Other Species / Isoforms
  PIN1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K6-sm
__MADEEkLPPGWEk
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • transcription, inhibited
Regulatory protein:
  • SENP2 (human)
  • SENP3 (human)
Treatment
  • H2O2
  • siRNA
PIN1 (human) __MADEEkLPPGWEk K6-sm
PIN1 (mouse) __MADEEKLPPGWEk K6
PIN1 (rat) __MADEEKLPSGWEK K6
K13-ub
kLPPGWEkRMsRSSG
0 7
PIN1 (human) kLPPGWEkRMsRSSG K13-ub
PIN1 (mouse) KLPPGWEkRMsRSSG K13-ub
PIN1 (rat) KLPSGWEKRMSRSSG K13
S16-p
PGWEkRMsRSSGRVy
Upstream
Downstream
12 2
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • AurA (human)
  • PKACA (human)
Putative in vivo kinases:
  • AurA (human)
  • PKACA (human)
Regulatory protein:
  • OLA1 (human)
Treatment
  • colforsin
  • MLN8054
  • okadaic_acid
  • progesterone
PIN1 (human) PGWEkRMsRSSGRVy S16-p
PIN1 (mouse) PGWEkRMsRSSGRVY S16-p
PIN1 (rat) SGWEKRMSRSSGRVY S16
Y23-p
sRSSGRVyYFNHITN
Downstream
2 4
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
PIN1 (human) sRSSGRVyYFNHITN Y23-p
PIN1 (mouse) sRSSGRVYyFNHITN Y23
PIN1 (rat) SRSSGRVYYFNHITN Y23
Y24
RSSGRVyYFNHITNA
0 1
PIN1 (human) RSSGRVyYFNHITNA Y24
PIN1 (mouse) RSSGRVYyFNHITNA Y24-p
PIN1 (rat) RSSGRVYYFNHITNA Y24
S38-p
ASQWERPsGNSSsGG
0 2
PIN1 (human) ASQWERPsGNSSsGG S38-p
PIN1 (mouse) ASQWERPSGGSTVGG S38
PIN1 (rat) ASQWERPSGGSTVGG S38
S43-p
RPsGNSSsGGkNGQG
0 2
PIN1 (human) RPsGNSSsGGkNGQG S43-p
PIN1 (mouse) RPSGGSTVGGSSKNG V43
PIN1 (rat) RPSGGSTVGGGSkNG V43
K46-ac
GNSSsGGkNGQGEPA
0 28
PIN1 (human) GNSSsGGkNGQGEPA K46-ac
PIN1 (mouse) STVGGSSKNGQGEPA K48
PIN1 (rat) STVGGGSkNGQGEPA K48-ac
S58-p
EPARVRCsHLLVkHs
0 1
PIN1 (human) EPARVRCsHLLVkHs S58-p
PIN1 (mouse) EPAKVRCSHLLVKHS S60
PIN1 (rat) EPARVRCSHLLVkHS S60
K63-ac
RCsHLLVkHsQSRRP
0 1
PIN1 (human) RCsHLLVkHsQSRRP K63-ac
PIN1 (mouse) RCSHLLVKHSQSRRP K65
PIN1 (rat) RCSHLLVKHSQSRRP K65
K63-ub
RCsHLLVkHsQSRRP
0 4
PIN1 (human) RCsHLLVkHsQSRRP K63-ub
PIN1 (mouse) RCSHLLVKHSQSRRP K65
PIN1 (rat) RCSHLLVkHSQSRRP K65-ub
K63-sm
RCsHLLVkHsQSRRP
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, inhibited
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell growth, inhibited
  • transcription, inhibited
Regulatory protein:
  • SENP2 (human)
  • SENP3 (human)
Treatment
  • H2O2
  • siRNA
PIN1 (human) RCsHLLVkHsQSRRP K63-sm
PIN1 (mouse) RCSHLLVKHSQSRRP K65
PIN1 (rat) RCSHLLVKHSQSRRP K65
S65-p
sHLLVkHsQSRRPss
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein stabilization
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
PIN1 (human) sHLLVkHsQSRRPss S65-p
PIN1 (mouse) SHLLVKHSQSRRPSS S67
PIN1 (rat) SHLLVkHSQSRRPSS S67
S71-p
HsQSRRPssWRQEKI
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell motility, inhibited
  • transcription, inhibited
Kinase, in vitro:
  • DAPK1 (human)
  • PKACA (human)
Putative in vivo kinases:
  • DAPK1 (human)
Treatment
  • H-89
  • NKH_477
  • progesterone
  • retinoic_acid
  • siRNA
  • UV
PIN1 (human) HsQSRRPssWRQEKI S71-p
PIN1 (mouse) HSQSRRPSSWRQEKI S73
PIN1 (rat) HSQSRRPSSWRQEKI S73
S72-p
sQSRRPssWRQEKIT
0 2
PIN1 (human) sQSRRPssWRQEKIT S72-p
PIN1 (mouse) SQSRRPSSWRQEKIT S74
PIN1 (rat) SQSRRPSSWRQEKIT S74
K82-ac
QEKITRTkEEALELI
0 2
PIN1 (human) QEKITRTkEEALELI K82-ac
PIN1 (mouse) QEKITRSKEEALELI K84
PIN1 (rat) QEKITRSkEEALELI K84-ac
K82-ub
QEKITRTkEEALELI
0 4
PIN1 (human) QEKITRTkEEALELI K82-ub
PIN1 (mouse) QEKITRSKEEALELI K84
PIN1 (rat) QEKITRSKEEALELI K84
K82-sm
QEKITRTkEEALELI
0 1
PIN1 (human) QEKITRTkEEALELI K82-sm
PIN1 (mouse) QEKITRSKEEALELI K84
PIN1 (rat) QEKITRSKEEALELI K84
K95-ub
LINGYIQkIkSGEED
0 2
PIN1 (human) LINGYIQkIkSGEED K95-ub
PIN1 (mouse) LINGYIQKIKSGEED K97
PIN1 (rat) LINGYIQKIKSGEED K97
K97-ub
NGYIQkIkSGEEDFE
0 3
PIN1 (human) NGYIQkIkSGEEDFE K97-ub
PIN1 (mouse) NGYIQKIKSGEEDFE K99
PIN1 (rat) NGYIQKIKSGEEDFE K99
S105-p
SGEEDFEsLAsQFSD
0 10
PIN1 (human) SGEEDFEsLAsQFSD S105-p
PIN1 (mouse) SGEEDFESLASQFsD S107
PIN1 (rat) SGEEDFESLASQFSD S107
S108-p
EDFEsLAsQFSDCsS
0 1
PIN1 (human) EDFEsLAsQFSDCsS S108-p
PIN1 (mouse) EDFESLASQFsDCSS S110
PIN1 (rat) EDFESLASQFSDCSS S110
S111
EsLAsQFSDCsSAkA
1 0
PIN1 (human) EsLAsQFSDCsSAkA S111
PIN1 (mouse) ESLASQFsDCSSAkA S113-p
PIN1 (rat) ESLASQFSDCSSAKA S113
S114-p
AsQFSDCsSAkARGD
Upstream
0 1
Treatment
  • BI2536
PIN1 (human) AsQFSDCsSAkARGD S114-p
PIN1 (mouse) ASQFsDCSSAkARGD S116
PIN1 (rat) ASQFSDCSSAKARGD S116
K117-ub
FSDCsSAkARGDLGA
0 6
PIN1 (human) FSDCsSAkARGDLGA K117-ub
PIN1 (mouse) FsDCSSAkARGDLGP K119-ub
PIN1 (rat) FSDCSSAKARGDLGA K119
K132
FSRGQMQKPFEDAsF
0 1
PIN1 (human) FSRGQMQKPFEDAsF K132
PIN1 (mouse) FSRGQMQKPFEDASF K134
PIN1 (rat) FSRGQMQkPFEDASF K134-ac
K132-ub
FSRGQMQkPFEDAsF
0 1
PIN1 (human) FSRGQMQkPFEDAsF K132-ub
PIN1 (mouse) FSRGQMQKPFEDASF K134
PIN1 (rat) FSRGQMQKPFEDASF K134
S138-p
QkPFEDAsFALrTGE
Upstream
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • MLK3 (human)
Putative in vivo kinases:
  • MLK3 (human)
PIN1 (human) QkPFEDAsFALrTGE S138-p
PIN1 (mouse) QKPFEDASFALRTGE S140
PIN1 (rat) QkPFEDASFALRTGE S140
R142-m1
EDAsFALrTGEMSGP
0 1
PIN1 (human) EDAsFALrTGEMSGP R142-m1
PIN1 (mouse) EDASFALRTGEMSGP R144
PIN1 (rat) EDASFALRTGEMSGP R144