Ser40
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Home > Phosphorylation Site Page: > Ser40  -  p70S6K (rat)

Site Information
DQPEDAGsEDELEEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450117

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (rat) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 1 )
Treatments:
TBB ( 1 )

Downstream Regulation
Effects of modification on p70S6K:
molecular association, regulation ( 1 )
Induce interaction with:
Exportin-1 (human) ( 1 )

References 

1

Panasyuk G, et al. (2006) Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem 281, 31188-201
16895915   Curated Info

2

Weng QP, et al. (1995) Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci U S A 92, 5744-8
7777579   Curated Info