Other Species / Isoforms
  Merlin (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S10-p
GAIASRMsFSsLkRK
Upstream
Downstream
2 10
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell motility, altered
  • cytoskeletal reorganization
Kinase, in vitro:
  • Akt1 (human)
  • Akt2 (human)
  • Akt3 (human)
  • PKACA (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • EGF
  • LY294002
Merlin (human) GAIASRMsFSsLkRK S10-p
Merlin (mouse) GAIASRMsFSsLKRK S10-p
Merlin (rat) __IASRMSFSsLKRK S6
Merlin (chicken) GAIASRMSFSSLKRK S10
S13-p
ASRMsFSsLkRKQPK
0 15
Merlin (human) ASRMsFSsLkRKQPK S13-p
Merlin (mouse) ASRMsFSsLKRKQPK S13-p
Merlin (rat) ASRMSFSsLKRKQPK S9-p
Merlin (chicken) ASRMSFSSLKRKQPK S13
K15-sm
RMsFSsLkRKQPKTF
0 1
Merlin (human) RMsFSsLkRKQPKTF K15-sm
Merlin (mouse) RMsFSsLKRKQPKTF K15
Merlin (rat) RMSFSsLKRKQPKTF K11
Merlin (chicken) RMSFSSLKRKQPKTF K15
K76-sm
KDTVAWLkMDKkVLD
1 0
Merlin (human) KDTVAWLkMDKkVLD K76-sm
Merlin (mouse) KDTVAWLKMDKkVLD K76
Merlin (rat) KDTVAWLKMDKKVLD K72
Merlin (chicken) KDTVAWLKMDKKVLD K76
K80-ub
AWLkMDKkVLDHDVS
0 4
Merlin (human) AWLkMDKkVLDHDVS K80-ub
Merlin (mouse) AWLKMDKkVLDHDVS K80-ub
Merlin (rat) AWLKMDKKVLDHDVS K76
Merlin (chicken) AWLKMDKKVLDHDVP K80
K88-ub
VLDHDVSkEEPVTFH
0 1
Merlin (human) VLDHDVSkEEPVTFH K88-ub
Merlin (mouse) VLDHDVSKEEPVTFH K88
Merlin (rat) VLDHDVSKEEPVTFH K84
Merlin (chicken) VLDHDVPTEEPVTFH T88
K159-ub
DYDPSVHkRGFLAQE
0 3
Merlin (human) DYDPSVHkRGFLAQE K159-ub
Merlin (mouse) DYDPSVHKRGFLAQE K159
Merlin (rat) DYDPSVHKRGFLAQE K155
Merlin (chicken) DYDPNVHKRGFLAQE K159
K171-ub
AQEELLPkRVINLYQ
0 1
Merlin (human) AQEELLPkRVINLYQ K171-ub
Merlin (mouse) AQEELLPKRVINLYQ K171
Merlin (rat) AQEELLPKRVINLYQ K167
Merlin (chicken) AQEELLPKRVINLYQ K171
T230-p
AIRNKKGtELLLGVD
Upstream
Downstream
3 1
Effects on Modified Protein
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
Kinase, in vitro:
  • Akt1 (rat)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • EGF
Merlin (human) AIRNKKGtELLLGVD T230-p
Merlin (mouse) TIRNKKGTELLLGVD T230
Merlin (rat) TIRNKKGTELLLGVD T226
Merlin (chicken) AIRNKKGTELLLGVD T230
K253-ub
PENRLTPkISFPWNE
0 1
Merlin (human) PENRLTPkISFPWNE K253-ub
Merlin (mouse) PENRLTPKISFPWNE K253
Merlin (rat) PENRLTPKISFPWNE K249
Merlin (chicken) PDNRLTPKISFPWNE K253
K269-ub
RNISYSDkEFTIKPL
0 3
Merlin (human) RNISYSDkEFTIKPL K269-ub
Merlin (mouse) RNISYSDKEFTIKPL K269
Merlin (rat) RNISYSDKEFTIKPL K265
Merlin (chicken) RNISYSDKEFTIKPL K269
K279-ac
TIKPLDKkIDVFKFN
0 1
Merlin (human) TIKPLDKkIDVFKFN K279-ac
Merlin (mouse) TIKPLDKKIDVFKFN K279
Merlin (rat) TIKPLDKKIDVFKFN K275
Merlin (chicken) TIKPLDKKIDVFKFN K279
K289-ub
VFKFNSSkLRVNKLI
0 1
Merlin (human) VFKFNSSkLRVNKLI K289-ub
Merlin (mouse) VFKFNSSKLRVNKLI K289
Merlin (rat) VFKFNSSKLRVNKLI K285
Merlin (chicken) VFKFNSSKLRVNKLI K289
S315-p
MRRRKADsLEVQQMk
Upstream
Downstream
3 6
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
Kinase, in vitro:
  • Akt1 (rat)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • EGF
  • GF109203X
  • LY294002
  • MG132
  • PD98059
  • wortmannin
Merlin (human) MRRRKADsLEVQQMk S315-p
Merlin (mouse) MRRRKADsLEVQQMK S315-p
Merlin (rat) MRRRKADSLEVQQMK S311
Merlin (chicken) MRRRKADSLEVQQMK S315
K322-ub
sLEVQQMkAQAREEK
0 1
Merlin (human) sLEVQQMkAQAREEK K322-ub
Merlin (mouse) sLEVQQMKAQAREEK K322
Merlin (rat) SLEVQQMKAQAREEK K318
Merlin (chicken) SLEVQQMKAQAREEK K322
R351-m2
QMREEAErTrDELER
0 2
Merlin (human) QMREEAErTrDELER R351-m2
Merlin (mouse) QMREEAERTRDELER R351
Merlin (rat) QMREEAERSRDEPER R347
Merlin (chicken) QMREEAERTRDELER R351
R353-m2
REEAErTrDELERRL
0 2
Merlin (human) REEAErTrDELERRL R353-m2
Merlin (mouse) REEAERTRDELERRL R353
Merlin (rat) REEAERSRDEPERRV R349
Merlin (chicken) REEAERTRDELERRL R353
K364-ub
ERRLLQMkEEATMAN
0 3
Merlin (human) ERRLLQMkEEATMAN K364-ub
Merlin (mouse) ERRLLQMkEEATMAN K364-ub
Merlin (rat) ERRVLHMKEEATMAN K360
Merlin (chicken) ERRLMQLKEEATMAN K364
K387-ub
TADLLAEkAQITEEE
0 2
Merlin (human) TADLLAEkAQITEEE K387-ub
Merlin (mouse) TADLLAEKAQItEEE K387
Merlin (rat) TADLLAEKAQITEEE K383
Merlin (chicken) TADLLAEKAQITEEE K387
T391
LAEkAQITEEEAkLL
0 1
Merlin (human) LAEkAQITEEEAkLL T391
Merlin (mouse) LAEKAQItEEEAkLL T391-p
Merlin (rat) LAEKAQITEEEAKLL T387
Merlin (chicken) LAEKAQITEEEAKLL T391
K396-ub
QITEEEAkLLAQkAA
0 11
Merlin (human) QITEEEAkLLAQkAA K396-ub
Merlin (mouse) QItEEEAkLLAQKAA K396-ub
Merlin (rat) QITEEEAKLLAQKAA K392
Merlin (chicken) QITEEEAKLLAQKAA K396
K401-ub
EAkLLAQkAAEAEQE
0 2
Merlin (human) EAkLLAQkAAEAEQE K401-ub
Merlin (mouse) EAkLLAQKAAEAEQE K401
Merlin (rat) EAKLLAQKAAEAEQE K397
Merlin (chicken) EAKLLAQKAAEAEQE K401
T415-p
EMQRIKAtAIRtEEE
0 1
Merlin (human) EMQRIKAtAIRtEEE T415-p
Merlin (mouse) EMQRIKATAIRTEEE T415
Merlin (rat) EMQRIKATAIRTEEE T411
Merlin (chicken) EMQRIKATAIRTEEE T415
T419-p
IKAtAIRtEEEKRLM
0 1
Merlin (human) IKAtAIRtEEEKRLM T419-p
Merlin (mouse) IKATAIRTEEEKRLM T419
Merlin (rat) IKATAIRTEEEKRLM T415
Merlin (chicken) IKATAIRTEEEKRLM T419
K439
EAEVLALKMAEESER
0 1
Merlin (human) EAEVLALKMAEESER K439
Merlin (mouse) EAEVLALkMAEESER K439-ac
Merlin (rat) EAEVLALKMAEESER K435
Merlin (chicken) EAEMLALKMAEESER K439
K439-ub
EAEVLALkMAEESER
0 1
Merlin (human) EAEVLALkMAEESER K439-ub
Merlin (mouse) EAEVLALKMAEESER K439
Merlin (rat) EAEVLALKMAEESER K435
Merlin (chicken) EAEMLALKMAEESER K439
K449-ub
EESERRAkEADQLkQ
0 1
Merlin (human) EESERRAkEADQLkQ K449-ub
Merlin (mouse) EESERRAKEADQLKQ K449
Merlin (rat) EESERRAKEADQLKQ K445
Merlin (chicken) EESERRAKEADQLKQ K449
K455-ub
AkEADQLkQDLQEAR
0 1
Merlin (human) AkEADQLkQDLQEAR K455-ub
Merlin (mouse) AKEADQLKQDLQEAR K455
Merlin (rat) AKEADQLKQDLQEAR K451
Merlin (chicken) AKEADQLKQDLQEAR K455
T477-p
QKLLEIAtKPTYPPM
0 1
Merlin (human) QKLLEIAtKPTYPPM T477-p
Merlin (mouse) QKLLEIATKPTYPPM T477
Merlin (rat) QKLLEIATKPTYPPM T473
Merlin (chicken) QKLLEITSKSSYTQS S477
S518-p
DTDMKRLsMEIEKEK
Upstream
Downstream
26 41
Merlin (human)
S518-p
Merlin (mouse)
S518-p
Merlin (rat)
S514-p
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell adhesion, altered
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
  • cell motility, altered
  • cytoskeletal reorganization
  • transcription, altered
Kinase, in vitro:
  • PAK1 (human)
  • PAK2 (human)
  • PKACA (cow)
  • PKACA (human)
Putative in vivo kinases:
  • PAK1 (human)
  • PAK2 (human)
  • PKACA (human)
Regulatory protein:
  • agrin (human)
  • Merlin (human)
  • PAK1 (human)
  • RAC1 (human)
  • TBK1 (human)
Treatment
  • colforsin
  • H-89
  • IBMX
  • nocodazole
  • Wnt3a
Merlin (human) DTDMKRLsMEIEKEK S518-p
Merlin (mouse) DTDMKRLsMEIEKEK S518-p
Merlin (rat) DTDMKRLsMEIEKEK S514-p
Merlin (chicken) DTDMKRLSMEIEKEK S519
K533-ub
VEYMEKSkHLQEQLN
0 3
Merlin (human) VEYMEKSkHLQEQLN K533-ub
Merlin (mouse) VEYMEKSKHLQEQLN K533
Merlin (rat) VEYMEKSKHLQEQLN K529
Merlin (chicken) VEYMEKSKHLQEQLN K534
K543
QEQLNELKTEIEALk
0 1
Merlin (human) QEQLNELKTEIEALk K543
Merlin (mouse) QEQLNELkTEIEALK K543-ac
Merlin (rat) QEQLNELKTEIEALK K539
Merlin (chicken) QEQLNELKTEIEALK K544
K550-ub
KTEIEALkLKERETA
0 1
Merlin (human) KTEIEALkLKERETA K550-ub
Merlin (mouse) kTEIEALKLKERETA K550
Merlin (rat) KTEIEALKLKERETA K546
Merlin (chicken) KTEIEALKLKERETA K551
K550-sm
KTEIEALkLKERETA
0 1
Merlin (human) KTEIEALkLKERETA K550-sm
Merlin (mouse) kTEIEALKLKERETA K550
Merlin (rat) KTEIEALKLKERETA K546
Merlin (chicken) KTEIEALKLKERETA K551
R568-m1
LHNENSDrGGSsKHN
0 3
Merlin (human) LHNENSDrGGSsKHN R568-m1
Merlin (mouse) LHSESSDrGGPSSKH R568-m1
Merlin (rat) LHSEHSDSGTSSKHN S564
Merlin (chicken) LHNENASRGNSKHNT R569
S572-p
NSDrGGSsKHNTIKk
0 1
Merlin (human) NSDrGGSsKHNTIKk S572-p
Merlin (mouse) SDrGGPSSKHNTIKK S573
Merlin (rat) HSDSGTSSKHNTIKK S568
Merlin (chicken) ENASRGNSKHNTIKK S572
K579-ub
sKHNTIKkLtLQSAk
0 1
Merlin (human) sKHNTIKkLtLQSAk K579-ub
Merlin (mouse) SKHNTIKKLtLQSAK K580
Merlin (rat) SKHNTIKKPQAQGRR K575
Merlin (chicken) SKHNTIKKLTLQSTK K579
T581-p
HNTIKkLtLQSAksR
0 12
Merlin (human) HNTIKkLtLQSAksR T581-p
Merlin (mouse) HNTIKKLtLQSAKSR T582-p
Merlin (rat) HNTIKKPQAQGRRPI Q577
Merlin (chicken) HNTIKKLTLQSTKSR T581
K586-ub
kLtLQSAksRVAFFE
0 2
Merlin (human) kLtLQSAksRVAFFE K586-ub
Merlin (mouse) KLtLQSAKSRVAFFE K587
Merlin (rat) under review -
Merlin (chicken) KLTLQSTKSRVAFFE K586
S587-p
LtLQSAksRVAFFEE
Upstream
0 4
Treatment
  • angiotensin_2
Merlin (human) LtLQSAksRVAFFEE S587-p
Merlin (mouse) LtLQSAKSRVAFFEE S588
Merlin (rat) gap -
Merlin (chicken) LTLQSTKSRVAFFEE S587