Other Species / Isoforms
  NFkB-p65 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K37-m1
RGMRFRYkCEGRsAG
1 0
NFkB-p65 (human) RGMRFRYkCEGRsAG K37-m1
NFkB-p65 (mouse) RGMRFRYKCEGRSAG K37
NFkB-p65 (rat) RGMRFRYKCEGRSAG K37
K37-me
RGMRFRYkCEGRsAG
2 0
NFkB-p65 (human) RGMRFRYkCEGRsAG K37-me
NFkB-p65 (mouse) RGMRFRYKCEGRSAG K37
NFkB-p65 (rat) RGMRFRYKCEGRSAG K37
S42-p
RYkCEGRsAGsIPGE
Upstream
Downstream
1 3
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • IKKB (human)
  • PKACA (human)
Treatment
  • TNF
NFkB-p65 (human) RYkCEGRsAGsIPGE S42-p
NFkB-p65 (mouse) RYKCEGRSAGsIPGE S42
NFkB-p65 (rat) RYKCEGRSAGSIPGE S42
S45-p
CEGRsAGsIPGERST
Upstream
Downstream
1 8
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • IKKB (human)
  • PKACA (human)
Treatment
  • TNF
NFkB-p65 (human) CEGRsAGsIPGERST S45-p
NFkB-p65 (mouse) CEGRSAGsIPGERST S45-p
NFkB-p65 (rat) CEGRSAGSIPGERST S45
K56-ub
ERSTDTTkTHPTIkI
1 1
NFkB-p65 (human) ERSTDTTkTHPTIkI K56-ub
NFkB-p65 (mouse) ERSTDTTKTHPTIKI K56
NFkB-p65 (rat) ERSTDTTKTHPTIKI K56
K62-ub
TkTHPTIkINGYTGP
2 0
NFkB-p65 (human) TkTHPTIkINGYTGP K62-ub
NFkB-p65 (mouse) TKTHPTIKINGYTGP K62
NFkB-p65 (rat) TKTHPTIKINGYTGP K62
T71-p
NGYTGPGtVRISLVT
0 1
NFkB-p65 (human) NGYTGPGtVRISLVT T71-p
NFkB-p65 (mouse) NGYTGPGTVRISLVT T71
NFkB-p65 (rat) NGYTGPGTVRISLVT T71
K79-ub
VRISLVTkDPPHRPH
1 0
NFkB-p65 (human) VRISLVTkDPPHRPH K79-ub
NFkB-p65 (mouse) VRISLVTKDPPHRPH K79
NFkB-p65 (rat) VRISLVTKDPPHRPH K79
K93-ub
HPHELVGkDCRDGFY
0 1
NFkB-p65 (human) HPHELVGkDCRDGFY K93-ub
NFkB-p65 (mouse) HPHELVGKDCRDGyY K93
NFkB-p65 (rat) HPHELVGKDCRDGFY K93
F99
GkDCRDGFYEAELCP
0 2
NFkB-p65 (human) GkDCRDGFYEAELCP F99
NFkB-p65 (mouse) GKDCRDGyYEADLCP Y99-p
NFkB-p65 (rat) GKDCRDGFYEAELCP F99
C109
AELCPDRCIHsFQNL
0 1
NFkB-p65 (human) AELCPDRCIHsFQNL C109
NFkB-p65 (mouse) ADLCPDRsIHsFQNL S109-p
NFkB-p65 (rat) AELCPDRCIHSFQNL C109
S112-p
CPDRCIHsFQNLGIQ
0 2
NFkB-p65 (human) CPDRCIHsFQNLGIQ S112-p
NFkB-p65 (mouse) CPDRsIHsFQNLGIQ S112-p
NFkB-p65 (rat) CPDRCIHSFQNLGIQ S112
K122-ac
NLGIQCVkkRDLEQA
Upstream
Downstream
6 26
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Treatment
  • beta-amyloid
  • Compound 11
  • siRNA
  • trichostatin_A
NFkB-p65 (human) NLGIQCVkkRDLEQA K122-ac
NFkB-p65 (mouse) NLGIQCVkkRDLEQA K122-ac
NFkB-p65 (rat) NLGIQCVKKRDLEQA K122
K122-ub
NLGIQCVkkRDLEQA
1 1
NFkB-p65 (human) NLGIQCVkkRDLEQA K122-ub
NFkB-p65 (mouse) NLGIQCVKkRDLEQA K122
NFkB-p65 (rat) NLGIQCVKKRDLEQA K122
K123-ac
LGIQCVkkRDLEQAI
Upstream
Downstream
4 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, inhibited
Treatment
  • trichostatin_A
NFkB-p65 (human) LGIQCVkkRDLEQAI K123-ac
NFkB-p65 (mouse) LGIQCVkkRDLEQAI K123-ac
NFkB-p65 (rat) LGIQCVKKRDLEQAI K123
K123-ub
LGIQCVkkRDLEQAI
1 1
NFkB-p65 (human) LGIQCVkkRDLEQAI K123-ub
NFkB-p65 (mouse) LGIQCVkkRDLEQAI K123-ub
NFkB-p65 (rat) LGIQCVKKRDLEQAI K123
S131-p
RDLEQAIsQRIQtNN
Upstream
1 3
Kinase, in vitro:
  • IKKB (human)
Treatment
  • TNF
NFkB-p65 (human) RDLEQAIsQRIQtNN S131-p
NFkB-p65 (mouse) RDLEQAIsQRIQTNN S131-p
NFkB-p65 (rat) RDLEQAISQRIQTNN S131
T136-p
AIsQRIQtNNNPFQV
Upstream
1 1
Treatment
  • TNF
NFkB-p65 (human) AIsQRIQtNNNPFQV T136-p
NFkB-p65 (mouse) AIsQRIQTNNNPFHV T136
NFkB-p65 (rat) AISQRIQTNNNPFQV T136
R174-m2
DPSGRPLrLPPVLsH
Upstream
Downstream
1 1
Effects on Biological Processes:
  • transcription, induced
Treatment
  • IFN-gamma
  • TNF
NFkB-p65 (human) DPSGRPLrLPPVLsH R174-m2
NFkB-p65 (mouse) DPAGRPLLLtPVLSH L174
NFkB-p65 (rat) DPSGRPLRLTPVLSH R174
P176
SGRPLrLPPVLsHPI
0 4
NFkB-p65 (human) SGRPLrLPPVLsHPI P176
NFkB-p65 (mouse) AGRPLLLtPVLSHPI T176-p
NFkB-p65 (rat) SGRPLRLTPVLSHPI T176
S180-p
LrLPPVLsHPIFDNr
0 2
NFkB-p65 (human) LrLPPVLsHPIFDNr S180-p
NFkB-p65 (mouse) LLLtPVLSHPIFDNR S180
NFkB-p65 (rat) LRLTPVLSHPIFDNR S180
R187-m1
sHPIFDNrAPNTAEL
0 1
NFkB-p65 (human) sHPIFDNrAPNTAEL R187-m1
NFkB-p65 (mouse) SHPIFDNRAPNTAEL R187
NFkB-p65 (rat) SHPIFDNRAPNTAEL R187
K195-ub
APNTAELkICRVNRN
Downstream
2 1
Effects on Modified Protein
  • activity, inhibited
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
NFkB-p65 (human) APNTAELkICRVNRN K195-ub
NFkB-p65 (mouse) APNTAELKICRVNRN K195
NFkB-p65 (rat) APNTAELKICRVNRN K195
S203
ICRVNRNSGsCLGGD
0 1
NFkB-p65 (human) ICRVNRNSGsCLGGD S203
NFkB-p65 (mouse) ICRVNRNsGsCLGGD S203-p
NFkB-p65 (rat) ICRVNRNSGSCLGGD S203
S205-p
RVNRNSGsCLGGDEI
Downstream
4 1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
NFkB-p65 (human) RVNRNSGsCLGGDEI S205-p
NFkB-p65 (mouse) RVNRNsGsCLGGDEI S205-p
NFkB-p65 (rat) RVNRNSGSCLGGDEI S205
K218-ac
EIFLLCDkVQkEDIE
Upstream
Downstream
6 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • carcinogenesis, induced
  • transcription, induced
Regulatory protein:
  • STAT3 (human)
Treatment
  • IL-10
  • TNF
  • trichostatin_A
NFkB-p65 (human) EIFLLCDkVQkEDIE K218-ac
NFkB-p65 (mouse) EIFLLCDkVQkEDIE K218-ac
NFkB-p65 (rat) EIFLLCDKVQKEDIE K218
K218-me
EIFLLCDkVQkEDIE
1 0
NFkB-p65 (human) EIFLLCDkVQkEDIE K218-me
NFkB-p65 (mouse) EIFLLCDKVQkEDIE K218
NFkB-p65 (rat) EIFLLCDKVQKEDIE K218
K221-ac
LLCDkVQkEDIEVYF
Upstream
Downstream
11 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • transcription, induced
Regulatory protein:
  • STAT3 (human)
Treatment
  • IL-10
  • TNF
  • trichostatin_A
NFkB-p65 (human) LLCDkVQkEDIEVYF K221-ac
NFkB-p65 (mouse) LLCDkVQkEDIEVYF K221-ac
NFkB-p65 (rat) LLCDKVQKEDIEVYF K221
K221-me
LLCDkVQkEDIEVYF
1 0
NFkB-p65 (human) LLCDkVQkEDIEVYF K221-me
NFkB-p65 (mouse) LLCDkVQKEDIEVYF K221
NFkB-p65 (rat) LLCDKVQKEDIEVYF K221
S238-p
PGWEARGsFSQADVH
Upstream
1 10
Treatment
  • ischemia
  • TNF
NFkB-p65 (human) PGWEARGsFSQADVH S238-p
NFkB-p65 (mouse) PGWEARGsFSQADVH S238-p
NFkB-p65 (rat) PGWEARGSFSQADVH S238
T254-p
QVAIVFRtPPYADPs
Upstream
Downstream
3 1
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Treatment
  • TNF
NFkB-p65 (human) QVAIVFRtPPYADPs T254-p
NFkB-p65 (mouse) QVAIVFRTPPYADPs T254
NFkB-p65 (rat) QVAIVFRtPPyADPS T254-p
Y257
IVFRtPPYADPsLQA
0 1
NFkB-p65 (human) IVFRtPPYADPsLQA Y257
NFkB-p65 (mouse) IVFRTPPYADPsLQA Y257
NFkB-p65 (rat) IVFRtPPyADPSLQA Y257-p
S261-p
tPPYADPsLQAPVRV
Upstream
1 2
Kinase, in vitro:
  • IKKB (human)
Treatment
  • TNF
NFkB-p65 (human) tPPYADPsLQAPVRV S261-p
NFkB-p65 (mouse) TPPYADPsLQAPVRV S261-p
NFkB-p65 (rat) tPPyADPSLQAPVRV S261
S269-p
LQAPVRVsMQLRRPs
Upstream
1 1
Treatment
  • TNF
NFkB-p65 (human) LQAPVRVsMQLRRPs S269-p
NFkB-p65 (mouse) LQAPVRVSMQLRRPs S269
NFkB-p65 (rat) LQAPVRVSMQLRRPs S269
S276-p
sMQLRRPsDRELsEP
Upstream
Downstream
72 0
Effects on Modified Protein
  • acetylation
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, inhibited
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • MSK1 (human)
  • Pim1 (human)
  • PKACA (human)
  • PKACA (mouse)
Putative in vivo kinases:
  • MSK1 (human)
  • MSK2 (human)
  • p90RSK (human)
  • Pim1 (human)
  • PKACA (human)
  • RSK2 (human)
Regulatory protein:
  • AKIP (human)
  • CDK5RAP3 (human)
  • DAXX (human)
  • GSK3B (human)
  • Pim1 (human)
  • Pim2 (human)
  • PTGER2 (mouse)
  • PTGER3 (mouse)
  • SPARC (human)
  • TLR3 (human)
Treatment
  • AH6809
  • cAMP_analog
  • CDDO-Me
  • dimethylfumarate
  • DMAT
  • DMSO
  • double-stranded_RNA
  • ethanol
  • farnesol
  • fluid_shear_stress
  • fumaric_acid
  • GW_5074
  • H-89
  • HGF
  • IL-1b
  • LPS
  • LY294002
  • methylhydrogenfumarate
  • NAC
  • NS398
  • PAR1-activating_peptide
  • PAR2-activating_peptide
  • PD98059
  • S-valproate
  • SB202190
  • SB203580
  • SEL24-B489
  • seliciclib
  • siRNA
  • SL0101
  • SP600125
  • status epilepticus
  • sulprostone
  • TAK1_inhibitor
  • TNF
  • U0126
  • UV
  • virus infection
  • wortmannin
NFkB-p65 (human) sMQLRRPsDRELsEP S276-p
NFkB-p65 (mouse) SMQLRRPsDRELSEP S276-p
NFkB-p65 (rat) SMQLRRPsDRELSEP S276-p
S281-p
RPsDRELsEPMEFQY
Downstream
5 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
NFkB-p65 (human) RPsDRELsEPMEFQY S281-p
NFkB-p65 (mouse) RPsDRELSEPMEFQY S281
NFkB-p65 (rat) RPsDRELSEPMEFQY S281
T305-p
IEEKRKRtyEtFksI
Downstream
1 2
Effects on Biological Processes:
  • transcription, inhibited
NFkB-p65 (human) IEEKRKRtyEtFksI T305-p
NFkB-p65 (mouse) IEEKRKRTYETFksI T305
NFkB-p65 (rat) IEEKRKRTYETFksI T305
T305-gl
IEEKRKRtyEtFksI
Downstream
2 1
Effects on Biological Processes:
  • transcription, induced
NFkB-p65 (human) IEEKRKRtyEtFksI T305-gl
NFkB-p65 (mouse) IEEKRKRTYETFksI T305
NFkB-p65 (rat) IEEKRKRTYETFksI T305
Y306-p
EEKRKRtyEtFksIM
0 2
NFkB-p65 (human) EEKRKRtyEtFksIM Y306-p
NFkB-p65 (mouse) EEKRKRTYETFksIM Y306
NFkB-p65 (rat) EEKRKRTYETFksIM Y306
T308-p
KRKRtyEtFksIMkk
1 2
NFkB-p65 (human) KRKRtyEtFksIMkk T308-p
NFkB-p65 (mouse) KRKRTYETFksIMKK T308
NFkB-p65 (rat) KRKRTYETFksIMKK T308
K310-ac
KRtyEtFksIMkksP
Upstream
Downstream
53 5
NFkB-p65 (human)
K310-ac
NFkB-p65 (mouse)
K310-ac
NFkB-p65 (rat)
K310-ac
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, induced
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
  • translation, induced
Regulatory protein:
  • ERR1 (human)
  • STAT3 (human)
  • Tax (retrovirus)
  • ZNF366 (human)
Treatment
  • AGK2
  • AK1
  • IL-10
  • LPS
  • MS275
  • nicotinamide
  • resveratrol
  • selisistat
  • siRNA
  • splitomicin
  • TNF
  • trichostatin_A
NFkB-p65 (human) KRtyEtFksIMkksP K310-ac
NFkB-p65 (mouse) KRTYETFksIMKKSP K310-ac
NFkB-p65 (rat) KRTYETFksIMKKSP K310-ac
K310-m1
KRtyEtFksIMkksP
2 0
NFkB-p65 (human)
K310-m1
NFkB-p65 (mouse)
K310-m1
NFkB-p65 (rat)
K310-m1
NFkB-p65 (human) KRtyEtFksIMkksP K310-m1
NFkB-p65 (mouse) KRTYETFKsIMKKSP K310
NFkB-p65 (rat) KRTYETFKsIMKKSP K310
K310-ub
KRtyEtFksIMkksP
1 1
NFkB-p65 (human) KRtyEtFksIMkksP K310-ub
NFkB-p65 (mouse) KRTYETFKsIMKKSP K310
NFkB-p65 (rat) KRTYETFKsIMKKSP K310
S311-p
RtyEtFksIMkksPF
Upstream
Downstream
13 2
Effects on Modified Protein
  • acetylation
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • IKKB (human)
Putative in vivo kinases:
  • PKCZ (human)
Treatment
  • glucose_starvation
  • TNF
NFkB-p65 (human) RtyEtFksIMkksPF S311-p
NFkB-p65 (mouse) RTYETFksIMKKSPF S311-p
NFkB-p65 (rat) RTYETFksIMKKSPF S311-p
K314-ac
EtFksIMkksPFsGP
Upstream
Downstream
4 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Treatment
  • nicotinamide
  • siRNA
  • TNF
  • trichostatin_A
  • vorinostat
NFkB-p65 (human) EtFksIMkksPFsGP K314-ac
NFkB-p65 (mouse) ETFksIMKKSPFNGP K314
NFkB-p65 (rat) ETFksIMKKSPFNGP K314
K314-m1
EtFksIMkksPFsGP
2 0
NFkB-p65 (human) EtFksIMkksPFsGP K314-m1
NFkB-p65 (mouse) ETFksIMKKSPFNGP K314
NFkB-p65 (rat) ETFksIMKKSPFNGP K314
K314-ub
EtFksIMkksPFsGP
1 0
NFkB-p65 (human) EtFksIMkksPFsGP K314-ub
NFkB-p65 (mouse) ETFksIMKKSPFNGP K314
NFkB-p65 (rat) ETFksIMKKSPFNGP K314
K315-ac
tFksIMkksPFsGPt
Upstream
Downstream
4 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Treatment
  • nicotinamide
  • siRNA
  • TNF
  • trichostatin_A
  • vorinostat
NFkB-p65 (human) tFksIMkksPFsGPt K315-ac
NFkB-p65 (mouse) TFksIMKKSPFNGPT K315
NFkB-p65 (rat) TFksIMKKSPFNGPT K315
K315-m1
tFksIMkksPFsGPt
2 0
NFkB-p65 (human) tFksIMkksPFsGPt K315-m1
NFkB-p65 (mouse) TFksIMKKSPFNGPT K315
NFkB-p65 (rat) TFksIMKKSPFNGPT K315
K315-ub
tFksIMkksPFsGPt
1 1
NFkB-p65 (human) tFksIMkksPFsGPt K315-ub
NFkB-p65 (mouse) TFksIMKKSPFNGPT K315
NFkB-p65 (rat) TFksIMKKSPFNGPT K315
S316-p
FksIMkksPFsGPtD
Upstream
Downstream
1 3
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Putative in vivo kinases:
  • CK1A (human)
Treatment
  • IL-1b
NFkB-p65 (human) FksIMkksPFsGPtD S316-p
NFkB-p65 (mouse) FksIMKKSPFNGPTE S316
NFkB-p65 (rat) FksIMKKSPFNGPTE S316
S319-gl
IMkksPFsGPtDPRP
1 1
NFkB-p65 (human) IMkksPFsGPtDPRP S319-gl
NFkB-p65 (mouse) IMKKSPFNGPTEPRP N319
NFkB-p65 (rat) IMKKSPFNGPTEPRP N319
T322-gl
ksPFsGPtDPRPPPR
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
NFkB-p65 (human) ksPFsGPtDPRPPPR T322-gl
NFkB-p65 (mouse) KSPFNGPTEPRPPTR T322
NFkB-p65 (rat) KSPFNGPTEPRPPPR T322
S337-gl
RIAVPSRsSASVPKP
1 1
NFkB-p65 (human) RIAVPSRsSASVPKP S337-gl
NFkB-p65 (mouse) RIAVPTRNSTSVPKP N337
NFkB-p65 (rat) RIAVPSRGPTSVPKP G337
T352-gl
APQPYPFtSSLSTIN
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, induced
NFkB-p65 (human) APQPYPFtSSLSTIN T352-gl
NFkB-p65 (mouse) APQPYTFPASLSTIN P352
NFkB-p65 (rat) APQPYAFSTSLSTIN S352
S374-gl
VFPSGQIsQAsALAP
1 1
NFkB-p65 (human) VFPSGQIsQAsALAP S374-gl
NFkB-p65 (mouse) LLPSGQISNQALALA S374
NFkB-p65 (rat) VLPPGQISNQALALA S374
S377-gl
SGQIsQAsALAPAPP
1 1
NFkB-p65 (human) SGQIsQAsALAPAPP S377-gl
NFkB-p65 (mouse) GQISNQALALAPSSA L378
NFkB-p65 (rat) GQISNQALALAPSSA L378
T435-p
PTQAGEGtLSEALLQ
Upstream
Downstream
2 0
Effects on Biological Processes:
  • transcription, inhibited
Putative upstream phosphatases:
  • PPP4C (human)
Treatment
  • calyculin_A
  • TNF
NFkB-p65 (human) PTQAGEGtLSEALLQ T435-p
NFkB-p65 (mouse) STQAGEGTLSEALLH T433
NFkB-p65 (rat) STQAGEGTLSEALLH T434
S468-p
AVFTDLAsVDNsEFQ
Upstream
Downstream
16 0
NFkB-p65 (human)
S468-p
NFkB-p65 (mouse)
S467-p
NFkB-p65 (rat)
S468-p
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • intracellular localization
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • GSK3B (human)
  • IKKB (human)
  • IKKE (human)
Putative in vivo kinases:
  • GSK3B (human)
  • IKKB (human)
  • IKKE (human)
Regulatory protein:
  • CK1G1 (human)
  • GSK3B (human)
Treatment
  • anti-CD3/CD28
  • anti-CD43
  • calyculin_A
  • GSK-3_inhibitor_I
  • HGF
  • IL-1b
  • ionomycin
  • LBH-589
  • lithium
  • LY294002
  • PD98059
  • phorbol_ester
  • PS-1145
  • S-valproate
  • SB203580
  • siRNA
  • SP600125
  • TNF
  • virus infection
  • vorinostat
NFkB-p65 (human) AVFTDLAsVDNsEFQ S468-p
NFkB-p65 (mouse) GVFTDLAsVDNSEFQ S467-p
NFkB-p65 (rat) GVFTDLAsVDNSEFQ S468-p
S472-p
DLAsVDNsEFQQLLN
Upstream
1 1
Treatment
  • TNF
NFkB-p65 (human) DLAsVDNsEFQQLLN S472-p
NFkB-p65 (mouse) DLAsVDNSEFQQLLN S471
NFkB-p65 (rat) DLAsVDNSEFQQLLN S472
T505-p
EAITRLVtGAQRPPD
Upstream
Downstream
4 0
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell growth, inhibited
  • cell motility, inhibited
  • cytoskeletal reorganization
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • Chk1 (human)
Putative in vivo kinases:
  • Chk1 (human)
Regulatory protein:
  • ARF1 (human)
  • ATR (human)
  • p16-INK4A (human)
Treatment
  • caffeine
  • cisplatin
  • daunorubicin
  • etoposide
  • Go_6976
  • siRNA
  • tamoxifen
  • UV
NFkB-p65 (human) EAITRLVtGAQRPPD T505-p
NFkB-p65 (mouse) EAITRLVtGSQRPPD T504-p
NFkB-p65 (rat) EAITRLVTGSQRPPD T505
S529-p
GLPNGLLsGDEDFSs
Upstream
Downstream
18 3
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
Regulatory protein:
  • CDK5RAP3 (human)
Treatment
  • 2-deoxyglucose
  • antitrypsin
  • ciclosporin
  • delphinidin
  • IL-1b
  • ionomycin
  • LPS
  • MG132
  • PD144795
  • phorbol_ester
  • piceatannol
  • silmitasertib
  • TNF
NFkB-p65 (human) GLPNGLLsGDEDFSs S529-p
NFkB-p65 (mouse) SGLPNGLsGDEDFss S527-p
NFkB-p65 (rat) SGLPNGLsGDEDFSs S528-p
S535
LsGDEDFSsIADMDF
0 1
NFkB-p65 (human) LsGDEDFSsIADMDF S535
NFkB-p65 (mouse) LsGDEDFssIADMDF S533-p
NFkB-p65 (rat) LsGDEDFSsIADMDF S534
S536-p
sGDEDFSsIADMDFS
Upstream
Downstream
145 4
NFkB-p65 (human)
S536-p
NFkB-p65 (mouse)
S534-p
NFkB-p65 (rat)
S535-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell growth, altered
  • cell motility, altered
  • cell motility, induced
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • CAMK4 (human)
  • CK1G1 (human)
  • IKKA (human)
  • IKKB (human)
  • IKKE (human)
  • TBK1 (human)
Phosphatases, in vitro:
  • PPM1D (human)
Putative in vivo kinases:
  • CK1G1 (human)
  • IKKA (human)
  • IKKB (human)
  • IKKE (human)
  • PKCA (human)
  • TBK1 (human)
Putative upstream phosphatases:
  • PPM1D (human)
  • PPP2CA (human)
  • PPP3CA (human)
Regulatory protein:
  • ANXA2 (human)
  • CDK5RAP3 (human)
  • CK1D (human)
  • CYBB (human)
  • DAXX (human)
  • DDX58 (human)
  • EGFR (human)
  • GIMAP6 (human)
  • IkB-alpha (human)
  • IKKA (human)
  • IKKB (human)
  • IKKE (human)
  • IKKE (mouse)
  • LMP1 (herpesvirus)
  • MAVS (human)
  • MDA5 (human)
  • Nik (human)
  • NRF2 (human)
  • PIK3R3 (human)
  • PPP2CA (human)
  • PTGER2 (mouse)
  • PTGER3 (mouse)
  • RICTOR (human)
  • SAMHD1 (human)
  • TBK1 (human)
  • TBKBP1 (human)
  • TLR3 (human)
  • TRAF2 (human)
  • TRAF3 (human)
  • TRAF6 (human)
  • USP6 (human)
  • yopJ (bacteria)
  • ZNF366 (human)
Treatment
  • 15d-PGJ2
  • A23187
  • acetyl-boswellic_acid
  • AG1478
  • AGEs
  • AH6809
  • Akt-I-1,2
  • angiotensin_2
  • anti-CD28
  • anti-CD3
  • anti-CD3/CD28
  • anti-LT(beta)R
  • antitrypsin
  • bacterial infection
  • Bay_11-7082
  • BI-D1870
  • bisindolylmaleimide
  • bortezomib
  • botulinum_C3_toxin
  • Ca(2+)
  • calyculin_A
  • CCL5
  • ciclosporin
  • cisplatin
  • CmpdA
  • compound_1
  • deferoxamine
  • delphinidin
  • dimethylfumarate
  • double-stranded_RNA
  • DPI
  • EGF
  • epoxomicin
  • ethanol
  • farnesol
  • fluid_shear_stress
  • genistein
  • gomisin_A
  • gomisin_N
  • GSK-3_inhibitor_X
  • H-89
  • heat_shock
  • IFN-gamma
  • IKK-beta_inhibitor_IV
  • IL-1a
  • IL-1b
  • ionomycin
  • isoliensinine
  • JSH-23
  • LBH-589
  • LFM-A13
  • LIGHT
  • LLnL
  • LPL
  • LPS
  • LY294002
  • MG132
  • NAC
  • NADA
  • NS398
  • okadaic_acid
  • PAR2-activating_peptide
  • parthenolide
  • PD98059
  • pemetrexed
  • phorbol_ester
  • pomegranate_wine
  • PP2
  • PP242
  • resiquimod
  • SB202190
  • SB203580
  • SC-514
  • seliciclib
  • siRNA
  • skin aging
  • sorafenib
  • SP600125
  • sulprostone
  • thrombin
  • TNF
  • TPCA1
  • trichostatin_A
  • triptolide
  • U0126
  • UV
  • UVB
  • vanadate
  • virus infection
  • vorinostat
  • wortmannin
  • wounding
  • Y27632
NFkB-p65 (human) sGDEDFSsIADMDFS S536-p
NFkB-p65 (mouse) sGDEDFssIADMDFS S534-p
NFkB-p65 (rat) sGDEDFSsIADMDFS S535-p
S547-p
MDFSALLsQISS___
1 1
NFkB-p65 (human) MDFSALLsQISS___ S547-p
NFkB-p65 (mouse) MDFSALLsQISS___ S545-p
NFkB-p65 (rat) MDFSALLSQISS___ S546