Ser350

Site Information
GRRGRLPsKPKQPPD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447942

In vivo Characterization
Methods used to characterize site in vivo:	electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:	adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , HEK293T (epithelial) [Akt1 (human)] ( 2 ) , HEK293T (epithelial) [Nur77 (rat)] ( 2 ) , PC-12 (chromaffin) ( 1 )

Downstream Regulation
Effects of modification on Nur77:	molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:	apoptosis, inhibited ( 2 )
Induce interaction with:	14-3-3 beta (rat) ( 2 ) , DNA ( 1 )

References
1	Hiromura M, et al. (2006) Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element. J Biol Chem 281, 27753-64 16835233 Curated Info
2	Masuyama N, et al. (2001) Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J Biol Chem 276, 32799-805 11438550 Curated Info
3	Hirata Y, et al. (1993) The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B. J Biol Chem 268, 24808-12 8227042 Curated Info