Other Species / Isoforms
  MEKK3 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
-
gap
0 2
MEKK3 (human) gap -
MEKK3 iso2 (human) SSSALLNsPtVTTSS S55-p
MEKK3 (mouse) gap -
MEKK3 (rat) gap -
-
gap
0 1
MEKK3 (human) gap -
MEKK3 iso2 (human) SALLNsPtVTTSSCA T57-p
MEKK3 (mouse) gap -
MEKK3 (rat) gap -
S61
ERRIIAFSRPVRYED
1 0
MEKK3 (human) ERRIIAFsRPVKYED S61-p
MEKK3 iso2 (human) ERRIIAFSRPVKYED S92
MEKK3 (mouse) ERRIIAFSRPVRYED S61
MEKK3 (rat) ERRIIAFSRPVRYED S61
K102
KNQDDLDKAIDILDR
0 1
MEKK3 (human) KNQDDLDkAIDILDR K102-ub
MEKK3 iso2 (human) KNQDDLDKAIDILDR K133
MEKK3 (mouse) KNQDDLDKAIDILDR K102
MEKK3 (rat) KNQDDLDKAIDILDR K102
S130
QDRNHTSSsPHSGVS
0 1
MEKK3 (human) QDRNHNSssPHSGVS S130-p
MEKK3 iso2 (human) QDRNHNSSSPHSGVS S161
MEKK3 (mouse) QDRNHTSSsPHSGVS S130
MEKK3 (rat) QDRNHTSSSPHSGVS S130
S131-p
DRNHTSSsPHSGVSR
Upstream
0 4
Treatment
  • insulin
MEKK3 (human) DRNHNSssPHSGVSR S131-p
MEKK3 iso2 (human) DRNHNSSSPHSGVSR S162
MEKK3 (mouse) DRNHTSSsPHSGVSR S131-p
MEKK3 (rat) DRNHTSSSPHSGVSR S131
S145-p
RQVRIKPsQsAGDIN
0 3
MEKK3 (human) RQVRIKAsQsAGDIN S145-p
MEKK3 iso2 (human) RQVRIKASQSAGDIN S176
MEKK3 (mouse) RQVRIKPsQsAGDIN S145-p
MEKK3 (rat) RQVRVKPSQSAGDIN S145
S147-p
VRIKPsQsAGDINtI
Upstream
0 25
Treatment
  • LPA
  • LPS
MEKK3 (human) VRIKAsQsAGDINTI S147-p
MEKK3 iso2 (human) VRIKASQSAGDINTI S178
MEKK3 (mouse) VRIKPsQsAGDINtI S147-p
MEKK3 (rat) VRVKPSQSAGDINTI S147
T153-p
QsAGDINtIyQAPEP
0 1
MEKK3 (human) QsAGDINTIyQPPEP T153
MEKK3 iso2 (human) QSAGDINTIYQPPEP T184
MEKK3 (mouse) QsAGDINtIyQAPEP T153-p
MEKK3 (rat) QSAGDINTIYQAPEP T153
Y155-p
AGDINtIyQAPEPRS
0 61
MEKK3 (human) AGDINTIyQPPEPRs Y155-p
MEKK3 iso2 (human) AGDINTIYQPPEPRS Y186
MEKK3 (mouse) AGDINtIyQAPEPRS Y155-p
MEKK3 (rat) AGDINTIYQAPEPRS Y155
S162
yQAPEPRSRHLsVsS
0 1
MEKK3 (human) yQPPEPRsRHLsVss S162-p
MEKK3 iso2 (human) YQPPEPRSRHLSVSS S193
MEKK3 (mouse) yQAPEPRSRHLsVsS S162
MEKK3 (rat) YQAPEPRSRHLSVSS S162
S166-p
EPRSRHLsVsSQNPG
Upstream
Downstream
2 71
Effects on Modified Protein
  • enzymatic activity, inhibited
Kinase, in vitro:
  • SGK1 (human)
Putative in vivo kinases:
  • SGK1 (human)
Treatment
  • colforsin
  • H-89
  • IL-33
  • insulin
  • serum
  • TNF
  • wortmannin
MEKK3 (human) EPRsRHLsVssQNPG S166-p
MEKK3 iso2 (human) EPRSRHLSVSSQNPG S197
MEKK3 (mouse) EPRSRHLsVsSQNPG S166-p
MEKK3 (rat) EPRSRHLSVSSQNPG S166
S168-p
RSRHLsVsSQNPGRs
0 3
MEKK3 (human) RsRHLsVssQNPGRs S168-p
MEKK3 iso2 (human) RSRHLSVSSQNPGRS S199
MEKK3 (mouse) RSRHLsVsSQNPGRs S168-p
MEKK3 (rat) RSRHLSVSSQNPGRS S168
S169
SRHLsVsSQNPGRss
0 8
MEKK3 (human) sRHLsVssQNPGRss S169-p
MEKK3 iso2 (human) SRHLSVSSQNPGRSS S200
MEKK3 (mouse) SRHLsVsSQNPGRss S169
MEKK3 (rat) SRHLSVSSQNPGRSS S169
S175-p
sSQNPGRssPPPGYV
0 4
MEKK3 (human) ssQNPGRssPPPGYV S175-p
MEKK3 iso2 (human) SSQNPGRSSPPPGYV S206
MEKK3 (mouse) sSQNPGRssPPPGYV S175-p
MEKK3 (rat) SSQNPGRSSPPPGYV S175
S176-p
SQNPGRssPPPGYVP
0 19
MEKK3 (human) sQNPGRssPPPGYVP S176-p
MEKK3 iso2 (human) SQNPGRSSPPPGYVP S207
MEKK3 (mouse) SQNPGRssPPPGYVP S176-p
MEKK3 (rat) SQNPGRSSPPPGYVP S176
S194
QHIARQGSYTSINSE
0 1
MEKK3 (human) QHIARQGsYTSINSE S194-p
MEKK3 iso2 (human) QHIARQGSYTSINSE S225
MEKK3 (mouse) QHIARQGSYTSINSE S194
MEKK3 (rat) QHIARQGSYTSINSE S194
S234
SCQSLDRSADsPSFR
0 2
MEKK3 (human) SCQSLDRsADsPSFR S234-p
MEKK3 iso2 (human) SCQSLDRSADSPSFR S265
MEKK3 (mouse) SCQSLDRSADsPSFR S234
MEKK3 (rat) SCQSLDRSADSPSFR S234
S237-p
SLDRSADsPSFRKSQ
Upstream
0 11
Treatment
  • insulin
MEKK3 (human) SLDRsADsPSFRKSR S237-p
MEKK3 iso2 (human) SLDRSADSPSFRKSR S268
MEKK3 (mouse) SLDRSADsPSFRKSQ S237-p
MEKK3 (rat) SLDRSADSPSFRKSQ S237
R249-m1
KSQMSRArsFPDNrK
0 1
MEKK3 (human) KSRMSRAQsFPDNRQ Q249
MEKK3 iso2 (human) KSRMSRAQSFPDNRQ Q280
MEKK3 (mouse) KSQMSRArsFPDNrK R249-m1
MEKK3 (rat) KSQMSRARSFPDNRK R249
S250-p
SQMSRArsFPDNrKE
Upstream
0 51
Treatment
  • insulin
  • LY294002
MEKK3 (human) SRMSRAQsFPDNRQE S250-p
MEKK3 iso2 (human) SRMSRAQSFPDNRQE S281
MEKK3 (mouse) SQMSRArsFPDNrKE S250-p
MEKK3 (rat) SQMSRARSFPDNRKE S250
R255-m1
ArsFPDNrKECSDRE
0 1
MEKK3 (human) AQsFPDNRQEYSDRE R255
MEKK3 iso2 (human) AQSFPDNRQEYSDRE R286
MEKK3 (mouse) ArsFPDNrKECSDRE R255-m1
MEKK3 (rat) ARSFPDNRKECSDRE R255
T263
KECSDRETQLYDKGV
0 1
MEKK3 (human) QEYSDREtQLyDKGV T263-p
MEKK3 iso2 (human) QEYSDRETQLYDKGV T294
MEKK3 (mouse) KECSDRETQLYDKGV T263
MEKK3 (rat) KECSDRETQLYDKGV T263
Y266
SDRETQLYDKGVKGG
0 1
MEKK3 (human) SDREtQLyDKGVKGG Y266-p
MEKK3 iso2 (human) SDRETQLYDKGVKGG Y297
MEKK3 (mouse) SDRETQLYDKGVKGG Y266
MEKK3 (rat) SDRETQLYDKGVKGG Y266
T274-p
DKGVKGGtYPRRYHV
0 4
MEKK3 (human) DKGVKGGtyPRRYHV T274-p
MEKK3 iso2 (human) DKGVKGGTYPRRYHV T305
MEKK3 (mouse) DKGVKGGtYPRRYHV T274-p
MEKK3 (rat) DKGVKGGTYPRRYHV T274
Y275
KGVKGGtYPRRYHVS
0 3
MEKK3 (human) KGVKGGtyPRRYHVS Y275-p
MEKK3 iso2 (human) KGVKGGTYPRRYHVS Y306
MEKK3 (mouse) KGVKGGtYPRRYHVS Y275
MEKK3 (rat) KGVKGGTYPRRYHVS Y275
Y288
VSVHHKDYNDGRRtF
0 1
MEKK3 (human) VSVHHKDysDGRRtF Y288-p
MEKK3 iso2 (human) VSVHHKDYSDGRRTF Y319
MEKK3 (mouse) VSVHHKDYNDGRRtF Y288
MEKK3 (rat) VSVHHKDYNDGRRTF Y288
N289
SVHHKDYNDGRRtFP
0 1
MEKK3 (human) SVHHKDysDGRRtFP S289-p
MEKK3 iso2 (human) SVHHKDYSDGRRTFP S320
MEKK3 (mouse) SVHHKDYNDGRRtFP N289
MEKK3 (rat) SVHHKDYNDGRRTFP N289
T294-p
DYNDGRRtFPRIRRH
1 5
MEKK3 (human) DysDGRRtFPRIRRH T294-p
MEKK3 iso2 (human) DYSDGRRTFPRIRRH T325
MEKK3 (mouse) DYNDGRRtFPRIRRH T294-p
MEKK3 (rat) DYNDGRRTFPRIRRH T294
S312-p
LFTLVPSsRSLStNG
0 2
MEKK3 (human) LFTLVPSsRsLstNG S312-p
MEKK3 iso2 (human) LFTLVPSSRSLSTNG S343
MEKK3 (mouse) LFTLVPSsRSLStNG S312-p
MEKK3 (rat) LFTLVPSSRSLSTNG S312
S314
TLVPSsRSLStNGEN
0 1
MEKK3 (human) TLVPSsRsLstNGEN S314-p
MEKK3 iso2 (human) TLVPSSRSLSTNGEN S345
MEKK3 (mouse) TLVPSsRSLStNGEN S314
MEKK3 (rat) TLVPSSRSLSTNGEN S314
S316
VPSsRSLStNGENMG
0 5
MEKK3 (human) VPSsRsLstNGENMG S316-p
MEKK3 iso2 (human) VPSSRSLSTNGENMG S347
MEKK3 (mouse) VPSsRSLStNGENMG S316
MEKK3 (rat) VPSSRSLSTNGENMG S316
T317-p
PSsRSLStNGENMGV
0 5
MEKK3 (human) PSsRsLstNGENMGL T317-p
MEKK3 iso2 (human) PSSRSLSTNGENMGL T348
MEKK3 (mouse) PSsRSLStNGENMGV T317-p
MEKK3 (rat) PSSRSLSTNGENMGA T317
S337-p
DPRGRLRsADsENAL
Upstream
Downstream
2 78
Effects on Modified Protein
  • enzymatic activity, inhibited
Kinase, in vitro:
  • SGK1 (human)
Putative in vivo kinases:
  • SGK1 (human)
Treatment
  • insulin
  • LPS
  • PDGF
MEKK3 (human) DPRGRLRsADsENAL S337-p
MEKK3 iso2 (human) DPRGRLRSADSENAL S368
MEKK3 (mouse) DPRGRLRsADsENAL S337-p
MEKK3 (rat) DPRGRLRsADsENAL S337-p
S340-p
GRLRsADsENALTVQ
Upstream
0 78
Treatment
  • insulin
  • ischemia
  • LPS
MEKK3 (human) GRLRsADsENALsVQ S340-p
MEKK3 iso2 (human) GRLRSADSENALSVQ S371
MEKK3 (mouse) GRLRsADsENALTVQ S340-p
MEKK3 (rat) GRLRsADsENALTVQ S340-p
T345
ADsENALTVQERNVP
0 1
MEKK3 (human) ADsENALsVQERNVP S345-p
MEKK3 iso2 (human) ADSENALSVQERNVP S376
MEKK3 (mouse) ADsENALTVQERNVP T345
MEKK3 (rat) ADsENALTVQERSVP T345
S355-p
ERNVPTKsPsAPINW
Upstream
0 14
Treatment
  • insulin
MEKK3 (human) ERNVPTKsPsAPINW S355-p
MEKK3 iso2 (human) ERNVPTKSPSAPINW S386
MEKK3 (mouse) ERNVPTKsPsAPINW S355-p
MEKK3 (rat) ERSVPTKSPSAPINW S355
S357-p
NVPTKsPsAPINWRR
0 3
MEKK3 (human) NVPTKsPsAPINWRR S357-p
MEKK3 iso2 (human) NVPTKSPSAPINWRR S388
MEKK3 (mouse) NVPTKsPsAPINWRR S357-p
MEKK3 (rat) SVPTKSPSAPINWRR S357
K391
TGRELASKQVQFDPD
0 1
MEKK3 (human) TGRELASkQVQFDPD K391-ub
MEKK3 iso2 (human) TGRELASKQVQFDPD K422
MEKK3 (mouse) TGRELASKQVQFDPD K391
MEKK3 (rat) TGRELASKQVQFDPD K391
K404
PDSPETSKEVSALEC
0 1
MEKK3 (human) PDSPETSkEVSALEC K404-ub
MEKK3 iso2 (human) PDSPETSKEVSALEC K435
MEKK3 (mouse) PDSPETSKEVSALEC K404
MEKK3 (rat) PDSPETSKEVSALEC K404
K417
ECEIQLLKNLQHERI
0 1
MEKK3 (human) ECEIQLLkNLQHERI K417-ub
MEKK3 iso2 (human) ECEIQLLKNLQHERI K448
MEKK3 (mouse) ECEIQLLKNLQHERI K417
MEKK3 (rat) ECEIQLLKNLQHERI K417
K456
GSVKDQLKAYGALTE
0 1
MEKK3 (human) GSVKDQLkAYGALTE K456-ub
MEKK3 iso2 (human) GSVKDQLKAYGALTE K487
MEKK3 (mouse) GSVKDQLKAYGALTE K456
MEKK3 (rat) GSVKDQLKAYGALTE K456
S464
AYGALTESVTRKYTR
0 1
MEKK3 (human) AYGALTEsVTRKYTR S464-p
MEKK3 iso2 (human) AYGALTESVTRKYTR S495
MEKK3 (mouse) AYGALTESVTRKYTR S464
MEKK3 (rat) AYGALTESVTRKYTR S464
K504
RDSAGNVKLGDFGAS
0 1
MEKK3 (human) RDSAGNVkLGDFGAS K504-ub
MEKK3 iso2 (human) RDSAGNVKLGDFGAS K535
MEKK3 (mouse) RDSAGNVKLGDFGAS K504
MEKK3 (rat) RDSAGNVKLGDFGAS K504
T516
GASKRLQTICMSGTG
2 0
MEKK3 (human) GASKRLQtICMsGTG T516-p
MEKK3 iso2 (human) GASKRLQTICMSGTG T547
MEKK3 (mouse) GASKRLQTICMSGTG T516
MEKK3 (rat) GASKRLQTICMSGTG T516
S520
RLQTICMSGTGIRsV
2 1
MEKK3 (human) RLQtICMsGTGMRsV S520-p
MEKK3 iso2 (human) RLQTICMSGTGMRSV S551
MEKK3 (mouse) RLQTICMSGTGIRsV S520
MEKK3 (rat) RLQTICMSGTGMRSV S520
S526-p
MSGTGIRsVTGTPYW
Upstream
Downstream
4 2
Effects on Modified Protein
  • enzymatic activity, induced
Putative in vivo kinases:
  • MKK3 (mouse)
MEKK3 (human) MsGTGMRsVtGtPYW S526-p
MEKK3 iso2 (human) MSGTGMRSVTGTPYW S557
MEKK3 (mouse) MSGTGIRsVTGTPYW S526-p
MEKK3 (rat) MSGTGMRSVTGTPYW S526
T528
GTGIRsVTGTPYWMS
1 0
MEKK3 (human) GTGMRsVtGtPYWMS T528-p
MEKK3 iso2 (human) GTGMRSVTGTPYWMS T559
MEKK3 (mouse) GTGIRsVTGTPYWMS T528
MEKK3 (rat) GTGMRSVTGTPYWMS T528
T530
GIRsVTGTPYWMSPE
1 0
MEKK3 (human) GMRsVtGtPYWMSPE T530-p
MEKK3 iso2 (human) GMRSVTGTPYWMSPE T561
MEKK3 (mouse) GIRsVTGTPYWMSPE T530
MEKK3 (rat) GMRSVTGTPYWMSPE T530