Ser774
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Home > Phosphorylation Site Page: > Ser774  -  DYN1 (mouse)

Site Information
SVPAGRRsPtssPtP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450205

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ) , phospho-antibody ( 2 , 5 ) , western blotting ( 1 , 2 , 5 )
Disease tissue studied:
anthrax infection ( 15 ) , neuroblastoma ( 14 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 , 6 , 8 ) , 3T3 (fibroblast) ( 18 ) , brain ( 1 , 10 , 11 , 16 , 17 ) , C2C12 (myoblast) ( 12 ) , E.coli (bacterial) ( 1 ) , heart ( 9 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 13 ) , N1E-115 (neuron) ( 14 ) , neuron-'brain, cerebral cortex' ( 5 ) , neuron:synaptosome-brain ( 2 ) , spleen ( 15 ) , stromal ( 7 ) , testis ( 16 )

Upstream Regulation
Regulatory protein:
SNCA (mouse) ( 2 ) , SNCB (mouse) ( 2 ) , SNCG (mouse) ( 2 )
Treatments:
depolarization ( 5 ) , insulin ( 8 ) , LPA ( 14 ) , LY294002 ( 8 ) , NAG-thiazoline ( 18 ) , okadaic_acid ( 18 ) , PUGNAc ( 18 )

Downstream Regulation
Effects of modification on DYN1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 )
Inhibit interaction with:
ITSN1 (human) ( 1 )

References 

1

Richter K, et al. (2017) VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context. Neuroscience 371, 29-37
29199069   Curated Info

2

Vargas KJ, et al. (2017) Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep 18, 161-173
28052246   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

5

Marland JR, Smillie KJ, Cousin MA (2016) Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome. PLoS One 11, e0147974
26808141   Curated Info

6

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

7

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

8

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

9

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

10

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

11

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

12

Knight JD, et al. (2012) A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle 2, 5
22394512   Curated Info

13

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

14

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

15

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

16

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

17

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

18

Wang Z, Gucek M, Hart GW (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-8
18779572   Curated Info