|
Y23
|
VFDVGPRYTNLSYIG
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
VFDVGPRyTNLsYIG
|
Y25-p
|
|
ERK2 (mouse)
|
VFDVGPRYTNLSYIG
|
Y23
|
|
ERK2 (rat)
|
VFDVGPRYTNLsyIG
|
Y23
|
|
ERK2 (chicken)
|
VFDVGPRYTNLSYIG
|
Y33
|
|
ERK2 (cow)
|
VFDVGPRYTNLSYIG
|
Y25
|
|
|
S27
|
GPRYTNLSYIGEGAY
|
|
|
1
|
0
|
|
|
ERK2 (human)
|
GPRyTNLsYIGEGAy
|
S29-p
|
|
ERK2 (mouse)
|
GPRYTNLSYIGEGAY
|
S27
|
|
ERK2 (rat)
|
GPRYTNLsyIGEGAY
|
S27-p
|
|
ERK2 (chicken)
|
GPRYTNLSYIGEGAY
|
S37
|
|
ERK2 (cow)
|
GPRYTNLSYIGEGAY
|
S29
|
|
|
Y28
|
PRYTNLSYIGEGAYG
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
PRyTNLsYIGEGAyG
|
Y30
|
|
ERK2 (mouse)
|
PRYTNLSYIGEGAYG
|
Y28
|
|
ERK2 (rat)
|
PRYTNLsyIGEGAYG
|
Y28-p
|
|
ERK2 (chicken)
|
PRYTNLSYIGEGAYG
|
Y38
|
|
ERK2 (cow)
|
PRYTNLSYIGEGAYG
|
Y30
|
|
|
Y34
|
SYIGEGAYGMVCSAY
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
sYIGEGAyGMVCSAy
|
Y36-p
|
|
ERK2 (mouse)
|
SYIGEGAYGMVCSAY
|
Y34
|
|
ERK2 (rat)
|
syIGEGAYGMVCSAy
|
Y34
|
|
ERK2 (chicken)
|
SYIGEGAYGMVCSAY
|
Y44
|
|
ERK2 (cow)
|
SYIGEGAYGMVCSAY
|
Y36
|
|
|
Y41
|
YGMVCSAYDNLNKVR
|
|
|
0
|
7
|
|
|
ERK2 (human)
|
yGMVCSAyDNVNKVR
|
Y43-p
|
|
ERK2 (mouse)
|
YGMVCSAYDNLNKVR
|
Y41
|
|
ERK2 (rat)
|
YGMVCSAyDNLNKVR
|
Y41-p
|
|
ERK2 (chicken)
|
YGMVCSAYDNVNKVR
|
Y51
|
|
ERK2 (cow)
|
YGMVCSAYDNVNKVR
|
Y43
|
|
|
K53
|
KVRVAIKKISPFEHQ
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
KVRVAIKkISPFEHQ
|
K55-ub
|
|
ERK2 (mouse)
|
KVRVAIKKISPFEHQ
|
K53
|
|
ERK2 (rat)
|
KVRVAIKKISPFEHQ
|
K53
|
|
ERK2 (chicken)
|
KVRVAIKKISPFEHQ
|
K63
|
|
ERK2 (cow)
|
KVRVAIKKISPFEHQ
|
K55
|
|
|
K97
|
APTIEQMKDVYIVQD
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
APTIEQMkDVYIVQD
|
K99-ub
|
|
ERK2 (mouse)
|
APTIEQMKDVYIVQD
|
K97
|
|
ERK2 (rat)
|
APTIEQMKDVYIVQD
|
K97
|
|
ERK2 (chicken)
|
APTIEQMKDVYIVQD
|
K107
|
|
ERK2 (cow)
|
APTIEQMKDVYIVQD
|
K99
|
|
|
Y111
|
DLMETDLYKLLKTQH
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
DLMETDLyKLLKTQH
|
Y113-p
|
|
ERK2 (mouse)
|
DLMETDLYKLLKTQH
|
Y111
|
|
ERK2 (rat)
|
DLMETDLYKLLKTQH
|
Y111
|
|
ERK2 (chicken)
|
DLMETDLYKLLKTQH
|
Y121
|
|
ERK2 (cow)
|
DLMETDLYKLLKTQH
|
Y113
|
|
|
S140
|
RGLKYIHSANVLHRD
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
RGLKYIHsANVLHRD
|
S142-p
|
|
ERK2 (mouse)
|
RGLKYIHSANVLHRD
|
S140
|
|
ERK2 (rat)
|
RGLKYIHSANVLHRD
|
S140
|
|
ERK2 (chicken)
|
RGLKYIHSANVLHRD
|
S150
|
|
ERK2 (cow)
|
RGLKYIHSANVLHRD
|
S142
|
|
|
K149-ub
|
NVLHRDLkPSNLLLN
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
NVLHRDLkPSNLLLN
|
K151-ub
|
|
ERK2 (mouse)
|
NVLHRDLkPSNLLLN
|
K149-ub
|
|
ERK2 (rat)
|
NVLHRDLKPSNLLLN
|
K149
|
|
ERK2 (chicken)
|
NVLHRDLKPSNLLLN
|
K159
|
|
ERK2 (cow)
|
NVLHRDLKPSNLLLN
|
K151
|
|
|
K162
|
LNTTCDLKICDFGLA
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
LNTTCDLkICDFGLA
|
K164-ub
|
|
ERK2 (mouse)
|
LNTTCDLKICDFGLA
|
K162
|
|
ERK2 (rat)
|
LNTTCDLKICDFGLA
|
K162
|
|
ERK2 (chicken)
|
LNTTCDLKICDFGLA
|
K172
|
|
ERK2 (cow)
|
LNTTCDLKICDFGLA
|
K164
|
|
|
T179-p
|
ADPDHDHtGFLtEyV
|
Upstream
|
|
3
|
51
|
|
|
|
|
ERK2 (human)
|
ADPDHDHtGFLtEyV
|
T181-p
|
|
ERK2 (mouse)
|
ADPDHDHtGFLtEyV
|
T179-p
|
|
ERK2 (rat)
|
ADPDHDHtGFLtEyV
|
T179-p
|
|
ERK2 (chicken)
|
ADPDHDHTGFLTEYV
|
T189
|
|
ERK2 (cow)
|
ADPDHDHTGFLtEyV
|
T181
|
|
|
T183-p
|
HDHtGFLtEyVAtRW
|
Upstream
|
Downstream
|
1098
|
2523
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- intracellular localization
|
|
Effects on Biological Processes:
- apoptosis, inhibited
- carcinogenesis, induced
- carcinogenesis, inhibited
- cell growth, inhibited
- cytoskeletal reorganization
- neural plasticity
- signaling pathway regulation
- transcription, altered
- transcription, induced
|
|
|
Kinase, in vitro:
- MEK1 (human)
- MEK1 (mouse)
- MEK1 (rabbit)
- MEK1 (rat)
|
|
Putative in vivo kinases:
- MEK1 (human)
- MEK1 (mouse)
|
|
Putative upstream phosphatases:
|
|
Regulatory protein:
|
|
Treatment
|
|
|
ERK2 (human)
|
HDHtGFLtEyVAtRW
|
T185-p
|
|
ERK2 (mouse)
|
HDHtGFLtEyVAtRW
|
T183-p
|
|
ERK2 (rat)
|
HDHtGFLtEyVAtRW
|
T183-p
|
|
ERK2 (chicken)
|
HDHTGFLTEYVATRW
|
T193
|
|
ERK2 (cow)
|
HDHTGFLtEyVATRW
|
T185-p
|
|
|
Y185-p
|
HtGFLtEyVAtRWYR
|
Upstream
|
Downstream
|
1121
|
4135
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- intracellular localization
|
|
Effects on Biological Processes:
- apoptosis, inhibited
- carcinogenesis, induced
- carcinogenesis, inhibited
- cell growth, inhibited
- cytoskeletal reorganization
- neural plasticity
- signaling pathway regulation
- transcription, altered
- transcription, induced
|
|
|
Kinase, in vitro:
- ERK2 (mouse)
- ERK2 (rat)
- Lck (mouse)
- MEK1 (human)
- MEK1 (mouse)
- MEK1 (rabbit)
- MEK1 (rat)
|
|
Putative in vivo kinases:
- MEK1 (human)
- MEK1 (mouse)
|
|
Putative upstream phosphatases:
|
|
Regulatory protein:
|
|
Treatment
|
|
|
ERK2 (human)
|
HtGFLtEyVAtRWyR
|
Y187-p
|
|
ERK2 (mouse)
|
HtGFLtEyVAtRWYR
|
Y185-p
|
|
ERK2 (rat)
|
HtGFLtEyVAtRWYR
|
Y185-p
|
|
ERK2 (chicken)
|
HTGFLTEYVATRWYR
|
Y195
|
|
ERK2 (cow)
|
HTGFLtEyVATRWYR
|
Y187-p
|
|
|
T188-p
|
FLtEyVAtRWYRAPE
|
Upstream
|
Downstream
|
3
|
34
|
|
|
Effects on Modified Protein
- intracellular localization
|
|
Effects on Biological Processes:
- cell growth, altered
- cytoskeletal reorganization
|
|
|
|
|
ERK2 (human)
|
FLtEyVAtRWyRAPE
|
T190-p
|
|
ERK2 (mouse)
|
FLtEyVAtRWYRAPE
|
T188-p
|
|
ERK2 (rat)
|
FLtEyVAtRWYRAPE
|
T188-p
|
|
ERK2 (chicken)
|
FLTEYVATRWYRAPE
|
T198
|
|
ERK2 (cow)
|
FLtEyVATRWYRAPE
|
T190
|
|
|
Y191
|
EyVAtRWYRAPEIML
|
|
|
0
|
5
|
|
|
ERK2 (human)
|
EyVAtRWyRAPEIML
|
Y193-p
|
|
ERK2 (mouse)
|
EyVAtRWYRAPEIML
|
Y191
|
|
ERK2 (rat)
|
EyVAtRWYRAPEIML
|
Y191
|
|
ERK2 (chicken)
|
EYVATRWYRAPEIML
|
Y201
|
|
ERK2 (cow)
|
EyVATRWYRAPEIML
|
Y193
|
|
|
K201-ub
|
PEIMLNSkGYTKSID
|
|
|
0
|
7
|
|
|
ERK2 (human)
|
PEIMLNSkGytKSID
|
K203-ub
|
|
ERK2 (mouse)
|
PEIMLNSkGYTKSID
|
K201-ub
|
|
ERK2 (rat)
|
PEIMLNSKGytKSID
|
K201
|
|
ERK2 (chicken)
|
PEIMLNSKGYTKSID
|
K211
|
|
ERK2 (cow)
|
PEIMLNSKGYTKSID
|
K203
|
|
|
Y203
|
IMLNSkGYTKSIDIW
|
|
|
1
|
1
|
|
|
ERK2 (human)
|
IMLNSkGytKSIDIW
|
Y205-p
|
|
ERK2 (mouse)
|
IMLNSkGYTKSIDIW
|
Y203
|
|
ERK2 (rat)
|
IMLNSKGytKSIDIW
|
Y203-p
|
|
ERK2 (chicken)
|
IMLNSKGYTKSIDIW
|
Y213
|
|
ERK2 (cow)
|
IMLNSKGYTKSIDIW
|
Y205
|
|
|
T204
|
MLNSkGYTKSIDIWS
|
|
|
1
|
1
|
|
|
ERK2 (human)
|
MLNSkGytKSIDIWS
|
T206-p
|
|
ERK2 (mouse)
|
MLNSkGYTKSIDIWS
|
T204
|
|
ERK2 (rat)
|
MLNSKGytKSIDIWS
|
T204-p
|
|
ERK2 (chicken)
|
MLNSKGYTKSIDIWS
|
T214
|
|
ERK2 (cow)
|
MLNSKGYTKSIDIWS
|
T206
|
|
|
S244
|
HILGILGSPSQEDLN
|
|
|
2
|
1
|
|
|
ERK2 (human)
|
HILGILGsPsQEDLN
|
S246-p
|
|
ERK2 (mouse)
|
HILGILGSPSQEDLN
|
S244
|
|
ERK2 (rat)
|
HILGILGSPSQEDLN
|
S244
|
|
ERK2 (chicken)
|
HILGILGSPSQEDLN
|
S254
|
|
ERK2 (cow)
|
HILGILGSPSQEDLN
|
S246
|
|
|
S246
|
LGILGSPSQEDLNCI
|
|
|
2
|
0
|
|
|
ERK2 (human)
|
LGILGsPsQEDLNCI
|
S248-p
|
|
ERK2 (mouse)
|
LGILGSPSQEDLNCI
|
S246
|
|
ERK2 (rat)
|
LGILGSPSQEDLNCI
|
S246
|
|
ERK2 (chicken)
|
LGILGSPSQEDLNCI
|
S256
|
|
ERK2 (cow)
|
LGILGSPSQEDLNCI
|
S248
|
|
|
K257-ub
|
LNCIINLkARNYLLS
|
|
|
0
|
2
|
|
|
ERK2 (human)
|
LNCIINLkARNyLLS
|
K259-ub
|
|
ERK2 (mouse)
|
LNCIINLkARNYLLS
|
K257-ub
|
|
ERK2 (rat)
|
LNCIINLKARNYLLS
|
K257
|
|
ERK2 (chicken)
|
LNCIINLKARNYLLS
|
K267
|
|
ERK2 (cow)
|
LNCIINLKARNYLLS
|
K259
|
|
|
Y261
|
INLkARNYLLSLPHK
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
INLkARNyLLSLPHk
|
Y263-p
|
|
ERK2 (mouse)
|
INLkARNYLLSLPHK
|
Y261
|
|
ERK2 (rat)
|
INLKARNYLLSLPHK
|
Y261
|
|
ERK2 (chicken)
|
INLKARNYLLSLPHK
|
Y271
|
|
ERK2 (cow)
|
INLKARNYLLSLPHK
|
Y263
|
|
|
K268
|
YLLSLPHKNKVPWNR
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
yLLSLPHkNkVPWNR
|
K270-ub
|
|
ERK2 (mouse)
|
YLLSLPHKNKVPWNR
|
K268
|
|
ERK2 (rat)
|
YLLSLPHKNKVPWNR
|
K268
|
|
ERK2 (chicken)
|
YLLSLPHKNKVPWNR
|
K278
|
|
ERK2 (cow)
|
YLLSLPHKNKVPWNR
|
K270
|
|
|
K270
|
LSLPHKNKVPWNRLF
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
LSLPHkNkVPWNRLF
|
K272-ub
|
|
ERK2 (mouse)
|
LSLPHKNKVPWNRLF
|
K270
|
|
ERK2 (rat)
|
LSLPHKNKVPWNRLF
|
K270
|
|
ERK2 (chicken)
|
LSLPHKNKVPWNRLF
|
K280
|
|
ERK2 (cow)
|
LSLPHKNKVPWNRLF
|
K272
|
|
|
S282
|
RLFPNADSKALDLLD
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
RLFPNADskALDLLD
|
S284-p
|
|
ERK2 (mouse)
|
RLFPNADSKALDLLD
|
S282
|
|
ERK2 (rat)
|
RLFPNADSkALDLLD
|
S282
|
|
ERK2 (chicken)
|
RLFPNADPKALDLLD
|
P292
|
|
ERK2 (cow)
|
RLFPNADSKALDLLD
|
S284
|
|
|
K283
|
LFPNADSKALDLLDK
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
LFPNADsKALDLLDk
|
K285
|
|
ERK2 (mouse)
|
LFPNADSKALDLLDK
|
K283
|
|
ERK2 (rat)
|
LFPNADSkALDLLDk
|
K283-ac
|
|
ERK2 (chicken)
|
LFPNADPKALDLLDK
|
K293
|
|
ERK2 (cow)
|
LFPNADSKALDLLDK
|
K285
|
|
|
K283
|
LFPNADSKALDLLDK
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
LFPNADskALDLLDk
|
K285-ub
|
|
ERK2 (mouse)
|
LFPNADSKALDLLDK
|
K283
|
|
ERK2 (rat)
|
LFPNADSKALDLLDk
|
K283
|
|
ERK2 (chicken)
|
LFPNADPKALDLLDK
|
K293
|
|
ERK2 (cow)
|
LFPNADSKALDLLDK
|
K285
|
|
|
K290
|
KALDLLDKMLTFNPH
|
|
|
0
|
3
|
|
|
ERK2 (human)
|
kALDLLDkMLTFNPH
|
K292-ub
|
|
ERK2 (mouse)
|
KALDLLDKMLTFNPH
|
K290
|
|
ERK2 (rat)
|
kALDLLDKMLTFNPH
|
K290
|
|
ERK2 (chicken)
|
KALDLLDKMLTFNPH
|
K300
|
|
ERK2 (cow)
|
KALDLLDKMLTFNPH
|
K292
|
|
|
K290
|
KALDLLDKMLTFNPH
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
kALDLLDKMLTFNPH
|
K292
|
|
ERK2 (mouse)
|
KALDLLDKMLTFNPH
|
K290
|
|
ERK2 (rat)
|
kALDLLDkMLTFNPH
|
K290-ac
|
|
ERK2 (chicken)
|
KALDLLDKMLTFNPH
|
K300
|
|
ERK2 (cow)
|
KALDLLDKMLTFNPH
|
K292
|
|
|
K328
|
PIAEAPFKFDMELDD
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
PIAEAPFkFDMELDD
|
K330-ub
|
|
ERK2 (mouse)
|
PIAEAPFKFDMELDD
|
K328
|
|
ERK2 (rat)
|
PIAEAPFKFDMELDD
|
K328
|
|
ERK2 (chicken)
|
PVAEAPFKFDMELDD
|
K338
|
|
ERK2 (cow)
|
PVAEAPFKFDMELDD
|
K330
|
|
|
K338
|
MELDDLPKEKLKELI
|
|
|
0
|
1
|
|
|
ERK2 (human)
|
MELDDLPkEKLkELI
|
K340-ub
|
|
ERK2 (mouse)
|
MELDDLPKEKLKELI
|
K338
|
|
ERK2 (rat)
|
MELDDLPKEKLKELI
|
K338
|
|
ERK2 (chicken)
|
MELDDLPKEKLKELI
|
K348
|
|
ERK2 (cow)
|
MELDDLPKEKLKELI
|
K340
|
|
|
K342
|
DLPKEKLKELIFEET
|
|
|
0
|
4
|
|
|
ERK2 (human)
|
DLPkEKLkELIFEET
|
K344-ub
|
|
ERK2 (mouse)
|
DLPKEKLKELIFEET
|
K342
|
|
ERK2 (rat)
|
DLPKEKLKELIFEET
|
K342
|
|
ERK2 (chicken)
|
DLPKEKLKELIFEET
|
K352
|
|
ERK2 (cow)
|
DLPKEKLKELIFEET
|
K344
|
|
|
S358-p
|
RFQPGYRs_______
|
|
|
0
|
4
|
|
|
ERK2 (human)
|
RFQPGYRs_______
|
S360-p
|
|
ERK2 (mouse)
|
RFQPGYRs_______
|
S358-p
|
|
ERK2 (rat)
|
RFQPGYRS_______
|
S358
|
|
ERK2 (chicken)
|
RFQPGYRS_______
|
S368
|
|
ERK2 (cow)
|
RFQPGYRS_______
|
S360
|
|
