Lys137
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Home > Ubiquitylation Site Page: > Lys137  -  PINK1 (human)

Site Information
AIFTQKSkPGPDPLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 964535576

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 2 ) , HEp-2 (squamous) ( 1 ) , MEF (fibroblast) ( 2 ) , SH-SY5Y (neural crest) ( 2 ) , SK-N-BE(2)-M17 ( 2 )

Upstream Regulation
Regulatory protein:
MARCH5 (human) ( 2 ) , MULAN (human) ( 2 ) , PARK2 (human) ( 2 )
Treatments:
valinomycin ( 2 )

Downstream Regulation
Effects of modification on PINK1:
protein degradation ( 2 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Liu Y, et al. (2017) The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form. Cell Rep 20, 30-39
28683321   Curated Info

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