Ser15
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Home > Phosphorylation Site Page: > Ser15  -  p53 (human)

Site Information
PsVEPPLsQEtFsDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447490

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 30 , 234 , 321 ) , [32P] ATP in vitro ( 108 ) , [32P] bio-synthetic labeling ( 298 ) , flow cytometry ( 5 , 95 , 119 , 126 , 173 ) , immunoassay ( 28 ) , immunoprecipitation ( 3 , 14 , 16 , 17 , 18 , 22 , 24 , 28 , 30 , 38 , 41 , 50 , 77 , 95 , 108 , 125 , 148 , 173 , 246 , 278 , 300 , 316 , 318 , 319 ) , mass spectrometry ( 3 , 14 , 19 , 28 , 30 , 148 , 310 ) , microscopy-colocalization with upstream kinase ( 22 , 140 , 141 ) , modification-specific antibody ( 246 , 249 , 308 ) , mutation of modification site ( 3 , 4 , 8 , 16 , 24 , 28 , 38 , 50 , 55 , 74 , 77 , 86 , 108 , 133 , 138 , 145 , 148 , 150 , 151 , 173 , 181 , 187 , 195 , 207 , 218 , 219 , 224 , 227 , 240 , 243 , 249 , 264 , 272 , 285 , 287 , 288 , 291 , 292 , 294 , 296 , 298 , 304 , 313 , 316 , 317 ) , peptide sequencing ( 274 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 14 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 27 , 28 , 31 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 46 , 50 , 51 , 55 , 56 , 58 , 60 , 62 , 64 , 65 , 66 , 67 , 68 , 69 , 73 , 74 , 76 , 77 , 81 , 82 , 85 , 86 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 100 , 101 , 102 , 105 , 107 , 108 , 109 , 111 , 112 , 113 , 114 , 115 , 116 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 130 , 131 , 132 , 133 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 158 , 159 , 160 , 161 , 162 , 165 , 166 , 167 , 168 , 170 , 171 , 173 , 174 , 175 , 176 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 187 , 188 , 189 , 190 , 192 , 193 , 195 , 196 , 197 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 225 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 275 , 276 , 277 , 278 , 279 , 282 , 283 , 284 , 285 , 286 , 287 , 289 , 290 , 292 , 293 , 294 , 295 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 307 , 308 , 309 , 315 , 316 , 317 , 318 , 319 , 320 ) , phosphoamino acid analysis ( 138 , 281 ) , phosphopeptide mapping ( 321 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 14 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 27 , 28 , 31 , 32 , 33 , 34 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 46 , 50 , 51 , 55 , 56 , 58 , 60 , 62 , 64 , 65 , 66 , 67 , 68 , 69 , 73 , 74 , 76 , 77 , 81 , 82 , 85 , 86 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 100 , 101 , 102 , 105 , 107 , 108 , 109 , 111 , 112 , 113 , 114 , 115 , 116 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 130 , 131 , 132 , 133 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 158 , 160 , 161 , 162 , 165 , 166 , 167 , 168 , 170 , 171 , 173 , 174 , 175 , 176 , 179 , 180 , 181 , 182 , 183 , 185 , 187 , 188 , 189 , 190 , 192 , 193 , 195 , 196 , 206 , 207 , 209 , 212 , 214 , 215 , 219 , 228 , 230 , 232 , 234 , 236 , 239 , 243 , 244 , 246 , 247 , 248 , 249 , 252 , 254 , 257 , 261 , 262 , 264 , 270 , 271 , 272 , 273 , 274 , 277 , 281 , 282 , 284 , 293 , 295 , 299 , 300 , 302 , 303 , 304 , 307 , 308 , 309 , 316 , 320 , 321 )
Disease tissue studied:
ataxia-telangiectasia ( 97 , 123 , 139 , 144 , 167 , 182 , 213 , 215 , 244 , 261 , 271 , 278 , 302 , 319 ) , adrenal cancer ( 76 , 232 ) , pheochromocytoma ( 232 ) , bone cancer ( 14 , 22 , 27 , 37 , 38 , 50 , 55 , 81 , 90 , 93 , 109 , 121 , 138 , 144 , 151 , 162 , 165 , 170 , 185 , 193 , 228 , 234 , 257 , 282 , 284 ) , brain cancer ( 2 , 4 , 8 , 82 , 89 , 91 , 219 , 281 , 321 ) , glioblastoma ( 2 , 4 , 8 , 82 , 89 , 219 , 281 , 321 ) , glioblastoma multiforme ( 281 , 321 ) , glioma ( 2 , 4 , 8 , 82 , 89 , 219 , 281 , 321 ) , medulloblastoma ( 91 ) , breast cancer ( 4 , 14 , 24 , 25 , 28 , 31 , 41 , 58 , 93 , 100 , 105 , 109 , 132 , 141 , 143 , 145 , 156 , 167 , 174 , 176 , 180 , 193 , 212 , 243 ) , breast adenocarcinoma ( 109 ) , breast ductal carcinoma ( 212 ) , HER2 positive breast cancer ( 19 ) , luminal A breast cancer ( 19 ) , luminal B breast cancer ( 19 ) , breast cancer, triple negative ( 19 , 109 ) , colorectal cancer ( 3 , 14 , 16 , 33 , 38 , 43 , 55 , 58 , 73 , 111 , 118 , 123 , 126 , 130 , 132 , 133 , 144 , 170 , 173 , 188 , 236 , 240 , 246 , 249 , 254 , 261 , 270 , 271 , 320 ) , colorectal carcinoma ( 3 , 14 , 16 , 33 , 38 , 43 , 55 , 58 , 73 , 111 , 118 , 123 , 126 , 130 , 132 , 133 , 144 , 170 , 173 , 188 , 236 , 240 , 246 , 249 , 254 , 261 , 270 , 271 , 320 ) , eye cancer ( 60 ) , HNSCC ( 34 ) , leukemia ( 7 , 25 , 30 , 94 , 101 , 125 , 166 , 193 , 243 , 310 ) , acute lymphocytic leukemia ( 94 ) , acute myelogenous leukemia ( 125 , 166 , 310 ) , chronic lymphocytic leukemia ( 7 , 30 ) , chronic myelogenous leukemia ( 101 ) , T cell leukemia ( 193 , 243 ) , liver cancer ( 18 , 39 , 68 , 160 , 167 , 284 ) , hepatocellular carcinoma ( 39 , 68 ) , lung cancer ( 4 , 22 , 24 , 28 , 36 , 50 , 77 , 96 , 118 , 123 , 135 , 137 , 138 , 145 , 154 , 179 , 188 , 195 , 213 , 214 , 238 , 245 , 249 , 261 , 262 , 263 , 304 , 309 , 321 ) , non-small cell lung cancer ( 4 , 22 , 24 , 28 , 50 , 96 , 118 , 135 , 137 , 138 , 145 , 188 , 213 , 214 , 238 , 249 , 261 , 304 , 309 , 321 ) , non-small cell lung adenocarcinoma ( 50 , 137 , 321 ) , non-small cell squamous cell lung carcinoma ( 118 , 238 ) , lymphoma ( 30 , 36 , 136 , 316 ) , anaplastic large cell lymphoma ( 316 ) , Burkitt's lymphoma ( 30 ) , neuroblastoma ( 67 , 88 , 116 , 120 , 158 , 212 , 278 ) , oropharyngeal cancer ( 195 ) , squamous cell carcinoma of the oropharynx ( 195 ) , ovarian cancer ( 152 , 190 , 300 ) , ovarian epithelial carcinoma ( 152 ) , pancreatic cancer ( 25 , 142 ) , pancreatic carcinoma ( 25 , 142 ) , multiple myeloma ( 21 ) , prostate cancer ( 46 , 107 , 109 , 122 , 132 , 166 , 183 , 187 , 189 , 192 , 196 , 212 , 247 , 320 ) , melanoma skin cancer ( 147 ) , fibrosarcoma of soft tissue ( 16 , 74 , 76 , 145 ) , MADA ( 124 )
Relevant cell line - cell type - tissue:
'epithelial, lung' ( 238 ) , 'hematopoietic progenitor, CD34+'-blood ( 101 ) , 'stem, embryonic' ( 210 ) , 'stem, mesenchymal' ( 66 ) , 1526 (lymphoblastoid) ( 319 ) , 2184 ( 319 ) , 22Rv1 (prostate cell) ( 192 ) , 293 (epithelial) ( 95 , 148 , 149 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 222 , 248 , 256 ) , A2182 ( 293 ) , A2780 (ovarian) ( 152 , 190 , 223 , 231 , 300 ) , A375 (melanocyte) ( 296 ) , A375MM (melanocyte) ( 51 ) , A549 (pulmonary) ( 50 , 77 , 118 , 123 , 135 , 154 , 179 , 195 , 213 , 214 , 218 , 241 , 245 , 249 , 262 , 263 , 287 , 301 , 304 ) , AG04405 (fibroblast) ( 302 ) , AHH1 (B lymphocyte) ( 227 ) , ap24 (fibroblast) ( 313 ) , ap29 (fibroblast) ( 313 ) , Aspc1 (pancreatic) ( 293 ) , AT1ABR (lymphoblastoid) ( 215 , 318 ) , AT22IJE-T (fibroblast) ( 271 ) , AT24RM (lymphoblastoid) ( 278 ) , AT2KY ( 93 , 283 ) , AT3B-1 (prostate cell) ( 317 ) , AT5BI (fibroblast) ( 182 , 222 , 283 , 297 ) , AT5BIVA (fibroblast) ( 97 , 291 , 297 ) , AT65RM (lymphoblastoid) ( 244 ) , B lymphocyte ( 43 ) , B lymphocyte-blood ( 30 ) , BaF3 ('B lymphocyte, precursor') [Abl (mouse), homozygous knockout] ( 101 ) , BEL7402 (hepatic) ( 18 ) , BJ (fibroblast) ( 108 ) , breast ( 19 , 212 ) , BT (epithelial) ( 215 , 278 , 295 ) , BxPC-3 (pancreatic) ( 142 ) , C3ABR (lymphoblastoid) ( 215 , 258 , 278 , 302 , 318 ) , C3H10T1/2 (fibroblast) ( 250 ) , Calu 6 (pulmonary) ( 321 ) , Caov-3 (ovarian) ( 223 ) , Capan1 (pancreatic) ( 142 ) , CCRF-CEM (T lymphocyte) ( 316 ) , chondrocyte ( 272 ) , CLBL-1 ( 36 ) , COLO-320 (intestinal) ( 293 ) , COS (fibroblast) ( 175 , 212 , 286 , 288 ) , D283 ( 91 ) , Daoy ( 91 ) , DF1 (fibroblast) ( 17 ) , DLD1 (intestinal) ( 3 , 33 ) , DU 145 (prostate cell) ( 212 ) , EHEB (B lymphocyte) ( 7 ) , epithelial-corneal ( 206 ) , ES (stem) ( 86 ) , fibroblast ( 41 , 92 , 124 , 146 , 155 , 221 , 271 , 304 ) , fibroblast-foreskin ( 69 , 127 , 144 ) , fibroblast-skin ( 230 ) , FT/pEBS7 (fibroblast) ( 139 ) , glial ( 266 ) , GM00536 (lymphoblast) ( 25 , 123 , 213 , 261 , 307 ) , GM00637 (lymphoblast) ( 290 ) , GM01526 (lymphoblast) ( 123 , 144 , 213 , 231 , 261 , 278 ) , GM02052 (fibroblast) ( 167 , 255 , 297 ) , GM02254 (lymphoblast) ( 231 , 278 ) , GM02782 (lymphoblastoid) ( 227 ) , GM03189 (lymphoblastoid) ( 182 , 227 ) , GM03395 (fibroblast) ( 255 ) , GM03397 (fibroblast) ( 255 ) , GM03440 (fibroblast) ( 255 ) , GM03491 (fibroblast) [ATM (human), homozygous knockout] ( 65 ) , GM03491 (fibroblast) ( 167 ) , GM09607 (fibroblast) ( 151 ) , GM638 (fibroblast) ( 283 ) , GM847 (fibroblast) ( 317 ) , H19-7 (neuron) ( 86 ) , HaCaT (keratinocyte) ( 96 , 115 ) , HAEC (endothelial) ( 6 ) , HCA2 (fibroblast) [TERT (human), transfection] ( 303 ) , HCC (hepatic) ( 68 ) , HCC1937 (breast cell) ( 229 ) , HCC2279 (pulmonary) ( 137 ) , HCT116 (intestinal) [p53 (human)] ( 173 ) , HCT116 (intestinal) ( 3 , 14 , 16 , 33 , 38 , 43 , 55 , 58 , 73 , 111 , 118 , 123 , 126 , 130 , 132 , 133 , 144 , 184 , 216 , 240 , 246 , 249 , 253 , 254 , 261 , 270 , 271 , 298 ) , HE49 (embryonic) ( 283 , 299 ) , HEK293T (epithelial) ( 22 , 38 , 46 , 121 , 141 , 150 , 193 , 197 , 203 , 205 , 229 , 279 ) , HeLa (cervical) ( 62 , 64 , 85 , 95 , 112 , 121 , 139 , 140 , 235 ) , hepatocyte-liver ( 68 , 114 ) , HepG2 (hepatic) ( 18 , 39 , 68 , 160 , 167 , 217 , 237 , 284 ) , HFFF-2 (fibroblast) ( 228 ) , HK2 (epithelial) ( 153 ) , HL60 (myeloid) ( 25 ) , Hs68 (fibroblast) ( 209 ) , HSF (fibroblast) ( 181 ) , HT-29 (intestinal) ( 316 ) , HT1080 (fibroblast) ( 16 , 74 , 76 ) , HT116 ( 293 ) , hTERT normal human urothelia ( 32 ) , hTERT-RPE1 (epithelial) ( 38 , 42 ) , Huh7 (hepatic) ( 160 ) , HUVEC (endothelial) ( 1 , 6 , 113 , 248 ) , IMR-90 (fibroblast) ( 3 , 102 , 132 , 222 , 275 ) , IMR32 (neural crest) ( 88 ) , JB (epithelial) ( 202 ) , K562 (erythroid) ( 227 , 317 ) , keratinocyte-skin ( 131 , 274 ) , L3 (lymphoblastoid) ( 139 , 258 , 278 , 302 ) , L40 (lymphoblastoid) ( 139 ) , L929 (fibroblast) ( 145 ) , LCL (lymphoblastoid) ( 168 , 220 , 244 ) , leukocyte-blood ( 166 ) , LN229 (glial) ( 2 ) , LNCaP (prostate cell) ( 46 , 107 , 109 , 122 , 166 , 183 , 189 , 196 , 247 , 316 , 320 ) , lymphoblastoid ( 92 , 182 , 244 ) , lymphocyte-blood ( 5 ) , M059J (glial) ( 219 ) , M059K (glial) ( 82 ) , macrophage ( 175 ) , MCF-10A (breast cell) ( 28 , 132 , 174 ) , MCF-7 (breast cell) ( 4 , 14 , 24 , 25 , 31 , 41 , 58 , 93 , 100 , 105 , 109 , 141 , 145 , 156 , 161 , 167 , 176 , 180 , 193 , 212 , 222 , 229 , 233 , 243 , 259 , 260 , 267 , 287 , 301 , 315 ) , MCF10A1 (epithelial) ( 23 , 31 ) , MDA-MB-231 (breast cell) ( 180 , 212 ) , MDA-MB-435S (breast cell) ( 212 ) , MDA-MB-468 (breast cell) ( 109 ) , MDAH041 (fibroblast) ( 285 , 294 ) , MEF (fibroblast) ( 56 , 175 , 230 , 249 ) , MEF (fibroblast) [IGF1R (mouse)] ( 224 , 292 ) , MEF (fibroblast) [LKB1 (human)] ( 173 ) , MEF (fibroblast) [MDM2 (human)] ( 151 ) , MEF (fibroblast) [PIN1 (human), homozygous knockout] ( 95 ) , MEF (fibroblast) [PML (human)] ( 125 ) , MEL202 (melanocyte) ( 60 ) , MG63 (bone cell) ( 284 ) , MM (B lymphocyte) ( 21 ) , MOLM 13 (myeloid) ( 166 ) , MOLT-4 (T lymphocyte) ( 193 , 243 ) , Mori (fibroblast) ( 287 ) , MRC5 (fibroblast) ( 146 , 249 , 302 ) , MT1 (lymphoblastoid) ( 225 ) , Mv1Lu (pulmonary) ( 212 ) , NALM6 (B lymphocyte) ( 94 ) , NB-4 (myeloid) ( 125 , 242 ) , NBS-ILB1 (fibroblast) ( 208 ) , NCI-H1299 (pulmonary) ( 4 , 22 , 24 , 28 , 50 , 96 , 118 , 135 , 138 , 145 , 213 , 214 , 218 , 249 , 261 , 288 , 298 , 301 , 304 , 309 , 315 ) , NCI-H1650 (pulmonary) ( 118 ) , NCI-H1703 (squamous) ( 118 ) , NCI-H23 (pulmonary) ( 118 ) , NCI-H460 (pulmonary) ( 118 , 188 ) , NCI-H596 (pulmonary) ( 293 ) , NHDF (fibroblast) ( 92 ) , NHF (fibroblast) ( 92 , 239 , 252 , 264 , 277 , 308 ) , OCI/AML3 (myeloid) ( 310 ) , OM431 ( 293 ) , OVCAR3 (ovarian) ( 223 ) , PANC-1 (pancreatic) ( 25 ) , PC-12 (chromaffin) ( 232 ) , PC-12 Adh ( 76 ) , PC3 (prostate cell) ( 132 , 187 , 192 , 196 , 203 ) , prostate ( 212 ) , RAMOS (B lymphocyte) ( 30 , 268 ) , RKO (intestinal) ( 200 , 216 , 236 , 261 , 279 , 298 , 320 ) , Saos-2 (bone cell) ( 55 , 151 , 185 , 292 , 296 ) , SF9 ( 207 ) , SH-SY5Y (neural crest) ( 67 , 116 , 120 , 158 ) , SHEP (neuron) ( 278 ) , SJSA-1 (bone cell) ( 293 ) , skin ( 250 , 276 ) , SKNSH (neural crest) ( 212 ) , SKOV-3 (ovarian) ( 223 ) , SN4741 (neuron) ( 232 ) , SNU-398 (hepatic) ( 39 ) , squamous ( 34 ) , SV40 ( 211 ) , SW480 (intestinal) ( 188 ) , SW680 (intestinal) ( 293 ) , T1 ( 147 ) , T47D (breast cell) ( 143 ) , T98G (glial) [p53 (human), transfection] ( 321 ) , testis ( 159 ) , thymocyte-thymus ( 40 ) , TIG (fibroblast) ( 93 , 301 ) , TK6 (lymphoblastoid) ( 225 ) , U-138 MG (glial) ( 2 ) , U-251 MG (glial) ( 8 , 281 ) , U-937 (myeloid) ( 136 ) , U266 (plasma cell) ( 265 ) , U2OS (bone cell) [GR (human)] ( 201 , 204 , 213 , 225 , 228 , 229 , 269 , 292 ) , U2OS (bone cell) ( 14 , 22 , 27 , 37 , 38 , 50 , 81 , 90 , 93 , 109 , 121 , 138 , 144 , 162 , 165 , 170 , 193 , 234 , 257 , 282 ) , U373 MG (glial) ( 281 ) , U87MG (glial) ( 2 , 4 , 8 , 89 , 281 ) , Vero (epithelial) ( 17 ) , WI-38 (fibroblast) ( 73 , 109 , 167 , 294 ) , WM4 ( 293 ) , WM5 ( 293 ) , WM793 ( 293 ) , WS1 (fibroblast) ( 249 , 289 , 304 ) , YZ5 ( 139 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 150 ) , ALOX15 (human) ( 111 ) , AML2 (human) ( 90 ) , AMPKA1 (human) ( 115 ) , ASK1 (human) ( 76 ) , ATM (human) ( 60 , 62 , 65 , 90 , 109 , 138 , 140 , 144 , 151 , 167 , 171 , 176 , 209 , 244 ) , ATR (human) ( 112 , 144 , 155 , 282 ) , BARD1 (human) ( 229 ) , Bcl-2 (human) ( 176 ) , BMI1 (human) ( 31 ) , BRCA1 (human) ( 209 , 229 ) , CCNB1 (human) ( 85 ) , CCNG1 (human) ( 230 ) , CD44 (human) ( 175 ) , CD74 (human) ( 175 ) , CDK5 (mouse) ( 158 ) , CDK5R1 (mouse) ( 158 ) , CLK2 (human) ( 112 ) , DEK (human) ( 34 ) , DNAPK (human) ( 111 ) , DUSP26 (human) ( 88 ) , E2F1 (human) ( 239 , 252 ) , EGFR (human) ( 105 ) , ERK1 (human) ( 84 ) , ERK2 (human) ( 84 ) , FAAP24 (human) ( 112 ) , FANCM (human) ( 112 ) , FBXW7 (human) ( 33 ) , HIPK2 (human) ( 167 ) , HRas (human) ( 108 ) , HSPA2 (human) ( 132 ) , Huntingtin (human) ( 67 ) , IHPK2 (human) ( 43 ) , ITGA5 (human) ( 180 ) , ITGB3 (human) ( 180 ) , lamin A/C (human) ( 124 ) , LATS1 (human) ( 28 ) , LATS2 (human) ( 28 ) , LKB1 (human) ( 77 , 118 ) , MDC1 (human) ( 97 ) , MDM2 (human) ( 162 ) , MKK3 (human) ( 181 ) , MLL5 (human) ( 73 ) , Myc (human) ( 76 , 252 ) , NBS1 (human) ( 140 ) , NKX3-1 (human) ( 46 ) , NPM1 (human) ( 221 , 236 ) , p16-INK4A (human) ( 209 ) , P38A (human) ( 62 ) , P38G (human) ( 108 ) , p53 (human) ( 160 , 185 , 281 ) , p63 (human) ( 96 ) , PHF1 (human) ( 54 ) , PKM (human) ( 14 ) , PLA2G6 (human) ( 144 ) , PML (human) ( 58 ) , POLR2A (human) ( 155 ) , PPM1D (human) ( 91 ) , PPP1CA (human) ( 187 ) , PPP4C (human) ( 121 ) , RACK1 (human) ( 76 ) , RPA1 (human) ( 155 ) , RPS3 (human) ( 76 ) , SIRT1 (human) ( 91 ) , SIRT6 (human) ( 21 ) , SMEK2 (human) ( 121 ) , SOCS1 (human) ( 102 ) , STAT5A (human) ( 102 ) , Tax (retrovirus) ( 148 ) , TERT (human) ( 303 ) , TTI1 (human) ( 43 ) , TWIST1 (human) ( 55 ) , WIPF1 (human) ( 151 ) , ZNHIT1 (human) ( 165 )
Putative in vivo kinases:
ATM (human) ( 1 , 41 , 43 , 68 , 96 , 123 , 138 , 194 , 213 , 225 , 227 , 228 , 231 , 248 , 255 , 257 , 267 , 295 , 318 , 319 ) , ATR (human) ( 105 , 134 , 149 , 209 , 213 , 225 , 231 ) , Btk (human) ( 16 ) , Chk1 (human) ( 309 ) , DNAPK (human) ( 43 ) , DYRK1A (human) ( 86 ) , ERK1 (human) ( 300 ) , ERK2 (human) ( 300 ) , LKB1 (human) ( 173 ) , NuaK1 (human) ( 77 ) , P38A (human) ( 76 , 272 ) , PRPK (human) ( 150 , 286 ) , SMG1 (human) ( 123 )
Kinases, in vitro:
ATM (human) ( 14 , 46 , 93 , 244 , 257 , 283 , 295 , 305 , 306 , 312 , 317 , 318 , 319 ) , ATR (human) ( 103 , 317 ) , Btk (human) ( 16 ) , CDK5 (human) ( 158 ) , Chk1 (human) ( 251 , 309 ) , Chk2 (human) ( 309 ) , DNAPK (human) ( 129 , 164 , 187 , 198 , 219 , 226 , 251 , 304 , 309 , 311 , 314 , 320 , 322 ) , DYRK1A (human) ( 86 ) , ERK2 (human) ( 250 , 280 ) , ERK2 (mouse) ( 300 ) , LKB1 (human) ( 173 ) , P38A (human) ( 272 ) , PRPK (human) ( 150 , 286 )
Putative upstream phosphatases:
PPM1D (human) ( 204 ) , PPP1CA (human) ( 187 )
Phosphatases, in vitro:
PPM1D (human) ( 177 , 204 ) , PPP1CA (human) ( 187 )
Treatments:
15d-PGJ2 ( 113 ) , 4-AP ( 206 ) , 4-HT ( 23 ) , 5-aza-CdR ( 134 ) , acadesine ( 205 ) , aciclovir ( 228 ) , actinomycin_D ( 81 , 155 , 160 ) , adriamycin ( 1 , 11 , 21 , 22 , 41 , 53 , 74 , 88 , 90 , 93 , 94 , 95 , 96 , 119 , 144 , 154 , 162 , 193 , 203 , 209 , 215 , 216 , 234 , 249 , 263 , 269 , 276 , 278 , 285 , 290 , 294 , 298 , 301 ) , AG1433 ( 248 ) , AG1478 ( 105 , 115 , 248 ) , alpha-dendrotoxin ( 206 ) , alvocidib ( 130 ) , amanitin ( 1 ) , aminoflavone ( 156 ) , aminothiazole_compound_25 ( 231 ) , androsterone ( 212 ) , anti-IgM ( 268 ) , anti-ITGAv ( 180 ) , anti-ITGB3 ( 180 ) , aphidicolin ( 112 ) , apigenin ( 192 ) , As2O3 ( 125 ) , asbestos ( 262 ) , ascorbic_acid ( 215 ) , Ba(2+) ( 206 ) , BDS-I ( 206 ) , BEL ( 144 ) , beta-D-(3,4-di-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside ( 107 ) , bleomycin ( 269 , 303 ) , bortezomib ( 247 , 265 ) , BPDE ( 174 ) , C-1027 ( 171 ) , cadmium_chloride ( 262 ) , caffeine ( 4 , 50 , 56 , 58 , 109 , 138 , 143 , 144 , 157 , 203 , 206 , 209 , 231 , 239 , 245 , 248 , 252 , 265 , 290 , 295 , 300 , 302 ) , calyculin_A ( 187 ) , cAMP_analog ( 266 ) , camptothecin ( 49 , 50 , 73 , 85 , 154 , 252 , 320 ) , catalase ( 126 , 262 ) , Cd(2+) ( 318 ) , Cdk2_inhibitor_II ( 120 ) , celecoxib ( 62 ) , cell_adhesion ( 126 ) , cisplatin ( 1 , 71 , 101 , 154 , 165 , 193 , 200 , 238 , 281 , 300 ) , colforsin ( 94 ) , compound_C ( 115 ) , cycloheximide ( 228 ) , DAMGO ( 259 ) , DDATHF ( 246 ) , decursin ( 107 ) , deferoxamine ( 254 ) , desferoxamine ( 279 ) , development ( 303 ) , dexamethasone ( 263 ) , doxycycline ( 213 , 222 ) , DPN ( 105 ) , DRB ( 130 ) , DSBs ( 161 ) , eeyarestatin_1 ( 36 ) , EF24 ( 152 ) , EGF ( 105 ) , estradiol ( 105 , 212 ) , etoposide ( 14 , 31 , 43 , 54 , 72 , 81 , 84 , 92 , 154 , 176 , 193 , 216 , 222 , 239 , 246 , 247 , 284 , 295 ) , ETS ( 18 ) , faslodex ( 105 ) , fluorouracil ( 43 , 217 , 254 ) , genistein ( 248 , 295 ) , glucose ( 77 ) , glucose_starvation ( 65 , 261 ) , Go_6976 ( 32 , 68 ) , granzyme_B ( 147 ) , grape_seed_extract ( 189 ) , H2O2 ( 115 , 120 , 126 , 139 , 232 , 245 , 248 , 260 , 290 ) , heat_shock ( 266 , 283 ) , herbimycin_A ( 295 ) , high_glucose ( 6 ) , hydroxyurea ( 1 , 105 , 112 , 121 , 258 , 264 , 279 ) , hyperoxia ( 123 , 245 ) , hypertonic_buffer ( 261 ) , hypoxia ( 56 , 221 , 254 , 261 , 279 ) , hypoxia/reoxygenation ( 261 ) , IBMX ( 94 ) , IC261 ( 125 ) , ICRF-193 ( 92 ) , idarubicin ( 166 ) , imatinib ( 101 ) , ionizing_radiation ( 1 , 24 , 25 , 30 , 41 , 42 , 46 , 64 , 66 , 85 , 87 , 93 , 97 , 100 , 105 , 109 , 124 , 125 , 137 , 138 , 149 , 151 , 157 , 159 , 161 , 167 , 168 , 194 , 199 , 204 , 208 , 211 , 213 , 219 , 220 , 225 , 229 , 230 , 238 , 239 , 241 , 244 , 246 , 249 , 257 , 258 , 270 , 271 , 278 , 279 , 281 , 282 , 283 , 287 , 295 , 298 , 299 , 301 , 302 , 303 , 304 , 307 , 309 , 310 , 316 , 317 , 318 , 319 , 320 , 323 ) , KU-55933 ( 32 , 60 , 68 , 82 , 96 , 138 , 140 , 149 , 168 ) , KU-60019 ( 1 , 25 ) , leptomycin_B ( 256 ) , LLnL ( 252 , 307 , 318 , 319 ) , low_pH ( 261 ) , LY294002 ( 105 , 150 , 202 , 231 , 248 ) , melatonin ( 58 ) , melphalan ( 206 ) , methotrexate ( 246 ) , methylcholanthrene ( 284 ) , MG132 ( 138 , 156 , 158 , 256 , 266 ) , MI-63 ( 119 ) , MIF ( 175 ) , miR-16 ( 8 ) , mitomycin_C ( 158 , 230 ) , MLN4924 ( 4 ) , MNNG ( 271 ) , MnTMPyP ( 183 , 196 ) , Na(2)CrO(4) ( 255 ) , NAC ( 115 , 142 , 215 , 261 , 262 , 277 ) , NaF ( 227 ) , naphthoflavone ( 284 ) , neocarzinostatin ( 241 , 277 ) , nitric_oxide ( 233 , 256 , 267 ) , nocodazole ( 64 , 154 , 249 , 298 ) , NSC348884 ( 122 ) , NU7441 ( 96 ) , nutlin-3 ( 60 , 119 ) , ODQ ( 190 ) , okadaic_acid ( 94 , 170 , 187 ) , olomoucine ( 231 , 235 ) , PALA ( 249 ) , PD153035 ( 115 ) , PD169316 ( 278 ) , PD98059 ( 58 , 202 , 231 , 232 , 248 , 300 ) , PGE2 ( 181 ) , phorbol_ester ( 126 ) , phosphatidylcholine ( 144 ) , pifithrin-alpha ( 142 , 147 ) , plicamycin ( 217 ) , plumbagin ( 179 ) , polyunsaturated_fatty_acid ( 144 ) , PP2 ( 248 ) , PPT ( 105 ) , quercetin ( 214 ) , quinacrine ( 74 ) , raltitrexed ( 246 ) , rapamycin ( 150 , 235 ) , resveratrol ( 5 , 180 ) , RGD ( 180 ) , RITA ( 60 ) , SB202190 ( 58 , 76 , 181 , 231 , 300 ) , SB203580 ( 62 , 89 , 113 , 115 , 231 , 248 , 262 , 272 , 274 , 284 ) , selenite ( 183 , 196 ) , seliciclib ( 158 , 231 , 235 ) , serum_starvation ( 261 , 303 ) , silibinin ( 202 ) , siRNA ( 64 , 111 , 112 , 118 , 123 , 132 , 154 , 158 , 162 , 167 , 176 , 180 , 187 , 209 , 231 , 236 , 263 , 318 ) , SJG-136 ( 184 ) , SN-38 ( 130 , 160 ) , SN-50 ( 272 ) , SNP ( 158 , 272 ) , SOD ( 126 ) , sorbitol ( 261 ) , SP600125 ( 113 , 179 , 265 ) , T-oligo ( 116 ) , tamoxifen ( 277 ) , Tat ( 89 ) , taxol ( 51 , 154 , 249 , 298 ) , THIF ( 143 ) , TMZ ( 2 , 225 ) , topotecan ( 60 ) , TRAIL ( 183 ) , triphala ( 142 ) , U0126 ( 142 , 157 , 231 , 262 ) , UCN-01 ( 270 , 323 ) , UV ( 11 , 33 , 93 , 96 , 105 , 109 , 115 , 126 , 131 , 132 , 138 , 149 , 155 , 160 , 165 , 170 , 173 , 182 , 187 , 202 , 204 , 206 , 210 , 213 , 229 , 236 , 245 , 248 , 249 , 250 , 258 , 263 , 269 , 274 , 275 , 276 , 279 , 282 , 283 , 285 , 289 , 292 , 293 , 294 , 301 , 303 , 308 , 315 , 316 , 317 , 320 ) , UVC ( 7 , 209 ) , VE822 ( 1 ) , vinorelbine ( 238 ) , virus infection ( 68 , 89 , 140 , 228 ) , VRX0466617 ( 87 , 168 ) , wortmannin ( 62 , 111 , 123 , 138 , 158 , 199 , 215 , 228 , 248 , 252 , 262 , 271 , 278 , 284 , 295 , 300 )

Downstream Regulation
Effects of modification on p53:
acetylation ( 133 , 134 , 249 , 278 ) , activity, induced ( 41 , 143 , 188 , 216 , 285 ) , activity, inhibited ( 38 ) , intracellular localization ( 141 , 188 , 189 , 209 , 227 , 250 , 256 , 265 , 268 , 273 , 292 ) , molecular association, regulation ( 24 , 26 , 28 , 41 , 77 , 83 , 145 , 154 , 224 , 294 , 300 , 311 , 320 ) , phosphorylation ( 43 , 55 , 133 , 249 , 304 , 314 ) , protein conformation ( 26 , 320 ) , protein degradation ( 24 , 41 ) , protein stabilization ( 16 , 43 , 68 , 76 , 83 , 266 , 274 , 279 , 294 , 300 ) , ubiquitination ( 24 )
Effects of modification on biological processes:
apoptosis, altered ( 90 , 118 , 216 ) , apoptosis, induced ( 43 , 68 , 145 , 154 , 187 , 188 , 189 , 240 , 274 , 281 ) , carcinogenesis, inhibited ( 60 ) , cell cycle regulation ( 76 , 77 , 92 , 126 , 138 , 229 , 267 , 279 , 301 ) , cell growth, altered ( 86 , 138 , 143 ) , cell growth, inhibited ( 43 , 77 , 209 ) , chromatin organization, altered ( 273 ) , signaling pathway regulation ( 43 , 92 ) , transcription, altered ( 181 , 224 , 240 , 267 , 292 , 296 , 320 ) , transcription, induced ( 16 , 36 , 43 , 109 , 134 , 187 , 217 , 294 ) , transcription, inhibited ( 1 , 243 )
Induce interaction with:
CBP (human) ( 26 , 83 ) , DNA ( 77 ) , MDM2 (human) ( 294 ) , NFkB-p65 (mouse) ( 224 ) , PKHF1 (human) ( 145 ) , PPP2R5C (human) ( 138 ) , TRIM24 (human) ( 41 ) , UBE4B (human) ( 24 )
Inhibit interaction with:
BLM (human) ( 273 ) , MDC1 (human) ( 154 ) , MDM2 (human) ( 300 , 311 , 320 ) , NFkB-p100 (human) ( 28 ) , WRN (human) ( 273 )

Disease / Diagnostics Relevance
Relevant diseases:
ataxia-telangiectasia ( 319 ) , colorectal cancer ( 33 ) , hepatocellular carcinoma ( 68 ) , Down syndrome ( 86 )

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