Other Species / Isoforms
  HPK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y28-p
QRLGGGTyGEVFkAR
0 26
HPK1 (human) QRLGGGTyGEVFkAR Y28-p
HPK1 (mouse) QRLGGGTYGEVFKAR Y28
HPK1 (rat) QRLGGGTYGEVFKAR Y28
K33-ub
GTyGEVFkARDkVSG
0 2
HPK1 (human) GTyGEVFkARDkVSG K33-ub
HPK1 (mouse) GTYGEVFKARDKVSK K33
HPK1 (rat) GTYGEVFKARDKVSK K33
K37-ub
EVFkARDkVSGDLVA
0 2
HPK1 (human) EVFkARDkVSGDLVA K37-ub
HPK1 (mouse) EVFKARDKVSKDLVA K37
HPK1 (rat) EVFKARDKVSKDLVA K37
K46-ub
SGDLVALkMVkMEPD
0 2
HPK1 (human) SGDLVALkMVkMEPD K46-ub
HPK1 (mouse) SKDLVALKMVKMEPD K46
HPK1 (rat) SKDLVALKMVKMEPD K46
K49-ub
LVALkMVkMEPDDDV
0 1
HPK1 (human) LVALkMVkMEPDDDV K49-ub
HPK1 (mouse) LVALKMVKMEPDDDV K49
HPK1 (rat) LVALKMVKMEPDDDV K49
T165-p
ISAQIGAtLARRLsF
Upstream
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • HPK1 (human)
HPK1 (human) ISAQIGAtLARRLsF T165-p
HPK1 (mouse) ISAQIGATLARRLsF T165
HPK1 (rat) ISAQIGATLARRLSF T165
S171-p
AtLARRLsFIGtPyW
Upstream
Downstream
3 12
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • PRKD1 (human)
HPK1 (human) AtLARRLsFIGtPyW S171-p
HPK1 (mouse) ATLARRLsFIGTPYW S171-p
HPK1 (rat) ATLARRLSFIGTPYW S171
T175-p
RRLsFIGtPyWMAPE
Downstream
2 3
Effects on Modified Protein
  • enzymatic activity, induced
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
HPK1 (human) RRLsFIGtPyWMAPE T175-p
HPK1 (mouse) RRLsFIGTPYWMAPE T175
HPK1 (rat) RRLSFIGTPYWMAPE T175
Y177-p
LsFIGtPyWMAPEVA
0 1
HPK1 (human) LsFIGtPyWMAPEVA Y177-p
HPK1 (mouse) LsFIGTPYWMAPEVA Y177
HPK1 (rat) LSFIGTPYWMAPEVA Y177
S230-p
VLFLMTKsGYQPPRL
0 1
HPK1 (human) VLFLMTKsGYQPPRL S230-p
HPK1 (mouse) VLFLMTKSGYQPPRL S230
HPK1 (rat) VLFLMTKSGYQPPRL S230
S258-p
IKVTLTKsPKKRPSA
0 1
HPK1 (human) IKVTLTKsPKKRPSA S258-p
HPK1 (mouse) VKVTLTKNSKKRPSA N258
HPK1 (rat) VKVTLTKNSKKRPSA N258
K296-ub
DKLKNPGkGPSIGDI
0 1
HPK1 (human) DKLKNPGkGPSIGDI K296-ub
HPK1 (mouse) DKMKNPGKGLPVDIE K296
HPK1 (rat) DKMKNPGKGLPVEIE K296
S320-p
AIPRRIRsTHRsssL
0 4
HPK1 (human) AIPRRIRsTHRsssL S320-p
HPK1 (mouse) AIPRRIRSTYRASSL S319
HPK1 (rat) AIPRRIRSTYRASSL S319
S324-p
RIRsTHRsssLGIPD
0 2
HPK1 (human) RIRsTHRsssLGIPD S324-p
HPK1 (mouse) RIRSTYRASSLGIPD A323
HPK1 (rat) RIRSTYRASSLGIPD A323
S325-p
IRsTHRsssLGIPDA
0 2
HPK1 (human) IRsTHRsssLGIPDA S325-p
HPK1 (mouse) IRSTYRASSLGIPDA S324
HPK1 (rat) IRSTYRASSLGIPDA S324
S326-p
RsTHRsssLGIPDAD
0 4
HPK1 (human) RsTHRsssLGIPDAD S326-p
HPK1 (mouse) RSTYRASSLGIPDAD S325
HPK1 (rat) RSTYRASSLGIPDAD S325
T349-p
RKLRGMEtRPPANtA
1 5
HPK1 (human) RKLRGMEtRPPANtA T349-p
HPK1 (mouse) QRPRCVDCRPQAETV C348
HPK1 (rat) QRPRCVECRSQADTV C348
T355-p
EtRPPANtARLQPPR
Upstream
Downstream
1 6
Effects on Modified Protein
  • ubiquitination
Putative upstream phosphatases:
  • PPP4C (human)
HPK1 (human) EtRPPANtARLQPPR T355-p
HPK1 (mouse) DCRPQAETVRLYPPA T354
HPK1 (rat) ECRSQADTVLLQPSA T354
S366-p
QPPRDLRsSsPRKQL
0 3
HPK1 (human) QPPRDLRsSsPRKQL S366-p
HPK1 (mouse) YPPAHFGstsPRsQL S365-p
HPK1 (rat) QPSADFRSTSPRSQL S365
S367
PPRDLRsSsPRKQLs
0 2
HPK1 (human) PPRDLRsSsPRKQLs S367
HPK1 (mouse) PPAHFGstsPRsQLs T366-p
HPK1 (rat) PSADFRSTSPRSQLS T366
S368-p
PRDLRsSsPRKQLsE
0 2
HPK1 (human) PRDLRsSsPRKQLsE S368-p
HPK1 (mouse) PAHFGstsPRsQLsD S367-p
HPK1 (rat) SADFRSTSPRSQLSD S367
K371
LRsSsPRKQLsEssD
0 1
HPK1 (human) LRsSsPRKQLsEssD K371
HPK1 (mouse) FGstsPRsQLsDsDD S370-p
HPK1 (rat) FRSTSPRSQLSDSDD S370
S374-p
SsPRKQLsEssDDDy
0 5
HPK1 (human) SsPRKQLsEssDDDy S374-p
HPK1 (mouse) tsPRsQLsDsDDDyD S373-p
HPK1 (rat) TSPRSQLSDSDDDYD S373
S376-p
PRKQLsEssDDDyDD
0 3
HPK1 (human) PRKQLsEssDDDyDD S376-p
HPK1 (mouse) gap -
HPK1 (rat) gap -
S377-p
RKQLsEssDDDyDDV
0 7
HPK1 (human) RKQLsEssDDDyDDV S377-p
HPK1 (mouse) PRsQLsDsDDDyDDV S375-p
HPK1 (rat) PRSQLSDSDDDYDDV S375
Y381-p
sEssDDDyDDVDIPT
2 1
HPK1 (human) sEssDDDyDDVDIPT Y381-p
HPK1 (mouse) LsDsDDDyDDVDIPA Y379-p
HPK1 (rat) LSDSDDDYDDVDIPA Y379
S405-p
PPKPKFRsPsDEGPG
Upstream
0 11
Treatment
  • anti-CD3
HPK1 (human) PPKPKFRsPsDEGPG S405-p
HPK1 (mouse) PPKPKFRsPsDDGSG S403-p
HPK1 (rat) PPKPKIRSPSDDGSG S403
S407-p
KPKFRsPsDEGPGsM
0 27
HPK1 (human) KPKFRsPsDEGPGsM S407-p
HPK1 (mouse) KPKFRsPsDDGSGGI S405-p
HPK1 (rat) KPKIRSPSDDGSGGV S405
S413-p
PsDEGPGsMGDDGQL
0 18
HPK1 (human) PsDEGPGsMGDDGQL S413-p
HPK1 (mouse) PsDDGSGGIRDDGQL G411
HPK1 (rat) PSDDGSGGVRDDGQL G411
S421-p
MGDDGQLsPGVLVRC
Upstream
0 61
Treatment
  • anti-CD3
HPK1 (human) MGDDGQLsPGVLVRC S421-p
HPK1 (mouse) IRDDGQLsPGVLVRC S419-p
HPK1 (rat) VRDDGQLsPGVLVRC S419-p
S430-p
GVLVRCAsGPPPNsP
0 26
HPK1 (human) GVLVRCAsGPPPNsP S430-p
HPK1 (mouse) GVLVRCASGPPPRTP S428
HPK1 (rat) GVLVRCASGPPPRIP S428
S436-p
AsGPPPNsPRPGPPP
0 9
HPK1 (human) AsGPPPNsPRPGPPP S436-p
HPK1 (mouse) ASGPPPRTPRPGPPP T434
HPK1 (rat) ASGPPPRIPRPGPPP I434
S444-p
PRPGPPPsTssPHLt
0 2
HPK1 (human) PRPGPPPsTssPHLt S444-p
HPK1 (mouse) PRPGPPPATCsPHLT A442
HPK1 (rat) PRPGPPPATRSPHLT A442
S446-p
PGPPPsTssPHLtAH
0 1
HPK1 (human) PGPPPsTssPHLtAH S446-p
HPK1 (mouse) PGPPPATCsPHLTAR C444
HPK1 (rat) PGPPPATRSPHLTAR R444
S447-p
GPPPsTssPHLtAHs
0 4
HPK1 (human) GPPPsTssPHLtAHs S447-p
HPK1 (mouse) GPPPATCsPHLTARs S445-p
HPK1 (rat) GPPPATRSPHLTARs S445
T451-p
sTssPHLtAHsEPSL
0 5
HPK1 (human) sTssPHLtAHsEPSL T451-p
HPK1 (mouse) ATCsPHLTARsDPSL T449
HPK1 (rat) ATRSPHLTARsDPSL T449
S454-p
sPHLtAHsEPSLWNP
0 8
HPK1 (human) sPHLtAHsEPSLWNP S454-p
HPK1 (mouse) sPHLTARsDPSLWNP S452-p
HPK1 (rat) SPHLTARsDPSLWNP S452-p
H561
SLSGKTPHLYSHSIL
0 3
HPK1 (human) SLSGKTPHLYSHSIL H561
HPK1 (mouse) SLSGKTPyLySHSIL Y567-p
HPK1 (rat) SLSGKTPHLYSHSIL H567
Y563
SGKTPHLYSHSILGL
0 1
HPK1 (human) SGKTPHLYSHSILGL Y563
HPK1 (mouse) SGKTPyLySHSILGL Y569-p
HPK1 (rat) SGKTPHLYSHSILGL Y569
S586-p
GNPIAHIsPHRLLAR
0 5
HPK1 (human) GNPIAHIsPHRLLAR S586-p
HPK1 (mouse) GSPIAHISPHRLLAR S592
HPK1 (rat) GSPIAHISPHRFLAR S592
K594-ub
PHRLLARkNMVstkI
0 1
HPK1 (human) PHRLLARkNMVstkI K594-ub
HPK1 (mouse) PHRLLARKNMVSsKI K600
HPK1 (rat) PHRFLARKNMVSSKI K600
S598-p
LARkNMVstkIQDTK
0 1
HPK1 (human) LARkNMVstkIQDTK S598-p
HPK1 (mouse) LARKNMVSsKIQDTK S604
HPK1 (rat) LARKNMVSSKIQDTK S604
T599-p
ARkNMVstkIQDTKG
0 2
HPK1 (human) ARkNMVstkIQDTKG T599-p
HPK1 (mouse) ARKNMVSsKIQDTKG S605-p
HPK1 (rat) ARKNMVSSKIQDTKG S605
K600-ub
RkNMVstkIQDTKGC
0 2
HPK1 (human) RkNMVstkIQDTKGC K600-ub
HPK1 (mouse) RKNMVSsKIQDTKGC K606
HPK1 (rat) RKNMVSSKIQDTKGC K606
S737-p
KLVTPEGsPVRGLRT
0 1
HPK1 (human) KLVTPEGsPVRGLRT S737-p
HPK1 (mouse) KLVTPEGAPAPGLRT A743
HPK1 (rat) KLVTPEGAPAPGLRT A743