Other Species / Isoforms mouse rat isoforms

RFA2 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

S4-p

____MWNsGFEsyGs

Upstream

Downstream

35

2

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
apoptosis, induced
cell cycle regulation
cell growth, altered
transcription, altered

Putative in vivo kinases:

DNAPK (human)

Putative upstream phosphatases:

PPP4C (human)

Regulatory protein:

ATM (human)
ATR (human)
BAT1 (human)
BRCA1 (human)
CDC5L (human)
CDK5 (human)
Chk1 (human)
CtIP (human)
DNAPK (human)
FAM44A (human)
FANCD2 (human)
FOXM1 (human)
MCPH1 (human)
NBS1 (human)
NONO (human)
p21Cip1 (human)
p53 (human)
PARG (human)
PIAS1 (human)
PIAS4 (human)
POLH (human)
PRPF19 (human)
PRPF3 (human)
SIRT6 (human)
TELO2 (human)
TOPBP1 (human)

Treatment

RFA2 (human)	____MWNsGFEsyGs	S4-p
RFA2 iso3 (human)	LILLFKTGGFESYGS	G92
RFA2 (mouse)	____MWNsGFESFtS	S4-p
RFA2 (rat)	____MWNSGFESFSS	S4

S8-p

MWNsGFEsyGsssyG

Upstream

Downstream

36

2

RFA2 (human)
S8-p

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
apoptosis, induced
cell cycle regulation
cell growth, altered
transcription, altered

Putative in vivo kinases:

DNAPK (human)

Putative upstream phosphatases:

PPP4C (human)

Regulatory protein:

ATM (human)
ATR (human)
BAT1 (human)
BRCA1 (human)
CDC5L (human)
CDK5 (human)
Chk1 (human)
CtIP (human)
DNAPK (human)
FAM44A (human)
FANCD2 (human)
FOXM1 (human)
MCPH1 (human)
NBS1 (human)
NONO (human)
p21Cip1 (human)
p53 (human)
PARG (human)
PIAS1 (human)
PIAS4 (human)
POLH (human)
PPP4R2 (human)
PRPF19 (human)
PRPF3 (human)
SIRT6 (human)
TELO2 (human)
TOPBP1 (human)

Treatment

RFA2 (human)	MWNsGFEsyGsssyG	S8-p
RFA2 iso3 (human)	FKTGGFESYGSSSYG	S96
RFA2 (mouse)	MWNsGFESFtSsTyG	S8
RFA2 (rat)	MWNSGFESFSSSSYG	S8

Y9-p

WNsGFEsyGsssyGG

0

1

RFA2 (human)	WNsGFEsyGsssyGG	Y9-p
RFA2 iso3 (human)	KTGGFESYGSSSYGG	Y97
RFA2 (mouse)	WNsGFESFtSsTyGG	F9
RFA2 (rat)	WNSGFESFSSSSYGA	F9

G10

NsGFEsyGsssyGGA

0

1

RFA2 (human)	NsGFEsyGsssyGGA	G10
RFA2 iso3 (human)	TGGFESYGSSSYGGA	G98
RFA2 (mouse)	NsGFESFtSsTyGGR	T10-p
RFA2 (rat)	NSGFESFSSSSYGAA	S10

S11-p

sGFEsyGsssyGGAG

Upstream

Downstream

3

0

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
cell growth, altered

Treatment

UV

RFA2 (human)	sGFEsyGsssyGGAG	S11-p
RFA2 iso3 (human)	GGFESYGSSSYGGAG	S99
RFA2 (mouse)	sGFESFtSsTyGGRG	S11
RFA2 (rat)	SGFESFSSSSYGAAG	S11

S12-p

GFEsyGsssyGGAGG

Upstream

Downstream

3

1

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
cell growth, altered

Treatment

UV

RFA2 (human)	GFEsyGsssyGGAGG	S12-p
RFA2 iso3 (human)	GFESYGSSSYGGAGG	S100
RFA2 (mouse)	GFESFtSsTyGGRGG	S12-p
RFA2 (rat)	GFESFSSSSYGAAGG	S12

S13-p

FEsyGsssyGGAGGY

Upstream

Downstream

3

0

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
cell growth, altered

Treatment

UV

RFA2 (human)	FEsyGsssyGGAGGY	S13-p
RFA2 iso3 (human)	FESYGSSSYGGAGGY	S101
RFA2 (mouse)	FESFtSsTyGGRGGY	T13
RFA2 (rat)	FESFSSSSYGAAGGY	S13

Y14-p

EsyGsssyGGAGGYt

0

2

RFA2 (human)	EsyGsssyGGAGGYt	Y14-p
RFA2 iso3 (human)	ESYGSSSYGGAGGYT	Y102
RFA2 (mouse)	ESFtSsTyGGRGGYT	Y14-p
RFA2 (rat)	ESFSSSSYGAAGGYT	Y14

T21-p

yGGAGGYtQsPGGFG

Upstream

Downstream

19

0

Effects on Modified Protein

intracellular localization
molecular association, regulation
phosphorylation

Effects on Biological Processes:

DNA repair, induced
apoptosis, altered
cell cycle regulation
cell growth, altered
transcription, altered

Kinase, in vitro:

ATM (human)
ATR (human)
DNAPK (human)

Putative in vivo kinases:

ATM (human)
DNAPK (human)

Putative upstream phosphatases:

PPP2CA (human)
PPP4C (human)

Regulatory protein:

ATM (human)
ATR (human)
BAT1 (human)
CDC5L (human)
CLK2 (human)
CtIP (human)
FAAP24 (human)
FANCM (human)
FBXO44 (human)
p21Cip1 (human)
p53 (human)
PRPF19 (human)
PRPF3 (human)
SUV39H1 (human)
TOPBP1 (human)

Treatment

adriamycin
aphidicolin
AZ20
caffeine
camptothecin
CPT
Et743
etoposide
hydroxyurea
ionizing_radiation
lurbinectedin
okadaic_acid
olaparib
release from HU
release_from_UV
seliciclib
siRNA
t-BH
UV
wortmannin

RFA2 (human)	yGGAGGYtQsPGGFG	T21-p
RFA2 iso3 (human)	YGGAGGYTQSPGGFG	T109
RFA2 (mouse)	yGGRGGYTQSPGGFG	T21
RFA2 (rat)	YGAAGGYTQSPGGFG	T21

S23-p

GAGGYtQsPGGFGsP

Upstream

Downstream

7

3

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
cell cycle regulation

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK5 (human)

Putative in vivo kinases:

ATM (human)
DNAPK (human)

Regulatory protein:

PPP4R2 (human)

Treatment

CPT
hydroxyurea
ionizing_radiation
KU-55933
nocodazole
NU7441
seliciclib
UV
wortmannin

RFA2 (human)	GAGGYtQsPGGFGsP	S23-p
RFA2 iso3 (human)	GAGGYTQSPGGFGSP	S111
RFA2 (mouse)	GRGGYTQSPGGFGsP	S23
RFA2 (rat)	AAGGYTQSPGGFGSP	S23

S29-p

QsPGGFGsPAPsQAE

Upstream

Downstream

11

5

Effects on Modified Protein

intracellular localization
molecular association, regulation

Effects on Biological Processes:

DNA repair, induced
cell cycle regulation
transcription, altered

Kinase, in vitro:

CDK1 (human)
CDK2 (human)
CDK5 (human)

Putative in vivo kinases:

ATM (human)
DNAPK (human)

Regulatory protein:

APC (human)
CDK2 (human)
CDK5 (human)
p21Cip1 (human)
p53 (human)
PPP4R2 (human)

Treatment

camptothecin
CPT
hydroxyurea
ionizing_radiation
KU-55933
nocodazole
NU7441
seliciclib
U0126
UV
wortmannin

RFA2 (human)	QsPGGFGsPAPsQAE	S29-p
RFA2 iso3 (human)	QSPGGFGSPAPSQAE	S117
RFA2 (mouse)	QSPGGFGsPtPsQAE	S29-p
RFA2 (rat)	QSPGGFGSPTPSQAE	S29

A31

PGGFGsPAPsQAEKK

0

1

RFA2 (human)	PGGFGsPAPsQAEKK	A31
RFA2 iso3 (human)	PGGFGSPAPSQAEKK	A119
RFA2 (mouse)	PGGFGsPtPsQAEKK	T31-p
RFA2 (rat)	PGGFGSPTPSQAEKK	T31

S33-p

GFGsPAPsQAEKKSR

Upstream

Downstream

33

2

Effects on Modified Protein

intracellular localization
molecular association, regulation
phosphorylation

Effects on Biological Processes:

DNA repair, induced
DNA repair, inhibited
apoptosis, altered
cell cycle regulation
cell growth, altered
cell growth, induced

Kinase, in vitro:

ATR (human)
CDK1 (human)
CDK2 (human)
CDK5 (human)
DNAPK (human)

Putative in vivo kinases:

ATR (human)

Putative upstream phosphatases:

PPP2CA (human)
PPP4C (human)

Regulatory protein:

APC (human)
ARID1A (human)
ATR (human)
CDC5L (human)
CDK5 (human)
CtIP (human)
DNAPK (human)
FANCD2 (human)
MCPH1 (human)
NBS1 (human)
PPP4R2 (human)
PRPF19 (human)
PRPF3 (human)
RAD17 (human)
RNASEH1 (human)
SSB1 (human)
TOP2A (human)
TOPBP1 (human)

Treatment

AP20187
aphidicolin
AZ20
caffeine
camptothecin
CGK733
cisplatin
CPT
ETAA1
etoposide
g_DNA
HAMNO
hydroxyurea
KU-55933
lncRNAs
nocodazole
NU7026
NU7441
okadaic_acid
olaparib
oxaliplatin
prexasertib
release from HU
release_from_UV
seliciclib
siRNA
UV
VE-821

RFA2 (human)	GFGsPAPsQAEKKSR	S33-p
RFA2 iso3 (human)	GFGSPAPSQAEKKSR	S121
RFA2 (mouse)	GFGsPtPsQAEKKsR	S33-p
RFA2 (rat)	GFGSPTPSQAEKKSR	S33

S39

PsQAEKKSRARAQHI

0

1

RFA2 (human)	PsQAEKKSRARAQHI	S39
RFA2 iso3 (human)	PSQAEKKSRARAQHI	S127
RFA2 (mouse)	PsQAEKKsRVRAQHI	S39-p
RFA2 (rat)	PSQAEKKSRARAQHI	S39

S52-p

HIVPCTIsQLLSATL

Upstream

1

0

Kinase, in vitro:

ATR (human)

RFA2 (human)	HIVPCTIsQLLSATL	S52-p
RFA2 iso3 (human)	HIVPCTISQLLSATL	S140
RFA2 (mouse)	HIVPCTISQLLSATL	S52
RFA2 (rat)	HIVPCTISQLLSATL	S52

S72-p

RIGNVEIsQVTIVGI

Upstream

1

0

Kinase, in vitro:

ATR (human)

RFA2 (human)	RIGNVEIsQVTIVGI	S72-p
RFA2 iso3 (human)	RIGNVEISQVTIVGI	S160
RFA2 (mouse)	RIGDVEISQVTIVGI	S72
RFA2 (rat)	KIGDVEISQVTIVGI	S72

K85-ub

GIIRHAEkAPtNIVY

0

6

RFA2 (human)	GIIRHAEkAPtNIVY	K85-ub
RFA2 iso3 (human)	GIIRHAEKAPTNIVY	K173
RFA2 (mouse)	GIIRHAEKAPTNIVY	K85
RFA2 (rat)	GIIRHAEKAPTNIVY	K85

T88-p

RHAEkAPtNIVYkID

0

1

RFA2 (human)	RHAEkAPtNIVYkID	T88-p
RFA2 iso3 (human)	RHAEKAPTNIVYKID	T176
RFA2 (mouse)	RHAEKAPTNIVYKID	T88
RFA2 (rat)	RHAEKAPTNIVYKID	T88

K93-ub

APtNIVYkIDDMTAA

0

3

RFA2 (human)	APtNIVYkIDDMTAA	K93-ub
RFA2 iso3 (human)	APTNIVYKIDDMTAA	K181
RFA2 (mouse)	APTNIVYKIDDMTAP	K93
RFA2 (rat)	APTNIVYKIDDMTAA	K93

R105-m1

TAAPMDVrQWVDTDD

0

1

RFA2 (human)	TAAPMDVrQWVDTDD	R105-m1
RFA2 iso3 (human)	TAAPMDVRQWVDTDD	R193
RFA2 (mouse)	TAPPMDVRQWVDTDD	R105
RFA2 (rat)	TAAPMDVRQWVDTDD	R105

K127-ub

VPPETYVkVAGHLrS

0

7

RFA2 (human)	VPPETYVkVAGHLrS	K127-ub
RFA2 iso3 (human)	VPPETYVKVAGHLRS	K215
RFA2 (mouse)	VPPETYVKVAGHLRS	K127
RFA2 (rat)	VPPETYVKVAGHLRS	K127

R133-m1

VkVAGHLrSFQNKkS

0

1

RFA2 (human)	VkVAGHLrSFQNKkS	R133-m1
RFA2 iso3 (human)	VKVAGHLRSFQNKKS	R221
RFA2 (mouse)	VKVAGHLRSFQNKKS	R133
RFA2 (rat)	VKVAGHLRSFQNKKS	R133

K139-ub

LrSFQNKkSLVAFKI

0

1

RFA2 (human)	LrSFQNKkSLVAFKI	K139-ub
RFA2 iso3 (human)	LRSFQNKKSLVAFKI	K227
RFA2 (mouse)	LRSFQNKKSLVAFKI	K139
RFA2 (rat)	LRSFQNKKSLVAFKI	K139

K171-ub

NAHMVLSkANsQPSA

0

1

RFA2 (human)	NAHMVLSkANsQPSA	K171-ub
RFA2 iso3 (human)	NAHMVLSKANSQPSA	K259
RFA2 (mouse)	NSHMMLSKPNSQASA	K171
RFA2 (rat)	NSHLMLSKANSQASV	K171

S174-p

MVLSkANsQPSAGRA

Upstream

1

0

Kinase, in vitro:

ATR (human)

RFA2 (human)	MVLSkANsQPSAGRA	S174-p
RFA2 iso3 (human)	MVLSKANSQPSAGRA	S262
RFA2 (mouse)	MMLSKPNSQASAGRP	S174
RFA2 (rat)	LMLSKANSQASVGRP	S174

K231-ub

GLNFQDLkNQLkHMs

0

2

RFA2 (human)	GLNFQDLkNQLkHMs	K231-ub
RFA2 iso3 (human)	GLNFQDLKNQLKHMS	K319
RFA2 (mouse)	GLNFQDLRsQLQHMP	R231
RFA2 (rat)	GLNFQDLRSQLQHMP	R231

K231-ac

GLNFQDLkNQLkHMs

0

1

RFA2 (human)	GLNFQDLkNQLkHMs	K231-ac
RFA2 iso3 (human)	GLNFQDLKNQLKHMS	K319
RFA2 (mouse)	GLNFQDLRsQLQHMP	R231
RFA2 (rat)	GLNFQDLRSQLQHMP	R231

N232

LNFQDLkNQLkHMsV

0

1

RFA2 (human)	LNFQDLkNQLkHMsV	N232
RFA2 iso3 (human)	LNFQDLKNQLKHMSV	N320
RFA2 (mouse)	LNFQDLRsQLQHMPV	S232-p
RFA2 (rat)	LNFQDLRSQLQHMPV	S232

K235-ub

QDLkNQLkHMsVsSI

0

4

RFA2 (human)	QDLkNQLkHMsVsSI	K235-ub
RFA2 iso3 (human)	QDLKNQLKHMSVSSI	K323
RFA2 (mouse)	QDLRsQLQHMPVPsI	Q235
RFA2 (rat)	QDLRSQLQHMPVASI	Q235

S238-p

kNQLkHMsVsSIkQA

0

9

RFA2 (human)	kNQLkHMsVsSIkQA	S238-p
RFA2 iso3 (human)	KNQLKHMSVSSIKQA	S326
RFA2 (mouse)	RsQLQHMPVPsIKQA	P238
RFA2 (rat)	RSQLQHMPVASIKQA	P238

S240-p

QLkHMsVsSIkQAVD

0

2

RFA2 (human)	QLkHMsVsSIkQAVD	S240-p
RFA2 iso3 (human)	QLKHMSVSSIKQAVD	S328
RFA2 (mouse)	QLQHMPVPsIKQAVD	P240
RFA2 (rat)	QLQHMPVASIKQAVD	A240

S241

LkHMsVsSIkQAVDF

0

1

RFA2 (human)	LkHMsVsSIkQAVDF	S241
RFA2 iso3 (human)	LKHMSVSSIKQAVDF	S329
RFA2 (mouse)	LQHMPVPsIKQAVDF	S241-p
RFA2 (rat)	LQHMPVASIKQAVDF	S241

K243-ub

HMsVsSIkQAVDFLS

0

1

RFA2 (human)	HMsVsSIkQAVDFLS	K243-ub
RFA2 iso3 (human)	HMSVSSIKQAVDFLS	K331
RFA2 (mouse)	HMPVPsIKQAVDFLC	K243
RFA2 (rat)	HMPVASIKQAVDFLC	K243