Tyr759
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr759  -  TLR3 (human)

Site Information
EQFEYAAyIIHAYKD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450187

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Treatments:
double-stranded_RNA ( 2 )

Downstream Regulation
Effects of modification on TLR3:
phosphorylation ( 2 )
Effects of modification on biological processes:
transcription, altered ( 2 , 3 )

References 

1

Yamashita M, et al. (2012) Epidermal growth factor receptor is essential for toll-like receptor 3 signaling. Sci Signal 5, ra50
22810896   Curated Info

2

Sarkar SN, et al. (2007) Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. J Biol Chem 282, 3423-7
17178723   Curated Info

3

Sarkar SN, Smith HL, Rowe TM, Sen GC (2003) Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain. J Biol Chem 278, 4393-6
12509442   Curated Info