Other Species / Isoforms
  IKKE (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K25-ub
GATASVYkARNKkSG
0 1
IKKE (human) GATASVYkARNKkSG K25-ub
IKKE (mouse) GATASVYKARNKkSG K25
IKKE (rat) GATANVYKARNKKSG K25
K30
VYkARNKKSGELVAV
0 1
IKKE (human) VYkARNKKSGELVAV K30
IKKE (mouse) VYKARNKkSGEVVAV K30-ac
IKKE (rat) VYKARNKKSGEVVAV K30
K30-ub
VYkARNKkSGELVAV
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, induced
Treatment
  • bortezomib
  • IL-1b
  • LPS
  • MG132
  • TNF
IKKE (human) VYkARNKkSGELVAV K30-ub
IKKE (mouse) VYKARNKKSGEVVAV K30
IKKE (rat) VYKARNKKSGEVVAV K30
K61-ub
REFEVLRkLNHQNIV
0 1
IKKE (human) REFEVLRkLNHQNIV K61-ub
IKKE (mouse) REFEVLRRLNHQNIV R61
IKKE (rat) REFEVLRRLDHENIV R61
Y153-p
GEEGQSIykLTDFGA
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell motility, induced
Putative in vivo kinases:
  • EGFR (human)
Treatment
  • afatinib
IKKE (human) GEEGQSIykLTDFGA Y153-p
IKKE (mouse) GEEGQSIYkLSDFGA Y153
IKKE (rat) GKEGQSIYKLSDFGA Y153
K154-ub
EEGQSIykLTDFGAA
0 3
IKKE (human) EEGQSIykLTDFGAA K154-ub
IKKE (mouse) EEGQSIYkLSDFGAA K154-ub
IKKE (rat) KEGQSIYKLSDFGAA K154
S172-p
DDDEKFVsVYGTEEy
Upstream
Downstream
6 4
IKKE (human)
S172-p
IKKE (mouse)
S172-p
IKKE (rat)
S172-p
Effects on Modified Protein
  • enzymatic activity, induced
Regulatory protein:
  • DDX3 (human)
Treatment
  • anti-CD3/CD28
  • ionomycin
  • phorbol_ester
  • virus infection
IKKE (human) DDDEKFVsVYGTEEy S172-p
IKKE (mouse) DDDEKFVsVYGTEEY S172-p
IKKE (rat) DDDEKFVSVYGTEEY S172
Y179-p
sVYGTEEyLHPDMYE
Upstream
Downstream
1 5
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell motility, induced
Putative in vivo kinases:
  • EGFR (human)
IKKE (human) sVYGTEEyLHPDMYE Y179-p
IKKE (mouse) sVYGTEEYLHPDMYE Y179
IKKE (rat) SVYGTEEYLHPDMYE Y179
K231-ub
FGGPRRNkEIMYRIT
0 1
IKKE (human) FGGPRRNkEIMYRIT K231-ub
IKKE (mouse) FGGPRRNKEIMYRIT K231
IKKE (rat) FGGPRRNKEIMYRIT K231
K231-sm
FGGPRRNkEIMYRIT
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
IKKE (human) FGGPRRNkEIMYRIT K231-sm
IKKE (mouse) FGGPRRNKEIMYRIT K231
IKKE (rat) FGGPRRNKEIMYRIT K231
K241-ub
MYRITTEkPAGAIAG
0 2
IKKE (human) MYRITTEkPAGAIAG K241-ub
IKKE (mouse) MYRITTEkPAGAISG K241-ub
IKKE (rat) MYRITTEKPAGAISG K241
K401-ub
DPALDVPkFVPKVDL
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, induced
Treatment
  • bortezomib
  • IL-1b
  • LPS
  • MG132
  • TNF
IKKE (human) DPALDVPkFVPKVDL K401-ub
IKKE (mouse) DPALDVPKFVPKVDL K403
IKKE (rat) DPALDVPKFVPKVDL K403
K416-ub
QADYNTAkGVLGAGY
0 1
IKKE (human) QADYNTAkGVLGAGY K416-ub
IKKE (mouse) QADYSTAKGVLGAGY K418
IKKE (rat) QADYSTAKGVLGAGY K418
T463-p
RTLEVARtsLLYLSS
0 1
IKKE (human) RTLEVARtsLLYLSS T463-p
IKKE (mouse) QTLEVTRTALLYLSS T465
IKKE (rat) QTLEITRTALLFLSS T465
S464-p
TLEVARtsLLYLSSS
0 1
IKKE (human) TLEVARtsLLYLSSS S464-p
IKKE (mouse) TLEVTRTALLYLSSS A466
IKKE (rat) TLEITRTALLFLSSS A466
T474-p
YLSSSLGtERFSsVA
0 1
IKKE (human) YLSSSLGtERFSsVA T474-p
IKKE (mouse) YLSSSLGTERFSSGA T476
IKKE (rat) FLSSSLGTERLSSGA T476
S479-p
LGtERFSsVAGTPEI
0 1
IKKE (human) LGtERFSsVAGTPEI S479-p
IKKE (mouse) LGTERFSSGAGMPDV S481
IKKE (rat) LGTERLSSGAGMLDI S481
K490-ub
TPEIQELkAAAELRS
0 1
IKKE (human) TPEIQELkAAAELRS K490-ub
IKKE (mouse) MPDVQERKEATELRT K492
IKKE (rat) MLDIQELKEATELRS K492
T501-p
ELRSRLRtLAEVLSR
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • IKKE (human)
Putative in vivo kinases:
  • IKKE (human)
Regulatory protein:
  • TRIM6 (human)
  • UBE2K (human)
Treatment
  • IFN-beta
  • virus infection
IKKE (human) ELRSRLRtLAEVLSR T501-p
IKKE (mouse) ELRTRLQTLSEILSk T503
IKKE (rat) ELRSRLQTFSEVLSK T503
R508
tLAEVLSRCSQNITE
0 1
IKKE (human) tLAEVLSRCSQNITE R508
IKKE (mouse) TLSEILSkCSHNVTE K510-ub
IKKE (rat) TFSEVLSKCSHNVTE K510
K529
SLNRELVKSRDQVHE
0 1
IKKE (human) SLNRELVKSRDQVHE K529
IKKE (mouse) CLGEELLkNRDQIHE K531-ub
IKKE (rat) CLVGELLKSRDQIHE K531
K549-ub
QIQCCLDkMNFIYKQ
0 2
IKKE (human) QIQCCLDkMNFIYKQ K549-ub
IKKE (mouse) KIQCCLDKMHFIYKQ K552
IKKE (rat) KIQCCLDKMHFIYKQ K552
K578-ub
EQIHKLDkVNFSHLA
0 1
IKKE (human) EQIHKLDkVNFSHLA K578-ub
IKKE (mouse) EQIHKLDKVNFSHLA K581
IKKE (rat) EQIHKLDKVNFSHLA K581
K609-ub
ASLVTHGkRMRVVHE
0 1
IKKE (human) ASLVTHGkRMRVVHE K609-ub
IKKE (mouse) VSLVTHGKRMRQVQR K612
IKKE (rat) VSLVTHGKRMRQVQK K612
S664-p
RAKGAQAsPPPIAPy
Upstream
0 10
Treatment
  • MG132_withdrawal
IKKE (human) RAKGAQAsPPPIAPy S664-p
IKKE (mouse) SEQGAEVsPQPMAPH S665-p
IKKE (rat) SKQGAEVSPQPMATH S665
Y671-p
sPPPIAPyPsPTRkD
0 1
IKKE (human) sPPPIAPyPsPTRkD Y671-p
IKKE (mouse) sPQPMAPHPGPDPKD H672
IKKE (rat) SPQPMATHPGPDPKD H672
S673-p
PPIAPyPsPTRkDLL
0 1
IKKE (human) PPIAPyPsPTRkDLL S673-p
IKKE (mouse) QPMAPHPGPDPKDLV G674
IKKE (rat) QPMATHPGPDPKDLV G674
K677-ub
PyPsPTRkDLLLHMQ
0 1
IKKE (human) PyPsPTRkDLLLHMQ K677-ub
IKKE (mouse) PHPGPDPKDLVFHMQ K678
IKKE (rat) THPGPDPKDLVFHMQ K678
A712
ERLNRVPAPPDV___
0 13
IKKE (human) ERLNRVPAPPDV___ A712
IKKE (mouse) ERLHRVPsAPDV___ S713-p
IKKE (rat) ERLHRVPPTPEV___ P713