Thr760
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Home > Phosphorylation Site Page: > Thr760  -  ITGB2 (human)

Site Information
LFksAtttVMNPkFA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450185

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 ) , peptide sequencing ( 2 ) , phosphoamino acid analysis ( 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , COS (fibroblast) ( 2 ) , TK-1 (T lymphocyte) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 )
Treatments:
phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on ITGB2:
molecular association, regulation ( 1 )
Induce interaction with:
kindlin-3 (human) ( 1 )

References 

1

Morrison VL, et al. (2013) The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo. Blood 122, 1428-36
23823319   Curated Info

2

Hilden TJ, Valmu L, Kärkkäinen S, Gahmberg CG (2003) Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides. J Immunol 170, 4170-7
12682249   Curated Info

3

Fagerholm S, Morrice N, Gahmberg CG, Cohen P (2002) Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes. J Biol Chem 277, 1728-38
11700305   Curated Info