Other Species / Isoforms
  CREB (rat)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K91-ac
QTVQSSCkDLkRLFS
Downstream
1 0
Effects on Biological Processes:
  • transcription, inhibited
CREB (human) gap -
CREB iso1 (human) QTVQSSCKDLKRLFs K91
CREB (mouse) gap -
CREB iso1 (mouse) QTVQSSCKDLKRLFs K91
CREB (rat) QTVQSSCkDLkRLFS K91-ac
K94-ac
QSSCkDLkRLFSGTQ
Downstream
1 0
Effects on Biological Processes:
  • transcription, inhibited
CREB (human) gap -
CREB iso1 (human) QSSCKDLKRLFsGtQ K94
CREB (mouse) gap -
CREB iso1 (mouse) QSSCKDLKRLFsGtQ K94
CREB (rat) QSSCkDLkRLFSGTQ K94-ac
S98
kDLkRLFSGTQISTI
2 0
CREB (human) gap -
CREB iso1 (human) KDLKRLFsGtQISTI S98-p
CREB (mouse) gap -
CREB iso1 (mouse) KDLKRLFsGtQISTI S98-p
CREB (rat) kDLkRLFSGTQISTI S98
T100
LkRLFSGTQISTIAE
3 0
CREB (human) gap -
CREB iso1 (human) LKRLFsGtQISTIAE T100-p
CREB (mouse) gap -
CREB iso1 (mouse) LKRLFsGtQISTIAE T100-p
CREB (rat) LkRLFSGTQISTIAE T100
S108-p
QISTIAEsEDsQEsV
Upstream
8 3
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • okadaic_acid
CREB (human) QISTIAEsEDsQEsV S94-p
CREB iso1 (human) QISTIAEsEDsQEsV S108-p
CREB (mouse) QISTIAEsEDsQEsV S94-p
CREB iso1 (mouse) QISTIAESEDSQESV S108
CREB (rat) QISTIAEsEDsQEsV S108-p
S111-p
TIAEsEDsQEsVDsV
Upstream
Downstream
9 6
Effects on Biological Processes:
  • transcription, altered
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • okadaic_acid
CREB (human) TIAEsEDsQEsVDsV S97-p
CREB iso1 (human) TIAEsEDsQEsVDsV S111-p
CREB (mouse) TIAEsEDsQEsVDsV S97-p
CREB iso1 (mouse) TIAESEDSQESVDSV S111
CREB (rat) TIAEsEDsQEsVDsV S111-p
S114-p
EsEDsQEsVDsVtDs
Upstream
Downstream
8 2
Effects on Biological Processes:
  • transcription, altered
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • okadaic_acid
CREB (human) EsEDsQEsVDsVtDs S100-p
CREB iso1 (human) EsEDsQEsVDsVTDs S114-p
CREB (mouse) EsEDsQEsVDsVTDs S100-p
CREB iso1 (mouse) ESEDSQESVDSVTDS S114
CREB (rat) EsEDsQEsVDsVtDs S114-p
S117-p
DsQEsVDsVtDsQKR
Downstream
5 0
Effects on Modified Protein
  • protein degradation
CREB (human) DsQEsVDsVtDsQKR S103-p
CREB iso1 (human) DsQEsVDsVTDsQKR S117-p
CREB (mouse) DsQEsVDsVTDsQKR S103-p
CREB iso1 (mouse) DSQESVDSVTDSQKR S117
CREB (rat) DsQEsVDsVtDsQKR S117-p
T119-p
QEsVDsVtDsQKRRE
1 1
CREB (human) QEsVDsVtDsQKRRE T105-p
CREB iso1 (human) QEsVDsVTDsQKRRE T119
CREB (mouse) QEsVDsVTDsQKRRE T105
CREB iso1 (mouse) QESVDSVTDSQKRRE T119
CREB (rat) QEsVDsVtDsQKRRE T119-p
S121-p
sVDsVtDsQKRREIL
Downstream
12 0
Effects on Modified Protein
  • protein degradation
CREB (human) sVDsVtDsQKRREIL S107-p
CREB iso1 (human) sVDsVTDsQKRREIL S121-p
CREB (mouse) sVDsVTDsQKRREIL S107-p
CREB iso1 (mouse) SVDSVTDSQKRREIL S121
CREB (rat) sVDsVtDsQKRREIL S121-p
S129-p
QKRREILsRRPsYRk
Upstream
Downstream
11 2
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • CK2A1 (human)
  • GSK3A (rat)
  • GSK3B (rat)
  • PKACA (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • EGF
  • H-89
  • insulin
  • PD98059
  • PTH
  • SB203580
CREB (human) QKRREILsRRPsyRk S115-p
CREB iso1 (human) QKRREILsRRPsyRK S129-p
CREB (mouse) QKRREILsRRPsyRk S115-p
CREB iso1 (mouse) QKRREILSRRPSYRK S129
CREB (rat) QKRREILsRRPsYRk S129-p
S133-p
EILsRRPsYRkILND
Upstream
Downstream
262 65
CREB (human)
S119-p
CREB (mouse)
S119-p
CREB (rat)
S133-p
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • cell growth, altered
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
  • CAMK1A (rat)
  • CAMK2A (human)
  • CAMK2A (mouse)
  • CAMK2A (rat)
  • CAMK4 (mouse)
  • GSK3A (rat)
  • MAPKAPK2 (human)
  • MSK1 (human)
  • p90RSK (rat)
  • PKACA (human)
  • PKACA (rat)
  • SGK1 (human)
Phosphatases, in vitro:
  • PPP1CA (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Btk (human)
  • CAMK2A (human)
  • CAMK2A (mouse)
  • CAMK4 (human)
  • CAMK4 (mouse)
  • PKACA (human)
  • PKACA (rat)
  • RSK2 (human)
  • SGK1 (human)
Regulatory protein:
  • AKAP5 (human)
  • CACNA1D (rat)
  • PKCA (rat)
  • PKCD (rat)
  • PKCE (rat)
  • PRKD1 (rat)
  • Rab7 (rat)
Treatment
  • 1-methoxyoctadecan-1-ol
  • 4-AP
  • 8-Rp-cAMP
  • A23187
  • ACTH
  • AG1478
  • AG825
  • angiotensin_2
  • anti-CD28
  • anti-CD3
  • anti-CD3/CD28
  • antisauvagine-30
  • APV
  • AR-A014418
  • astressin
  • BAPTA-AM
  • BDNF
  • beta-amyloid_42
  • bicuculline
  • bisindolylmaleimide
  • calphostin_C
  • cAMP_analog
  • cGMP_analog
  • CGS_21680
  • chelerythrine
  • cholera_toxin
  • ciclosporin
  • CNQX
  • cobalt
  • colforsin
  • CP154526
  • CRF
  • culturing_of_cells
  • CV11974
  • deoxygenation
  • depolarization
  • desipramine
  • DRB
  • EGF
  • electrical_stimulation
  • ephrin_B2
  • estradiol
  • exercise
  • FGF1
  • FGF2
  • FK506
  • FR167653
  • GABA
  • gallein
  • genistein
  • GF109203X
  • GIP
  • glutamic acid
  • glycine
  • Go_6976
  • H-89
  • H2O2
  • HDBA
  • heparin sodium
  • herbimycin_A
  • heroin_withdrawal
  • histamine
  • hypoxia
  • IGF-1
  • IGF-2
  • insulin
  • ischemia
  • ischemia/reperfusion
  • isoproterenol
  • JNK_inhibitor_VIII
  • K252a
  • KCl
  • KN-62
  • KN-93
  • KT5720
  • lactoferrin
  • laminin-1
  • learning
  • light
  • lithium
  • long-term_potentiation
  • LY294002
  • m119
  • memantine
  • metribolone
  • MG132
  • muscimol
  • NAC
  • neuregulin
  • NGF
  • nifedipine
  • nimodipine
  • NKH_477
  • NMDA
  • norepinephrine
  • okadaic_acid
  • osmotic_stress
  • PAR1-activating_peptide
  • Pasteurella_multocida_toxin
  • PCP
  • PD90059
  • PD98059
  • PDGF
  • peptide inhibitor
  • phenylephrine
  • phorbol_ester
  • PKI-(14-22)amide
  • prazosin
  • propranolol
  • PTH
  • PTX
  • PTZ
  • rapamycin
  • Ro31-8220
  • rolipram
  • SB203580
  • SB216763
  • serum
  • SH-5
  • siRNA
  • SQ22536
  • staurosporine
  • SU6656
  • testosterone
  • TeTx
  • TGF-beta
  • thrombin
  • TNF
  • TTX
  • tyrphostin_A47
  • U0126
  • urofollitropin
  • UV
  • W-7
  • wortmannin
CREB (human) EILsRRPsyRkILND S119-p
CREB iso1 (human) EILsRRPsyRKILND S133-p
CREB (mouse) EILsRRPsyRkILND S119-p
CREB iso1 (mouse) EILSRRPSYRKILND S133
CREB (rat) EILsRRPsYRkILND S133-p
Y134
ILsRRPsYRkILNDL
3 4
CREB (human) ILsRRPsyRkILNDL Y120-p
CREB iso1 (human) ILsRRPsyRKILNDL Y134-p
CREB (mouse) ILsRRPsyRkILNDL Y120-p
CREB iso1 (mouse) ILSRRPSYRKILNDL Y134
CREB (rat) ILsRRPsYRkILNDL Y134
K136-ac
sRRPsYRkILNDLss
Downstream
4 0
Effects on Biological Processes:
  • transcription, inhibited
CREB (human) sRRPsyRkILNDLss K122-ac
CREB iso1 (human) sRRPsyRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ac
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) sRRPsYRkILNDLss K136-ac
K136
sRRPsYRKILNDLss
0 4
CREB (human) sRRPsyRkILNDLss K122-ub
CREB iso1 (human) sRRPsyRKILNDLSS K136
CREB (mouse) sRRPsyRkILNDLss K122-ub
CREB iso1 (mouse) SRRPSYRKILNDLSS K136
CREB (rat) sRRPsYRKILNDLss K136
S142-p
RkILNDLssDAPGVP
Upstream
Downstream
10 22
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • CAMK2A (human)
  • CAMK2A (mouse)
  • CAMK2A (rat)
  • CK2A1 (human)
Putative in vivo kinases:
  • CAMK2A (mouse)
  • CAMK2A (rat)
Treatment
  • BDNF
  • depolarization
  • glutamic acid
  • KN-62
  • PD98059
  • PTZ
CREB (human) RkILNDLssDAPGVP S128-p
CREB iso1 (human) RKILNDLSSDAPGVP S142
CREB (mouse) RkILNDLssDAPGVP S128-p
CREB iso1 (mouse) RKILNDLSSDAPGVP S142
CREB (rat) RkILNDLssDAPGVP S142-p
S143-p
kILNDLssDAPGVPR
Upstream
4 1
Kinase, in vitro:
  • CK2A1 (human)
Treatment
  • BDNF
  • cAMP_analog
  • depolarization
  • glutamic acid
  • PTZ
CREB (human) kILNDLssDAPGVPR S129-p
CREB iso1 (human) KILNDLSSDAPGVPR S143
CREB (mouse) kILNDLssDAPGVPR S129-p
CREB iso1 (mouse) KILNDLSSDAPGVPR S143
CREB (rat) kILNDLssDAPGVPR S143-p
S156
PRIEEEKSEEETSAP
2 0
CREB (human) PRIEEEKsEEETSAP S142-p
CREB iso1 (human) PRIEEEKSEEETSAP S156
CREB (mouse) PRIEEEKsEEETSAP S142-p
CREB iso1 (mouse) PRIEEEKSEEETSAP S156
CREB (rat) PRIEEEKSEEETSAP S156
T256
VQTYQIRTAPTSTIA
0 1
CREB (human) VQTYQIRtAPTSTIA T242-p
CREB iso1 (human) VQTYQIRTAPTSTIA T256
CREB (mouse) VQTYQIRTAPTstIA T242
CREB iso1 (mouse) VQTYQIRTAPTSTIA T256
CREB (rat) VQTYQIRTAPTSTIA T256
S260
QIRTAPTSTIAPGVV
0 1
CREB (human) QIRtAPTSTIAPGVV S246
CREB iso1 (human) QIRTAPTSTIAPGVV S260
CREB (mouse) QIRTAPTstIAPGVV S246-p
CREB iso1 (mouse) QIRTAPTSTIAPGVV S260
CREB (rat) QIRTAPTSTIAPGVV S260
T261
IRTAPTSTIAPGVVM
0 1
CREB (human) IRtAPTSTIAPGVVM T247
CREB iso1 (human) IRTAPTSTIAPGVVM T261
CREB (mouse) IRTAPTstIAPGVVM T247-p
CREB iso1 (mouse) IRTAPTSTIAPGVVM T261
CREB (rat) IRTAPTSTIAPGVVM T261
S270
APGVVMASSPALPTQ
1 2
CREB (human) APGVVMAssPALPTQ S256-p
CREB iso1 (human) APGVVMASSPALPTQ S270
CREB (mouse) APGVVMAssPALPTQ S256-p
CREB iso1 (mouse) APGVVMASSPALPTQ S270
CREB (rat) APGVVMASSPALPTQ S270
S271
PGVVMASSPALPTQP
3 8
CREB (human) PGVVMAssPALPTQP S257-p
CREB iso1 (human) PGVVMASSPALPTQP S271
CREB (mouse) PGVVMAssPALPTQP S257-p
CREB iso1 (mouse) PGVVMASSPALPTQP S271
CREB (rat) PGVVMASSPALPTQP S271
K285
PAEEAARKREVRLMK
1 0
CREB (human) PAEEAARkREVRLMK K271-sm
CREB iso1 (human) PAEEAARKREVRLMK K285
CREB (mouse) PAEEAARKREVRLMK K271
CREB iso1 (mouse) PAEEAARKREVRLMK K285
CREB (rat) PAEEAARKREVRLMK K285
K304
ARECRRKKKEYVKCL
1 0
CREB (human) ARECRRKkKEYVKCL K290-sm
CREB iso1 (human) ARECRRKKKEYVKCL K304
CREB (mouse) ARECRRKKKEYVKCL K290
CREB iso1 (mouse) ARECRRKKKEYVKCL K304
CREB (rat) ARECRRKKKEYVKCL K304
K330
KTLIEELKALKDLYC
0 5
CREB (human) KTLIEELkALKDLYC K316-ub
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELkALKDLYC K316-ub
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELKALKDLYC K330
K330-ac
KTLIEELkALKDLYC
0 1
CREB (human) KTLIEELKALKDLYC K316
CREB iso1 (human) KTLIEELKALKDLYC K330
CREB (mouse) KTLIEELKALKDLYC K316
CREB iso1 (mouse) KTLIEELKALKDLYC K330
CREB (rat) KTLIEELkALKDLYC K330-ac
K339
LKDLYCHKSD_____
0 1
CREB (human) LKDLYCHksD_____ K325-ub
CREB iso1 (human) LKDLYCHKSD_____ K339
CREB (mouse) LKDLYCHKsD_____ K325
CREB iso1 (mouse) LKDLYCHKSD_____ K339
CREB (rat) LKDLYCHKSD_____ K339
S340
KDLYCHKSD______
1 10
CREB (human) KDLYCHksD______ S326-p
CREB iso1 (human) KDLYCHKSD______ S340
CREB (mouse) KDLYCHKsD______ S326-p
CREB iso1 (mouse) KDLYCHKSD______ S340
CREB (rat) KDLYCHKSD______ S340