Ser162
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Home > Phosphorylation Site Page: > Ser162  -  PR (human)

Site Information
PATQRVLsPLMSRSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450156

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 7 , 8 , 9 , 11 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 7 ) , peptide sequencing ( 11 ) , phospho-antibody ( 6 ) , phosphopeptide mapping ( 8 , 9 , 11 ) , western blotting ( 6 )
Disease tissue studied:
breast cancer ( 2 , 6 , 9 , 11 ) , breast ductal carcinoma ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293E (epithelial) ( 4 ) , breast ( 1 , 2 ) , K562 (erythroid) ( 3 ) , platelet-blood ( 5 ) , SF9 ( 7 , 9 ) , T47D (breast cell) ( 6 , 7 , 8 , 9 , 11 )

Upstream Regulation
Kinases, in vitro:
CDK2 (human) ( 7 , 8 )
Treatments:
progestin_R5020 ( 6 , 7 , 8 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 10 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Zahedi RP, et al. (2008) Phosphoproteome of resting human platelets. J Proteome Res 7, 526-34
18088087   Curated Info

6

Narayanan R, Edwards DP, Weigel NL (2005) Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. Mol Cell Biol 25, 2885-98
15798179   Curated Info

7

Knotts TA, et al. (2001) Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J Biol Chem 276, 8475-83
11110801   Curated Info

8

Zhang Y, et al. (1997) Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. Mol Endocrinol 11, 823-32
9171245   Curated Info

9

Beck CA, et al. (1996) Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system. J Biol Chem 271, 19546-55
8702648   Curated Info

10

Takimoto GS, et al. (1996) Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors. J Biol Chem 271, 13308-16
8662865   Curated Info

11

Zhang Y, et al. (1994) Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II. J Biol Chem 269, 31034-40
7983041   Curated Info

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