Ser778
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Home > Phosphorylation Site Page: > Ser778  -  DYN1 (human)

Site Information
GRRsPtssPtPQRRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450206

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 19 ) , [32P] bio-synthetic labeling ( 19 ) , mass spectrometry ( 3 , 6 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 ) , phospho-antibody ( 1 , 2 , 4 , 17 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
breast cancer ( 2 ) , HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, surrounding tissue ( 3 ) , breast cancer, triple negative ( 3 ) , lung cancer ( 9 , 10 , 13 , 14 , 15 ) , non-small cell lung cancer ( 9 , 10 , 13 , 14 , 15 ) , non-small cell squamous cell lung carcinoma ( 9 , 10 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PPP3CC (human) ( 4 )
Putative in vivo kinases:
PKCA (human) ( 17 )
Putative upstream phosphatases:
PPP3CA (human) ( 17 )
Treatments:
angiotensin_2 ( 11 ) , CAS_220749-41-7 ( 1 ) , ciclosporin ( 17 ) , depolarization ( 19 ) , GF109203X ( 17 ) , LPA ( 12 ) , phorbol_ester ( 17 ) , progesterone ( 1 )

References 

1

Zhou W, et al. (2017) Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis. Mol Hum Reprod 23, 657-673
29044420   Curated Info

2

Reis CR, Chen PH, Bendris N, Schmid SL (2017) TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation. Proc Natl Acad Sci U S A 114, 504-509
28049841   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Cottrell JR, et al. (2016) Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem 291, 1948-56
26627835   Curated Info

5

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

6

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

7

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

8

Mulhern D (2012) CST Curation Set: 13112; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

9

Rikova K (2011) CST Curation Set: 10891; Year: 2011; Biosample/Treatment: cell line, LOU-NH91/untreated; Disease: non-small cell squamous cell lung carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

10

Rikova K (2011) CST Curation Set: 10911; Year: 2011; Biosample/Treatment: cell line, NCI-H520/untreated; Disease: non-small cell squamous cell lung carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

11

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

12

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

13

Rikova K (2010) CST Curation Set: 9772; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

14

Rikova K (2010) CST Curation Set: 9752; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

15

Rikova K (2010) CST Curation Set: 9211; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

16

Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808
19651622   Curated Info

17

Padovano V, Massari S, Mazzucchelli S, Pietrini G (2009) PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells. Am J Physiol Cell Physiol 297, C835-44
19605734   Curated Info

18

Zahedi RP, et al. (2008) Phosphoproteome of resting human platelets. J Proteome Res 7, 526-34
18088087   Curated Info

19

Graham ME, et al. (2007) The in vivo phosphorylation sites of rat brain dynamin I. J Biol Chem 282, 14695-707
17376771   Curated Info