OTUD5 (mouse)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

R32

PLPPAPRRGAGVGVG

OTUD5 (human)	PMPPAPRrGGGVGVG	R32-m1
OTUD5 (mouse)	PLPPAPRRGAGVGVG	R32
OTUD5 (rat)	PLPPAPRRGGGVGVG	R32

S54-p

GGERDRDsGVVGARP

OTUD5 (human)	GGDRDRDSGVVGARP	S54
OTUD5 (mouse)	GGERDRDsGVVGARP	S54-p
OTUD5 (rat)	GGERDRDSGVVGARP	S54

S64-p

VGARPRAsPPPQGPL

OTUD5 (human)	VGARPRAsPPPQGPL	S64-p
OTUD5 (mouse)	VGARPRAsPPPQGPL	S64-p
OTUD5 (rat)	VGARPRAsPPPQGPL	S64-p

S165-p

VGAVGGAsPEREEVG

Upstream

Regulatory protein:

FLT3 (mouse)

OTUD5 (human)	VGAVGGGsPEREEVG	S165-p
OTUD5 (mouse)	VGAVGGAsPEREEVG	S165-p
OTUD5 (rat)	VGAVGGAsPEREEVG	S165-p

Y175-p

REEVGAGyNsEDEYE

Upstream

Regulatory protein:

FLT3 (mouse)

OTUD5 (human)	REEVGAGyNsEDEyE	Y175-p
OTUD5 (mouse)	REEVGAGyNsEDEYE	Y175-p
OTUD5 (rat)	REEVGAGYNsEDEYE	Y175

S177-p

EVGAGyNsEDEYEAA

Upstream

Treatment

antibody
IL-2
ionomycin
phorbol_ester
siRNA
TGF-beta

OTUD5 (human)	EVGAGyNsEDEyEAA	S177-p
OTUD5 (mouse)	EVGAGyNsEDEYEAA	S177-p
OTUD5 (rat)	EVGAGYNsEDEYEAA	S177-p

Y181

GyNsEDEYEAAAARI

OTUD5 (human)	GyNsEDEyEAAAARI	Y181-p
OTUD5 (mouse)	GyNsEDEYEAAAARI	Y181
OTUD5 (rat)	GYNsEDEYEAAAARI	Y181

T195-p

IEAMDPAtVEQQEHW

OTUD5 (human)	IEAMDPATVEQQEHW	T195
OTUD5 (mouse)	IEAMDPAtVEQQEHW	T195-p
OTUD5 (rat)	IEAMDPATVEQQEHW	T195

K205

QQEHWFEKALRDKKG

OTUD5 (human)	QQEHWFEkALRDKKG	K205-ub
OTUD5 (mouse)	QQEHWFEKALRDKKG	K205
OTUD5 (rat)	QQEHWFEKALRDKKG	K205

K219

GFIIKQMKEDGACLF

OTUD5 (human)	GFIIKQMkEDGACLF	K219-ub
OTUD5 (mouse)	GFIIKQMKEDGACLF	K219
OTUD5 (rat)	GFIIKQMKEDGACLF	K219

K245

DMHEVVRKHCMDYLM

OTUD5 (human)	DMHEVVRkHCMDYLM	K245-ub
OTUD5 (mouse)	DMHEVVRKHCMDYLM	K245
OTUD5 (rat)	DMHEVVRKHCMDYLM	K245

K253

HCMDYLMKNADYFSN

OTUD5 (human)	HCMDYLMkNADYFSN	K253-ub
OTUD5 (mouse)	HCMDYLMKNADYFSN	K253
OTUD5 (rat)	HCMDYLMKNADYFSN	K253

S323-p

EDEPIRVsYHRNIHY

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation
phosphorylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

autophagy, inhibited
cell cycle regulation
cell growth, induced
signaling pathway regulation
transcription, altered

Kinase, in vitro:

mTOR (mouse)

Putative in vivo kinases:

mTOR (mouse)

Regulatory protein:

TSC1 (human)

Treatment

amino_acids
bortezomib
glucose
rapamycin
starvation

OTUD5 (human)	EDEPIRVSYHRNIHY	S328
OTUD5 (mouse)	EDEPIRVsYHRNIHY	S323-p
OTUD5 (rat)	EDEPIRVSYHRNIHY	S323

S332-p

HRNIHYNsVVNPNKA

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation
phosphorylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

autophagy, inhibited
cell cycle regulation
cell growth, induced
signaling pathway regulation
transcription, altered

Kinase, in vitro:

mTOR (mouse)

Putative in vivo kinases:

mTOR (mouse)

Regulatory protein:

TSC1 (human)

Treatment

amino_acids
bortezomib
glucose
rapamycin
starvation

OTUD5 (human)	DEPIRVSYHRNIHYN	Y329
OTUD5 (mouse)	HRNIHYNsVVNPNKA	S332-p
OTUD5 (rat)	DEPIRVSYHRNIHYN	Y324

K338

NsVVNPNKATIGVGL

OTUD5 (human)	NSVVNPNkATIGVGL	K343-ub
OTUD5 (mouse)	NsVVNPNKATIGVGL	K338
OTUD5 (rat)	NSVVNPNKATIGVGL	K338

K351-ub

GLGLPSFkPGFAEQS

OTUD5 (human)	GLGLPSFkPGFAEQS	K356-ub
OTUD5 (mouse)	GLGLPSFkPGFAEQS	K351-ub
OTUD5 (rat)	GLGLPSFKPGFAEQS	K351

K361

FAEQSLMKNAIKTSE

OTUD5 (human)	FAEQSLMkNAIkTSE	K366-ub
OTUD5 (mouse)	FAEQSLMKNAIKTSE	K361
OTUD5 (rat)	FAEQSLMKNAIKTSE	K361

K365

SLMKNAIKTSEEsWI

OTUD5 (human)	SLMkNAIkTSEEsWI	K370-ub
OTUD5 (mouse)	SLMKNAIKTSEEsWI	K365
OTUD5 (rat)	SLMKNAIKTSEESWI	K365

S370-p

AIKTSEEsWIEQQML

OTUD5 (human)	AIkTSEEsWIEQQML	S375-p
OTUD5 (mouse)	AIKTSEEsWIEQQML	S370-p
OTUD5 (rat)	AIKTSEESWIEQQML	S370

K380-ub

EQQMLEDkkRATDWE

OTUD5 (human)	EQQMLEDkkRATDWE	K385-ub
OTUD5 (mouse)	EQQMLEDkkRATDWE	K380-ub
OTUD5 (rat)	EQQMLEDKKRATDWE	K380

K381-ub

QQMLEDkkRATDWEA

OTUD5 (human)	QQMLEDkkRATDWEA	K386-ub
OTUD5 (mouse)	QQMLEDkkRATDWEA	K381-ub
OTUD5 (rat)	QQMLEDKKRATDWEA	K381

K424

RGPSQPRKAsATCSS

OTUD5 (human)	RGPSQPRkAsATCsS	K429-ub
OTUD5 (mouse)	RGPSQPRKAsATCSS	K424
OTUD5 (rat)	RGPSQPRKASATCSS	K424

S426-p

PSQPRKAsATCSSAT

OTUD5 (human)	PSQPRkAsATCsSAT	S431-p
OTUD5 (mouse)	PSQPRKAsATCSSAT	S426-p
OTUD5 (rat)	PSQPRKASATCSSAT	S426

S430

RKAsATCSSATAAAS

OTUD5 (human)	RkAsATCsSATAAAs	S435-p
OTUD5 (mouse)	RKAsATCSSATAAAS	S430
OTUD5 (rat)	RKASATCSSATAAAS	S430

S437

SSATAAASSGLEEWT

OTUD5 (human)	sSATAAAsSGLEEWt	S442-p
OTUD5 (mouse)	SSATAAASSGLEEWT	S437
OTUD5 (rat)	SSATAAASSGLEEWT	S437

T444

SSGLEEWTSRsPRQR

OTUD5 (human)	sSGLEEWtsRsPRQR	T449-p
OTUD5 (mouse)	SSGLEEWTSRsPRQR	T444
OTUD5 (rat)	SSGLEEWTSRSPRQR	T444

S445

SGLEEWTSRsPRQRS

OTUD5 (human)	SGLEEWtsRsPRQRs	S450-p
OTUD5 (mouse)	SGLEEWTSRsPRQRS	S445
OTUD5 (rat)	SGLEEWTSRSPRQRS	S445

S447-p

LEEWTSRsPRQRSSA

OTUD5 (human)	LEEWtsRsPRQRssA	S452-p
OTUD5 (mouse)	LEEWTSRsPRQRSSA	S447-p
OTUD5 (rat)	LEEWTSRSPRQRSSA	S447

S452

SRsPRQRSSASSPEH

OTUD5 (human)	sRsPRQRssAssPEH	S457-p
OTUD5 (mouse)	SRsPRQRSSASSPEH	S452
OTUD5 (rat)	SRSPRQRSSASSPEH	S452

S453

RsPRQRSSASSPEHP

OTUD5 (human)	RsPRQRssAssPEHP	S458-p
OTUD5 (mouse)	RsPRQRSSASSPEHP	S453
OTUD5 (rat)	RSPRQRSSASSPEHP	S453

S455

PRQRSSASSPEHPEL

OTUD5 (human)	PRQRssAssPEHPEL	S460-p
OTUD5 (mouse)	PRQRSSASSPEHPEL	S455
OTUD5 (rat)	PRQRSSASSPEHPEL	S455

S456

RQRSSASSPEHPELH

OTUD5 (human)	RQRssAssPEHPELH	S461-p
OTUD5 (mouse)	RQRSSASSPEHPELH	S456
OTUD5 (rat)	RQRSSASSPEHPELH	S456

S484

LALAKPPSPCAPGTS

OTUD5 (human)	LALAKPPsPCAPGTS	S489-p
OTUD5 (mouse)	LALAKPPSPCAPGTS	S484
OTUD5 (rat)	LALAKPPSPCAPGTS	S484

T502-p

SAGGDRAtsPLVSLY

OTUD5 (human)	SAGADRAtsPLVsLy	T507-p
OTUD5 (mouse)	SAGGDRAtsPLVSLY	T502-p
OTUD5 (rat)	SAGADRATSPLVSLY	T502

S503-p

AGGDRAtsPLVSLYP

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation
phosphorylation
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

autophagy, inhibited
cell cycle regulation
cell growth, induced
signaling pathway regulation
transcription, altered

Kinase, in vitro:

mTOR (mouse)

Putative in vivo kinases:

mTOR (mouse)

Regulatory protein:

TSC1 (human)

Treatment

amino_acid_starvation
amino_acids
bortezomib
glucose
rapamycin
starvation

OTUD5 (human)	AGADRAtsPLVsLyP	S508-p
OTUD5 (mouse)	AGGDRAtsPLVSLYP	S503-p
OTUD5 (rat)	AGADRATSPLVSLYP	S503

S507

RAtsPLVSLYPALEC

OTUD5 (human)	RAtsPLVsLyPALEC	S512-p
OTUD5 (mouse)	RAtsPLVSLYPALEC	S507
OTUD5 (rat)	RATSPLVSLYPALEC	S507

Y509

tsPLVSLYPALECRA

OTUD5 (human)	tsPLVsLyPALECRA	Y514-p
OTUD5 (mouse)	tsPLVSLYPALECRA	Y509
OTUD5 (rat)	TSPLVSLYPALECRA	Y509

S522

RALIQQMSPSAFGLN

OTUD5 (human)	RALIQQMsPSAFGLN	S527-p
OTUD5 (mouse)	RALIQQMSPSAFGLN	S522
OTUD5 (rat)	RALIQQMSPSAFGLN	S522