Other Species / Isoforms
  SIRT1 (mouse)    LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S14-p
LALQAAGsPsAAAAM
2 25
SIRT1 (human) LALQPGGsPsAAGAD S14-p
SIRT1 (mouse) LALQAAGsPsAAAAM S14-p
SIRT1 (rat) gap -
S16-p
LQAAGsPsAAAAMEA
0 3
SIRT1 (human) LQPGGsPsAAGADRE S16-p
SIRT1 (mouse) LQAAGsPsAAAAMEA S16-p
SIRT1 (rat) gap -
S25
AAAMEAASQPADEPL
0 8
SIRT1 (human) GADREAAssPAGEPL S26-p
SIRT1 (mouse) AAAMEAASQPADEPL S25
SIRT1 (rat) gap -
Q26
AAMEAASQPADEPLR
4 18
SIRT1 (human)
S27-p
SIRT1 (human) ADREAAssPAGEPLR S27-p
SIRT1 (mouse) AAMEAASQPADEPLR Q26
SIRT1 (rat) gap -
S46-p
DGPGLGRsPGEPsAA
Effect
6 56
SIRT1 (human)
S47-p
Effects on Modified Protein
  • protein degradation
  • ubiquitination
SIRT1 (human) DGPGLERsPGEPGGA S47-p
SIRT1 (mouse) DGPGLGRsPGEPsAA S46-p
SIRT1 (rat) gap -
S51-p
GRsPGEPsAAVAPAA
0 2
SIRT1 (human) ERsPGEPGGAAPERE G52
SIRT1 (mouse) GRsPGEPsAAVAPAA S51-p
SIRT1 (rat) gap -
T146-p
LLTDGLLtNGFHsCE
0 1
SIRT1 (human) LFGDEIITNGFHsCE T154
SIRT1 (mouse) LLTDGLLtNGFHsCE T146-p
SIRT1 (rat) LLADEIITNGFHSCE T158
S151-p
LLtNGFHsCEsDDDD
0 5
SIRT1 (human) IITNGFHsCEsDEED S159-p
SIRT1 (mouse) LLtNGFHsCEsDDDD S151-p
SIRT1 (rat) IITNGFHSCESDDDD S163
S154-p
NGFHsCEsDDDDRTS
Effect
2 4
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
  • transcription, induced
SIRT1 (human) NGFHsCEsDEEDRAS S162-p
SIRT1 (mouse) NGFHsCEsDDDDRTS S154-p
SIRT1 (rat) NGFHSCESDDDDRAS S166
S164-p
DDRTSHAsSSDWtPR
Effect
1 4
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
SIRT1 (human) EDRASHAssSDWTPR S172-p
SIRT1 (mouse) DDRTSHAsSSDWtPR S164-p
SIRT1 (rat) DDRASHASSSDWTPR S176
S165
DRTSHAsSSDWtPRP
0 2
SIRT1 (human) DRASHAssSDWTPRP S173-p
SIRT1 (mouse) DRTSHAsSSDWtPRP S165
SIRT1 (rat) DRASHASSSDWTPRP S177
T169-p
HAsSSDWtPRPRIGP
0 1
SIRT1 (human) HAssSDWTPRPRIGP T177
SIRT1 (mouse) HAsSSDWtPRPRIGP T169-p
SIRT1 (rat) HASSSDWTPRPRIGP T181
K230
PPKRKKRKDINTIED
0 6
SIRT1 (human) PPKRKKRkDINTIED K238-ub
SIRT1 (mouse) PPKRKKRKDINTIED K230
SIRT1 (rat) PPKRKKRKDINTIED K242
K240
NTIEDAVKLLQECKK
0 1
SIRT1 (human) NTIEDAVkLLQECKK K248-ub
SIRT1 (mouse) NTIEDAVKLLQECKK K240
SIRT1 (rat) NTIEDAVKLLQECKK K252
Y272
FRSRDGIYARLAVDF
1 1
SIRT1 (human) FRSRDGIyARLAVDF Y280-p
SIRT1 (mouse) FRSRDGIYARLAVDF Y272
SIRT1 (rat) FRSRDGIYARLAVDF Y284
Y293
QAMFDIEYFRKDPRP
1 1
SIRT1 (human) QAMFDIEyFRKDPRP Y301-p
SIRT1 (mouse) QAMFDIEYFRKDPRP Y293
SIRT1 (rat) QAMFDIEYFRKDPRP Y305
K303
KDPRPFFKFAKEIYP
0 1
SIRT1 (human) KDPRPFFkFAkEIYP K311-ub
SIRT1 (mouse) KDPRPFFKFAKEIYP K303
SIRT1 (rat) KDPRPFFKFAKEIYP K315
K306
RPFFKFAKEIYPGQF
0 3
SIRT1 (human) RPFFkFAkEIYPGQF K314-ub
SIRT1 (mouse) RPFFKFAKEIYPGQF K306
SIRT1 (rat) RPFFKFAKEIYPGQF K318
K320
FQPSLCHKFIALSDK
0 1
SIRT1 (human) FQPSLCHkFIALsDk K328-ub
SIRT1 (mouse) FQPSLCHKFIALSDK K320
SIRT1 (rat) FQPSLCHKFIALSDK K332
S325
CHKFIALSDKEGKLL
0 2
SIRT1 (human) CHkFIALsDkEGkLL S333-p
SIRT1 (mouse) CHKFIALSDKEGKLL S325
SIRT1 (rat) CHKFIALSDKEGKLL S337
K327
KFIALSDKEGKLLRN
0 1
SIRT1 (human) kFIALsDkEGkLLRN K335-ub
SIRT1 (mouse) KFIALSDKEGKLLRN K327
SIRT1 (rat) KFIALSDKEGKLLRN K339
K330
ALSDKEGKLLRNYTQ
0 1
SIRT1 (human) ALsDkEGkLLRNYtQ K338-ub
SIRT1 (mouse) ALSDKEGKLLRNYTQ K330
SIRT1 (rat) ALSDKEGKLLRNYTQ K342
T336
GKLLRNYTQNIDTLE
2 0
SIRT1 (human) GkLLRNYtQNIDTLE T344-p
SIRT1 (mouse) GKLLRNYTQNIDTLE T336
SIRT1 (rat) GKLLRNYTQNIDTLE T348
Y420
QFHRAMKYDKDEVDL
0 1
SIRT1 (human) QFHRAMKyDkDEVDL Y428-p
SIRT1 (mouse) QFHRAMKYDKDEVDL Y420
SIRT1 (rat) QFHRAMKYDKDEVDL Y432
K422
HRAMKYDKDEVDLLI
0 1
SIRT1 (human) HRAMKyDkDEVDLLI K430-ac
SIRT1 (mouse) HRAMKYDKDEVDLLI K422
SIRT1 (rat) HRAMKYDKDEVDLLI K434
S433
DLLIVIGSsLKVRPV
0 1
SIRT1 (human) DLLIVIGssLkVRPV S441-p
SIRT1 (mouse) DLLIVIGSsLKVRPV S433
SIRT1 (rat) DLLIVIGSSLKVRPV S445
S434-p
LLIVIGSsLKVRPVA
1 1
SIRT1 (human) LLIVIGssLkVRPVA S442-p
SIRT1 (mouse) LLIVIGSsLKVRPVA S434-p
SIRT1 (rat) LLIVIGSSLKVRPVA S446
K436
IVIGSsLKVRPVALI
0 1
SIRT1 (human) IVIGssLkVRPVALI K444-ac
SIRT1 (mouse) IVIGSsLKVRPVALI K436
SIRT1 (rat) IVIGSSLKVRPVALI K448
K491
RLGGEYAKLCCNPVK
0 4
SIRT1 (human) RLGGEYAkLCCNPVk K499-ub
SIRT1 (mouse) RLGGEYAKLCCNPVK K491
SIRT1 (rat) RLGGEYAKLCCNPVK K503
K498
KLCCNPVKLSEITEK
0 1
SIRT1 (human) kLCCNPVkLSEITEk K506-ub
SIRT1 (mouse) KLCCNPVKLSEITEK K498
SIRT1 (rat) KLCCNPVKLSEITEK K510
K505
KLSEITEKPPRPQKE
0 2
SIRT1 (human) kLSEITEkPPRTQKE K513-ub
SIRT1 (mouse) KLSEITEKPPRPQKE K505
SIRT1 (rat) KLSEITEKPPRTQKE K517
T522-p
HLSELPPtPLHIsED
Effect
6 43
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • cell differentiation, inhibited
SIRT1 (human) YLSELPPtPLHVsED T530-p
SIRT1 (mouse) HLSELPPtPLHIsED T522-p
SIRT1 (rat) HLSELPPTPLHISED T534
S527-p
PPtPLHIsEDsSsPE
0 12
SIRT1 (human) PPtPLHVsEDsssPE S535-p
SIRT1 (mouse) PPtPLHIsEDsSsPE S527-p
SIRT1 (rat) PPTPLHISEDSSsPE S539
S530-p
PLHIsEDsSsPERTV
0 8
SIRT1 (human) PLHVsEDsssPERts S538-p
SIRT1 (mouse) PLHIsEDsSsPERTV S530-p
SIRT1 (rat) PLHISEDSSsPERTV S542
S531
LHIsEDsSsPERTVP
0 3
SIRT1 (human) LHVsEDsssPERtsP S539-p
SIRT1 (mouse) LHIsEDsSsPERTVP S531
SIRT1 (rat) LHISEDSSsPERTVP S543
S532-p
HIsEDsSsPERTVPQ
1 9
SIRT1 (human) HVsEDsssPERtsPP S540-p
SIRT1 (mouse) HIsEDsSsPERTVPQ S532-p
SIRT1 (rat) HISEDSSsPERTVPQ S544-p
T536
DsSsPERTVPQDSSV
0 2
SIRT1 (human) DsssPERtsPPDsSV T544-p
SIRT1 (mouse) DsSsPERTVPQDSSV T536
SIRT1 (rat) DSSsPERTVPQDSSV T548
V537
sSsPERTVPQDSSVI
0 1
SIRT1 (human) sssPERtsPPDsSVI S545-p
SIRT1 (mouse) sSsPERTVPQDSSVI V537
SIRT1 (rat) SSsPERTVPQDSSVI V549
S541
ERTVPQDSSVIATLV
0 1
SIRT1 (human) ERtsPPDsSVIVTLL S549-p
SIRT1 (mouse) ERTVPQDSSVIATLV S541
SIRT1 (rat) ERTVPQDSSVIATLV S553
-
under review
0 1
SIRT1 (human) TLLDQAAksNDDLDV K561-ub
SIRT1 (mouse) under review -
SIRT1 (rat) under review -
N554
LVDQATNNNVNDLEV
0 2
SIRT1 (human) LLDQAAksNDDLDVs S562-p
SIRT1 (mouse) LVDQATNNNVNDLEV N554
SIRT1 (rat) LVDQTIKNKVDDLEV N566
S562
NVNDLEVSESSCVEE
0 2
SIRT1 (human) sNDDLDVsESkGCME S569-p
SIRT1 (mouse) NVNDLEVSESSCVEE S562
SIRT1 (rat) KVDDLEVSEPKSCVE S574
-
under review
0 1
SIRT1 (human) DLDVsESkGCMEEkP K572-ub
SIRT1 (mouse) under review -
SIRT1 (rat) DLEVSEPKSCVEEKS K577
K570
ESSCVEEKPQEVQTS
0 1
SIRT1 (human) SkGCMEEkPQEVQTS K578-ac
SIRT1 (mouse) ESSCVEEKPQEVQTS K570
SIRT1 (rat) PKSCVEEKSQEVQTY K583
K570
ESSCVEEKPQEVQTS
0 1
SIRT1 (human) SkGCMEEkPQEVQTS K578-ub
SIRT1 (mouse) ESSCVEEKPQEVQTS K570
SIRT1 (rat) PKSCVEEKSQEVQTY K583
N582
QTSRNVENINVENPD
0 1
SIRT1 (human) QTSRNVEsIAEQMEN S590-p
SIRT1 (mouse) QTSRNVENINVENPD N582
SIRT1 (rat) QTYRNVESINVENPD S595
K591
NVENPDFKAVGSSTA
0 5
SIRT1 (human) QMENPDLkNVGSSTG K601-ub
SIRT1 (mouse) NVENPDFKAVGSSTA K591
SIRT1 (rat) NVENPDFKAVGSSTG K604
K600
VGSSTADKNERTSVA
0 2
SIRT1 (human) VGSSTGEkNERtsVA K610-ub
SIRT1 (mouse) VGSSTADKNERTSVA K600
SIRT1 (rat) VGSSTGDKNERTSVA K613
T604
TADKNERTSVAETVR
0 1
SIRT1 (human) TGEkNERtsVAGtVR T614-p
SIRT1 (mouse) TADKNERTSVAETVR T604
SIRT1 (rat) TGDKNERTSVAETVR T617
S605
ADKNERTSVAETVRK
0 12
SIRT1 (human) GEkNERtsVAGtVRk S615-p
SIRT1 (mouse) ADKNERTSVAETVRK S605
SIRT1 (rat) GDKNERTSVAETVRK S618
T609
ERTSVAETVRKCWPN
0 2
SIRT1 (human) ERtsVAGtVRkCWPN T619-p
SIRT1 (mouse) ERTSVAETVRKCWPN T609
SIRT1 (rat) ERTSVAETVRKCWPN T622
K612
SVAETVRKCWPNRLA
1 1
SIRT1 (human) sVAGtVRkCWPNRVA K622-me
SIRT1 (mouse) SVAETVRKCWPNRLA K612
SIRT1 (rat) SVAETVRKCWPNRLA K625
S649-p
FHGAEVYsDsEDDVL
Effect
2 0
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
SIRT1 (human) FHGAEVYsDsEDDVL S659-p
SIRT1 (mouse) FHGAEVYsDsEDDVL S649-p
SIRT1 (rat) FHGAEVYSDSEDDAL S662
S651-p
GAEVYsDsEDDVLSS
Effect
2 0
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
SIRT1 (human) GAEVYsDsEDDVLSS S661-p
SIRT1 (mouse) GAEVYsDsEDDVLSS S651-p
SIRT1 (rat) GAEVYSDSEDDALSS S664
S672
SDSGTCQSPSLEEPL
1 0
SIRT1 (human) SDSGTCQsPSLEEPM S682-p
SIRT1 (mouse) SDSGTCQSPSLEEPL S672
SIRT1 (rat) SDSGTCQSPSLEEPL S685
S683-p
EEPLEDEsEIEEFYN
Effect
1 0
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, inhibited
SIRT1 (human) EEPMEDESEIEEFYN S693
SIRT1 (mouse) EEPLEDEsEIEEFYN S683-p
SIRT1 (rat) EEPLEDESEIEEFYN S696
A709
AGGSGFGADGGDQEV
2 30
SIRT1 (human) AGGAGFGtDGDDQEA T719-p
SIRT1 (mouse) AGGSGFGADGGDQEV A709
SIRT1 (rat) ECAGGSGADGGDQEA A720
R724
VNEAIATRQELTDVN
1 0
SIRT1 (human) INEAISVkQEVTDMN K734-sm
SIRT1 (mouse) VNEAIATRQELTDVN R724
SIRT1 (rat) VNEAIAMKQELTDVN K735
S737
VNYPSDKS_______
0 4
SIRT1 (human) MNYPSNKs_______ S747-p
SIRT1 (mouse) VNYPSDKS_______ S737
SIRT1 (rat) VNCTPDKSEHY____ S748