Tyr491
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Home > Phosphorylation Site Page: > Tyr491  -  DAPK1 (human)

Site Information
CAAWHGyySVAKALC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 487484

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
EGF (human) ( 1 )
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 1 )
Putative upstream phosphatases:
PTPRF (human) ( 1 )
Phosphatases, in vitro:
PTPRF (human) ( 1 )
Treatments:
PP2 ( 1 ) , siRNA ( 1 ) , SU6656 ( 1 )

Downstream Regulation
Effects of modification on DAPK1:
enzymatic activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell adhesion, induced ( 1 ) , cell motility, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal cancer ( 1 )

References 

1

Wang WJ, et al. (2007) The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol Cell 27, 701-16
17803936   Curated Info