouse) FSFQPESNPMPAVHR N56
Bcl-2 (rat) FSFQPESNRTPAVHR N56
T69-p
HRDMAARtsPLRPLV
Downstream
11 0
Effects on Modified Protein
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, inhibited
  • autophagy, induced
  • cell cycle regulation
Bcl-2 (human) SRDPVARtsPLQtPA T69-p
Bcl-2 (mouse) HRDMAARtsPLRPLV T69-p
Bcl-2 (rat) HRDTAARTsPLRPLV T69
S70-p
RDMAARtsPLRPLVA
Upstream
Downstream
50 1
Bcl-2 (human)
S70-p
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, inhibited
  • autophagy, induced
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, induced
Kinase, in vitro:
  • CDK5 (mouse)
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
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Phosphatases, in vitro:
  • PPP2CA (mouse)
Putative in vivo kinases:
  • CDK5 (mouse)
  • ERK1 (human)
  • ERK1 (mouse)
  • ERK2 (human)
  • ERK2 (mouse)
  • JNK1 (human)
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Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • FGF18 (mouse)
  • TNFSF11 (human)
Treatment
  • 3-piperidinylethoxypterocarpan
  • anisomycin
  • aurintricarboxylic_acid
  • bryostatin_1
  • C2-ceramide
  • curcumin
  • etoposide
  • IL-3
  • IL-3_withdrawal
  • lithium
  • okadaic_acid
  • PD98059
  • SP600125
  • staurosporine
  • U0126
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Bcl-2 (human) RDPVARtsPLQtPAA S70-p
Bcl-2 (mouse) RDMAARtsPLRPLVA S70-p
Bcl-2 (rat) RDTAARTsPLRPLVA S70-p
P74
ARtsPLRPLVATAGP
4 0
Bcl-2 (human) ARtsPLQtPAAPGAA T74-p
Bcl-2 (mouse) ARtsPLRPLVATAGP P74
Bcl-2 (rat) ARTsPLRPLVANAGP P74
S84-p
ATAGPALsPVPPVVH
Upstream
Downstream
22 1
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • autophagy, induced
  • cell cycle regulation
Regulatory protein:
  • TNFSF11 (human)
Bcl-2 (human) AAAGPALsPVPPVVH S87-p
Bcl-2 (mouse) ATAGPALsPVPPVVH S84-p
Bcl-2 (rat) ANAGPALsPVPPVVH S84-p
Y232
ACITLGAYLGHK___
0 1
Bcl-2 (human) ACITLGAyLGHK___ Y235-p
Bcl-2 (mouse) ACITLGAYLGHK___ Y232
Bcl-2 (rat) ACITLGAYLGHK___ Y232