Other Species / Isoforms
  CDC25A (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S18-p
RRLLFACsPPPASQP
Upstream
Downstream
4 5
Effects on Modified Protein
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • DYRK2 (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • grape_seed_extract
  • harmine
  • LDN-192960
  • seliciclib
  • siRNA
view more >
CDC25A (human) RRLLFACsPPPASQP S18-p
CDC25A iso2 (human) RRLLFACSPPPASQP S18
CDC25A (mouse) RRLFFACSPTPAPQP S18
CDC25A (rat) RRLLFTCSPTPAPQP S18
S40-p
ASAAGGLsPVTNLTV
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CDK4 (human)
Treatment
  • MG132
  • palbociclib
  • PD0325901
  • PD0332991
  • seliciclib
view more >
CDC25A (human) ASAAGGLsPVTNLTV S40-p
CDC25A iso2 (human) ASAAGGLSPVTNLTV S40
CDC25A (mouse) ASAAGGLSPVTNLTV S40
CDC25A (rat) ASRAGGLSPVTNLTV S40
Y59-p
LQGLGSDyEQPLEVK
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • Src (human)
Putative in vivo kinases:
  • Src (human)
CDC25A (human) LQGLGSDyEQPLEVK Y59-p
CDC25A iso2 (human) LQGLGSDYEQPLEVK Y59
CDC25A (mouse) LEGLGSDCEKMEVRN C59
CDC25A (rat) LEGLGSDYEKPMDVR Y59
S76-p
SNLQRMGssEstDsG
Upstream
Downstream
12 2
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • Chk1 (human)
  • GSK3B (human)
Putative in vivo kinases:
  • Chk1 (human)
  • GSK3B (human)
Treatment
  • cycloheximide
  • Go_6976
  • lithium
  • UV
view more >
CDC25A (human) SNLQRMGssEstDsG S76-p
CDC25A iso2 (human) SNLQRMGSSESTDSG S76
CDC25A (mouse) SSLQRMGsSESTDSG S75-p
CDC25A (rat) SSLQRMGSSESTDSG S76
S77-p
NLQRMGssEstDsGF
0 1
CDC25A (human) NLQRMGssEstDsGF S77-p
CDC25A iso2 (human) NLQRMGSSESTDSGF S77
CDC25A (mouse) SLQRMGsSESTDSGF S76
CDC25A (rat) SLQRMGSSESTDSGF S77
S79-p
QRMGssEstDsGFCL
Upstream
Downstream
3 0
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Kinase, in vitro:
  • CK1A (human)
  • NEK11 (human)
Putative in vivo kinases:
  • CK1A (human)
Treatment
  • D4476
CDC25A (human) QRMGssEstDsGFCL S79-p
CDC25A iso2 (human) QRMGSSESTDSGFCL S79
CDC25A (mouse) QRMGsSESTDSGFCL S78
CDC25A (rat) QRMGSSESTDSGFCL S79
T80-p
RMGssEstDsGFCLD
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Kinase, in vitro:
  • PLK3 (human)
Putative in vivo kinases:
  • PLK3 (human)
CDC25A (human) RMGssEstDsGFCLD T80-p
CDC25A iso2 (human) RMGSSESTDSGFCLD T80
CDC25A (mouse) RMGsSESTDSGFCLD T79
CDC25A (rat) RMGSSESTDSGFCLD T80
S82-p
GssEstDsGFCLDsP
Upstream
Downstream
6 0
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CK1A (human)
  • NEK11 (human)
Putative in vivo kinases:
  • CK1A (human)
  • NEK11 (human)
Regulatory protein:
  • SMAD3 (human)
Treatment
  • D4476
  • ionizing_radiation
  • siRNA
  • TGF-beta
view more >
CDC25A (human) GssEstDsGFCLDsP S82-p
CDC25A iso2 (human) GSSESTDSGFCLDSP S82
CDC25A (mouse) GsSESTDSGFCLDSP S81
CDC25A (rat) GSSESTDSGFCLDSP S82
S88-p
DsGFCLDsPGPLDSK
Upstream
Downstream
7 2
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • NEK11 (human)
Putative in vivo kinases:
  • DYRK2 (human)
  • NEK11 (human)
Regulatory protein:
  • SMAD3 (human)
Treatment
  • harmine
  • ionizing_radiation
  • LDN-192960
  • MG132
  • siRNA
  • TGF-beta
view more >
CDC25A (human) DsGFCLDsPGPLDSK S88-p
CDC25A iso2 (human) DSGFCLDSPGPLDSK S88
CDC25A (mouse) DSGFCLDSPGPLDSK S87
CDC25A (rat) DSGFCLDSPGPLDSK S88
S107-p
NPMRRIHsLPQkLLG
Upstream
Downstream
1 3
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • DYRK2 (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) NPMRRIHsLPQkLLG S107-p
CDC25A iso2 (human) NPMRRIHSLPQKLLG S107
CDC25A (mouse) ISLTRINSLPQKLLG S106
CDC25A (rat) ISLRRINCLPQKLLG C107
K111-ub
RIHsLPQkLLGCsPA
0 1
CDC25A (human) RIHsLPQkLLGCsPA K111-ub
CDC25A iso2 (human) RIHSLPQKLLGCSPA K111
CDC25A (mouse) RINSLPQKLLGCSPA K110
CDC25A (rat) RINCLPQKLLGCSPA K111
S116-p
PQkLLGCsPALkRSH
Upstream
Downstream
2 6
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
Phosphatases, in vitro:
  • CDC14A (human)
Treatment
  • seliciclib
CDC25A (human) PQkLLGCsPALkRSH S116-p
CDC25A iso2 (human) PQKLLGCSPALKRSH S116
CDC25A (mouse) PQKLLGCSPALKRSH S115
CDC25A (rat) PQKLLGCSPALKRSH S116
K120-ub
LGCsPALkRSHsDsL
0 2
CDC25A (human) LGCsPALkRSHsDsL K120-ub
CDC25A iso2 (human) LGCSPALKRSHSDSL K120
CDC25A (mouse) LGCSPALKRSHsDSL K119
CDC25A (rat) LGCSPALKRSHSDSL K120
S124-p
PALkRSHsDsLDHDI
Upstream
Downstream
7 0
Effects on Modified Protein
  • protein degradation
Kinase, in vitro:
  • Chk1 (human)
  • Chk2 (human)
Putative in vivo kinases:
  • Chk1 (human)
  • Chk2 (human)
Regulatory protein:
  • Fyn (human)
Treatment
  • ionizing_radiation
  • UCN-01
CDC25A (human) PALkRSHsDsLDHDI S124-p
CDC25A iso2 (human) PALKRSHSDSLDHDI S124
CDC25A (mouse) PALKRSHsDSLDHDT S123-p
CDC25A (rat) PALKRSHSDSLDHDI S124
S126-p
LkRSHsDsLDHDIFQ
Upstream
0 1
Treatment
  • angiotensin_2
CDC25A (human) LkRSHsDsLDHDIFQ S126-p
CDC25A iso2 (human) LKRSHSDSLDHDIFQ S126
CDC25A (mouse) LKRSHsDSLDHDTFH S125
CDC25A (rat) LKRSHSDSLDHDIFQ S126
K150-ac
NEAFEFKkPVRPVsR
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • cell cycle regulation
Treatment
  • C646
  • siRNA
  • trichostatin_A
view more >
CDC25A (human) NEAFEFKkPVRPVsR K150-ac
CDC25A iso2 (human) gap -
CDC25A (mouse) NEAFEFKKPIRPASR K149
CDC25A (rat) NEAFEFKKPIRPASR K150
K150-ub
NEAFEFKkPVRPVsR
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
CDC25A (human) NEAFEFKkPVRPVsR K150-ub
CDC25A iso2 (human) gap -
CDC25A (mouse) NEAFEFKKPIRPASR K149
CDC25A (rat) NEAFEFKKPIRPASR K150
S156-p
KkPVRPVsRGCLHSH
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • DYRK2 (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) KkPVRPVsRGCLHSH S156-p
CDC25A iso2 (human) gap -
CDC25A (mouse) KKPIRPASRHIYEES S155
CDC25A (rat) KKPIRPASRGCLNAH S156
K169-ub
SHGLQEGkDLFTQRQ
Downstream
1 3
Effects on Modified Protein
  • intracellular localization
CDC25A (human) SHGLQEGkDLFTQRQ K169-ub
CDC25A iso2 (human) gap -
CDC25A (mouse) RHIYEESKDPFTHRQ K163
CDC25A (rat) AHVHEESKDPFTHRQ K169
S178-p
LFTQRQNsAPARMLs
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein degradation
Kinase, in vitro:
  • Chk1 (human)
  • Chk2 (human)
Putative in vivo kinases:
  • Chk1 (human)
Treatment
  • ionizing_radiation
  • UCN-01
CDC25A (human) LFTQRQNsAPARMLs S178-p
CDC25A iso2 (human) gap -
CDC25A (mouse) PFTHRQNSAPARMLS S172
CDC25A (rat) PFTHRQNSAPARMLS S178
S185-p
sAPARMLsSNERDSS
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • DYRK2 (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) sAPARMLsSNERDSS S185-p
CDC25A iso2 (human) DENKENLSSNERDSS S145
CDC25A (mouse) SAPARMLSSNESESG S179
CDC25A (rat) SAPARMLSSNESDIS S185
K257-ub
TNLDNRCkLFDsPSL
0 2
CDC25A (human) TNLDNRCkLFDsPSL K257-ub
CDC25A iso2 (human) TNLDNRCKLFDSPSL K217
CDC25A (mouse) ANLADRCGLFDSPSP G249
CDC25A (rat) TNLADRCGLFDSPSP G258
S261-p
NRCkLFDsPSLCSSS
0 3
CDC25A (human) NRCkLFDsPSLCSSS S261-p
CDC25A iso2 (human) NRCKLFDSPSLCSSS S221
CDC25A (mouse) DRCGLFDSPSPCGSS S253
CDC25A (rat) DRCGLFDSPSPCSST S262
R278-m2
SVLKRPErsQEEsPP
0 1
CDC25A (human) SVLKRPErsQEEsPP R278-m2
CDC25A iso2 (human) SVLKRPERSQEESPP R238
CDC25A (mouse) AVLKRADRSHEEPPR R270
CDC25A (rat) RAVKRADRSHEESPR R282
S279-p
VLKRPErsQEEsPPG
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Kinase, in vitro:
  • Chk1 (human)
  • Chk2 (human)
Putative in vivo kinases:
  • Chk1 (human)
Treatment
  • ionizing_radiation
  • UCN-01
CDC25A (human) VLKRPErsQEEsPPG S279-p
CDC25A iso2 (human) VLKRPERSQEESPPG S239
CDC25A (mouse) VLKRADRSHEEPPRG S271
CDC25A (rat) AVKRADRSHEESPRG S283
S283-p
PErsQEEsPPGSTKr
Upstream
Downstream
2 2
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • DYRK2 (human)
view more >
Putative in vivo kinases:
  • CDK1 (human)
  • CDK2 (human)
  • DYRK2 (human)
view more >
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) PErsQEEsPPGSTKr S283-p
CDC25A iso2 (human) PERSQEESPPGSTKR S243
CDC25A (mouse) gap -
CDC25A (rat) ADRSHEESPRGTKRR S287
R290-m2
sPPGSTKrRKsMsGA
0 1
CDC25A (human) sPPGSTKrRKsMsGA R290-m2
CDC25A iso2 (human) SPPGSTKRRKSMSGA R250
CDC25A (mouse) EPPRGTKRRKSVPSP R281
CDC25A (rat) ESPRGTKRRKSsEAS R293
S293-p
GSTKrRKsMsGASPk
Upstream
Downstream
2 2
Effects on Modified Protein
  • protein degradation
Kinase, in vitro:
  • Chk1 (human)
  • Chk2 (human)
  • p90RSK (human)
view more >
Putative in vivo kinases:
  • Chk1 (human)
  • p90RSK (human)
Treatment
  • BI-D1870
  • ionizing_radiation
  • SL0101
  • UCN-01
view more >
CDC25A (human) GSTKrRKsMsGASPk S293-p
CDC25A iso2 (human) GSTKRRKSMSGASPK S253
CDC25A (mouse) RGTKRRKSVPSPVKA S284
CDC25A (rat) RGTKRRKSsEASPVK S296
S295-p
TKrRKsMsGASPkES
Upstream
1 2
Kinase, in vitro:
  • p90RSK (human)
Putative in vivo kinases:
  • p90RSK (human)
CDC25A (human) TKrRKsMsGASPkES S295-p
CDC25A iso2 (human) TKRRKSMSGASPKES S255
CDC25A (mouse) TKRRKSVPSPVKAKA P286
CDC25A (rat) GTKRRKSsEASPVKA S297-p
K300-ub
sMsGASPkESTNPEK
0 1
CDC25A (human) sMsGASPkESTNPEK K300-ub
CDC25A iso2 (human) SMSGASPKESTNPEK K260
CDC25A (mouse) SVPSPVKAKADVPEP A291
CDC25A (rat) KSsEASPVKADVPEP V302
S315
AHETLHQSLSLAssP
0 1
CDC25A (human) AHETLHQSLSLAssP S315
CDC25A iso2 (human) AHETLHQSLSLASSP S275
CDC25A (mouse) PAQLPSQsLSLMSSP S305-p
CDC25A (rat) PTQLPHQSLSLTSFP S316
S320-p
HQSLSLAssPKGTIE
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • DYRK2 (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) HQSLSLAssPKGTIE S320-p
CDC25A iso2 (human) HQSLSLASSPKGTIE S280
CDC25A (mouse) SQsLSLMSSPKGTIE S310
CDC25A (rat) HQSLSLTSFPKGTIE S321
S321-p
QSLSLAssPKGTIEN
Upstream
Downstream
2 3
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • DYRK2 (human)
Phosphatases, in vitro:
  • CDC14A (human)
Putative in vivo kinases:
  • DYRK2 (human)
Treatment
  • harmine
  • LDN-192960
  • siRNA
view more >
CDC25A (human) QSLSLAssPKGTIEN S321-p
CDC25A iso2 (human) QSLSLASSPKGTIEN S281
CDC25A (mouse) QsLSLMSSPKGTIEN S311
CDC25A (rat) QSLSLTSFPKGTIEN F322
K343-ub
DLIGDFSkGYLFHTV
0 3
CDC25A (human) DLIGDFSkGYLFHTV K343-ub
CDC25A iso2 (human) DLIGDFSKGYLFHTV K303
CDC25A (mouse) DLIGDFSKGYLFNTV K333
CDC25A (rat) DLIGDFSKGYLFHTV K344
K353-ub
LFHTVAGkHQDLkyI
0 2
CDC25A (human) LFHTVAGkHQDLkyI K353-ub
CDC25A iso2 (human) LFHTVAGKHQDLKYI K313
CDC25A (mouse) LFNTVSGKHQDLKYI K343
CDC25A (rat) LFHTVSGKHQDLKYI K354
K358-ub
AGkHQDLkyIsPEIM
0 1
CDC25A (human) AGkHQDLkyIsPEIM K358-ub
CDC25A iso2 (human) AGKHQDLKYISPEIM K318
CDC25A (mouse) SGKHQDLKYISPEIM K348
CDC25A (rat) SGKHQDLKYISPEIM K359
Y359-p
GkHQDLkyIsPEIMA
0 1
CDC25A (human) GkHQDLkyIsPEIMA Y359-p
CDC25A iso2 (human) GKHQDLKYISPEIMA Y319
CDC25A (mouse) GKHQDLKYISPEIMA Y349
CDC25A (rat) GKHQDLKYISPEIMA Y360
S361-p
HQDLkyIsPEIMAsV
0 1
CDC25A (human) HQDLkyIsPEIMAsV S361-p
CDC25A iso2 (human) HQDLKYISPEIMASV S321
CDC25A (mouse) HQDLKYISPEIMASV S351
CDC25A (rat) HQDLKYISPEIMASV S362
S367-p
IsPEIMAsVLNGkFA
0 1
CDC25A (human) IsPEIMAsVLNGkFA S367-p
CDC25A iso2 (human) ISPEIMASVLNGKFA S327
CDC25A (mouse) ISPEIMASVLNGKFA S357
CDC25A (rat) ISPEIMASVLNGKFA S368
K372-ub
MAsVLNGkFANLIkE
0 1
CDC25A (human) MAsVLNGkFANLIkE K372-ub
CDC25A iso2 (human) MASVLNGKFANLIKE K332
CDC25A (mouse) MASVLNGKFAGLIKE K362
CDC25A (rat) MASVLNGKFANLIKE K373
K378-ub
GkFANLIkEFVIIDC
0 1
CDC25A (human) GkFANLIkEFVIIDC K378-ub
CDC25A iso2 (human) GKFANLIKEFVIIDC K338
CDC25A (mouse) GKFAGLIKEFVIIDC K368
CDC25A (rat) GKFANLIKEFVIIDC K379
K415-ub
VEDFLLKkPIVPTDG
0 2
CDC25A (human) VEDFLLKkPIVPTDG K415-ub
CDC25A iso2 (human) VEDFLLKKPIVPTDG K375
CDC25A (mouse) VEDFLLKNPIVPTDG N405
CDC25A (rat) VEEFLLKKPIVPADG K416
K471-ub
YVLKGGYkEFFMKCQ
0 1
CDC25A (human) YVLKGGYkEFFMKCQ K471-ub
CDC25A iso2 (human) YVLKGGYKEFFMKCQ K431
CDC25A (mouse) YVLKGGYKEFFLKCQ K461
CDC25A (rat) YVLKGGYKEFFLKCQ K472
Y486-p
SYCEPPSyRPMHHED
Upstream
1 0
Kinase, in vitro:
  • Src (human)
CDC25A (human) SYCEPPSyRPMHHED Y486-p
CDC25A iso2 (human) SYCEPPSYRPMHHED Y446
CDC25A (mouse) SHCEPPSYRPMHHED Y476
CDC25A (rat) SHCEPPSYRPMHHED Y487
T507-p
KFRTKSRtWAGEKsK
Upstream
Downstream
4 2
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
Kinase, in vitro:
  • Chk1 (human)
Putative in vivo kinases:
  • Chk1 (human)
Treatment
  • caffeine
  • ionizing_radiation
  • staurosporine
  • U0126
view more >
CDC25A (human) KFRTKSRtWAGEKsK T507-p
CDC25A iso2 (human) KFRTKSRTWAGEKSK T467
CDC25A (mouse) KFRTKSRTWAGEkSK T497
CDC25A (rat) KFRTKSRTWAGEKSK T508
K512
SRtWAGEKsKREMYs
0 1
CDC25A (human) SRtWAGEKsKREMYs K512
CDC25A iso2 (human) SRTWAGEKSKREMYS K472
CDC25A (mouse) SRTWAGEkSKREMYS K502-ac
CDC25A (rat) SRTWAGEKSKREMYS K513
S513-p
RtWAGEKsKREMYsR
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK3 (mouse)
Treatment
  • ionizing_radiation
  • MG132
CDC25A (human) RtWAGEKsKREMYsR S513-p
CDC25A iso2 (human) RTWAGEKSKREMYSR S473
CDC25A (mouse) RTWAGEkSKREMYSR S503
CDC25A (rat) RTWAGEKSKREMYSR S514
S519-p
KsKREMYsRLKKL__
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK3 (mouse)
Treatment
  • ionizing_radiation
  • MG132
CDC25A (human) KsKREMYsRLKKL__ S519-p
CDC25A iso2 (human) KSKREMYSRLKKL__ S479
CDC25A (mouse) kSKREMYSRLKKL__ S509
CDC25A (rat) KSKREMYSRLKKL__ S520