Other Species / Isoforms
  p21Cip1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2
______MSEPAGDVR
0 3
p21Cip1 (human) ______MSEPAGDVR S2
p21Cip1 (mouse) ______MsNPGDVRP S2-p
p21Cip1 (dog) gap -
K16-ub
RQNPCGSkACRRLFG
Downstream
3 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) RQNPCGSkACRRLFG K16-ub
p21Cip1 (mouse) RPVPHRSKVCRCLFG K15
p21Cip1 (dog) gap -
S31-p
PVDSEQLsRDCDALM
0 2
p21Cip1 (human) PVDSEQLsRDCDALM S31-p
p21Cip1 (mouse) PVDSEQLRRDCDALM R30
p21Cip1 (dog) gap -
T57-p
NFDFVTEtPLEGDFA
Upstream
Downstream
8 0
Effects on Modified Protein
  • intracellular localization
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • ERK2 (human)
  • GSK3B (human)
  • JNK1 (human)
  • JNK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • ERK2 (human)
Regulatory protein:
  • MST1 (mouse)
  • MST2 (mouse)
Treatment
  • botulinum_C3_toxin
  • EGF
  • U0126
p21Cip1 (human) NFDFVTEtPLEGDFA T57-p
p21Cip1 (mouse) NFDFVTETPLEGNFV T56
p21Cip1 (dog) NFDFVTETPLEGDFA T25
K75-ub
VRGLGLPkLYLPtGP
Downstream
3 10
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) VRGLGLPkLYLPtGP K75-ub
p21Cip1 (mouse) VRSLGLPKVyLsPGS K74
p21Cip1 (dog) VRGLGLSKVSLPAGP K43
Y77
GLGLPkLYLPtGPRR
1 0
p21Cip1 (human) GLGLPkLYLPtGPRR Y77
p21Cip1 (mouse) SLGLPKVyLsPGSRS Y76-p
p21Cip1 (dog) GLGLSKVSLPAGPRG S45
P79
GLPkLYLPtGPRRGR
2 8
p21Cip1 (human) GLPkLYLPtGPRRGR P79
p21Cip1 (mouse) GLPKVyLsPGSRSRD S78-p
p21Cip1 (dog) GLSKVSLPAGPRGGR P47
T80-p
LPkLYLPtGPRRGRD
1 0
p21Cip1 (human) LPkLYLPtGPRRGRD T80-p
p21Cip1 (mouse) LPKVyLsPGSRSRDD P79
p21Cip1 (dog) LSKVSLPAGPRGGRD A48
S98-p
GGRRPGTsPALLQGT
Upstream
4 0
Kinase, in vitro:
  • ASK1 (human)
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
  • JNK2 (human)
  • JNK3 (human)
  • P38A (human)
Putative in vivo kinases:
  • ASK1 (human)
p21Cip1 (human) GGRRPGTsPALLQGT S98-p
p21Cip1 (mouse) GDKRPSTSSALLQGP S96
p21Cip1 (dog) GGKRPGTSPALLQGT S66
S114-p
EEDHVDLsLSCTLVP
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • caffeine
  • lithium
  • siRNA
  • TDZD-8
  • UV
p21Cip1 (human) EEDHVDLsLSCTLVP S114-p
p21Cip1 (mouse) PEDHVALSLSCTLVS S112
p21Cip1 (dog) QEDHLDLSLTCTLLP S82
S123-p
SCTLVPRsGEQAEGs
2 0
p21Cip1 (human) SCTLVPRsGEQAEGs S123-p
p21Cip1 (mouse) gap -
p21Cip1 (dog) TCTLLPHsPERPEAS S91-p
S130-p
sGEQAEGsPGGPGDs
Upstream
Downstream
11 17
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • CDK6 (human)
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
  • JNK2 (human)
  • JNK3 (human)
  • P38A (human)
Putative in vivo kinases:
  • CDK1 (human)
  • CDK2 (human)
  • ERK2 (human)
  • JNK1 (human)
  • P38A (human)
  • P38A (mouse)
Regulatory protein:
  • CDK6 (human)
Treatment
  • EGF
  • MG132
  • neferine
  • SB203580
  • seliciclib
  • siRNA
  • SP600125
  • TGF-beta
  • U0126
p21Cip1 (human) sGEQAEGsPGGPGDs S130-p
p21Cip1 (mouse) VSERPEDSPGGPGTS S125
p21Cip1 (dog) sPERPEASPGVPGTS S98
S137-p
sPGGPGDsQGRkRRQ
0 6
p21Cip1 (human) sPGGPGDsQGRkRRQ S137-p
p21Cip1 (mouse) SPGGPGTSQGRKRRQ S132
p21Cip1 (dog) SPGVPGTSQGRKRRQ S105
K141-ac
PGDsQGRkRRQtsMT
1 0
p21Cip1 (human) PGDsQGRkRRQtsMT K141-ac
p21Cip1 (mouse) PGTSQGRKRRQtsLT K136
p21Cip1 (dog) PGTSQGRKRRQTSMT K109
K141-ub
PGDsQGRkRRQtsMT
Downstream
3 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) PGDsQGRkRRQtsMT K141-ub
p21Cip1 (mouse) PGTSQGRKRRQtsLT K136
p21Cip1 (dog) PGTSQGRKRRQTSMT K109
T145-p
QGRkRRQtsMTDFyH
Upstream
Downstream
18 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • DAPK3 (human)
  • Pim1 (human)
  • Pim2 (human)
Putative in vivo kinases:
  • Akt1 (human)
  • DAPK3 (human)
  • Pim1 (human)
  • Pim2 (human)
Regulatory protein:
  • Pim1 (human)
Treatment
  • insulin
  • LY294002
  • serum
  • silmitasertib
  • taxol
  • wortmannin
p21Cip1 (human) QGRkRRQtsMTDFyH T145-p
p21Cip1 (mouse) QGRKRRQtsLTDFYH T140-p
p21Cip1 (dog) QGRKRRQTSMTDFYH T113
S146-p
GRkRRQtsMTDFyHs
Upstream
Downstream
9 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • Akt1 (human)
  • Pim1 (human)
  • Pim2 (human)
  • PKCA (human)
Putative in vivo kinases:
  • Akt1 (human)
  • LATS2 (human)
Regulatory protein:
  • Pim1 (human)
Treatment
  • LY294002
  • okadaic_acid
  • serum
  • taxol
  • wortmannin
p21Cip1 (human) GRkRRQtsMTDFyHs S146-p
p21Cip1 (mouse) GRKRRQtsLTDFYHS S141-p
p21Cip1 (dog) GRKRRQTSMTDFYHS S114
Y151-p
QtsMTDFyHskRrLI
0 1
p21Cip1 (human) QtsMTDFyHskRrLI Y151-p
p21Cip1 (mouse) QtsLTDFYHSKRRLV Y146
p21Cip1 (dog) QTSMTDFYHSKRRLI Y119
S153-p
sMTDFyHskRrLIFS
Upstream
Downstream
2 1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • DYRK1B (human)
  • PKCA (human)
Putative in vivo kinases:
  • DYRK1B (human)
  • PKCA (human)
Treatment
  • phorbol_ester
  • SB203580
p21Cip1 (human) sMTDFyHskRrLIFS S153-p
p21Cip1 (mouse) sLTDFYHSKRRLVFC S148
p21Cip1 (dog) SMTDFYHSKRRLIFS S121
K154-ac
MTDFyHskRrLIFSk
1 0
p21Cip1 (human) MTDFyHskRrLIFSk K154-ac
p21Cip1 (mouse) LTDFYHSKRRLVFCK K149
p21Cip1 (dog) MTDFYHSKRRLIFSK K122
K154-ub
MTDFyHskRrLIFSk
Downstream
3 1
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) MTDFyHskRrLIFSk K154-ub
p21Cip1 (mouse) LTDFYHSKRRLVFCK K149
p21Cip1 (dog) MTDFYHSKRRLIFSK K122
R156-m2
DFyHskRrLIFSkRk
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
p21Cip1 (human) DFyHskRrLIFSkRk R156-m2
p21Cip1 (mouse) DFYHSKRRLVFCKRK R151
p21Cip1 (dog) DFYHSKRRLIFSKRK R124
K161-ac
kRrLIFSkRkP____
2 0
p21Cip1 (human) kRrLIFSkRkP____ K161-ac
p21Cip1 (mouse) KRRLVFCKRKP____ K156
p21Cip1 (dog) KRRLIFSKRKP____ K129
K161-ub
kRrLIFSkRkP____
Downstream
3 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) kRrLIFSkRkP____ K161-ub
p21Cip1 (mouse) KRRLVFCKRKP____ K156
p21Cip1 (dog) KRRLIFSKRKP____ K129
K163-ac
rLIFSkRkP______
2 0
p21Cip1 (human) rLIFSkRkP______ K163-ac
p21Cip1 (mouse) RLVFCKRKP______ K158
p21Cip1 (dog) RLIFSKRKP______ K131
K163-ub
rLIFSkRkP______
Downstream
3 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
p21Cip1 (human) rLIFSkRkP______ K163-ub
p21Cip1 (mouse) RLVFCKRKP______ K158
p21Cip1 (dog) RLIFSKRKP______ K131