Ser102
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Home > Phosphorylation Site Page: > Ser102  -  PR (human)

Site Information
GAGGSSssPPEKDSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450158

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 , 5 ) , electrophoretic mobility shift ( 5 ) , mass spectrometry ( 1 , 2 ) , peptide sequencing ( 5 ) , phosphopeptide mapping ( 3 , 5 )
Disease tissue studied:
breast cancer ( 3 , 5 )
Relevant cell line - cell type - tissue:
MCF-7 (breast cell) ( 1 ) , SF9 ( 2 , 3 ) , T47D (breast cell) ( 3 , 5 )

Upstream Regulation
Treatments:
progestin_R5020 ( 2 , 5 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 4 )

References 

1

Sacco F, et al. (2016) Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-71
27135362   Curated Info

2

Knotts TA, et al. (2001) Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J Biol Chem 276, 8475-83
11110801   Curated Info

3

Beck CA, et al. (1996) Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system. J Biol Chem 271, 19546-55
8702648   Curated Info

4

Takimoto GS, et al. (1996) Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors. J Biol Chem 271, 13308-16
8662865   Curated Info

5

Zhang Y, et al. (1995) Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor. Mol Endocrinol 9, 1029-40
7476977   Curated Info

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