PGC-1 alpha (mouse)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T177-p

NHTHRIRtNPAIVkT

Upstream

Downstream

Effects on Biological Processes:

transcription, altered

Kinase, in vitro:

AMPKA2 (rat)

Putative in vivo kinases:

AMPKA2 (human)

PGC-1 alpha (human)	NHNHRIRTNPAIVKT	T178
PGC-1 alpha (mouse)	NHTHRIRtNPAIVkT	T177-p
PGC-1 alpha (rat)	NHTHRIRTNPAIVKT	T176

K183-sm

RtNPAIVkTENSWSN

Downstream

Effects on Biological Processes:

transcription, inhibited

PGC-1 alpha (human)	RTNPAIVKTENSWSN	K184
PGC-1 alpha (mouse)	RtNPAIVkTENSWSN	K183-sm
PGC-1 alpha (rat)	RTNPAIVKTENSWSN	K182

S194-p

SWSNKAKsICQQQkP

Upstream

Downstream

Effects on Modified Protein

intracellular localization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

PKACA (human)

Putative in vivo kinases:

PKACA (human)

Treatment

cAMP_analog
H-89

PGC-1 alpha (human)	SWSNKAKSICQQQKP	S195
PGC-1 alpha (mouse)	SWSNKAKsICQQQkP	S194-p
PGC-1 alpha (rat)	SWSNKAKSICQQQKP	S193

K200-ac

KsICQQQkPQRRPCS

PGC-1 alpha (human)	KSICQQQKPQRRPCs	K201
PGC-1 alpha (mouse)	KsICQQQkPQRRPCS	K200-ac
PGC-1 alpha (rat)	KSICQQQKPQRRPCS	K199

S207

kPQRRPCSELLKYLT

PGC-1 alpha (human)	KPQRRPCsELLKYLT	S208-p
PGC-1 alpha (mouse)	kPQRRPCSELLKYLT	S207
PGC-1 alpha (rat)	KPQRRPCSELLKYLT	S206

K223-ac

NDDPPHTkPTENRNS

PGC-1 alpha (human)	NDDPPHTKPTENRNS	K224
PGC-1 alpha (mouse)	NDDPPHTkPTENRNS	K223-ac
PGC-1 alpha (rat)	NDDPPHTKPTENRNS	K222

K223

NDDPPHTKPTENRNS

PGC-1 alpha (human)	NDDPPHTkPTENRNS	K224-m1
PGC-1 alpha (mouse)	NDDPPHTKPTENRNS	K223
PGC-1 alpha (rat)	NDDPPHTKPTENRNS	K222

S231-p

PTENRNSsRDKCASK

PGC-1 alpha (human)	PTENRNSSRDKCTSK	S232
PGC-1 alpha (mouse)	PTENRNSsRDKCASK	S231-p
PGC-1 alpha (rat)	PTENRNSSRDKCASK	S230

S241-p

KCASKKKsHTQPQSQ

Upstream

Downstream

Effects on Modified Protein

intracellular localization
protein stabilization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

PKACA (human)

Putative in vivo kinases:

PKACA (human)
PKACA (mouse)

Treatment

cAMP_analog
H-89
NKH_477

PGC-1 alpha (human)	KCTSKKKSHTQsQSQ	S242
PGC-1 alpha (mouse)	KCASKKKsHTQPQSQ	S241-p
PGC-1 alpha (rat)	KCASKKKSHTQPQSQ	S240

P245

KKKsHTQPQSQHAQA

PGC-1 alpha (human)	KKKSHTQsQSQHLQA	S246-p
PGC-1 alpha (mouse)	KKKsHTQPQSQHAQA	P245
PGC-1 alpha (rat)	KKKSHTQPQSQHAQA	P244

T256-p

HAQAKPTtLSLPLTP

Upstream

Downstream

Effects on Modified Protein

intracellular localization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

PKACA (human)

Putative in vivo kinases:

PKACA (human)

Treatment

cAMP_analog
H-89

PGC-1 alpha (human)	HLQAKPTTLSLPLtP	T257
PGC-1 alpha (mouse)	HAQAKPTtLSLPLTP	T256-p
PGC-1 alpha (rat)	HAQAKPTTLSLPLTP	T255

T262

TtLSLPLTPEsPNDP

PGC-1 alpha (human)	TTLSLPLtPEsPNDP	T263-p
PGC-1 alpha (mouse)	TtLSLPLTPEsPNDP	T262
PGC-1 alpha (rat)	TTLSLPLTPESPNDP	T261

S265-p

SLPLTPEsPNDPKGs

Upstream

Regulatory protein:

DUSP1 (human)
DUSP1 (mouse)
MKK6 (human)

Treatment

high-fat diet
IL-1b
siRNA
TNF

PGC-1 alpha (human)	SLPLtPEsPNDPKGs	S266-p
PGC-1 alpha (mouse)	SLPLTPEsPNDPKGs	S265-p
PGC-1 alpha (rat)	SLPLTPESPNDPKGS	S264

S272-p

sPNDPKGsPFENKTI

PGC-1 alpha (human)	sPNDPKGsPFENkTI	S273-p
PGC-1 alpha (mouse)	sPNDPKGsPFENKTI	S272-p
PGC-1 alpha (rat)	SPNDPKGSPFENKTI	S271

K277

KGsPFENKTIERTLs

PGC-1 alpha (human)	KGsPFENkTIERTLs	K278-ac
PGC-1 alpha (mouse)	KGsPFENKTIERTLs	K277
PGC-1 alpha (rat)	KGSPFENKTIERTLS	K276

S284-p

KTIERTLsVELSGTA

Downstream

Effects on Modified Protein

protein stabilization

PGC-1 alpha (human)	kTIERTLsVELSGTA	S285-p
PGC-1 alpha (mouse)	KTIERTLsVELSGTA	S284-p
PGC-1 alpha (rat)	KTIERTLSVELSGTA	S283

T294-p

LSGTAGLtPPTtPPH

PGC-1 alpha (human)	LSGTAGLtPPTtPPH	T295-p
PGC-1 alpha (mouse)	LSGTAGLtPPTtPPH	T294-p
PGC-1 alpha (rat)	LSGTAGLTPPTTPPH	T293

T298-p

AGLtPPTtPPHKANQ

Upstream

Regulatory protein:

DUSP1 (human)
DUSP1 (mouse)
MKK6 (human)

Treatment

IL-1b
siRNA
TNF

PGC-1 alpha (human)	AGLtPPTtPPHKANQ	T299-p
PGC-1 alpha (mouse)	AGLtPPTtPPHKANQ	T298-p
PGC-1 alpha (rat)	AGLTPPTTPPHKANQ	T297

S312-p

QDNPFKAsPKLKPSC

PGC-1 alpha (human)	QDNPFRAsPKLKSSC	S313-p
PGC-1 alpha (mouse)	QDNPFKAsPKLKPSC	S312-p
PGC-1 alpha (rat)	QDNPFKASPKLKPSC	S311

S333-gl

PTKRARYsECSGTQG

PGC-1 alpha (human)	PSKKPRYSESSGTQG	S334
PGC-1 alpha (mouse)	PTKRARYsECSGTQG	S333-gl
PGC-1 alpha (rat)	PTKRARYSECSGTQG	S332

K346

QGSHSTKKGPEQSEL

PGC-1 alpha (human)	QGNNSTKkGPEQSEL	K347-ac
PGC-1 alpha (mouse)	QGSHSTKKGPEQSEL	K346
PGC-1 alpha (rat)	QGSHSTKKGPEQSEL	K345

S358-p

SELYAQLsKssGLsr

PGC-1 alpha (human)	SELYAQLSkSSVLTG	S359
PGC-1 alpha (mouse)	SELYAQLsKssGLsr	S358-p
PGC-1 alpha (rat)	SELYAQLSKSSVLSR	S357

K359

ELYAQLsKssGLsrG

PGC-1 alpha (human)	ELYAQLSkSSVLTGG	K360-ac
PGC-1 alpha (mouse)	ELYAQLsKssGLsrG	K359
PGC-1 alpha (rat)	ELYAQLSKSSVLSRG	K358

K359

ELYAQLsKssGLsrG

PGC-1 alpha (human)	ELYAQLSkSSVLTGG	K360-ub
PGC-1 alpha (mouse)	ELYAQLsKssGLsrG	K359
PGC-1 alpha (rat)	ELYAQLSKSSVLSRG	K358

S360-p

LYAQLsKssGLsrGH

PGC-1 alpha (human)	LYAQLSkSSVLTGGH	S361
PGC-1 alpha (mouse)	LYAQLsKssGLsrGH	S360-p
PGC-1 alpha (rat)	LYAQLSKSSVLSRGH	S359

S361-p

YAQLsKssGLsrGHE

PGC-1 alpha (human)	YAQLSkSSVLTGGHE	S362
PGC-1 alpha (mouse)	YAQLsKssGLsrGHE	S361-p
PGC-1 alpha (rat)	YAQLSKSSVLSRGHE	S360

S364-p

LsKssGLsrGHEERK

PGC-1 alpha (human)	LSkSSVLTGGHEERK	T365
PGC-1 alpha (mouse)	LsKssGLsrGHEERK	S364-p
PGC-1 alpha (rat)	LSKSSVLSRGHEERK	S363

R365-m1

sKssGLsrGHEERKT

PGC-1 alpha (human)	SkSSVLTGGHEERKT	G366
PGC-1 alpha (mouse)	sKssGLsrGHEERKT	R365-m1
PGC-1 alpha (rat)	SKSSVLSRGHEERKT	R364

S415

QLDFKDASCDWQGHI

PGC-1 alpha (human)	QLENKDVssDWQGQI	S416-p
PGC-1 alpha (mouse)	QLDFKDASCDWQGHI	S415
PGC-1 alpha (rat)	QLDFKDASCDWQGHI	S414

C416

LDFKDASCDWQGHIC

PGC-1 alpha (human)	LENKDVssDWQGQIC	S417-p
PGC-1 alpha (mouse)	LDFKDASCDWQGHIC	C416
PGC-1 alpha (rat)	LDFKDASCDWQGHIC	C415

K441

RETLEASKQVsPCST

PGC-1 alpha (human)	RETLEASkQVSPCST	K442-ub
PGC-1 alpha (mouse)	RETLEASKQVsPCST	K441
PGC-1 alpha (rat)	RETLEASKQVSPCST	K440

S444-p

LEASKQVsPCSTRKQ

PGC-1 alpha (human)	LEASkQVSPCSTRKQ	S445
PGC-1 alpha (mouse)	LEASKQVsPCSTRKQ	S444-p
PGC-1 alpha (rat)	LEASKQVSPCSTRKQ	S443

K463

EIRAELNKHFGHPCQ

PGC-1 alpha (human)	EIRAELNkHFGHPSQ	K464-ub
PGC-1 alpha (mouse)	EIRAELNKHFGHPCQ	K463
PGC-1 alpha (rat)	EIRAELNKHFGHPSQ	K462

K479

VFDDKSDKTSELRDG

PGC-1 alpha (human)	VFDDEADkTGELRDS	K480-ub
PGC-1 alpha (mouse)	VFDDKSDKTSELRDG	K479
PGC-1 alpha (rat)	VFDDKVDKTSELRDG	K478

S538-p

SLFDVSPsCSSFNSP

Upstream

Downstream

Effects on Biological Processes:

transcription, altered

Kinase, in vitro:

AMPKA2 (rat)

Putative in vivo kinases:

AMPKA2 (human)

PGC-1 alpha (human)	SLFNVSPSCSSFNSP	S539
PGC-1 alpha (mouse)	SLFDVSPsCSSFNSP	S538-p
PGC-1 alpha (rat)	SLFDVSPSCSSFNSP	S537

R547

SSFNSPCRDSVSPPK

PGC-1 alpha (human)	SSFNSPCrDSVSPPK	R548-m1
PGC-1 alpha (mouse)	SSFNSPCRDSVSPPK	R547
PGC-1 alpha (rat)	SSFNSPCRDSVSPPK	R546

S568-p

PQRMRSRsRsFsRHR

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
molecular association, regulation
protein stabilization

Effects on Biological Processes:

signaling pathway regulation
transcription, inhibited

Kinase, in vitro:

p70S6K (human)

Putative in vivo kinases:

p70S6K (human)

Treatment

glucose
insulin
rapamycin

PGC-1 alpha (human)	PQRMRSRSrsFSRHR	S569
PGC-1 alpha (mouse)	PQRMRSRsRsFsRHR	S568-p
PGC-1 alpha (rat)	PQRMRSRSRsFSRHR	S567

R569

QRMRSRsRsFsRHRS

PGC-1 alpha (human)	QRMRSRSrsFSRHRS	R570-me
PGC-1 alpha (mouse)	QRMRSRsRsFsRHRS	R569
PGC-1 alpha (rat)	QRMRSRSRsFSRHRS	R568

S570-p

RMRSRsRsFsRHRSC

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

signaling pathway regulation
transcription, inhibited

Kinase, in vitro:

Akt1 (human)

Putative in vivo kinases:

Akt2 (mouse)

Treatment

insulin
LY294002

PGC-1 alpha (human)	RMRSRSrsFSRHRSC	S571-p
PGC-1 alpha (mouse)	RMRSRsRsFsRHRSC	S570-p
PGC-1 alpha (rat)	RMRSRSRsFSRHRSC	S569-p

S572-p

RSRsRsFsRHRSCSR

Upstream

Downstream

Effects on Modified Protein

activity, inhibited
molecular association, regulation

Effects on Biological Processes:

signaling pathway regulation
transcription, inhibited

Kinase, in vitro:

p70S6K (human)

Putative in vivo kinases:

p70S6K (human)

Treatment

glucose
insulin
rapamycin

PGC-1 alpha (human)	RSRSrsFSRHRSCSR	S573
PGC-1 alpha (mouse)	RSRsRsFsRHRSCSR	S572-p
PGC-1 alpha (rat)	RSRSRsFSRHRSCSR	S571

S615-p

RHRTHRNsPLYVRSR

Downstream

Effects on Modified Protein

protein stabilization

PGC-1 alpha (human)	RHRTHRNsPLYVRSR	S616-p
PGC-1 alpha (mouse)	RHRTHRNsPLYVRSR	S615-p
PGC-1 alpha (rat)	RHRTHRNSPLYVRSR	S614

Y633

PYSRRPRYDSYEAYE

PGC-1 alpha (human)	PYSRRPRyDsYEEYQ	Y634-p
PGC-1 alpha (mouse)	PYSRRPRYDSYEAYE	Y633
PGC-1 alpha (rat)	PYSRRPRYDSYEANE	Y632

S635

SRRPRYDSYEAYEHE

PGC-1 alpha (human)	SRRPRyDsYEEYQHE	S636-p
PGC-1 alpha (mouse)	SRRPRYDSYEAYEHE	S635
PGC-1 alpha (rat)	SRRPRYDSYEANEHE	S634

R664

ESERAKQRERQKQKA

PGC-1 alpha (human)	ESERAKQrErQrQKA	R665-m2
PGC-1 alpha (mouse)	ESERAKQRERQKQKA	R664
PGC-1 alpha (rat)	ESERAKQRERQKQKA	R663

R666

ERAKQRERQKQKAIE

PGC-1 alpha (human)	ERAKQrErQrQKAIE	R667-m2
PGC-1 alpha (mouse)	ERAKQRERQKQKAIE	R666
PGC-1 alpha (rat)	ERAKQRERQKQKAIE	R665

K668

AKQRERQKQKAIEER

PGC-1 alpha (human)	AKQrErQrQKAIEER	R669-m2
PGC-1 alpha (mouse)	AKQRERQKQKAIEER	K668
PGC-1 alpha (rat)	AKQRERQKQKAIEER	K667

R752

FELYFCGRKQFFKSN

PGC-1 alpha (human)	FELYFCGrKQFFkSN	R753-m1
PGC-1 alpha (mouse)	FELYFCGRKQFFKSN	R752
PGC-1 alpha (rat)	FELYFCGRKQFFKSN	R751

K757

CGRKQFFKSNYADLD

PGC-1 alpha (human)	CGrKQFFkSNYADLD	K758-ub
PGC-1 alpha (mouse)	CGRKQFFKSNYADLD	K757
PGC-1 alpha (rat)	CGRKQFFKSNYADLD	K756

S767

YADLDTNSDDFDPAS

PGC-1 alpha (human)	YADLDSNsDDFDPAS	S768-p
PGC-1 alpha (mouse)	YADLDTNSDDFDPAS	S767
PGC-1 alpha (rat)	YADLDSNSDDFDPAS	S766

K776

DFDPASTKSKYDSLD

PGC-1 alpha (human)	DFDPASTkSkYDsLD	K777-ub
PGC-1 alpha (mouse)	DFDPASTKSKYDSLD	K776
PGC-1 alpha (rat)	DFDPASTKSKYDSLD	K775

K778

DPASTKSKYDSLDFD

PGC-1 alpha (human)	DPASTkSkYDsLDFD	K779-me
PGC-1 alpha (mouse)	DPASTKSKYDSLDFD	K778
PGC-1 alpha (rat)	DPASTKSKYDSLDFD	K777

K778

DPASTKSKYDSLDFD

PGC-1 alpha (human)	DPASTkSkYDsLDFD	K779-ub
PGC-1 alpha (mouse)	DPASTKSKYDSLDFD	K778
PGC-1 alpha (rat)	DPASTKSKYDSLDFD	K777

S781

STKSKYDSLDFDSLL

PGC-1 alpha (human)	STkSkYDsLDFDsLL	S782-p
PGC-1 alpha (mouse)	STKSKYDSLDFDSLL	S781
PGC-1 alpha (rat)	STKSKYDSLDFDSLL	S780

S786

YDSLDFDSLLKEAQR

PGC-1 alpha (human)	YDsLDFDsLLkEAQR	S787-p
PGC-1 alpha (mouse)	YDSLDFDSLLKEAQR	S786
PGC-1 alpha (rat)	YDSLDFDSLLKEAQR	S785

K789

LDFDSLLKEAQRSLR

PGC-1 alpha (human)	LDFDsLLkEAQRSLR	K790-ub
PGC-1 alpha (mouse)	LDFDSLLKEAQRSLR	K789
PGC-1 alpha (rat)	LDFDSLLKEAQRSLR	K788