Tyr586
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Home > Phosphorylation Site Page: > Tyr586  -  Ret iso3 (human)

Site Information
TWIENKLyGRISHAF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447625

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
Ret iso3 (human) ( 2 )

Downstream Regulation
Effects of modification on Ret iso3:
molecular association, regulation ( 2 )
Induce interaction with:
SHC1 (human) ( 2 )

References 

1

Guo A (2009) CST Curation Set: 6121; Year: 2009; Biosample/Treatment: cell line, LAN-6/NGF; Disease: neuroblastoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Arighi E, et al. (1997) Identification of Shc docking site on Ret tyrosine kinase. Oncogene 14, 773-82
9047384   Curated Info