Ser350
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Home > Phosphorylation Site Page: > Ser350  -  Nur77 (rat)

Site Information
GRRGRLPsKPKQPPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447942

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 2 ) , PKACA (rat) ( 3 )
Treatments:
NGF ( 1 ) , PDGF ( 1 )

Downstream Regulation
Effects of modification on Nur77:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 )
Induce interaction with:
14-3-3 beta (rat) ( 2 ) , DNA ( 1 )

References 

1

Hiromura M, et al. (2006) Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element. J Biol Chem 281, 27753-64
16835233   Curated Info

2

Masuyama N, et al. (2001) Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J Biol Chem 276, 32799-805
11438550   Curated Info

3

Hirata Y, et al. (1993) The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B. J Biol Chem 268, 24808-12
8227042   Curated Info