Other Species / Isoforms
  MLKL (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
N52
LQAQGKKNLPDDITA
0 2
MLKL (human) LQDQGKRsVPSEKLt S52
MLKL (mouse) LQAQGKKNLPDDITA N52
MLKL iso2 (mouse) LQAQGKKNLPDDITA N52
MLKL (rat) LQAQEKKSLPSDITA S52
T58
KNLPDDITAALGRFD
0 2
MLKL (human) sVPSEKLtTAMNRFK T59
MLKL (mouse) KNLPDDITAALGRFD T58
MLKL iso2 (mouse) KNLPDDITAALGRFD T58
MLKL (rat) KSLPSDITAALGRFE T58
S79
NQQIEKFsKKSHIWK
0 1
MLKL (human) NGEIEKFSNRSNICR S80
MLKL (mouse) NQQIEKFsKKSHIWK S79
MLKL iso2 (mouse) NQQIEKFSKKSHIWK S79
MLKL (rat) RQQIEKFSQKSNIWK S79
G91
IWKFVSVGNDKILFH
0 1
MLKL (human) ICRFLTAsQDKILFK S92
MLKL (mouse) IWKFVSVGNDKILFH G91
MLKL iso2 (mouse) IWKFVSVGNDKILFH G91
MLKL (rat) IWKFATVGSDKILFH G91
R105
HEVNEKLRDVWEELL
0 3
MLKL (human) KDVNRKLsDVWKELS S106
MLKL (mouse) HEVNEKLRDVWEELL R105
MLKL iso2 (mouse) HEVNEKLRDVWEELL R105
MLKL (rat) HEVNEKLRDIWEELL R105
S124
VYHWNTVsDVSQPAS
1 20
MLKL (human) VEQRMPVsPIsQGAS S125
MLKL (mouse) VYHWNTVsDVSQPAS S124
MLKL iso2 (mouse) VYHWNTVSDVSQPAS S124
MLKL (rat) VDQWKSDSEVSQPAS S124
S127
WNTVsDVSQPASWQQ
0 1
MLKL (human) RMPVsPIsQGASWAQ S128
MLKL (mouse) WNTVsDVSQPASWQQ S127
MLKL iso2 (mouse) WNTVSDVSQPASWQQ S127
MLKL (rat) WKSDSEVSQPASWQQ S127
I151
GNENMKVILMQLQIs
0 2
MLKL (human) DNEKIEAsLRRLEIN S161
MLKL (mouse) GNENMKVILMQLQIs I151
MLKL iso2 (mouse) GNENMKVILMQLQIS I151
MLKL (rat) GNENMKVILVKLQIS I151
S158
ILMQLQIsVEEINKT
1 1
MLKL (human) sLRRLEINMKEIKET N168
MLKL (mouse) ILMQLQIsVEEINKT S158
MLKL iso2 (mouse) ILMQLQISVEEINKT S158
MLKL (rat) ILVKLQISMEEIKEA S158
S228
FNNPQAEsVGIVRFT
1 1
MLKL (human) FKKLQAGSIAIVRQt S239
MLKL (mouse) FNNPQAEsVGIVRFT S228
MLKL iso2 (mouse) FNNPQAESVGIVRFT S228
MLKL (rat) FNNPKAESVGIVRLT S228
T235
sVGIVRFTFNDEIKT
0 1
MLKL (human) SIAIVRQtFNKEIKT T246
MLKL (mouse) sVGIVRFTFNDEIKT T235
MLKL iso2 (mouse) SVGIVRFTFNDEIKT T235
MLKL (rat) SVGIVRLTFNEEIKT T235
S248
KTMKKFDsPNILRIF
1 1
MLKL (human) KTMKKFESPNILRIF S259
MLKL (mouse) KTMKKFDsPNILRIF S248
MLKL iso2 (mouse) KTMKKFDSPNILRIF S248
MLKL (rat) KTMKKFDSPNILRIF S248
T291
LDREKDLTMSVRSLL
0 1
MLKL (human) LDREKDLtLGKRMVL T302
MLKL (mouse) LDREKDLTMSVRSLL T291
MLKL iso2 (mouse) LDREKDLTMSVRSLL T291
MLKL (rat) LDRDKDLTMSVRSLL T291
S321
TLHRNISSSSFLVAG
0 1
MLKL (human) ELHGKIRsSNFLVTQ S334
MLKL (mouse) TLHRNISSSSFLVAG S321
MLKL iso2 (mouse) TLHRNISSSSFLVAG S321
MLKL (rat) TLHGNISSSSFLVAG S321
N344
FELSKTQNsIsRtAK
7 2
MLKL (human) FELRKTQtsMSLGTt T357
MLKL (mouse) FELSKTQNsIsRtAK N344
MLKL iso2 (mouse) FELSKTQNSISRTAK N344
MLKL (rat) FELSKTQTsISRATK T344
S345
ELSKTQNsIsRtAKS
Upstream
Downstream
41 3
MLKL (human)
S358
MLKL (mouse)
S345
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • apoptosis, induced
  • cell growth, inhibited
  • signaling pathway regulation
Kinase, in vitro:
  • RIPK3 (mouse)
Putative in vivo kinases:
  • RIPK3 (human)
  • RIPK3 (mouse)
Regulatory protein:
  • ABCA1 (human)
  • APP (mouse)
  • ATR (human)
  • CASP8 (human)
  • CK1G2 (mouse)
  • FADD (mouse)
  • FAM105B (human)
  • IFNB1 (mouse)
  • ITGB1 (human)
  • MAPKAPK2 (mouse)
  • MYD88 (mouse)
  • NHE1 (human)
  • OASL (human)
  • PSEN1 (mouse)
  • RDH8 (human)
  • RIPK1 (human)
  • RIPK1 (mouse)
  • RIPK3 (human)
  • RIPK3 (mouse)
  • SPATA2 (mouse)
  • STING (mouse)
  • TICAM1 (mouse)
  • TTP (mouse)
  • ULK1 (human)
view more >
Treatment
  • 1,6-Hexanediol
  • all-trans-retinal dimer
  • amiloride
  • cariporide
  • circRNA
  • cycloheximide
  • development
  • digitonin
  • EP4-D
  • GSK'872
  • GW440139B
  • hypertonic_buffer
  • hypotonic_buffer
  • hypoxia/reoxygenation
  • ischemia/reperfusion
  • isoproterenol
  • low_pH
  • LPS
  • LY2228820
  • N-retinilidene-N- retinyl ethanolamine
  • Necrostatin-1
  • Necrostatin7
  • palmitate
  • phenhydan
  • primidone
  • Q-VD-OPh
  • SM-164
  • smac
  • sucrose
  • TNF
  • TRAIL
  • virus infection
  • Z-IETD-fmk
  • Z-VAD-FMK
view more >
MLKL (human) ELRKTQtsMSLGTtR S358
MLKL (mouse) ELSKTQNsIsRtAKS S345
MLKL iso2 (mouse) ELSKTQNSISRTAKS S345
MLKL (rat) ELSKTQTsISRATKS S345
S347
SKTQNsIsRtAKSTK
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein conformation
Kinase, in vitro:
  • RIPK3 (mouse)
Putative in vivo kinases:
  • RIPK3 (human)
MLKL (human) RKTQtsMSLGTtREK S360
MLKL (mouse) SKTQNsIsRtAKSTK S347
MLKL iso2 (mouse) SKTQNSISRTAKSTK S347
MLKL (rat) SKTQTsISRATKSTK S347
T349
TQNsIsRtAKSTKAE
Upstream
Downstream
1 2
Effects on Modified Protein
  • protein conformation
Kinase, in vitro:
  • RIPK3 (mouse)
Putative in vivo kinases:
  • RIPK3 (human)
MLKL (human) TQtsMSLGTtREKTD G362
MLKL (mouse) TQNsIsRtAKSTKAE T349
MLKL iso2 (mouse) TQNSISRTAKSTKAE T349
MLKL (rat) TQTsISRATKSTKAE A349
K351
NsIsRtAKSTKAERS
0 1
MLKL (human) tsMSLGTtREKTDRV T364
MLKL (mouse) NsIsRtAKSTKAERS K351
MLKL iso2 (mouse) NSISRTAKSTKAERS K351
MLKL (rat) TsISRATKSTKAERF K351
S360
TKAERSSstIYVSPE
0 2
MLKL (human) EKTDRVKstAyLSPQ S373
MLKL (mouse) TKAERSSstIYVSPE S360
MLKL iso2 (mouse) TKAERSSSTIYVSPE S360
MLKL (rat) TKAERFSSTAYVSPE S360
T361
KAERSSstIYVSPER
0 2
MLKL (human) KTDRVKstAyLSPQE T374
MLKL (mouse) KAERSSstIYVSPER T361
MLKL iso2 (mouse) KAERSSSTIYVSPER T361
MLKL (rat) KAERFSSTAYVSPER T361
Y363
ERSSstIYVSPERLK
1 1
MLKL (human) DRVKstAyLSPQELE Y376
MLKL (mouse) ERSSstIYVSPERLK Y363
MLKL iso2 (mouse) ERSSSTIYVSPERLK Y363
MLKL (rat) ERFSSTAYVSPERLQ Y363
A380
FCLYDIKAEIYSFGI
0 1
MLKL (human) FYQYDVKsEIYSFGI S393
MLKL (mouse) FCLYDIKAEIYSFGI A380
MLKL iso2 (mouse) FCLYDIKAEIYSFGI A380
MLKL (rat) FCKYDTKAEIYSFGI A380
S404
IPFEGCDSKKIRELV
0 1
MLKL (human) IPFQGCNsEKIRKLV S417
MLKL (mouse) IPFEGCDSKKIRELV S404
MLKL iso2 (mouse) IPFEGCDSKKIRELV S404
MLKL (rat) IPFEGCDSEKIYELV S404
S441
ECRAHEPsQRPSVDG
Upstream
1 1
Treatment
  • injury
MLKL (human) ECRAHDPSVRPSVDE S454
MLKL (mouse) ECRAHEPsQRPSVDG S441
MLKL iso2 (mouse) ECRAHEPSQRPSVDG S441
MLKL (rat) ECRAHEPSNRPSADG S441
S462
ERILERLSAVEESTD
0 1
MLKL (human) DEILKKLsTFSK___ S467
MLKL (mouse) ERILERLSAVEESTD S462
MLKL iso2 (mouse) DGILERLSAVEESTD S454
MLKL (rat) DGILERLPAIEDSMD P454
S204
KLKTSKMSTIYRGEY
0 1
MLKL (human) LLRENEVsTLYKGEY S215
MLKL (mouse) KLKTSKMSTIYRGEY S204
MLKL iso2 (mouse) KLKTSKMSTIYRGEY S204
MLKL (rat) KLKTNKLSTIYRGEY S204