S4-p
|
____MWNsGFEsyGs
|
Upstream
|
Downstream
|
36
|
2
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- apoptosis, induced
- cell cycle regulation
- cell growth, altered
- transcription, altered
|
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- ATM (human)
- ATR (human)
- BAT1 (human)
- BRCA1 (human)
- CDC5L (human)
- CDK5 (human)
- Chk1 (human)
- CtIP (human)
- DKFZp686L1814 (human)
- DNAPK (human)
- FAM44A (human)
- FANCD2 (human)
- FOXM1 (human)
- HEL308 (human)
- MCPH1 (human)
- NBS1 (human)
- NONO (human)
- p21Cip1 (human)
- p53 (human)
- PARG (human)
- PIAS1 (human)
- PIAS4 (human)
- POLH (human)
- PRPF19 (human)
- PRPF3 (human)
- SIRT6 (human)
- TELO2 (human)
- TOPBP1 (human)
|
Treatment
- 4-nitroquinoline_1-oxide
- adriamycin
- aphidicolin
- AZ20
- caffeine
- camptothecin
- carboplatin
- CGK733
- cisplatin
- CPT
- etoposide
- gemcitabine
- HAMNO
- hydroxyurea
- ionizing_radiation
- KU-55933
- mirin
- miRNA
- mitomycin_C
- MK-8776
- MMS
- NU7026
- NU7441
- olaparib
- oxaliplatin
- prexasertib
- seliciclib
- siRNA
- UCN-01
- UV
- VE-821
|
|
RFA2 (human)
|
____MWNsGFEsyGs
|
S4-p
|
RFA2 iso3 (human)
|
LILLFKTGGFESYGS
|
G92
|
RFA2 (mouse)
|
____MWNsGFESFtS
|
S4-p
|
RFA2 (rat)
|
____MWNSGFESFSS
|
S4
|
|
S8-p
|
MWNsGFEsyGsssyG
|
Upstream
|
Downstream
|
37
|
2
|
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- apoptosis, induced
- cell cycle regulation
- cell growth, altered
- transcription, altered
|
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- ATM (human)
- ATR (human)
- BAT1 (human)
- BRCA1 (human)
- CDC5L (human)
- CDK5 (human)
- Chk1 (human)
- CtIP (human)
- DKFZp686L1814 (human)
- DNAPK (human)
- FAM44A (human)
- FANCD2 (human)
- FOXM1 (human)
- HEL308 (human)
- MCPH1 (human)
- NBS1 (human)
- NONO (human)
- p21Cip1 (human)
- p53 (human)
- PARG (human)
- PIAS1 (human)
- PIAS4 (human)
- POLH (human)
- PPP4R2 (human)
- PRPF19 (human)
- PRPF3 (human)
- SIRT6 (human)
- TELO2 (human)
- TOPBP1 (human)
|
Treatment
- 4-nitroquinoline_1-oxide
- adriamycin
- aphidicolin
- AZ20
- caffeine
- camptothecin
- carboplatin
- CGK733
- cisplatin
- CPT
- etoposide
- gemcitabine
- HAMNO
- hydroxyurea
- ionizing_radiation
- KU-55933
- mirin
- miRNA
- mitomycin_C
- MK-8776
- MMS
- NU7026
- NU7441
- olaparib
- oxaliplatin
- prexasertib
- seliciclib
- siRNA
- UCN-01
- UV
- VE-821
|
|
RFA2 (human)
|
MWNsGFEsyGsssyG
|
S8-p
|
RFA2 iso3 (human)
|
FKTGGFESYGSSSYG
|
S96
|
RFA2 (mouse)
|
MWNsGFESFtSsTyG
|
S8
|
RFA2 (rat)
|
MWNSGFESFSSSSYG
|
S8
|
|
Y9-p
|
WNsGFEsyGsssyGG
|
|
|
0
|
1
|
|
RFA2 (human)
|
WNsGFEsyGsssyGG
|
Y9-p
|
RFA2 iso3 (human)
|
KTGGFESYGSSSYGG
|
Y97
|
RFA2 (mouse)
|
WNsGFESFtSsTyGG
|
F9
|
RFA2 (rat)
|
WNSGFESFSSSSYGA
|
F9
|
|
G10
|
NsGFEsyGsssyGGA
|
|
|
0
|
1
|
|
RFA2 (human)
|
NsGFEsyGsssyGGA
|
G10
|
RFA2 iso3 (human)
|
TGGFESYGSSSYGGA
|
G98
|
RFA2 (mouse)
|
NsGFESFtSsTyGGR
|
T10-p
|
RFA2 (rat)
|
NSGFESFSSSSYGAA
|
S10
|
|
S11-p
|
sGFEsyGsssyGGAG
|
Upstream
|
Downstream
|
3
|
0
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- cell growth, altered
|
|
|
RFA2 (human)
|
sGFEsyGsssyGGAG
|
S11-p
|
RFA2 iso3 (human)
|
GGFESYGSSSYGGAG
|
S99
|
RFA2 (mouse)
|
sGFESFtSsTyGGRG
|
S11
|
RFA2 (rat)
|
SGFESFSSSSYGAAG
|
S11
|
|
S12-p
|
GFEsyGsssyGGAGG
|
Upstream
|
Downstream
|
3
|
1
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- cell growth, altered
|
|
|
RFA2 (human)
|
GFEsyGsssyGGAGG
|
S12-p
|
RFA2 iso3 (human)
|
GFESYGSSSYGGAGG
|
S100
|
RFA2 (mouse)
|
GFESFtSsTyGGRGG
|
S12-p
|
RFA2 (rat)
|
GFESFSSSSYGAAGG
|
S12
|
|
S13-p
|
FEsyGsssyGGAGGY
|
Upstream
|
Downstream
|
3
|
0
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- cell growth, altered
|
|
|
RFA2 (human)
|
FEsyGsssyGGAGGY
|
S13-p
|
RFA2 iso3 (human)
|
FESYGSSSYGGAGGY
|
S101
|
RFA2 (mouse)
|
FESFtSsTyGGRGGY
|
T13
|
RFA2 (rat)
|
FESFSSSSYGAAGGY
|
S13
|
|
Y14-p
|
EsyGsssyGGAGGYt
|
|
|
0
|
2
|
|
RFA2 (human)
|
EsyGsssyGGAGGYt
|
Y14-p
|
RFA2 iso3 (human)
|
ESYGSSSYGGAGGYT
|
Y102
|
RFA2 (mouse)
|
ESFtSsTyGGRGGYT
|
Y14-p
|
RFA2 (rat)
|
ESFSSSSYGAAGGYT
|
Y14
|
|
T21-p
|
yGGAGGYtQsPGGFG
|
Upstream
|
Downstream
|
20
|
0
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
- phosphorylation
|
Effects on Biological Processes:
- DNA repair, induced
- apoptosis, altered
- cell cycle regulation
- cell growth, altered
- transcription, altered
|
|
Kinase, in vitro:
- ATM (human)
- ATR (human)
- DNAPK (human)
|
Putative in vivo kinases:
- ATM (human)
- DNAPK (human)
|
Putative upstream phosphatases:
- PPP2CA (human)
- PPP4C (human)
|
Regulatory protein:
- ATM (human)
- ATR (human)
- BAT1 (human)
- CDC5L (human)
- CLK2 (human)
- CtIP (human)
- FAAP24 (human)
- FANCM (human)
- FBXO44 (human)
- p21Cip1 (human)
- p53 (human)
- PRPF19 (human)
- PRPF3 (human)
- SUV39H1 (human)
- TOPBP1 (human)
|
Treatment
- adriamycin
- aphidicolin
- AZ20
- caffeine
- camptothecin
- CPT
- Et743
- etoposide
- hydroxyurea
- ionizing_radiation
- lurbinectedin
- okadaic_acid
- olaparib
- release from HU
- release_from_UV
- seliciclib
- siRNA
- t-BH
- UV
- wortmannin
|
|
RFA2 (human)
|
yGGAGGYtQsPGGFG
|
T21-p
|
RFA2 iso3 (human)
|
YGGAGGYTQSPGGFG
|
T109
|
RFA2 (mouse)
|
yGGRGGYTQSPGGFG
|
T21
|
RFA2 (rat)
|
YGAAGGYTQSPGGFG
|
T21
|
|
S23-p
|
GAGGYtQsPGGFGsP
|
Upstream
|
Downstream
|
7
|
3
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- cell cycle regulation
|
|
Kinase, in vitro:
- CDK1 (human)
- CDK2 (human)
- CDK5 (human)
|
Putative in vivo kinases:
- ATM (human)
- DNAPK (human)
|
Regulatory protein:
|
Treatment
- CPT
- hydroxyurea
- ionizing_radiation
- KU-55933
- nocodazole
- NU7441
- seliciclib
- UV
- wortmannin
|
|
RFA2 (human)
|
GAGGYtQsPGGFGsP
|
S23-p
|
RFA2 iso3 (human)
|
GAGGYTQSPGGFGSP
|
S111
|
RFA2 (mouse)
|
GRGGYTQSPGGFGsP
|
S23
|
RFA2 (rat)
|
AAGGYTQSPGGFGSP
|
S23
|
|
S29-p
|
QsPGGFGsPAPsQAE
|
Upstream
|
Downstream
|
11
|
5
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
|
Effects on Biological Processes:
- DNA repair, induced
- cell cycle regulation
- transcription, altered
|
|
Kinase, in vitro:
- CDK1 (human)
- CDK2 (human)
- CDK5 (human)
|
Putative in vivo kinases:
- ATM (human)
- DNAPK (human)
|
Regulatory protein:
- APC (human)
- CDK2 (human)
- CDK5 (human)
- p21Cip1 (human)
- p53 (human)
- PPP4R2 (human)
|
Treatment
- camptothecin
- CPT
- hydroxyurea
- ionizing_radiation
- KU-55933
- nocodazole
- NU7441
- seliciclib
- U0126
- UV
- wortmannin
|
|
RFA2 (human)
|
QsPGGFGsPAPsQAE
|
S29-p
|
RFA2 iso3 (human)
|
QSPGGFGSPAPSQAE
|
S117
|
RFA2 (mouse)
|
QSPGGFGsPtPsQAE
|
S29-p
|
RFA2 (rat)
|
QSPGGFGSPTPSQAE
|
S29
|
|
A31
|
PGGFGsPAPsQAEkk
|
|
|
0
|
1
|
|
RFA2 (human)
|
PGGFGsPAPsQAEkk
|
A31
|
RFA2 iso3 (human)
|
PGGFGSPAPSQAEKK
|
A119
|
RFA2 (mouse)
|
PGGFGsPtPsQAEKK
|
T31-p
|
RFA2 (rat)
|
PGGFGSPTPSQAEKK
|
T31
|
|
S33-p
|
GFGsPAPsQAEkkSR
|
Upstream
|
Downstream
|
34
|
2
|
|
|
Effects on Modified Protein
- intracellular localization
- molecular association, regulation
- phosphorylation
|
Effects on Biological Processes:
- DNA repair, induced
- DNA repair, inhibited
- apoptosis, altered
- cell cycle regulation
- cell growth, altered
- cell growth, induced
|
|
Kinase, in vitro:
- ATR (human)
- CDK1 (human)
- CDK2 (human)
- CDK5 (human)
- DNAPK (human)
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
- PPP2CA (human)
- PPP4C (human)
|
Regulatory protein:
- APC (human)
- ARID1A (human)
- ATR (human)
- BRCA1 (human)
- BRCA2 (human)
- CDC5L (human)
- CDK5 (human)
- CtIP (human)
- DNAPK (human)
- FANCD2 (human)
- MCPH1 (human)
- NBS1 (human)
- PPP4R2 (human)
- PRPF19 (human)
- PRPF3 (human)
- RAD17 (human)
- RNASEH1 (human)
- SSB1 (human)
- TOP2A (human)
- TOPBP1 (human)
|
Treatment
- 680C91
- AP20187
- aphidicolin
- AZ20
- caffeine
- camptothecin
- carmustine
- CGK733
- cisplatin
- CPT
- ETAA1
- etoposide
- g_DNA
- HAMNO
- hydroxyurea
- KU-55933
- kynurenine
- lncRNAs
- nocodazole
- NU7026
- NU7441
- okadaic_acid
- olaparib
- oxaliplatin
- prexasertib
- release from HU
- release_from_UV
- seliciclib
- siRNA
- UV
- VE-821
|
|
RFA2 (human)
|
GFGsPAPsQAEkkSR
|
S33-p
|
RFA2 iso3 (human)
|
GFGSPAPSQAEKKSR
|
S121
|
RFA2 (mouse)
|
GFGsPtPsQAEKKsR
|
S33-p
|
RFA2 (rat)
|
GFGSPTPSQAEKKSR
|
S33
|
|
K37-ub
|
PAPsQAEkkSRARAQ
|
Upstream
|
|
1
|
0
|
|
Regulatory protein:
|
Treatment
|
|
RFA2 (human)
|
PAPsQAEkkSRARAQ
|
K37-ub
|
RFA2 iso3 (human)
|
PAPSQAEKKSRARAQ
|
K125
|
RFA2 (mouse)
|
PtPsQAEKKsRVRAQ
|
K37
|
RFA2 (rat)
|
PTPSQAEKKSRARAQ
|
K37
|
|
K38-ub
|
APsQAEkkSRARAQH
|
Upstream
|
|
1
|
0
|
|
Regulatory protein:
|
Treatment
|
|
RFA2 (human)
|
APsQAEkkSRARAQH
|
K38-ub
|
RFA2 iso3 (human)
|
APSQAEKKSRARAQH
|
K126
|
RFA2 (mouse)
|
tPsQAEKKsRVRAQH
|
K38
|
RFA2 (rat)
|
TPSQAEKKSRARAQH
|
K38
|
|
S39
|
PsQAEkkSRARAQHI
|
|
|
0
|
1
|
|
RFA2 (human)
|
PsQAEkkSRARAQHI
|
S39
|
RFA2 iso3 (human)
|
PSQAEKKSRARAQHI
|
S127
|
RFA2 (mouse)
|
PsQAEKKsRVRAQHI
|
S39-p
|
RFA2 (rat)
|
PSQAEKKSRARAQHI
|
S39
|
|
S52-p
|
HIVPCTIsQLLSATL
|
Upstream
|
|
1
|
0
|
|
|
RFA2 (human)
|
HIVPCTIsQLLSATL
|
S52-p
|
RFA2 iso3 (human)
|
HIVPCTISQLLSATL
|
S140
|
RFA2 (mouse)
|
HIVPCTISQLLSATL
|
S52
|
RFA2 (rat)
|
HIVPCTISQLLSATL
|
S52
|
|
S72-p
|
RIGNVEIsQVTIVGI
|
Upstream
|
|
1
|
0
|
|
|
RFA2 (human)
|
RIGNVEIsQVTIVGI
|
S72-p
|
RFA2 iso3 (human)
|
RIGNVEISQVTIVGI
|
S160
|
RFA2 (mouse)
|
RIGDVEISQVTIVGI
|
S72
|
RFA2 (rat)
|
KIGDVEISQVTIVGI
|
S72
|
|
K85-ub
|
GIIRHAEkAPtNIVY
|
|
|
0
|
6
|
|
RFA2 (human)
|
GIIRHAEkAPtNIVY
|
K85-ub
|
RFA2 iso3 (human)
|
GIIRHAEKAPTNIVY
|
K173
|
RFA2 (mouse)
|
GIIRHAEKAPTNIVY
|
K85
|
RFA2 (rat)
|
GIIRHAEKAPTNIVY
|
K85
|
|
T88-p
|
RHAEkAPtNIVYkID
|
|
|
0
|
1
|
|
RFA2 (human)
|
RHAEkAPtNIVYkID
|
T88-p
|
RFA2 iso3 (human)
|
RHAEKAPTNIVYKID
|
T176
|
RFA2 (mouse)
|
RHAEKAPTNIVYKID
|
T88
|
RFA2 (rat)
|
RHAEKAPTNIVYKID
|
T88
|
|
K93-ub
|
APtNIVYkIDDMTAA
|
|
|
0
|
3
|
|
RFA2 (human)
|
APtNIVYkIDDMTAA
|
K93-ub
|
RFA2 iso3 (human)
|
APTNIVYKIDDMTAA
|
K181
|
RFA2 (mouse)
|
APTNIVYKIDDMTAP
|
K93
|
RFA2 (rat)
|
APTNIVYKIDDMTAA
|
K93
|
|
R105-m1
|
TAAPMDVrQWVDTDD
|
|
|
0
|
1
|
|
RFA2 (human)
|
TAAPMDVrQWVDTDD
|
R105-m1
|
RFA2 iso3 (human)
|
TAAPMDVRQWVDTDD
|
R193
|
RFA2 (mouse)
|
TAPPMDVRQWVDTDD
|
R105
|
RFA2 (rat)
|
TAAPMDVRQWVDTDD
|
R105
|
|
K127-ub
|
VPPETYVkVAGHLrS
|
|
|
0
|
7
|
|
RFA2 (human)
|
VPPETYVkVAGHLrS
|
K127-ub
|
RFA2 iso3 (human)
|
VPPETYVKVAGHLRS
|
K215
|
RFA2 (mouse)
|
VPPETYVKVAGHLRS
|
K127
|
RFA2 (rat)
|
VPPETYVKVAGHLRS
|
K127
|
|
R133-m1
|
VkVAGHLrSFQNKkS
|
|
|
0
|
1
|
|
RFA2 (human)
|
VkVAGHLrSFQNKkS
|
R133-m1
|
RFA2 iso3 (human)
|
VKVAGHLRSFQNKKS
|
R221
|
RFA2 (mouse)
|
VKVAGHLRSFQNKKS
|
R133
|
RFA2 (rat)
|
VKVAGHLRSFQNKKS
|
R133
|
|
K139-ub
|
LrSFQNKkSLVAFKI
|
|
|
0
|
1
|
|
RFA2 (human)
|
LrSFQNKkSLVAFKI
|
K139-ub
|
RFA2 iso3 (human)
|
LRSFQNKKSLVAFKI
|
K227
|
RFA2 (mouse)
|
LRSFQNKKSLVAFKI
|
K139
|
RFA2 (rat)
|
LRSFQNKKSLVAFKI
|
K139
|
|
K171-ub
|
NAHMVLSkANsQPSA
|
|
|
0
|
1
|
|
RFA2 (human)
|
NAHMVLSkANsQPSA
|
K171-ub
|
RFA2 iso3 (human)
|
NAHMVLSKANSQPSA
|
K259
|
RFA2 (mouse)
|
NSHMMLSKPNSQASA
|
K171
|
RFA2 (rat)
|
NSHLMLSKANSQASV
|
K171
|
|
S174-p
|
MVLSkANsQPSAGRA
|
Upstream
|
|
1
|
0
|
|
|
RFA2 (human)
|
MVLSkANsQPSAGRA
|
S174-p
|
RFA2 iso3 (human)
|
MVLSKANSQPSAGRA
|
S262
|
RFA2 (mouse)
|
MMLSKPNSQASAGRP
|
S174
|
RFA2 (rat)
|
LMLSKANSQASVGRP
|
S174
|
|
K231-ac
|
GLNFQDLkNQLkHMs
|
|
|
0
|
1
|
|
RFA2 (human)
|
GLNFQDLkNQLkHMs
|
K231-ac
|
RFA2 iso3 (human)
|
GLNFQDLKNQLKHMS
|
K319
|
RFA2 (mouse)
|
GLNFQDLRsQLQHMP
|
R231
|
RFA2 (rat)
|
GLNFQDLRSQLQHMP
|
R231
|
|
K231-ub
|
GLNFQDLkNQLkHMs
|
|
|
0
|
2
|
|
RFA2 (human)
|
GLNFQDLkNQLkHMs
|
K231-ub
|
RFA2 iso3 (human)
|
GLNFQDLKNQLKHMS
|
K319
|
RFA2 (mouse)
|
GLNFQDLRsQLQHMP
|
R231
|
RFA2 (rat)
|
GLNFQDLRSQLQHMP
|
R231
|
|
N232
|
LNFQDLkNQLkHMsV
|
|
|
0
|
1
|
|
RFA2 (human)
|
LNFQDLkNQLkHMsV
|
N232
|
RFA2 iso3 (human)
|
LNFQDLKNQLKHMSV
|
N320
|
RFA2 (mouse)
|
LNFQDLRsQLQHMPV
|
S232-p
|
RFA2 (rat)
|
LNFQDLRSQLQHMPV
|
S232
|
|
K235-ub
|
QDLkNQLkHMsVsSI
|
|
|
0
|
4
|
|
RFA2 (human)
|
QDLkNQLkHMsVsSI
|
K235-ub
|
RFA2 iso3 (human)
|
QDLKNQLKHMSVSSI
|
K323
|
RFA2 (mouse)
|
QDLRsQLQHMPVPsI
|
Q235
|
RFA2 (rat)
|
QDLRSQLQHMPVASI
|
Q235
|
|
S238-p
|
kNQLkHMsVsSIkQA
|
|
|
0
|
9
|
|
RFA2 (human)
|
kNQLkHMsVsSIkQA
|
S238-p
|
RFA2 iso3 (human)
|
KNQLKHMSVSSIKQA
|
S326
|
RFA2 (mouse)
|
RsQLQHMPVPsIKQA
|
P238
|
RFA2 (rat)
|
RSQLQHMPVASIKQA
|
P238
|
|
S240-p
|
QLkHMsVsSIkQAVD
|
|
|
0
|
2
|
|
RFA2 (human)
|
QLkHMsVsSIkQAVD
|
S240-p
|
RFA2 iso3 (human)
|
QLKHMSVSSIKQAVD
|
S328
|
RFA2 (mouse)
|
QLQHMPVPsIKQAVD
|
P240
|
RFA2 (rat)
|
QLQHMPVASIKQAVD
|
A240
|
|
S241
|
LkHMsVsSIkQAVDF
|
|
|
0
|
1
|
|
RFA2 (human)
|
LkHMsVsSIkQAVDF
|
S241
|
RFA2 iso3 (human)
|
LKHMSVSSIKQAVDF
|
S329
|
RFA2 (mouse)
|
LQHMPVPsIKQAVDF
|
S241-p
|
RFA2 (rat)
|
LQHMPVASIKQAVDF
|
S241
|
|
K243-ub
|
HMsVsSIkQAVDFLS
|
|
|
0
|
1
|
|
RFA2 (human)
|
HMsVsSIkQAVDFLS
|
K243-ub
|
RFA2 iso3 (human)
|
HMSVSSIKQAVDFLS
|
K331
|
RFA2 (mouse)
|
HMPVPsIKQAVDFLC
|
K243
|
RFA2 (rat)
|
HMPVASIKQAVDFLC
|
K243
|
|