Ser778
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Home > Phosphorylation Site Page: > Ser778  -  DYN1 (mouse)

Site Information
GRRsPtssPtPQRRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450206

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 , 6 , 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ) , phospho-antibody ( 1 , 2 , 5 ) , western blotting ( 1 , 2 , 5 )
Disease tissue studied:
anthrax infection ( 12 ) , melanoma skin cancer ( 15 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 , 6 ) , 3T3 (fibroblast) ( 16 ) , brain ( 9 , 13 , 14 ) , C2C12 (myoblast) ( 10 ) , heart ( 7 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 11 ) , neuron-'brain, cerebral cortex' ( 5 ) , neuron:synaptosome-brain ( 2 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 15 ) , spermatozoa ( 1 ) , spleen ( 12 ) , testis ( 13 )

Upstream Regulation
Regulatory protein:
SNCA (mouse) ( 2 ) , SNCB (mouse) ( 2 ) , SNCG (mouse) ( 2 )
Treatments:
depolarization ( 5 )

References 

1

Zhou W, et al. (2017) Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis. Mol Hum Reprod 23, 657-673
29044420   Curated Info

2

Vargas KJ, et al. (2017) Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep 18, 161-173
28052246   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

5

Marland JR, Smillie KJ, Cousin MA (2016) Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome. PLoS One 11, e0147974
26808141   Curated Info

6

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

7

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

8

Qin Z, et al. (2013) Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One 8, e80758
24224061   Curated Info

9

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

10

Knight JD, et al. (2012) A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle 2, 5
22394512   Curated Info

11

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

12

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

13

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

14

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

15

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

16

Wang Z, Gucek M, Hart GW (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-8
18779572   Curated Info