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Site Information |
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DDFADDIsLLk____ SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 450178 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
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Downstream Regulation | |
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Effects of modification on BACE: | |
Induce interaction with: | |
Inhibit interaction with: |
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Relevant diseases: |
References | |
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Zhao Y, et al. (2023) BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology. J Neurochem
37286480 Curated Info |
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Sun M, Zhang H (2017) Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging 60, 129-140
28946017 Curated Info |
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Herskowitz JH, et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J Neurosci 33, 19086-98
24305806 Curated Info |
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Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004 Curated Info |
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He X, Li F, Chang WP, Tang J (2005) GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem 280, 11696-703
15615712 Curated Info |
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Pastorino L, et al. (2002) The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci 19, 175-85
11860271 Curated Info |
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Walter J, et al. (2001) Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 276, 14634-41
11278841 Curated Info |