Ser897
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser897  -  NMDAR1 (mouse)

Site Information
sFKRRRssKDTSTGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448256

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , 'brain, nucleus accumbens' ( 1 ) , 'brain, striatum' ( 2 , 3 ) , 'neuron, dorsal horn'-spinal cord ( 4 ) , MSN (neuron) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
BD-1047 ( 4 ) , BMY-14802 ( 4 ) , caffeine ( 3 ) , CGS_21680 ( 3 ) , colforsin ( 3 ) , electrical_stimulation ( 1 ) , isoflurane ( 2 ) , ketamine ( 2 ) , painful stimulus ( 4 ) , PCP ( 2 ) , propofol ( 2 )

Downstream Regulation
Effects of modification on biological processes:
neural plasticity ( 1 ) , signaling pathway regulation ( 1 )

References 

1

Lin YH, et al. (2020) Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochem Int 143, 104935
33301817   Curated Info

2

Snyder GL, Galdi S, Hendrick JP, Hemmings HC (2007) General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology 53, 619-30
17826804   Curated Info

3

Sahin B, et al. (2007) Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling. Brain Res 1129, 1-14
17157277   Curated Info

4

Kim HW, et al. (2006) Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice. Br J Pharmacol 148, 490-8
16682960   Curated Info

5

Jarabek BR, Yasuda RP, Wolfe BB (2004) Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model. Brain 127, 505-16
14662521   Curated Info