Other Species / Isoforms
  SHP-1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S10-p
RWFHRDLsGLDAETL
0 16
SHP-1 (human) RWFHRDLsGLDAETL S10-p
SHP-1 iso2 (human) gap -
SHP-1 iso4 (human) RWFHRDLSGLDAETL S10
SHP-1 (mouse) RWFHRDLsGPDAETL S10-p
SHP-1 (rat) GWFHRDLsGPDAETL S12-p
K19-ub
LDAETLLkGRGVHGs
0 7
SHP-1 (human) LDAETLLkGRGVHGs K19-ub
SHP-1 iso2 (human) gap -
SHP-1 iso4 (human) LDAETLLKGRGVHGS K19
SHP-1 (mouse) PDAETLLKGRGVPGS K19
SHP-1 (rat) PDAETLLKGRGVPGs K21
S26-p
kGRGVHGsFLARPSR
0 4
SHP-1 (human) kGRGVHGsFLARPSR S26-p
SHP-1 iso2 (human) gap -
SHP-1 iso4 (human) KGRGVHGSFLARPSR S26
SHP-1 (mouse) KGRGVPGSFLARPSR S26
SHP-1 (rat) KGRGVPGsFLARPSR S28-p
K34-ub
FLARPSRkNQGDFSL
0 1
SHP-1 (human) FLARPSRkNQGDFSL K34-ub
SHP-1 iso2 (human) under review -
SHP-1 iso4 (human) FLARPSRKNQGDFSL K34
SHP-1 (mouse) FLARPSRKNQGDFSL K34
SHP-1 (rat) FLARPSRKNQGDFSL K36
S57-p
THIRIQNsGDFyDLy
0 4
SHP-1 (human) THIRIQNsGDFyDLy S57-p
SHP-1 iso2 (human) THIRIQNSGDFYDLY S18
SHP-1 iso4 (human) THIRIQNSGDFYDLY S57
SHP-1 (mouse) THIRIQNsGDFYDLy S57-p
SHP-1 (rat) THIRIQNSGDFYDLY S59
Y61-p
IQNsGDFyDLyGGEK
0 26
SHP-1 (human) IQNsGDFyDLyGGEK Y61-p
SHP-1 iso2 (human) IQNSGDFYDLYGGEK Y22
SHP-1 iso4 (human) IQNSGDFYDLYGGEK Y61
SHP-1 (mouse) IQNsGDFYDLyGGEK Y61
SHP-1 (rat) IQNSGDFYDLYGGEK Y63
Y64-p
sGDFyDLyGGEKFAT
0 35
SHP-1 (human) sGDFyDLyGGEKFAT Y64-p
SHP-1 iso2 (human) SGDFYDLYGGEKFAT Y25
SHP-1 iso4 (human) SGDFYDLYGGEKFAT Y64
SHP-1 (mouse) sGDFYDLyGGEKFAT Y64-p
SHP-1 (rat) SGDFYDLYGGEKFAT Y66
K97-ub
DGTIIHLkyPLNCSD
0 1
SHP-1 (human) DGTIIHLkyPLNCSD K97-ub
SHP-1 iso2 (human) DGTIIHLKYPLNCSD K58
SHP-1 iso4 (human) DGTIIHLKYPLNCSD K97
SHP-1 (mouse) DGTIIHLKyPLNCSD K97
SHP-1 (rat) DGTIIHLKYPLNCSD K99
Y98-p
GTIIHLkyPLNCSDP
0 3
SHP-1 (human) GTIIHLkyPLNCSDP Y98-p
SHP-1 iso2 (human) GTIIHLKYPLNCSDP Y59
SHP-1 iso4 (human) GTIIHLKYPLNCSDP Y98
SHP-1 (mouse) GTIIHLKyPLNCSDP Y98-p
SHP-1 (rat) GTIIHLKYPLNCSDP Y100
Y111-p
DPTSERWyHGHMSGG
0 1
SHP-1 (human) DPTSERWyHGHMSGG Y111-p
SHP-1 iso2 (human) DPTSERWYHGHMSGG Y72
SHP-1 iso4 (human) DPTSERWYHGHMSGG Y111
SHP-1 (mouse) DPTSERWYHGHISGG Y111
SHP-1 (rat) DPTSERWYHGHMSGG Y113
S140-p
FLVRESLsQPGDFVL
0 1
SHP-1 (human) FLVRESLsQPGDFVL S140-p
SHP-1 iso2 (human) FLVRESLSQPGDFVL S101
SHP-1 iso4 (human) FLVRESLSQPGDFVL S140
SHP-1 (mouse) FLVRESLSQPGDFVL S140
SHP-1 (rat) FLVRESLSQPGDFVL S142
K155-ub
SVLSDQPkAGPGSPL
0 1
SHP-1 (human) SVLSDQPkAGPGSPL K155-ub
SHP-1 iso2 (human) SVLSDQPKAGPGSPL K116
SHP-1 iso4 (human) SVLSDQPKAGPGSPL K155
SHP-1 (mouse) SVLNDQPKAGPGSPL K155
SHP-1 (rat) SVLNDQPKAAPGSPL K157
K168-ub
PLRVTHIkVMCEGGR
0 1
SHP-1 (human) PLRVTHIkVMCEGGR K168-ub
SHP-1 iso2 (human) PLRVTHIKVMCEGGR K129
SHP-1 iso4 (human) PLRVTHIKVMCEGGR K168
SHP-1 (mouse) PLRVTHIKVMCEGGR K168
SHP-1 (rat) PLRVTHIKVMCEGGR K170
Y176-p
VMCEGGRytVGGLET
0 1
SHP-1 (human) VMCEGGRytVGGLET Y176-p
SHP-1 iso2 (human) VMCEGGRYTVGGLET Y137
SHP-1 iso4 (human) VMCEGGRYTVGGLET Y176
SHP-1 (mouse) VMCEGGRYTVGGSET Y176
SHP-1 (rat) VMCEGGRYTVGGSET Y178
T177-p
MCEGGRytVGGLETF
0 1
SHP-1 (human) MCEGGRytVGGLETF T177-p
SHP-1 iso2 (human) MCEGGRYTVGGLETF T138
SHP-1 iso4 (human) MCEGGRYTVGGLETF T177
SHP-1 (mouse) MCEGGRYTVGGSETF T177
SHP-1 (rat) MCEGGRYTVGGSETF T179
S186-p
GGLETFDsLtDLVEH
0 5
SHP-1 (human) GGLETFDsLtDLVEH S186-p
SHP-1 iso2 (human) GGLETFDSLTDLVEH S147
SHP-1 iso4 (human) GGLETFDSLTDLVEH S186
SHP-1 (mouse) GGSETFDSLtDLVEH S186
SHP-1 (rat) GGSETFDSLTDLVEH S188
T188-p
LETFDsLtDLVEHFk
0 3
SHP-1 (human) LETFDsLtDLVEHFk T188-p
SHP-1 iso2 (human) LETFDSLTDLVEHFK T149
SHP-1 iso4 (human) LETFDSLTDLVEHFK T188
SHP-1 (mouse) SETFDSLtDLVEHFK T188-p
SHP-1 (rat) SETFDSLTDLVEHFK T190
K195-ub
tDLVEHFkkTGIEEA
0 1
SHP-1 (human) tDLVEHFkkTGIEEA K195-ub
SHP-1 iso2 (human) TDLVEHFKKTGIEEA K156
SHP-1 iso4 (human) TDLVEHFKKTGIEEA K195
SHP-1 (mouse) tDLVEHFKKTGIEEA K195
SHP-1 (rat) TDLVEHFKKTGIEEA K197
K196-ub
DLVEHFkkTGIEEAS
0 1
SHP-1 (human) DLVEHFkkTGIEEAS K196-ub
SHP-1 iso2 (human) DLVEHFKKTGIEEAS K157
SHP-1 iso4 (human) DLVEHFKKTGIEEAS K196
SHP-1 (mouse) DLVEHFKKTGIEEAS K196
SHP-1 (rat) DLVEHFKKTGIEEAS K198
Y208
EASGAFVYLRQPyyA
1 0
SHP-1 (human) EASGAFVYLRQPyyA Y208
SHP-1 iso2 (human) EASGAFVYLRQPYYA Y169
SHP-1 iso4 (human) EASGAFVYLRQPYYA Y208
SHP-1 (mouse) EASGAFVyLRQPyyA Y208-p
SHP-1 (rat) EASGAFVYLRQPYYA Y210
Y213-p
FVYLRQPyyATRVNA
0 3
SHP-1 (human) FVYLRQPyyATRVNA Y213-p
SHP-1 iso2 (human) FVYLRQPYYATRVNA Y174
SHP-1 iso4 (human) FVYLRQPYYATRVNA Y213
SHP-1 (mouse) FVyLRQPyyATRVNA Y213-p
SHP-1 (rat) FVYLRQPYYATRVNA Y215
Y214-p
VYLRQPyyATRVNAA
0 6
SHP-1 (human) VYLRQPyyATRVNAA Y214-p
SHP-1 iso2 (human) VYLRQPYYATRVNAA Y175
SHP-1 iso4 (human) VYLRQPYYATRVNAA Y214
SHP-1 (mouse) VyLRQPyyATRVNAA Y214-p
SHP-1 (rat) VYLRQPYYATRVNAA Y216
K232-ub
NRVLELNkKQESEDT
0 1
SHP-1 (human) NRVLELNkKQESEDT K232-ub
SHP-1 iso2 (human) NRVLELNKKQESEDT K193
SHP-1 iso4 (human) NRVLELNKKQESEDT K232
SHP-1 (mouse) NRVLELNKKQESEDT K232
SHP-1 (rat) NRVLELNKKQESEDT K234
K241-ub
QESEDTAkAGFWEEF
0 1
SHP-1 (human) QESEDTAkAGFWEEF K241-ub
SHP-1 iso2 (human) QESEDTAKAGFWEEF K202
SHP-1 iso4 (human) QESEDTAKAGFWEEF K241
SHP-1 (mouse) QESEDTAKAGFWEEF K241
SHP-1 (rat) QESEDTAKAGFWEEF K243
S250-p
GFWEEFEsLQkQEVk
0 5
SHP-1 (human) GFWEEFEsLQkQEVk S250-p
SHP-1 iso2 (human) GFWEEFESLQKQEVK S211
SHP-1 iso4 (human) GFWEEFESLQKQEVK S250
SHP-1 (mouse) GFWEEFEsLQKQEVK S250-p
SHP-1 (rat) GFWEEFESLQKQEAK S252
K253-ub
EEFEsLQkQEVkNLH
0 2
SHP-1 (human) EEFEsLQkQEVkNLH K253-ub
SHP-1 iso2 (human) EEFESLQKQEVKNLH K214
SHP-1 iso4 (human) EEFESLQKQEVKNLH K253
SHP-1 (mouse) EEFEsLQKQEVKNLH K253
SHP-1 (rat) EEFESLQKQEAKNLH K255
K257-ub
sLQkQEVkNLHQRLE
0 1
SHP-1 (human) sLQkQEVkNLHQRLE K257-ub
SHP-1 iso2 (human) SLQKQEVKNLHQRLE K218
SHP-1 iso4 (human) SLQKQEVKNLHQRLE K257
SHP-1 (mouse) sLQKQEVKNLHQRLE K257
SHP-1 (rat) SLQKQEAKNLHQRLE K259
K271-ub
EGQRPENkGKNRykN
0 1
SHP-1 (human) EGQRPENkGKNRykN K271-ub
SHP-1 iso2 (human) EGQRPENKGKNRYKN K232
SHP-1 iso4 (human) EGQRPENKGKNRYKN K271
SHP-1 (mouse) EGQRPENKSKNRyKN K271
SHP-1 (rat) EGQRPENKSKNRYKN K273
Y276-p
ENkGKNRykNILPFD
Upstream
Downstream
1 42
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
Treatment
  • PRL
SHP-1 (human) ENkGKNRykNILPFD Y276-p
SHP-1 iso2 (human) ENKGKNRYKNILPFD Y237
SHP-1 iso4 (human) ENKGKNRYKNILPFD Y276
SHP-1 (mouse) ENKSKNRyKNILPFD Y276-p
SHP-1 (rat) ENKSKNRYKNILPFD Y278
K277-ac
NkGKNRykNILPFDH
0 1
SHP-1 (human) NkGKNRykNILPFDH K277-ac
SHP-1 iso2 (human) NKGKNRYKNILPFDH K238
SHP-1 iso4 (human) NKGKNRYKNILPFDH K277
SHP-1 (mouse) NKSKNRyKNILPFDH K277
SHP-1 (rat) NKSKNRYKNILPFDH K279
K277-ub
NkGKNRykNILPFDH
Upstream
0 3
Treatment
  • MG132
SHP-1 (human) NkGKNRykNILPFDH K277-ub
SHP-1 iso2 (human) NKGKNRYKNILPFDH K238
SHP-1 iso4 (human) NKGKNRYKNILPFDH K277
SHP-1 (mouse) NKSKNRyKNILPFDH K277
SHP-1 (rat) NKSKNRYKNILPFDH K279
S285-p
NILPFDHsrVILQGR
0 1
SHP-1 (human) NILPFDHsrVILQGR S285-p
SHP-1 iso2 (human) NILPFDHSRVILQGR S246
SHP-1 iso4 (human) NILPFDHSRVILQGR S285
SHP-1 (mouse) NILPFDHSRVILQGR S285
SHP-1 (rat) NILPFDHSRVILQGR S287
R286-m1
ILPFDHsrVILQGRD
0 1
SHP-1 (human) ILPFDHsrVILQGRD R286-m1
SHP-1 iso2 (human) ILPFDHSRVILQGRD R247
SHP-1 iso4 (human) ILPFDHSRVILQGRD R286
SHP-1 (mouse) ILPFDHSRVILQGRD R286
SHP-1 (rat) ILPFDHSRVILQGRD R288
S299-p
RDSNIPGsDyINANy
0 2
SHP-1 (human) RDSNIPGsDyINANy S299-p
SHP-1 iso2 (human) RDSNIPGSDYINANY S260
SHP-1 iso4 (human) RDSNIPGSDYINANY S299
SHP-1 (mouse) RDSNIPGSDYINANY S299
SHP-1 (rat) RDSNIPGSDYINANY S301
Y301-p
SNIPGsDyINANyIk
Upstream
Downstream
1 69
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
Treatment
  • PRL
SHP-1 (human) SNIPGsDyINANyIk Y301-p
SHP-1 iso2 (human) SNIPGSDYINANYIK Y262
SHP-1 iso4 (human) SNIPGSDYINANYIK Y301
SHP-1 (mouse) SNIPGSDYINANYVK Y301
SHP-1 (rat) SNIPGSDYINANYVK Y303
Y306-p
sDyINANyIkNQLLG
0 9
SHP-1 (human) sDyINANyIkNQLLG Y306-p
SHP-1 iso2 (human) SDYINANYIKNQLLG Y267
SHP-1 iso4 (human) SDYINANYIKNQLLG Y306
SHP-1 (mouse) SDYINANYVKNQLLG Y306
SHP-1 (rat) SDYINANYVKNQLLG Y308
K308-ub
yINANyIkNQLLGPD
0 2
SHP-1 (human) yINANyIkNQLLGPD K308-ub
SHP-1 iso2 (human) YINANYIKNQLLGPD K269
SHP-1 iso4 (human) YINANYIKNQLLGPD K308
SHP-1 (mouse) YINANYVKNQLLGPD K308
SHP-1 (rat) YINANYVKNQLLGPD K310
K360-ub
EVEKGRNkCVPyWPE
0 2
SHP-1 (human) EVEKGRNkCVPyWPE K360-ub
SHP-1 iso2 (human) EVEKGRNKCVPYWPE K321
SHP-1 iso4 (human) EVEKGRNKCVPYWPE K360
SHP-1 (mouse) EVEKGRNKCVPYWPE K360
SHP-1 (rat) EVEKGRNKCVPYWPE K362
Y364-p
GRNkCVPyWPEVGMQ
0 1
SHP-1 (human) GRNkCVPyWPEVGMQ Y364-p
SHP-1 iso2 (human) GRNKCVPYWPEVGMQ Y325
SHP-1 iso4 (human) GRNKCVPYWPEVGMQ Y364
SHP-1 (mouse) GRNKCVPYWPEVGTQ Y364
SHP-1 (rat) GRNKCVPYWPEVGTQ Y366
Y374-p
EVGMQRAyGPysVTN
0 1
SHP-1 (human) EVGMQRAyGPysVTN Y374-p
SHP-1 iso2 (human) EVGMQRAYGPYSVTN Y335
SHP-1 iso4 (human) EVGMQRAYGPYSVTN Y374
SHP-1 (mouse) EVGTQRVYGLySVTN Y374
SHP-1 (rat) EVGTQRVYGLYSVTN Y376
Y377-p
MQRAyGPysVTNCGE
0 6
SHP-1 (human) MQRAyGPysVTNCGE Y377-p
SHP-1 iso2 (human) MQRAYGPYSVTNCGE Y338
SHP-1 iso4 (human) MQRAYGPYSVTNCGE Y377
SHP-1 (mouse) TQRVYGLySVTNSRE Y377-p
SHP-1 (rat) TQRVYGLYSVTNCKE Y379
S378-p
QRAyGPysVTNCGEH
0 1
SHP-1 (human) QRAyGPysVTNCGEH S378-p
SHP-1 iso2 (human) QRAYGPYSVTNCGEH S339
SHP-1 iso4 (human) QRAYGPYSVTNCGEH S378
SHP-1 (mouse) QRVYGLySVTNSREH S378
SHP-1 (rat) QRVYGLYSVTNCKEH S380
K391-ub
EHDTTEYkLRtLQVs
0 4
SHP-1 (human) EHDTTEYkLRtLQVs K391-ub
SHP-1 iso2 (human) EHDTTEYKLRTLQVS K352
SHP-1 iso4 (human) EHDTTEYKLRTLQVS K391
SHP-1 (mouse) EHDTAEYkLRTLQIS K391-ub
SHP-1 (rat) EHDTAEYKLRTLQIS K393
T394-p
TTEYkLRtLQVsPLD
0 1
SHP-1 (human) TTEYkLRtLQVsPLD T394-p
SHP-1 iso2 (human) TTEYKLRTLQVSPLD T355
SHP-1 iso4 (human) TTEYKLRTLQVSPLD T394
SHP-1 (mouse) TAEYkLRTLQISPLD T394
SHP-1 (rat) TAEYKLRTLQISPLD T396
S398-p
kLRtLQVsPLDNGDL
0 3
SHP-1 (human) kLRtLQVsPLDNGDL S398-p
SHP-1 iso2 (human) KLRTLQVSPLDNGDL S359
SHP-1 iso4 (human) KLRTLQVSPLDNGDL S398
SHP-1 (mouse) kLRTLQISPLDNGDL S398
SHP-1 (rat) KLRTLQISPLDNGDL S400
K486-ub
DCDIDIQkTIQMVRA
0 1
SHP-1 (human) DCDIDIQkTIQMVRA K486-ub
SHP-1 iso2 (human) DCDIDIQKTIQMVRA K447
SHP-1 iso4 (human) DCDIDIQKTIQMVRA K486
SHP-1 (mouse) DCDIDIQKTIQMVRA K486
SHP-1 (rat) DCDIDIQKTIQMVRA K488
S496-p
QMVRAQRsGMVQTEA
0 1
SHP-1 (human) QMVRAQRsGMVQTEA S496-p
SHP-1 iso2 (human) QMVRAQRSGMVQTEA S457
SHP-1 iso4 (human) QMVRAQRSGMVQTEA S496
SHP-1 (mouse) QMVRAQRSGMVQTEA S496
SHP-1 (rat) QMVRAQRSGMVQTEA S498
Y509-p
EAQYKFIyVAIAQFI
0 2
SHP-1 (human) EAQYKFIyVAIAQFI Y509-p
SHP-1 iso2 (human) EAQYKFIYVAIAQFI Y470
SHP-1 iso4 (human) EAQYKFIYVAIAQFI Y509
SHP-1 (mouse) EAQYKFIYVAIAQFI Y509
SHP-1 (rat) EAQYKFIYVAIAQFI Y511
K521-ub
QFIETTKkkLEVLQs
0 1
SHP-1 (human) QFIETTKkkLEVLQs K521-ub
SHP-1 iso2 (human) QFIETTKKKLEVLQS K482
SHP-1 iso4 (human) QFIETTKKKLEVLQS K521
SHP-1 (mouse) QFIETTKKKLEIIQs K521
SHP-1 (rat) QFIETTKKKLEIIQS K523
K522-ub
FIETTKkkLEVLQsQ
0 2
SHP-1 (human) FIETTKkkLEVLQsQ K522-ub
SHP-1 iso2 (human) FIETTKKKLEVLQSQ K483
SHP-1 iso4 (human) FIETTKKKLEVLQSQ K522
SHP-1 (mouse) FIETTKKKLEIIQsQ K522
SHP-1 (rat) FIETTKKKLEIIQSQ K524
S528-p
kkLEVLQsQkGQEsE
0 5
SHP-1 (human) kkLEVLQsQkGQEsE S528-p
SHP-1 iso2 (human) KKLEVLQSQKGQESE S489
SHP-1 iso4 (human) KKLEVLQSQKGQESE S528
SHP-1 (mouse) KKLEIIQsQKGQEsE S528-p
SHP-1 (rat) KKLEIIQSQRGQESE S530
K530-ub
LEVLQsQkGQEsEyG
0 1
SHP-1 (human) LEVLQsQkGQEsEyG K530-ub
SHP-1 iso2 (human) LEVLQSQKGQESEYG K491
SHP-1 iso4 (human) LEVLQSQKGQESEYG K530
SHP-1 (mouse) LEIIQsQKGQEsEyG K530
SHP-1 (rat) LEIIQSQRGQESEyG R532
S534-p
QsQkGQEsEyGNIty
0 91
SHP-1 (human) QsQkGQEsEyGNIty S534-p
SHP-1 iso2 (human) QSQKGQESEYGNITY S495
SHP-1 iso4 (human) QSQKGQESEYGNITY S534
SHP-1 (mouse) QsQKGQEsEyGNIty S534-p
SHP-1 (rat) QSQRGQESEyGNITy S536
Y536-p
QkGQEsEyGNItyPP
Upstream
Downstream
16 648
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, induced
  • cell motility, induced
  • signaling pathway regulation
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • INSR (human)
  • Lck (human)
  • LYN (human)
  • Src (human)
Phosphatases, in vitro:
  • SHP-1 (human)
Putative in vivo kinases:
  • INSR (human)
Putative upstream phosphatases:
  • SHP-1 (human)
Regulatory protein:
  • PDZK1 (human)
Treatment
  • anti-CD28
  • anti-CD3
  • cAMP_analog
  • erlotinib
  • gefitinib
  • hemolysin
  • insulin
  • LPS
  • PRL
  • Su11274
SHP-1 (human) QkGQEsEyGNItyPP Y536-p
SHP-1 iso2 (human) QKGQESEYGNITYPP Y497
SHP-1 iso4 (human) QKGQESEYGNITYPP Y536
SHP-1 (mouse) QKGQEsEyGNItyPP Y536-p
SHP-1 (rat) QRGQESEyGNITyPP Y538-p
T540-p
EsEyGNItyPPAMkN
0 25
SHP-1 (human) EsEyGNItyPPAMkN T540-p
SHP-1 iso2 (human) ESEYGNITYPPAMKN T501
SHP-1 iso4 (human) ESEYGNITYPPAMKN T540
SHP-1 (mouse) EsEyGNItyPPAVRS T540-p
SHP-1 (rat) ESEyGNITyPPALRS T542
Y541-p
sEyGNItyPPAMkNA
1 209
SHP-1 (human) sEyGNItyPPAMkNA Y541-p
SHP-1 iso2 (human) SEYGNITYPPAMKNA Y502
SHP-1 iso4 (human) SEYGNITYPPAMKNA Y541
SHP-1 (mouse) sEyGNItyPPAVRSA Y541-p
SHP-1 (rat) SEyGNITyPPALRSA Y543-p
K546-ub
ItyPPAMkNAHAKAs
0 1
SHP-1 (human) ItyPPAMkNAHAKAs K546-ub
SHP-1 iso2 (human) ITYPPAMKNAHAKAS K507
SHP-1 iso4 (human) ITYPPAMKNAHAKAS K546
SHP-1 (mouse) ItyPPAVRSAHAKAS R546
SHP-1 (rat) ITyPPALRSAHAKAS R548
S553-p
kNAHAKAsRtssKHk
Upstream
Downstream
1 2
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
Putative in vivo kinases:
  • PKG2 (human)
Treatment
  • 8pCPT-cGMP
SHP-1 (human) kNAHAKAsRtssKHk S553-p
SHP-1 iso2 (human) KNAHAKASRTSSKHK S514
SHP-1 iso4 (human) KNAHAKASRTSSKSL S553
SHP-1 (mouse) RSAHAKASRTssKHK S553
SHP-1 (rat) RSAHAKASRTSSKHK S555
T555-p
AHAKAsRtssKHkED
0 4
SHP-1 (human) AHAKAsRtssKHkED T555-p
SHP-1 iso2 (human) AHAKASRTSSKHKED T516
SHP-1 iso4 (human) AHAKASRTSSKSLES T555
SHP-1 (mouse) AHAKASRTssKHKEE T555
SHP-1 (rat) AHAKASRTSSKHKEE T557
S556-p
HAKAsRtssKHkEDV
Upstream
Downstream
1 7
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
Putative in vivo kinases:
  • PKG2 (human)
Treatment
  • 8pCPT-cGMP
SHP-1 (human) HAKAsRtssKHkEDV S556-p
SHP-1 iso2 (human) HAKASRTSSKHKEDV S517
SHP-1 iso4 (human) HAKASRTSSKSLESs S556
SHP-1 (mouse) HAKASRTssKHKEEV S556-p
SHP-1 (rat) HAKASRTSSKHKEEV S558
S557-p
AKAsRtssKHkEDVy
Upstream
Downstream
1 68
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
Putative in vivo kinases:
  • PKG2 (human)
Treatment
  • 8pCPT-cGMP
  • U0126
SHP-1 (human) AKAsRtssKHkEDVy S557-p
SHP-1 iso2 (human) AKASRTSSKHKEDVY S518
SHP-1 iso4 (human) AKASRTSSKSLESsA S557
SHP-1 (mouse) AKASRTssKHKEEVy S557-p
SHP-1 (rat) AKASRTSSKHKEEVY S559
K560-ub
sRtssKHkEDVyENL
0 1
SHP-1 (human) sRtssKHkEDVyENL K560-ub
SHP-1 iso2 (human) SRTSSKHKEDVYENL K521
SHP-1 iso4 (human) under review -
SHP-1 (mouse) SRTssKHKEEVyENV K560
SHP-1 (rat) SRTSSKHKEEVYENV K562
-
gap
0 1
SHP-1 (human) gap -
SHP-1 iso2 (human) gap -
SHP-1 iso4 (human) SSKSLESsAGTVAAS S563-p
SHP-1 (mouse) gap -
SHP-1 (rat) gap -
Y564-p
sKHkEDVyENLHTkN
Upstream
Downstream
10 781
SHP-1 (human)
Y564-p
SHP-1 (mouse)
Y564-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, inhibited
Kinase, in vitro:
  • Lck (human)
  • Src (human)
Putative in vivo kinases:
  • Lck (human)
Treatment
  • cAMP_analog
  • hemolysin
  • LPS
  • PP2
  • PRL
  • Su11274
  • U0126
SHP-1 (human) sKHkEDVyENLHTkN Y564-p
SHP-1 iso2 (human) SKHKEDVYENLHTKN Y525
SHP-1 iso4 (human) gap -
SHP-1 (mouse) sKHKEEVyENVHsKS Y564-p
SHP-1 (rat) SKHKEEVYENVHSKN Y566
T569
DVyENLHTkNKREEK
0 1
SHP-1 (human) DVyENLHTkNKREEK T569
SHP-1 iso2 (human) DVYENLHTKNKREEK T530
SHP-1 iso4 (human) gap -
SHP-1 (mouse) EVyENVHsKSKKEEK S569-p
SHP-1 (rat) EVYENVHSKNKKEEK S571
K570-ub
VyENLHTkNKREEKV
0 1
SHP-1 (human) VyENLHTkNKREEKV K570-ub
SHP-1 iso2 (human) VYENLHTKNKREEKV K531
SHP-1 iso4 (human) under review -
SHP-1 (mouse) VyENVHsKSKKEEKV K570
SHP-1 (rat) VYENVHSKNKKEEKV K572
S582-p
EKVKKQRsADKEKsK
0 3
SHP-1 (human) EKVKKQRsADKEKsK S582-p
SHP-1 iso2 (human) EKVKKQRSADKEKSK S543
SHP-1 iso4 (human) gap -
SHP-1 (mouse) EKVKKQRSADKEKNK S582
SHP-1 (rat) EKVKKQRSADKEKNK S584
S588-p
RsADKEKsKGsLKRK
0 2
SHP-1 (human) RsADKEKsKGsLKRK S588-p
SHP-1 iso2 (human) RSADKEKSKGSLKRK S549
SHP-1 iso4 (human) gap -
SHP-1 (mouse) RSADKEKNKGsLKRK N588
SHP-1 (rat) RSADKEKNKGSLKRN N590
S591-p
DKEKsKGsLKRK___
Upstream
8 17
Kinase, in vitro:
  • PKCA (human)
Putative in vivo kinases:
  • PKCA (human)
Treatment
  • cAMP_analog
  • hemolysin
  • LPS
  • phorbol_ester
  • thrombin
SHP-1 (human) DKEKsKGsLKRK___ S591-p
SHP-1 iso2 (human) DKEKSKGSLKRK___ S552
SHP-1 iso4 (human) gap -
SHP-1 (mouse) DKEKNKGsLKRK___ S591-p
SHP-1 (rat) DKEKNKGSLKRNISL S593