Other Species / Isoforms
  SHP-2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S28-p
LTRGVDGsFLARPsK
0 1
SHP-2 (human) LTRGVDGsFLARPsK S28-p
SHP-2 iso1 (human) LTRGVDGSFLARPSK S28
SHP-2 (mouse) LTRGVDGSFLARPSK S28
SHP-2 (rat) LTRGVDGSFLARPSK S28
S34-p
GsFLARPsKsNPGDF
0 3
SHP-2 (human) GsFLARPsKsNPGDF S34-p
SHP-2 iso1 (human) GSFLARPSKSNPGDF S34
SHP-2 (mouse) GSFLARPSKsNPGDF S34
SHP-2 (rat) GSFLARPSKSNPGDF S34
S36-p
FLARPsKsNPGDFTL
0 2
SHP-2 (human) FLARPsKsNPGDFTL S36-p
SHP-2 iso1 (human) FLARPSKSNPGDFTL S36
SHP-2 (mouse) FLARPSKsNPGDFTL S36-p
SHP-2 (rat) FLARPSKSNPGDFTL S36
T59-p
THIKIQNtGDyyDLy
0 3
SHP-2 (human) THIKIQNtGDyyDLy T59-p
SHP-2 iso1 (human) THIKIQNTGDYYDLY T59
SHP-2 (mouse) THIKIQNTGDyyDLy T59
SHP-2 (rat) THIKIQNTGDyyDLY T59
Y62-p
KIQNtGDyyDLyGGE
Upstream
0 2114
Regulatory protein:
  • EGFR (human)
  • ZAP70 (human)
Treatment
  • EGF
  • ephrin_B1
  • ephrin_B2
  • FGF7
SHP-2 (human) KIQNtGDyyDLyGGE Y62-p
SHP-2 iso1 (human) KIQNTGDYYDLYGGE Y62
SHP-2 (mouse) KIQNTGDyyDLyGGE Y62-p
SHP-2 (rat) KIQNTGDyyDLYGGE Y62-p
Y63-p
IQNtGDyyDLyGGEK
1 84
SHP-2 (human) IQNtGDyyDLyGGEK Y63-p
SHP-2 iso1 (human) IQNTGDYYDLYGGEK Y63
SHP-2 (mouse) IQNTGDyyDLyGGEK Y63-p
SHP-2 (rat) IQNTGDyyDLYGGEK Y63-p
Y66-p
tGDyyDLyGGEKFAT
0 15
SHP-2 (human) tGDyyDLyGGEKFAT Y66-p
SHP-2 iso1 (human) TGDYYDLYGGEKFAt Y66
SHP-2 (mouse) TGDyyDLyGGEKFAT Y66-p
SHP-2 (rat) TGDyyDLYGGEKFAT Y66
T73
yGGEKFATLAELVQy
1 0
SHP-2 (human) yGGEKFATLAELVQy T73
SHP-2 iso1 (human) YGGEKFAtLAELVQY T73-p
SHP-2 (mouse) yGGEKFATLAELVQY T73
SHP-2 (rat) YGGEKFATLAELVQY T73
Y80-p
TLAELVQyYMEHHGQ
0 1
SHP-2 (human) TLAELVQyYMEHHGQ Y80-p
SHP-2 iso1 (human) tLAELVQYYMEHHGQ Y80
SHP-2 (mouse) TLAELVQYYMEHHGQ Y80
SHP-2 (rat) TLAELVQYYMEHHGQ Y80
K91
HHGQLKEKNGDVIEL
0 1
SHP-2 (human) HHGQLKEKNGDVIEL K91
SHP-2 iso1 (human) HHGQLKEKNGDVIEL K91
SHP-2 (mouse) HHGQLKEkNGDVIEL K91-ub
SHP-2 (rat) HHGQLKEKNGDVIEL K91
K120
FHGHLSGKEAEkLLT
0 1
SHP-2 (human) FHGHLSGKEAEkLLT K120
SHP-2 iso1 (human) FHGHLSGKEAEKLLT K120
SHP-2 (mouse) FHGHLSGKEAEKLLT K120
SHP-2 (rat) FHGHLSGkEAEkLLT K120-ac
K120-ub
FHGHLSGkEAEkLLT
0 1
SHP-2 (human) FHGHLSGkEAEkLLT K120-ub
SHP-2 iso1 (human) FHGHLSGKEAEKLLT K120
SHP-2 (mouse) FHGHLSGKEAEKLLT K120
SHP-2 (rat) FHGHLSGKEAEkLLT K120
K124
LSGkEAEKLLTEKGk
0 1
SHP-2 (human) LSGkEAEKLLTEKGk K124
SHP-2 iso1 (human) LSGKEAEKLLTEKGK K124
SHP-2 (mouse) LSGKEAEKLLTEKGK K124
SHP-2 (rat) LSGkEAEkLLTEKGk K124-ac
K124-ub
LSGkEAEkLLTEKGk
0 1
SHP-2 (human) LSGkEAEkLLTEKGk K124-ub
SHP-2 iso1 (human) LSGKEAEKLLTEKGK K124
SHP-2 (mouse) LSGKEAEKLLTEKGK K124
SHP-2 (rat) LSGkEAEKLLTEKGk K124
K131
kLLTEKGKHGSFLVR
0 1
SHP-2 (human) kLLTEKGKHGSFLVR K131
SHP-2 iso1 (human) KLLTEKGKHGSFLVR K131
SHP-2 (mouse) KLLTEKGKHGSFLVR K131
SHP-2 (rat) kLLTEKGkHGSFLVR K131-ac
K131-ub
kLLTEKGkHGSFLVR
0 1
SHP-2 (human) kLLTEKGkHGSFLVR K131-ub
SHP-2 iso1 (human) KLLTEKGKHGSFLVR K131
SHP-2 (mouse) KLLTEKGKHGSFLVR K131
SHP-2 (rat) kLLTEKGKHGSFLVR K131
S142-p
FLVRESQsHPGDFVL
0 2
SHP-2 (human) FLVRESQsHPGDFVL S142-p
SHP-2 iso1 (human) FLVRESQSHPGDFVL S142
SHP-2 (mouse) FLVRESQSHPGDFVL S142
SHP-2 (rat) FLVRESQSHPGDFVL S142
T153-p
DFVLSVRtGDDKGES
0 3
SHP-2 (human) DFVLSVRtGDDKGES T153-p
SHP-2 iso1 (human) DFVLSVRTGDDKGES T153
SHP-2 (mouse) DFVLSVRTGDDKGES T153
SHP-2 (rat) DFVLSVRTGDDKGES T153
S165-p
GESNDGKsKVTHVMI
0 1
SHP-2 (human) GESNDGKsKVTHVMI S165-p
SHP-2 iso1 (human) GESNDGKSKVTHVMI S165
SHP-2 (mouse) GESNDGKSKVTHVMI S165
SHP-2 (rat) GESNDSKSKVTHVMI S165
K178-ac
MIRCQELkyDVGGGE
0 1
SHP-2 (human) MIRCQELkyDVGGGE K178-ac
SHP-2 iso1 (human) MIRCQELKYDVGGGE K178
SHP-2 (mouse) MIRCQELKYDVGGGE K178
SHP-2 (rat) MIRCQELKYDVGGGE K178
Y179-p
IRCQELkyDVGGGER
0 3
SHP-2 (human) IRCQELkyDVGGGER Y179-p
SHP-2 iso1 (human) IRCQELKYDVGGGER Y179
SHP-2 (mouse) IRCQELKYDVGGGER Y179
SHP-2 (rat) IRCQELKYDVGGGER Y179
S189-p
GGGERFDsLTDLVEH
1 1
SHP-2 (human) GGGERFDsLTDLVEH S189-p
SHP-2 iso1 (human) GGGERFDsLTDLVEH S189-p
SHP-2 (mouse) GGGERFDSLTDLVEH S189
SHP-2 (rat) GGGERFDSLTDLVEH S189
K198-ac
TDLVEHYkKNPMVET
0 4
SHP-2 (human) TDLVEHYkKNPMVET K198-ac
SHP-2 iso1 (human) TDLVEHYKKNPMVET K198
SHP-2 (mouse) TDLVEHYkKNPMVET K198-ac
SHP-2 (rat) TDLVEHYkKNPMVET K198-ac
K198-ub
TDLVEHYkKNPMVET
0 1
SHP-2 (human) TDLVEHYkKNPMVET K198-ub
SHP-2 iso1 (human) TDLVEHYKKNPMVET K198
SHP-2 (mouse) TDLVEHYKKNPMVET K198
SHP-2 (rat) TDLVEHYKKNPMVET K198
K235-ub
SRVRELSkLAETTDk
0 1
SHP-2 (human) SRVRELSkLAETTDk K235-ub
SHP-2 iso1 (human) SRVRELSKLAETTDK K235
SHP-2 (mouse) SRVRELSKLAETTDK K235
SHP-2 (rat) SRVRELSKLAETTDK K235
K242-ub
kLAETTDkVkQGFWE
0 1
SHP-2 (human) kLAETTDkVkQGFWE K242-ub
SHP-2 iso1 (human) KLAETTDKVKQGFWE K242
SHP-2 (mouse) KLAETTDKVKQGFWE K242
SHP-2 (rat) KLAETTDKVKQGFWE K242
K244-ub
AETTDkVkQGFWEEF
0 1
SHP-2 (human) AETTDkVkQGFWEEF K244-ub
SHP-2 iso1 (human) AETTDKVKQGFWEEF K244
SHP-2 (mouse) AETTDKVKQGFWEEF K244
SHP-2 (rat) AETTDKVKQGFWEEF K244
K260-ub
TLQQQECkLLysRKE
0 1
SHP-2 (human) TLQQQECkLLysRKE K260-ub
SHP-2 iso1 (human) TLQQQECKLLYSRKE K260
SHP-2 (mouse) TLQQQECKLLYSRKE K260
SHP-2 (rat) TLQQQECKLLYSRKE K260
Y263-p
QQECkLLysRKEGQR
0 8
SHP-2 (human) QQECkLLysRKEGQR Y263-p
SHP-2 iso1 (human) QQECKLLYSRKEGQR Y263
SHP-2 (mouse) QQECKLLYSRKEGQR Y263
SHP-2 (rat) QQECKLLYSRKEGQR Y263
S264-p
QECkLLysRKEGQRQ
0 1
SHP-2 (human) QECkLLysRKEGQRQ S264-p
SHP-2 iso1 (human) QECKLLYSRKEGQRQ S264
SHP-2 (mouse) QECKLLYSRKEGQRQ S264
SHP-2 (rat) QECKLLYSRKEGQRQ S264
K274-ac
EGQRQENkNkNRykN
0 1
SHP-2 (human) EGQRQENkNkNRykN K274-ac
SHP-2 iso1 (human) EGQRQENKNKNRYKN K274
SHP-2 (mouse) EGQRQENKNKNRyKN K274
SHP-2 (rat) EGQRQENKNKNRYkN K274
K276-ac
QRQENkNkNRykNIL
0 1
SHP-2 (human) QRQENkNkNRykNIL K276-ac
SHP-2 iso1 (human) QRQENKNKNRYKNIL K276
SHP-2 (mouse) QRQENKNKNRyKNIL K276
SHP-2 (rat) QRQENKNKNRYkNIL K276
Y279-p
ENkNkNRykNILPFD
1 63
SHP-2 (human) ENkNkNRykNILPFD Y279-p
SHP-2 iso1 (human) ENKNKNRYKNILPFD Y279
SHP-2 (mouse) ENKNKNRyKNILPFD Y279-p
SHP-2 (rat) ENKNKNRYkNILPFD Y279
K280-ac
NkNkNRykNILPFDH
Upstream
0 2
Treatment
  • MS275
SHP-2 (human) NkNkNRykNILPFDH K280-ac
SHP-2 iso1 (human) NKNKNRYKNILPFDH K280
SHP-2 (mouse) NKNKNRyKNILPFDH K280
SHP-2 (rat) NKNKNRYkNILPFDH K280-ac
K280-ub
NkNkNRykNILPFDH
0 1
SHP-2 (human) NkNkNRykNILPFDH K280-ub
SHP-2 iso1 (human) NKNKNRYKNILPFDH K280
SHP-2 (mouse) NKNKNRyKNILPFDH K280
SHP-2 (rat) NKNKNRYKNILPFDH K280
S302-p
GDPNEPVsDyINANI
0 20
SHP-2 (human) GDPNEPVsDyINANI S302-p
SHP-2 iso1 (human) GDPNEPVSDYINANI S302
SHP-2 (mouse) GDPNEPVSDyINANI S302
SHP-2 (rat) GDPNEPVSDYINANI S302
Y304-p
PNEPVsDyINANIIM
Upstream
2 56
Treatment
  • PRL
SHP-2 (human) PNEPVsDyINANIIM Y304-p
SHP-2 iso1 (human) PNEPVSDYINANIIM Y304
SHP-2 (mouse) PNEPVSDyINANIIM Y304-p
SHP-2 (rat) PNEPVSDYINANIIM Y304
K317-ub
IMPEFETkCNNSKPK
0 1
SHP-2 (human) IMPEFETkCNNSKPK K317-ub
SHP-2 iso1 (human) IMPEFETKCNNSKPK K317
SHP-2 (mouse) IMPEFETKCNNSKPK K317
SHP-2 (rat) IMPEFETKCNNSKPK K317
Y327
NSKPKKSYIATQGCL
1 0
SHP-2 (human) NSKPKKSYIATQGCL Y327
SHP-2 iso1 (human) NSKPKKSYIATQGCL Y327
SHP-2 (mouse) NSKPKKSyIATQGCL Y327-p
SHP-2 (rat) NSKPKKSYIATQGCL Y327
K389-ub
VMRVRNVkESAAHDY
0 1
SHP-2 (human) VMRVRNVkESAAHDY K389-ub
SHP-2 iso1 (human) VMRVRNVKESAAHDY K389
SHP-2 (mouse) VMRVRNVKESAAHDY K389
SHP-2 (rat) VMRVRNVRESAAHDY R389
T411-p
SKVGQGNtERTVWQY
0 1
SHP-2 (human) SKVGQGNtERTVWQY T411-p
SHP-2 iso1 (human) QALLQGNTERTVWQY T415
SHP-2 (mouse) SKVGQGNTERTVWQY T411
SHP-2 (rat) QALLQGNTERTVWQY T415
K482-ac
LIDIIREkGVDCDID
0 3
SHP-2 (human) LIDIIREkGVDCDID K482-ac
SHP-2 iso1 (human) LIDIIREKGVDCDID K486
SHP-2 (mouse) LIDIIREKGVDCDID K482
SHP-2 (rat) LIDIIREkGVDCDID K486-ac
Y511-p
MVQTEAQyRFIyMAV
1 39
SHP-2 (human) MVQTEAQyRFIyMAV Y511-p
SHP-2 iso1 (human) MVQTEAQyRFIYMAV Y515-p
SHP-2 (mouse) MVQTEAQyRFIYMAV Y511-p
SHP-2 (rat) MVQTEAQYRFIYMAV Y515
Y515-p
EAQyRFIyMAVQHYI
0 16
SHP-2 (human) EAQyRFIyMAVQHYI Y515-p
SHP-2 iso1 (human) EAQyRFIYMAVQHYI Y519
SHP-2 (mouse) EAQyRFIYMAVQHYI Y515
SHP-2 (rat) EAQYRFIYMAVQHYI Y519
S535-p
RIEEEQKsKRkGHEy
0 1
SHP-2 (human) RIEEEQKsKRkGHEy S535-p
SHP-2 iso1 (human) RIEEEQKSKRKGHEy S539
SHP-2 (mouse) RIEEEQKsKRKGHEy S535-p
SHP-2 (rat) RIEEEQKSKRKGHEy S539
K538-ub
EEQKsKRkGHEytNI
0 1
SHP-2 (human) EEQKsKRkGHEytNI K538-ub
SHP-2 iso1 (human) EEQKSKRKGHEyTNI K542
SHP-2 (mouse) EEQKsKRKGHEytNI K538
SHP-2 (rat) EEQKSKRKGHEyTNI K542
Y542-p
sKRkGHEytNIKysL
Upstream
Downstream
27 452
SHP-2 (human)
Y542-p
SHP-2 iso1 (human)
Y546-p
SHP-2 (mouse)
Y542-p
SHP-2 (rat)
Y546-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell motility, altered
  • cytoskeletal reorganization
  • transcription, altered
Kinase, in vitro:
  • PDGFRB (mouse)
Putative in vivo kinases:
  • ALK (human)
  • Fyn (human)
Regulatory protein:
  • EGFR (human)
  • PXN iso2 (human)
  • S100A7 (human)
  • SHP-2 (human)
  • SHPS1 (human)
Treatment
  • AG1478
  • EGF
  • ephrin_B1
  • herbimycin_A
  • IL-1b
  • IL-2
  • IL-3
  • netrin-1
  • PDGF
  • PRL
  • SU5402
  • TNF
  • vanadate
SHP-2 (human) sKRkGHEytNIKysL Y542-p
SHP-2 iso1 (human) SKRKGHEyTNIKYSL Y546-p
SHP-2 (mouse) sKRKGHEytNIKYSL Y542-p
SHP-2 (rat) SKRKGHEyTNIKYSL Y546-p
T543-p
KRkGHEytNIKysLA
0 30
SHP-2 (human) KRkGHEytNIKysLA T543-p
SHP-2 iso1 (human) KRKGHEyTNIKYSLA T547
SHP-2 (mouse) KRKGHEytNIKYSLV T543-p
SHP-2 (rat) KRKGHEyTNIKYSLV T547
Y547-p
HEytNIKysLADQts
0 2
SHP-2 (human) HEytNIKysLADQts Y547-p
SHP-2 iso1 (human) HEyTNIKYSLADQTS Y551
SHP-2 (mouse) HEytNIKYSLVDQTS Y547
SHP-2 (rat) HEyTNIKYSLVDQTS Y551
S548-p
EytNIKysLADQtsG
0 1
SHP-2 (human) EytNIKysLADQtsG S548-p
SHP-2 iso1 (human) EyTNIKYSLADQTSG S552
SHP-2 (mouse) EytNIKYSLVDQTSG S548
SHP-2 (rat) EyTNIKYSLVDQTSG S552
T553-p
KysLADQtsGDQsPL
0 10
SHP-2 (human) KysLADQtsGDQsPL T553-p
SHP-2 iso1 (human) KYSLADQTSGDQSPL T557
SHP-2 (mouse) KYSLVDQTSGDQsPL T553
SHP-2 (rat) KYSLVDQTSGDQsPL T557
S554-p
ysLADQtsGDQsPLP
0 1
SHP-2 (human) ysLADQtsGDQsPLP S554-p
SHP-2 iso1 (human) YSLADQTSGDQSPLP S558
SHP-2 (mouse) YSLVDQTSGDQsPLP S554
SHP-2 (rat) YSLVDQTSGDQsPLP S558
S558-p
DQtsGDQsPLPPCtP
Upstream
0 16
Treatment
  • anti-CD3
SHP-2 (human) DQtsGDQsPLPPCtP S558-p
SHP-2 iso1 (human) DQTSGDQSPLPPCTP S562
SHP-2 (mouse) DQTSGDQsPLPPCTP S558-p
SHP-2 (rat) DQTSGDQsPLPPCTP S562-p
T564-p
QsPLPPCtPtPPCAE
0 17
SHP-2 (human) QsPLPPCtPtPPCAE T564-p
SHP-2 iso1 (human) QSPLPPCTPTPPCAE T568
SHP-2 (mouse) QsPLPPCTPTPPCAE T564
SHP-2 (rat) QsPLPPCTPtPPCAE T568
T566-p
PLPPCtPtPPCAEMR
0 6
SHP-2 (human) PLPPCtPtPPCAEMR T566-p
SHP-2 iso1 (human) PLPPCTPTPPCAEMR T570
SHP-2 (mouse) PLPPCTPTPPCAEMR T566
SHP-2 (rat) PLPPCTPtPPCAEMR T570-p
S576-p
CAEMREDsARVyENV
Upstream
3 11
Putative in vivo kinases:
  • PKCA (human)
  • PKCB (human)
  • PKCB iso2 (human)
  • PKCH (human)
Treatment
  • 2-deoxyglucose
  • bisindolylmaleimide
  • phorbol_ester
  • sunitinib
SHP-2 (human) CAEMREDsARVyENV S576-p
SHP-2 iso1 (human) CAEMREDSARVyENV S580
SHP-2 (mouse) CAEMREDsARVyENV S576-p
SHP-2 (rat) CAEMREDsARVyENV S580-p
Y580-p
REDsARVyENVGLMQ
Upstream
Downstream
16 1233
SHP-2 (human)
Y580-p
SHP-2 iso1 (human)
Y584-p
SHP-2 (mouse)
Y580-p
SHP-2 (rat)
Y584-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell motility, altered
Putative in vivo kinases:
  • ALK (human)
Regulatory protein:
  • CCKBR (human)
  • SHPS1 (human)
Treatment
  • AG1478
  • anti-CD3
  • dasatinib
  • EGF
  • ephrin_B1
  • ephrin_B2
  • erlotinib
  • gastrin
  • gefitinib
  • IL-15
  • IL-2
  • IL-3
  • imatinib
  • ischemia
  • PDGF
  • PRL
  • Su11274
SHP-2 (human) REDsARVyENVGLMQ Y580-p
SHP-2 iso1 (human) REDSARVyENVGLMQ Y584-p
SHP-2 (mouse) REDsARVyENVGLMQ Y580-p
SHP-2 (rat) REDsARVyENVGLMQ Y584-p
K590-ub
VGLMQQQksFR____
0 3
SHP-2 (human) VGLMQQQksFR____ K590-ub
SHP-2 iso1 (human) VGLMQQQKSFR____ K594
SHP-2 (mouse) VGLMQQQRsFR____ R590
SHP-2 (rat) VGLMQQQRSFR____ R594
K590
VGLMQQQKsFR____
1 0
SHP-2 (human) VGLMQQQKsFR____ K590
SHP-2 iso1 (human) VGLMQQQkSFR____ K594-sm
SHP-2 (mouse) VGLMQQQRsFR____ R590
SHP-2 (rat) VGLMQQQRSFR____ R594
S591-p
GLMQQQksFR_____
Upstream
1 53
Putative in vivo kinases:
  • PKCA (human)
  • PKCB (human)
  • PKCB iso2 (human)
  • PKCH (human)
Treatment
  • bisindolylmaleimide
  • phorbol_ester
  • SII_angiotensin_2
SHP-2 (human) GLMQQQksFR_____ S591-p
SHP-2 iso1 (human) GLMQQQkSFR_____ S595
SHP-2 (mouse) GLMQQQRsFR_____ S591-p
SHP-2 (rat) GLMQQQRSFR_____ S595