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Site Information |
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TPQSPSysPtsPsYS SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 450204 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on POLR2A: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
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Dobrinić P, Szczurek AT, Klose RJ (2021) PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency. Nat Struct Mol Biol 28, 811-824
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Kumari N, et al. (2019) AFF1 acetylation by p300 temporally inhibits transcription during genotoxic stress response. Proc Natl Acad Sci U S A 116, 22140-22151
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Lu P, et al. (2019) THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer. Oncogene 38, 3932-3945
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Beauchamp EM, et al. (2018) Identification and targeting of novel CDK9 complexes in acute myeloid leukemia. Blood
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Narita T, et al. (2017) Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. Blood 130, 1114-1124
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Martínez-Alonso M, Hengrung N, Fodor E (2016) RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II. J Virol 90, 6014-21
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Zhao Y, et al. (2016) Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer. Cell Rep 15, 599-610
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Baranello L, et al. (2016) RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription. Cell 165, 357-71
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Schüller R, et al. (2016) Heptad-Specific Phosphorylation of RNA Polymerase II CTD. Mol Cell 61, 305-14
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Greifenberg AK, et al. (2016) Structural and Functional Analysis of the Cdk13/Cyclin K Complex. Cell Rep 14, 320-31
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Jaenicke LA, et al. (2016) Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation. Mol Cell 61, 54-67
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Zhao DY, et al. (2016) SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature 529, 48-53
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Chen F, et al. (2015) Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes Dev 29, 2377-90
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Liang K, et al. (2015) Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis. Mol Cell 60, 435-45
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Chen FX, et al. (2015) PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Cell 162, 1003-15
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Mayer A, et al. (2015) Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution. Cell 161, 541-54
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Liang K, et al. (2015) Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing. Mol Cell Biol 35, 928-38
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Yeh YY, et al. (2015) Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia. Oncotarget 6, 2667-79
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Calo E, et al. (2015) RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature 518, 249-53
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Di Vona C, et al. (2015) Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase. Mol Cell 57, 506-20
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Bösken CA, et al. (2014) The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun 5, 3505
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Schwartz JC, et al. (2012) FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev 26, 2690-5
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Devaiah BN, et al. (2012) BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A 109, 6927-32
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Egloff S, et al. (2012) Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes. Mol Cell 45, 111-22
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Ray-Gallet D, et al. (2011) Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell 44, 928-41
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Clemente-Blanco A, et al. (2011) Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription. Nat Cell Biol 13, 1450-6
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Hsin JP, Sheth A, Manley JL (2011) RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. Science 334, 683-6
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Dawson MA, et al. (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478, 529-33
21964340 Curated Info |
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Blazek D, et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev 25, 2158-72
22012619 Curated Info |
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Preker P, et al. (2011) PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters. Nucleic Acids Res 39, 7179-93
21596787 Curated Info |
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Lenasi T, Peterlin BM, Barboric M (2011) Cap-binding protein complex links pre-mRNA capping to transcription elongation and alternative splicing through positive transcription elongation factor b (P-TEFb). J Biol Chem 286, 22758-68
21536667 Curated Info |
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Werner-Allen JW, et al. (2011) cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. J Biol Chem 286, 5717-26
21159777 Curated Info |
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Tran K, Gralla JD (2010) The TFIIB tip domain couples transcription initiation to events involved in RNA processing. J Biol Chem 285, 39580-7
20880846 Curated Info |
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Mapendano CK, et al. (2010) Crosstalk between mRNA 3' end processing and transcription initiation. Mol Cell 40, 410-22
21070967 Curated Info |
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Lucio-Eterovic AK, et al. (2010) Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc Natl Acad Sci U S A 107, 16952-7
20837538 Curated Info |
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Egloff S, et al. (2010) The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain. J Biol Chem 285, 20564-9
20457598 Curated Info |
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Shanbhag NM, et al. (2010) ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 141, 970-81
20550933 Curated Info |
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Sobhian B, et al. (2010) HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell 38, 439-51
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Gringhuis SI, et al. (2010) HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat Immunol 11, 419-26
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Rahl PB, et al. (2010) c-Myc regulates transcriptional pause release. Cell 141, 432-45
20434984 Curated Info |
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Ma Y, et al. (2010) CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem 285, 9813-22
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Akhtar MS, et al. (2009) TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. Mol Cell 34, 387-93
19450536 Curated Info |
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Ogba N, et al. (2008) HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res 68, 7015-24
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Leuenroth SJ, Crews CM (2008) Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Res 68, 5257-66
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Hou T, Ray S, Brasier AR (2007) The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. J Biol Chem 282, 37091-102
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Egloff S, et al. (2007) Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression. Science 318, 1777-9
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Chapman RD, et al. (2007) Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science 318, 1780-2
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Cho WK, et al. (2007) Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein. J Virol 81, 11179-86
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Fujita T, et al. (2007) Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells. Nucleic Acids Res 35, 1007-17
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Zhang Y, et al. (2006) Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell 24, 759-70
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Gao N, et al. (2006) The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism. Mol Pharmacol 70, 645-55
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Moisan A, Gaudreau L (2006) The BRCA1 COOH-terminal region acts as an RNA polymerase II carboxyl-terminal domain kinase inhibitor that modulates p21WAF1/CIP1 expression. J Biol Chem 281, 21119-30
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Sambol EB, et al. (2006) Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. Cancer Res 66, 5858-66
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Ohrmalm C, Akusjärvi G (2006) Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II. J Virol 80, 5010-20
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Bark-Jones SJ, Webb HM, West MJ (2006) EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5. Oncogene 25, 1775-85
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Jiang Y, Liu M, Spencer CA, Price DH (2004) Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Mol Cell 14, 375-85
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Inukai N, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. J Biol Chem 279, 8190-5
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Spilianakis C, et al. (2003) CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II. EMBO J 22, 5125-36
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Yeo M, Lin PS, Dahmus ME, Gill GN (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem 278, 26078-85
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Comer FI, Hart GW (2001) Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II. Biochemistry 40, 7845-52
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Nissen RM, Yamamoto KR (2000) The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 14, 2314-29
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Garber ME, et al. (2000) CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Mol Cell Biol 20, 6958-69
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